Nagao Toshikage 長尾俊景

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NAGAO TOSHIKAGE 長尾俊景

NAGAO Toshikage 長尾俊景

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Researcher Number	10622798
Other IDs
Affiliation (Current)	2025: 東京科学大学, 大学院医歯学総合研究科, 講師
Affiliation (based on the past Project Information) *help	2025: 東京科学大学, 大学院医歯学総合研究科, 講師 2022 – 2023: 東京医科歯科大学, 大学院医歯学総合研究科, 講師 2021: 東京医科歯科大学, 東京医科歯科大学病院, 助教 2019 – 2020: 東京医科歯科大学, 医学部附属病院, 助教 2012 – 2013: 東京医科歯科大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology
Keywords	Principal Investigator 難治性B細胞腫瘍 / 治療プライミング効果 / 抗体-TLRリガンド複合体 / 抗体-オリゴヌクレオチド複合体 / S化CpG-ODN / 細胞内浸透抗体 / COT / 臨床的バイオマーカー / COT（TPL2） / MYD88 / Jak2-V617F / 造血器腫瘍

The novel TLR4 ligand-antibody conjugate effectively sensitizes refractory B-cell lymphoma to target therapies.Principal Investigator
- Principal Investigator
  
  長尾俊景
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Institute of Science Tokyo
Therapeutic potential of novel antibody-oligonucleotide conjugate for intractable B-cell lymphomasPrincipal Investigator
- Principal Investigator
  
  長尾俊景
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokyo Medical and Dental University
COT, a new molecular target in refractory B-cell malignancies and its clinical applicationPrincipal Investigator
- Principal Investigator
  
  NAGAO TOSHIKAGE
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Tokyo Medical and Dental University
Mechanisms involved in degradation of activated thyrosine kinase mutants induced by anti-cancer drugs and its clinical applicationPrincipal Investigator
- Principal Investigator
  
  NAGAO Toshikage
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical and Dental University

All 2021 2020 2019 2014 2013 2012

All Journal Article Presentation

[Journal Article] Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera.2014
- Author(s)
  Nagao T, Kurosu T, Umezawa Y, Nogami A, Oshikawa G, Tohda S, Yamamoto M, Miura O
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 1 Pages: e84746-e84746
- DOI
  10.1371/journal.pone.0084746
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591384, KAKENHI-PROJECT-24790966, KAKENHI-PROJECT-26461416
[Journal Article] PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positiveleukemia cells2013
- Author(s)
  Wu N, Kurosu T, Oshikawa G, Nagao T,Miura O
- Journal Title
  
