Sakai Daisuke 坂井大介

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SAKAI Daisuke 坂井大介

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Researcher Number	10621071
Other IDs	https://orcid.org/0000-0002-9436-7553
Affiliation (Current)	2025: 大阪大学, 医学部附属病院, 特任講師(常勤)
Affiliation (based on the past Project Information) *help	2020: 大阪大学, 医学部附属病院, 特任講師(常勤) 2019: 大阪大学, 医学部附属病院, 特任講師 2016 – 2018: 大阪大学, 医学系研究科, 寄附講座助教 2014 – 2015: 大阪大学, 医学(系)研究科(研究院), 寄附講座助教
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Digestive surgery Except Principal Investigator Basic Section 55020:Digestive surgery-related / General surgery
Keywords	Principal Investigator 人工知能 / 消化器がん / 化学療法 / 発生・分化 / 糖尿病 / 再生医学 Except Principal Investigator 癌 / バイオマーカー / 創薬 / ピルビン酸キナーゼ … More / 代謝 / 転移 / がん / シングル細胞 / 化学療法 / 酵素 Less

Realization of precision medicine for cancer chemotherapyPrincipal Investigator
- Principal Investigator
  
  SAKAI Daisuke
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
Elucidation and application of early brain metastasis mechanism by Warburg regulator MPC
- Principal Investigator
  
  KUDO Toshihiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka International Cancer Institute
New development of epigenome drug discovery to realize oncogene selectivity
- Principal Investigator
  
  SATOH Taroh
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General surgery
- Research Institution
  Osaka University
Identification of new chemical compound to induce pancreatic beta-cellsPrincipal Investigator
- Principal Investigator
  
  SAKAI Daisuke
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University

All 2020 2018 2017 2016 2014

All Journal Article

[Journal Article] Comparison of S-1?cisplatin every 5?weeks with capecitabine-cisplatin every 3?weeks for HER2-negative gastric cancer (recurrent after S-1 adjuvant therapy or chemotherapy-na?ve advanced): pooled analysis of HERBIS-2 (OGSG 1103) and HERBIS-4A (OGSG 1105) trials2020
- Author(s)
  Kawakami Hisato、for the Osaka Gastrointestinal Cancer Chemotherapy Study Group (OGSG)、Fujitani Kazumasa、Matsuyama Jin、Akamaru Yusuke、Tamura Shigeyuki、Endo Shunji、Kimura Yutaka、Makari Youichi、Tamura Takao、Sugimoto Naotoshi、Sakai Daisuke et al
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 25 Issue: 9 Pages: 1635-1643
- DOI
  10.1007/s10147-020-01711-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08617
[Journal Article] A phase II trial of dose-reduced nab-paclitaxel for patients with previously treated, advanced or recurrent gastric cancer (OGSG 1302)2020
- Author(s)
  Tamura Shigeyuki、Taniguchi Hirokazu、Nishikawa Kazuhiro、Imamura Hiroshi、Fujita Junya、Takeno Atsushi、Matsuyama Jin、Kimura Yutaka、Kawada Junji、Hirao Motohiro、Hirota Masashi、Fujitani Kazumasa、Kurokawa Yukinori、Sakai Daisuke、Kawakami Hisato、Shimokawa Toshio、Satoh Taroh
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 25 Issue: 12 Pages: 2035-2043
- DOI
  10.1007/s10147-020-01768-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08617
[Journal Article] Evaluation of FOLFOX or CAPOX reintroduction with or without bevacizumab in relapsed colorectal cancer patients treated with oxaliplatin as adjuvant chemotherapy (REACT study)2020
- Author(s)
  Kotaka Masahito、Iwamoto Shigeyoshi、Satake Hironaga、Sakai Daisuke、Kudo Toshihiro、Fukunaga Mutsumi、Konishi Ken、Ide Yoshihito、Ikumoto Taro、Tsuji Akihito、Sano Yasushi、Kato Takeshi、Sugimoto Naotoshi、Satoh Taroh、Kanazawa Akiyoshi、Kurata Takayasu、Yamanaka Takeharu、Tomita Naohiro
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 25 Issue: 8 Pages: 1515-1522
- DOI
  10.1007/s10147-020-01701-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08617, KAKENHI-PROJECT-18K08704
[Journal Article] Computational trans-omics approach characterised methylomic and transcriptomic involvements and identified novel therapeutic targets for chemoresistance in gastrointestinal cancer stem cells2018
- Author(s)
  Konno Masamitsu、Matsui Hidetoshi、Koseki Jun、Asai Ayumu、Kano Yoshihiro、Kawamoto Koichi、Nishida Naohiro、Sakai Daisuke、Kudo Toshihiro、Satoh Taroh、Doki Yuichiro、Mori Masaki、Ishii Hideshi
- Journal Title
  
  Sci. Rep.
  
