Yanai Kosuke 梁井公輔

Researcher Number	10621055
Affiliation (Current)	2025: 九州大学, 医学研究院, 共同研究員
Affiliation (based on the past Project Information) *help	2016 – 2023: 九州大学, 医学研究院, 共同研究員
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery Except Principal Investigator Basic Section 55040:Respiratory surgery-related / Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator 浸潤能 / 膵癌 / 遊走能 / 診断補助因子 / 予後予測因子 / 膵癌治療 / 腫瘍形成能 / 新規治療法開発 / 増殖能 / 悪性形質誘導 … More / 低酸素環境 / 再酸素化 / 転移 / 癌新規治療法開発 / がん再発 / 細胞周期 / 癌休眠 / 膵癌転移 / C4orf47 / 新規治療標的 / 腫瘍形成 / 浸潤 / 増殖 / 癌微小環境 / 治療標的因子 / チロシンキナーゼ / MAPK経路 / 癌悪性形質 / PTPN3 / ＢＤＮＦ / ＴｒｋＢ / 膵癌悪性化 / 膵癌悪性形質 / TrkB/BDNFシグナル / 治療標的分子 / 治療法開発 / BDNF / TrkB … More Except Principal Investigator 浸潤 / 増殖 / 新規治療法開発 / 浸潤能 / 増殖能 / 予後因子 / FAM115c / 癌微小環境 / 遊走 / 診断補助因子 / 予後予測因子 / 治療標的因子 / バイオマーカー / 遊走抑制 / 浸潤抑制 / 増殖抑制 / 癌治療法開発 / 肺神経内分泌腫瘍 / 抗腫瘍効果 / 癌悪性形質 / 肺NET / FAM115C / Notchシグナル / 胆嚢癌 / 癌悪性形質誘導 / 胆のうがん / 形態形成シグナル / NOTCHシグナル / Hedgehogシグナル / MAML3 Less

Analysis of the mechanism of pancreatic cancer metastasis targeting the kinetics of C4orf47 expression by reoxygenationPrincipal Investigator
- Principal Investigator
  
  梁井公輔
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
Development of a new therapeutic strategy for gallbladder cancer targeting MAML3 by the inhibition of both Hh and Notch signaling
- Principal Investigator
  
  山崎章生
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
Analysis of biological significance of FAM115c for development of a new therapeutic strategy of lung NET
- Principal Investigator
  
  永井俊太郎
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Kyushu University
Development of new therapeutic strateg for pancreatic cancer targeting protein tyrosine phosphatase non-receptor type 3 (PTPN3)Principal Investigator
- Principal Investigator
  
  YANAI Kosuke
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kyushu University
Analysis of TrkB/BDNF signaling for development of a new therapeutic strategy for pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  Yanai Kosuke
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kyushu University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Cancer therapy that targets the HEDGEHOG signaling pathway considering the cancer microenvironment2022
- Author(s)
  Onishi H, Nakamura K, Yanai K, Nagai S, Nakayama K, Oyama Y, Fujimura A, Ozono K, Yamasaki A
- Journal Title
  
  Oncol Rep
  
  Volume: 47(5) Issue: 5 Pages: 93-93
- DOI
  10.3892/or.2022.8304
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22662, KAKENHI-PROJECT-20K09180, KAKENHI-PROJECT-21K08906, KAKENHI-PROJECT-21K08673, KAKENHI-PROJECT-21K08712, KAKENHI-PROJECT-21K09583, KAKENHI-PROJECT-22K08715, KAKENHI-PROJECT-23K24422
[Journal Article] PTPN3 could be a therapeutic target of pancreatic cancer2022
- Author(s)
  Onishi H, Iwamoto N, Sakanashi K, Koga S, Oyama Y, Yanai K, Nakamura K, Nagai S, Fujimura A, Nakayama K, Ozono K, Yamasaki A
- Journal Title
  
  Anticancer Res
  
  Volume: 42 Issue: 6 Pages: 2869-2874
- DOI
  10.21873/anticanres.15768
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08672, KAKENHI-PROJECT-21K08673, KAKENHI-PROJECT-21K08712, KAKENHI-PROJECT-21K08906, KAKENHI-PROJECT-21K09583, KAKENHI-PROJECT-22K08715, KAKENHI-PROJECT-20K09180, KAKENHI-PROJECT-23K24422
[Journal Article] TrkB/BDNF signaling could be a new therapeutic target for pancreatic cancer2021
- Author(s)
  Oyama Y, Nagao S, Na L, Yanai K, Umebayashi M, Nakamura K, Nagai S, Fujimura A, Nakayama K, Morisaki T, Onishi H
- Journal Title
  