  Int J Oncol
  
  Volume: 42(2) Issue: 2 Pages: 419-28
- DOI
  10.3892/ijo.2012.1729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591030, KAKENHI-PROJECT-24591384, KAKENHI-PROJECT-24790966
[Journal Article] Inhibition of the PI3K/Akt/GSK3 Pathway Downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD Downregulates DNA Damage-Induced Chk1 Activation as Well as G2/M Arrest and Prominently Enhances Induction of Apoptosis2013
- Author(s)
  Kurosu T, Nagao T, Wu N, Oshikawa G, Miura O
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 11 Pages: e79478-e79478
- DOI
  10.1371/journal.pone.0079478
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591384, KAKENHI-PROJECT-24790966
[Presentation] Involvement of TPL2/p105/STAT3 axis in tumorigenesis of ABC-DLBCL2021
- Author(s)
  吉藤康太、本村鷹多朗、野上彩子、岡田啓五、森毅彦、長尾俊景
- Organizer
  日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08832
[Presentation] Tpl2 (COT kinase) regulates cell survival and proliferation in ABC-like DLBCL.2020
- Author(s)
  Toshikage Nagao
- Organizer
  第82回日本血液学術集会
- Data Source
  KAKENHI-PROJECT-19K08832
[Presentation] Establishment and characterization of the new ABC-type DLBCL cell line TMD122019
- Author(s)
  Toshikage Nagao
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08832
[Presentation] Establishment of TNET-1, a novel cell line derived from triple-negative essential thrombocythemia2019
- Author(s)
  Toshikage Nagao
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K08832
[Presentation] Molecular biological analysis of a novel MYD88 mutation, L265-RPP, in Waldenstrom macrogloblinemia2013
- Author(s)
  長尾俊景, 梅澤佳央, 野上彩子, 黒須哲也, 三浦修
- Organizer
  第75回日本血液学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24790966
[Presentation] Molecular biological analysis of a novel MYD88 mutation, L265-RPP, in Waldenstrom macroglobulinemia2013
- Author(s)
  Nagao T, Umezawa Y, Nogami A, Kurosu T, Miura O.
- Organizer
  第７５回日本血液学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24790966
[Presentation] Molecular basis for differential response of Flt3-ITD and TKD toPI3K/Akt and proteasome inhibitors2013
- Author(s)
  野上彩子, 押川学, 福武周作, 長尾俊景, 梅澤佳央, 黒須哲也, 三浦修
- Organizer
  第75回日本血液学会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24790966
[Presentation] Molecular basis for differential response of Flt3-ITD and TDK to PI3K/Akt and proteasome inhibitors.2013
- Author(s)
  野上　彩子、押川　学、福武　周作、長尾　俊景、梅澤　佳央、黒須　哲也、三浦　修
- Organizer
  第７５回日本血液学会総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24790966
[Presentation] Flt3-ITD及びFlt3-TKD発現細胞の分子標的薬への感受性の差違とその分子基盤2012
- Author(s)
  押川　学、長尾　俊景、野上　彩子、呉　楠、黒須　哲也、三浦　修
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24790966
[Presentation] 新規樹立Jak2-V617F発現白血病細胞株PV-T1でのLyn活性化を伴う細胞増殖シグナル伝達機構2012
- Author(s)
  長尾　俊景、山本　正英、押川　学、野上　彩子、呉　楠、黒須　哲也、東田　修二、三浦　修
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24790966
[Presentation] 新規樹立Jak2-V617F 発現白血病細胞株PV-T1 でのLyn 活性化を伴う細胞増殖シグナル伝達機構2012
- Author(s)
  長尾俊景, 山本正英, 押川学, 野上彩子, 呉楠, 黒須哲也, 東田修二, 三浦修
- Organizer
  第74回日本血液学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24790966
[Presentation] BCR/ABL 発現細胞におけるChk1 とp53 を介した細胞周期チェックポイント活性化の相互調節機構2012
- Author(s)
  黒須哲也, 呉楠, 野上彩子, 押川学, 長尾俊景, 三浦修
- Organizer
  第74回日本血液学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24790966
[Presentation] BCR/ABL発現細胞におけるChk1とp53を介した細胞周期チェックポイント活性化の相互調節機構2012
- Author(s)
  黒須　哲也、呉　楠、野上　彩子、押川　学、長尾　俊景、三浦　修
- Organizer
  第74回日本血液学会学術集会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24790966
[Presentation] Flt3-ITD 及びFlt3-TKD 発現細胞の分子標的薬への感受性の差異とその分子基盤2012
- Author(s)
  押川学, 長尾俊景, 野上彩子, 呉楠, 黒須哲也, 三浦修
- Organizer
  第74回日本血液学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-24790966

1. 黒須哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 三浦修

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Nagao Toshikage 長尾 俊景

NAGAO TOSHIKAGE 長尾 俊景

NAGAO Toshikage 長尾 俊景

Research Projects

Research Products

Co-Researchers

The novel TLR4 ligand-antibody conjugate effectively sensitizes refractory B-cell lymphoma to target therapies.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Therapeutic potential of novel antibody-oligonucleotide conjugate for intractable B-cell lymphomasPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

COT, a new molecular target in refractory B-cell malignancies and its clinical applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms involved in degradation of activated thyrosine kinase mutants induced by anti-cancer drugs and its clinical applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PECAM-1 is involved in BCR/ABL signaling and may downregulate imatinib-induced apoptosis of Philadelphia chromosome-positiveleukemia cells2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inhibition of the PI3K/Akt/GSK3 Pathway Downstream of BCR/ABL, Jak2-V617F, or FLT3-ITD Downregulates DNA Damage-Induced Chk1 Activation as Well as G2/M Arrest and Prominently Enhances Induction of Apoptosis2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] Involvement of TPL2/p105/STAT3 axis in tumorigenesis of ABC-DLBCL2021

Author(s)

Organizer

Data Source

[Presentation] Tpl2 (COT kinase) regulates cell survival and proliferation in ABC-like DLBCL.2020

Author(s)

Organizer

Data Source

[Presentation] Establishment and characterization of the new ABC-type DLBCL cell line TMD122019

Author(s)

Organizer

Data Source

[Presentation] Establishment of TNET-1, a novel cell line derived from triple-negative essential thrombocythemia2019

Author(s)

Organizer

Data Source

[Presentation] Molecular biological analysis of a novel MYD88 mutation, L265-RPP, in Waldenstrom macrogloblinemia2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Molecular biological analysis of a novel MYD88 mutation, L265-RPP, in Waldenstrom macroglobulinemia2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Molecular basis for differential response of Flt3-ITD and TKD toPI3K/Akt and proteasome inhibitors2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Molecular basis for differential response of Flt3-ITD and TDK to PI3K/Akt and proteasome inhibitors.2013

Author(s)

Organizer

Place of Presentation

Nagao Toshikage 長尾俊景

NAGAO TOSHIKAGE 長尾俊景

NAGAO Toshikage 長尾俊景