  Volume: 8 Issue: 1 Pages: 899-899
- DOI
  10.1038/s41598-018-19284-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19698, KAKENHI-PROJECT-15H01678, KAKENHI-PROJECT-17H04282, KAKENHI-PROJECT-15H05664, KAKENHI-PROJECT-16K15591, KAKENHI-PROJECT-16K15592, KAKENHI-PROJECT-16K15615, KAKENHI-PROJECT-16K15616
[Journal Article] Enzymes of the one-carbon folate metabolism as anticancer targets predicted by survival rate analysis2018
- Author(s)
  Koseki Jun、Konno Masamitsu、Asai Ayumu、Colvin Hugh、Kawamoto Koichi、Nishida Naohiro、Sakai Daisuke、Kudo Toshihiro、Satoh Taroh、Doki Yuichiro、Mori Masaki、Ishii Hideshi
- Journal Title
  
  Sci. Rep.
  
  Volume: 8 Issue: 1 Pages: 303-303
- DOI
  10.1038/s41598-017-18456-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19698, KAKENHI-PROJECT-17H04282, KAKENHI-PROJECT-15H05664, KAKENHI-PROJECT-16K15591, KAKENHI-PROJECT-16K15592, KAKENHI-PROJECT-16K15615, KAKENHI-PROJECT-16K15616
[Journal Article] A Convolutional Neural Network Uses Microscopic Images to Differentiate between Mouse and Human Cell Lines and Their Radioresistant Clones2018
- Author(s)
  Toratani Masayasu、Konno Masamitsu、Asai Ayumu、Koseki Jun、Kawamoto Koichi、Tamari Keisuke、Li Zhihao、Sakai Daisuke、Kudo Toshihiro、Satoh Taroh、Sato Katsutoshi、Motooka Daisuke、Okuzaki Daisuke、Doki Yuichiro、Mori Masaki、Ogawa Kazuhiko、Ishii Hideshi
- Journal Title
  
  Cancer Research
  
  Volume: 78 Issue: 23 Pages: 6703-6707
- DOI
  10.1158/0008-5472.can-18-0653
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08617, KAKENHI-PROJECT-18K16355, KAKENHI-PROJECT-18K16356, KAKENHI-PROJECT-18KK0251, KAKENHI-PROJECT-17H04282, KAKENHI-PROJECT-17K19698, KAKENHI-PROJECT-16H06279
[Journal Article] Cell?free culture conditioned medium elicits pancreatic β cell lineage?specific epigenetic reprogramming in mice2018
- Author(s)
  Kawamoto Koichi、Ohashi Tomofumi、Konno Masamitsu、Nishida Naohiro、Koseki Jun、Matsui Hidetoshi、Sakai Daisuke、Kudo Toshihiro、Eguchi Hidetoshi、Satoh Taroh、Doki Yuichiro、Mori Masaki、Ishii Hideshi
- Journal Title
  
  Oncology Letters
  
  Volume: 16 Pages: 3255-3259
- DOI
  10.3892/ol.2018.9008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08617, KAKENHI-PROJECT-18K08704, KAKENHI-PROJECT-18K16356, KAKENHI-PROJECT-18KK0251, KAKENHI-PROJECT-16H02790, KAKENHI-PROJECT-17H04282, KAKENHI-PROJECT-17K19698
[Journal Article] Hypoxia stimulates the cytoplasmic localization of oncogenic long noncoding RNA LINC00152 in colorectal cancer2017
- Author(s)
  Nishizawa Yujiro、Konno Masamitsu、Asai Ayumu、Koseki Jun、Kawamoto Koichi、Miyoshi Norikatsu、Takahashi Hidekazu、Nishida Naohiro、Haraguchi Naotsugu、Sakai Daisuke、Kudo Toshihiro、Hata Taishi、Matsuda Chu、Mizushima Tsunekazu、Satoh Taroh、Doki Yuichiro、Mori Masaki、Ishii Hideshi
- Journal Title
  
  Int. J. Oncol.
  
  Volume: 52 Pages: 453-460
- DOI
  10.3892/ijo.2017.4218
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19698, KAKENHI-PROJECT-17H04282, KAKENHI-PROJECT-15H05664, KAKENHI-PROJECT-16K15591, KAKENHI-PROJECT-16K15592, KAKENHI-PROJECT-16K15615, KAKENHI-PROJECT-16K15616
[Journal Article] Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer2017
- Author(s)
  Nishizawa Yujiro、Konno Masamitsu、Asai Ayumu、Koseki Jun、Kawamoto Koichi、Miyoshi Norikatsu、Takahashi Hidekazu、Nishida Naohiro、Haraguchi Naotsugu、Sakai Daisuke、Kudo Toshihiro、Hata Taishi、Matsuda Chu、Mizushima Tsunekazu、Satoh Taroh、Doki Yuichiro、Mori Masaki、Ishii Hideshi
- Journal Title
  
  Oncotarget.
  