  Anticancer Res
  
  Volume: 41(8) Issue: 8 Pages: 4047-4052
- DOI
  10.21873/anticanres.15205
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09124, KAKENHI-PROJECT-19K22662, KAKENHI-PROJECT-20K09180, KAKENHI-PROJECT-21K08673, KAKENHI-PROJECT-21K08712, KAKENHI-PROJECT-21K08906, KAKENHI-PROJECT-21K09583
[Journal Article] Liprin-alphaa new therapeutic target for SCLC as an upstream mediator of HIF1alpha2019
- Author(s)
  Onishi H, Yamasaki A, Nakamura K, Ichimiya S, Yanai K, Umebayashi M, Nagai S, Morisaki T
- Journal Title
  
  Anticancer Research
  
  Volume: 39(3) Issue: 3 Pages: 1179-1184
- DOI
  10.21873/anticanres.13227
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04283, KAKENHI-PROJECT-16K10603, KAKENHI-PROJECT-18K08620, KAKENHI-PROJECT-18K08682, KAKENHI-PROJECT-18K08788, KAKENHI-PROJECT-17K10792
[Journal Article] RBPJ and MAML3: Potential therapeutic targets for small cell lung cancer.2018
- Author(s)
  Onishi H, Ichimiya S, Yanai K, Umebayashi M, Nakamura K, Yamasaki A, Imaizumi A, Nagai S, Murahashi M, Ogata H, Morisaki T
- Journal Title
  
  Anticancer Research
  
  Volume: 38(5) Issue: 8 Pages: 4543-4547
- DOI
  10.21873/anticanres.12758
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10792, KAKENHI-PROJECT-18K08620, KAKENHI-PROJECT-18K08788, KAKENHI-PROJECT-17H04283, KAKENHI-PROJECT-16K10603, KAKENHI-PROJECT-17K09464
[Journal Article] Hedgehog inhibition upregulates TRK expression to antagonize tumor suppression in small cell lung cancer cells.2017
- Author(s)
  Onishi H, Nakamura K, Nagai S, Yanai K, Yamasaki A, Kawamoto M, Imaizumi A, Morisaki T
- Journal Title
  
  Anticancer Res
  
  Volume: 37(9) Pages: 4987-4992
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10603
[Presentation] 低酸素環境で発現亢進する形態形成関連分子： SMO、MAML3、CPAMD8を標的とした新たな膵癌治療開発2023
- Author(s)
  大西秀哉、山崎章生、大山康博、永井俊太郎、梁井公輔、中山和典、中村雅史
- Organizer
  第78回日本消化器外科学会
- Data Source
  KAKENHI-PROJECT-21K08906
[Presentation] 低酸素環境で発現亢進する形態形成関連分子： SMO、MAML3、CPAMD8を標的とした新たな膵癌治療開発2023
- Author(s)
  大西秀哉、山崎章生、大山康博、永井俊太郎、梁井公輔、中山和典、中村雅史
- Organizer
  第78回日本消化器外科学会
- Data Source
  KAKENHI-PROJECT-21K08712
[Presentation] 低酸素環境で発現亢進する形態形成関連分子： SMO、MAML3、CPAMD8を標的とした新たな膵癌治療開発2023
- Author(s)
  大西秀哉、山崎章生、大山康博、永井俊太郎、梁井公輔、中山和典、中村雅史
- Organizer
  第78回日本消化器外科学会
- Data Source
  KAKENHI-PROJECT-23K08132
[Presentation] 低酸素環境を考慮した固形癌包括的治療を目指した癌病態解析2021
- Author(s)
  大西秀哉、山崎章生、永井俊太郎、梁井公輔、中村雅史
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K08906
[Presentation] 低酸素環境を考慮した固形癌包括的治療を目指した癌病態解析2021
- Author(s)
  大西秀哉、山崎章生、永井俊太郎、梁井公輔、中村雅史
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K08712
[Presentation] 低酸素環境を考慮した固形癌包括的治療を目指した癌病態解析2021
- Author(s)
  大西秀哉、山崎章生、永井俊太郎、梁井公輔、中村雅史
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09124
[Presentation] チロシン脱リン酸化酵素PTPN3を標的とした新規膵癌治療開発（第2報）2021
- Author(s)
  山崎章生、大西秀哉、梁井公輔、中村雅史
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09124
[Presentation] チロシン脱リン酸化酵素PTPN3を標的とした新規膵癌治療開発（第2報）2021
- Author(s)
  山崎章生、大西秀哉、梁井公輔、中村雅史
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K08906
[Presentation] チロシン脱リン酸化酵素PTPN3を標的とした新規膵癌治療開発（第2報）2021
- Author(s)
  山崎章生、大西秀哉、梁井公輔、中村雅史
- Organizer
  第121回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-21K08712
[Presentation] チロシン脱リン酸化酵素(PTPN3)は新規膵癌治療法の標的となりうる2020
- Author(s)
  山崎章生、大西秀哉、梁井公輔、森崎　隆、中村雅史
- Organizer
  第24回バイオ治療法研究会
- Data Source
  KAKENHI-PROJECT-19K09124
[Presentation] チロシン脱リン酸化酵素PTPN3を標的とした新規膵癌治療開発2020
- Author(s)
  山崎章生、大西秀哉、梁井公輔、中村雅史
- Organizer
  第120回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-19K09124
[Presentation] 肺癌における神経栄養因子受容体TrkBの治療標的としての可能性の検討2018
- Author(s)
  中村勝也、大西秀哉、尾立西市、大薗慶吾、梁井公輔、中村雅史
- Organizer
  第31回　日本バイオセラピィ学会学術集会総会
- Data Source
  KAKENHI-PROJECT-16K10603
[Presentation] TrkBシグナルとHedgehogシグナルの負のクロストークを考慮した小細胞肺癌に対する新たな治療法の開発2018
- Author(s)
  大西秀哉、中村勝也、梁井公輔、川元　真、大山康博、中山和典、山崎章生、三好　圭、中村雅史
- Organizer
  第118回　日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-16K10603
[Presentation] TrkB/BDNF signaling pathway could be a therapeutic target for lung cancer2018
- Author(s)
  Nakamura K, Onishi H, Odate S, Ozono K, Yanai K, Nakamura M
- Organizer
  第77回　日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K10603
[Presentation] HedgehogシグナルとTrkBシグナルとのクロストークの視点に立った小細胞肺癌に対する新規治療法開発2017
- Author(s)
  大西秀哉、中村勝也、梁井公輔、川元　真、藤村晶子、大山康弘、中山和典、山崎章生、中村雅史
- Organizer
  第３０回日本バイオセラピィ学会学術集会総会
- Data Source
  KAKENHI-PROJECT-16K10603