  Volume: 9 Issue: 7 Pages: 7476-7486
- DOI
  10.18632/oncotarget.23554
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19698, KAKENHI-PROJECT-17H04282, KAKENHI-PROJECT-15H05664, KAKENHI-PROJECT-16K15591, KAKENHI-PROJECT-16K15592, KAKENHI-PROJECT-16K15615, KAKENHI-PROJECT-16K15616
[Journal Article] BRAF V600E inhibition stimulates AMPK-mediated autophagy in colorectal cancer.2016
- Author(s)
  Sueda, T., Sakai, D., Kawamoto, K., Konno, M., Nishida, N., Koseki, J., Colvin, S. H., Takahashi, H., Haraguchi, N., Nishimura, J., Hata, T., Takemasa, I., Mizushima, T., Yamamoto, H., Satoh, T., Doki, Y., Mori, M., Ishii, H.
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 18949-18949
- DOI
  10.1038/srep18949
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26670603, KAKENHI-PROJECT-26670604
[Journal Article] Impact of capecitabine and S-1 on anticoagulant activity of warfarin in patients with gastrointestinal cancer.2016
- Author(s)
  Hata, T., Kudo, T., Sakai, D., Takahashi, H., Haraguchi, N., Nishimura, J., Hata, T., Mizushima, T., Yamamoto, H., Doki, Y., Mori, M., Satoh, T.
- Journal Title
  
  Cancer Chemother Pharmacol.
  
  Volume: 78 Issue: 2 Pages: 389-396
- DOI
  10.1007/s00280-016-3080-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K15475, KAKENHI-PROJECT-16K15592
[Journal Article] Safety and pharmacokinetics of S-1 in a recurrent colon cancer patient with chronic myeloid leukemia treated with dasatinib: A case report.2014
- Author(s)
  Sueda T., Kudo T., Sakai D., Uemura M., Nishimura J., Hata T., Takemasa I., Mizushima T., Yamamoto H., Ezoe S., Matsumoto K., Doki Y., Mori M., Satoh T.
- Journal Title
  
  Cancer Chemother Pharmacol.
  
  Volume: 74 Issue: 6 Pages: 1321-1324
- DOI
  10.1007/s00280-014-2620-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670576, KAKENHI-PROJECT-25670577, KAKENHI-PROJECT-26670603

1. ISHII Hideshi (10280736)

# of Collaborated Projects: 4 results

# of Collaborated Products: 7 results
2. KONNO Masamitsu (80618207)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
3. SATOH Taroh (40368303)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. KUDO Toshihiro (20593859)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 小関準 (20616669)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. MORI Masaki (70190999)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
7. 西田尚弘 (50588118)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 川本弘一 (30432470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
9. DOKI yuichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

Sakai Daisuke 坂井 大介

SAKAI Daisuke 坂井 大介

Research Projects

Research Products

Co-Researchers

Realization of precision medicine for cancer chemotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation and application of early brain metastasis mechanism by Warburg regulator MPC

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New development of epigenome drug discovery to realize oncogene selectivity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of new chemical compound to induce pancreatic beta-cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Comparison of S-1?cisplatin every 5?weeks with capecitabine-cisplatin every 3?weeks for HER2-negative gastric cancer (recurrent after S-1 adjuvant therapy or chemotherapy-na?ve advanced): pooled analysis of HERBIS-2 (OGSG 1103) and HERBIS-4A (OGSG 1105) trials2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A phase II trial of dose-reduced nab-paclitaxel for patients with previously treated, advanced or recurrent gastric cancer (OGSG 1302)2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of FOLFOX or CAPOX reintroduction with or without bevacizumab in relapsed colorectal cancer patients treated with oxaliplatin as adjuvant chemotherapy (REACT study)2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Computational trans-omics approach characterised methylomic and transcriptomic involvements and identified novel therapeutic targets for chemoresistance in gastrointestinal cancer stem cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enzymes of the one-carbon folate metabolism as anticancer targets predicted by survival rate analysis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Convolutional Neural Network Uses Microscopic Images to Differentiate between Mouse and Human Cell Lines and Their Radioresistant Clones2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cell?free culture conditioned medium elicits pancreatic β cell lineage?specific epigenetic reprogramming in mice2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hypoxia stimulates the cytoplasmic localization of oncogenic long noncoding RNA LINC00152 in colorectal cancer2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] BRAF V600E inhibition stimulates AMPK-mediated autophagy in colorectal cancer.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of capecitabine and S-1 on anticoagulant activity of warfarin in patients with gastrointestinal cancer.2016

Sakai Daisuke 坂井大介

SAKAI Daisuke 坂井大介