1. 大西秀哉 (30553276)

# of Collaborated Projects: 5 results

# of Collaborated Products: 21 results
2. 永井俊太郎 (90755240)

# of Collaborated Projects: 5 results

# of Collaborated Products: 11 results
3. 三好圭 (70755272)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. 中村勝也 (60585743)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
5. 山崎章生 (80404440)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
6. 今泉晃 (30624051)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 大薗慶吾 (60912847)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 緒方久修 (70432945)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KENJI Nakano

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 中村雅史

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Yanai Kosuke 梁井 公輔

Research Projects

Research Products

Co-Researchers

Analysis of the mechanism of pancreatic cancer metastasis targeting the kinetics of C4orf47 expression by reoxygenationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new therapeutic strategy for gallbladder cancer targeting MAML3 by the inhibition of both Hh and Notch signaling

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of biological significance of FAM115c for development of a new therapeutic strategy of lung NET

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new therapeutic strateg for pancreatic cancer targeting protein tyrosine phosphatase non-receptor type 3 (PTPN3)Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of TrkB/BDNF signaling for development of a new therapeutic strategy for pancreatic cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Cancer therapy that targets the HEDGEHOG signaling pathway considering the cancer microenvironment2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PTPN3 could be a therapeutic target of pancreatic cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TrkB/BDNF signaling could be a new therapeutic target for pancreatic cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Liprin-alphaa new therapeutic target for SCLC as an upstream mediator of HIF1alpha2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RBPJ and MAML3: Potential therapeutic targets for small cell lung cancer.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hedgehog inhibition upregulates TRK expression to antagonize tumor suppression in small cell lung cancer cells.2017

Author(s)

Journal Title

Data Source

[Presentation] 低酸素環境で発現亢進する形態形成関連分子： SMO、MAML3、CPAMD8を標的とした新たな膵癌治療開発2023

Author(s)

Organizer

Data Source

[Presentation] 低酸素環境で発現亢進する形態形成関連分子： SMO、MAML3、CPAMD8を標的とした新たな膵癌治療開発2023

Author(s)

Organizer

Data Source

[Presentation] 低酸素環境で発現亢進する形態形成関連分子： SMO、MAML3、CPAMD8を標的とした新たな膵癌治療開発2023

Author(s)

Organizer

Data Source

[Presentation] 低酸素環境を考慮した固形癌包括的治療を目指した癌病態解析2021

Author(s)

Organizer

Data Source

[Presentation] 低酸素環境を考慮した固形癌包括的治療を目指した癌病態解析2021

Yanai Kosuke 梁井公輔