Odagiri Naoshi 小田桐直志

Researcher Number	10623241
Other IDs
Affiliation (Current)	2025: 大阪公立大学, 大学院医学研究科, 病院講師
Affiliation (based on the past Project Information) *help	2022 – 2023: 大阪公立大学, 大学院医学研究科, 病院講師 2019 – 2021: 大阪市立大学, 大学院医学研究科, 病院講師
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / 0902:General internal medicine and related fields
Keywords	Principal Investigator 肝がん / 細胞老化 / 肝星細胞 / バイオマーカー / 分泌因子 / 肝細胞癌 / 肝硬変 / 老化関連分泌表現型 / 好中球 / IL-8 … More / 可溶性免疫チェックポイント蛋白 / 免疫治療 / グリピカン3 / 化学療法 Less

肝星細胞老化関連分泌因子IL-8が肝がん治療効果に与える分子機序の解明Principal Investigator
- Principal Investigator
  
  小田桐直志
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka Metropolitan University
Molecular mechanism of senescence-associated secretory factor-induced liver cancerPrincipal Investigator
- Principal Investigator
  
  Odagiri Naoshi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Osaka Metropolitan University
  Osaka City University
functional analysis of senescence-associated secretory factors from human hepatic stellate cells in liver cancer microenvironmentPrincipal Investigator
- Principal Investigator
  
  Odagiri Naoshi
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0902:General internal medicine and related fields
- Research Institution
  Osaka City University

All 2023 2022 2021 2020 2019 Other

All Journal Article Presentation Other

[Journal Article] A case of hepatocellular carcinoma with “pseudoprogression” followed by complete response to atezolizumab plus bevacizumab2023
- Author(s)
  Odagiri Naoshi、Tamori Akihiro、Kotani Kohei、Motoyama Hiroyuki、Kawamura Etsushi、Hagihara Atsushi、Fujii Hideki、Uchida?Kobayashi Sawako、Enomoto Masaru、Kawada Norifumi
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: - Issue: 3 Pages: 392-396
- DOI
  10.1007/s12328-023-01761-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16967, KAKENHI-PROJECT-17K09467, KAKENHI-PROJECT-23K24322
[Journal Article] 肝線維化進展の分子機序、血中肝線維化マーカー2022
- Author(s)
  小田桐直志、河田則文
- Journal Title
  
  日本内科学会雑誌
  
  Volume: 111 Pages: 15-21
- Data Source
  KAKENHI-PROJECT-20K16967
[Journal Article] Anti-fibrotic treatments for chronic liver diseases: the present and the future2021
- Author(s)
  Naoshi Odagiri, Tsutomu Matsubara, Misako Sato-Matsubara, Hideki Fujii, Masaru Enomoto, Norifumi Kawada
- Journal Title
  
  Clinical and molecular hepatology
  
  Volume: - Issue: 3 Pages: 413-424
- DOI
  10.3350/cmh.2020.0187
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07952, KAKENHI-PROJECT-19K23951, KAKENHI-PROJECT-21K07968, KAKENHI-PROJECT-20K16967, KAKENHI-PROJECT-23K21359
[Journal Article] Clinical significance of circulating soluble immune checkpoint proteins in sorafenib-treated patients with advanced hepatocellular carcinoma.2020
- Author(s)
  Dong MP, Enomoto M, Thuy LTT, Hai H, Hieu VN, Hoang DV, Iida-Ueno A, Odagiri N, Amano-Teranishi Y, Hagihara A, Fujii H, Uchida-Kobayashi S, Tamori A, Kawada N.
- Journal Title
  
  Sci Rep
  
  Volume: 10 Issue: 1 Pages: 3392-3392
- DOI
  10.1038/s41598-020-60440-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09467, KAKENHI-PROJECT-19K08428, KAKENHI-PROJECT-19K23951, KAKENHI-PROJECT-19H03641
[Presentation] 切除不能肝細胞癌に対するアテゾリズマブ＋ベバシズマブ治療における血中バイオマーカー探索2023
- Author(s)
  小田桐直志、Hoang Hai、武藤芳美、小谷晃平、元山宏行、小塚立蔵、川村悦史、萩原淳司、藤井英樹、打田佐和子、榎本大、河田則文
- Organizer
  第59回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-23K15081
[Presentation] 切除不能肝細胞癌に対するアテゾリズマブ+ベバシズマブ治療における予後予測マーカーとしてのGlypican-3の有用性2023
- Author(s)
  小田桐直志、榎本　大、武藤芳美、小谷晃平、元山宏行、小塚立蔵、川村悦史、萩原淳司、藤井　英樹、打田佐和子、河田則文
- Organizer
  第45回　日本肝臓学会西部会
- Data Source
  KAKENHI-PROJECT-20K16967
[Presentation] Serum levels of circulating soluble B- and T- lymphocyte attenuator in unresectable hepatocellular carcinoma as a predictor of response to atezolizumab and bevacizumab2023
- Author(s)
  Naoshi Odagiri, Hoang Hai, Le Thi Thanh Thuy, Yoshimi Yukawa-Muto, Kohei Kotani, Hiroyuki Motoyama, Ritsuzo Kozuka, Etsushi Kawamura, Atsushi Hagihara, Hideki Fujii, Sawako Uchida-Kobayashi, Masaru Enomoto, and Norifumi Kawada
- Organizer
  AASLD 2023 THE Liver Meeting
- Data Source
  KAKENHI-PROJECT-20K16967
[Presentation] 切除不能肝細胞癌に対するアテゾリズマブ+ベバシズマブ治療における予後予測マーカーとしてのGlypican-3の有用性2023
- Author(s)
  小田桐直志、榎本　大、武藤芳美、小谷晃平、元山宏行、小塚立蔵、川村悦史、萩原淳司、藤井　英樹、打田佐和子、河田則文
- Organizer
  第45回　日本肝臓学会西部会
- Data Source
  KAKENHI-PROJECT-23K15081
[Presentation] 当院におけるアテゾリズマブ・ベバシズマブ早期中止例の検討2023
- Author(s)
  小田桐直志、榎本大、武藤芳美、小谷晃平、元山宏行、小塚立蔵、川村悦史、萩原淳司、藤井英樹、打田佐和子、石沢武彰、河田則文
- Organizer
  第59回　日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-23K15081
[Presentation] 当院におけるアテゾリズマブ・ベバシズマブ早期中止例の検討2023
- Author(s)
  小田桐直志、榎本大、武藤芳美、小谷晃平、元山宏行、小塚立蔵、川村悦史、萩原淳司、藤井英樹、打田佐和子、石沢武彰、河田則文
- Organizer
  第59回　日本肝癌研究会
- Data Source
  KAKENHI-PROJECT-20K16967
[Presentation] 当院におけるがん遺伝子パネル検査の現状と課題2023
- Author(s)
  小田桐直志、石沢武彰、藤原靖弘、八代正和
- Organizer
  第119回　日本消化器病学会　近畿支部例会
- Data Source
  KAKENHI-PROJECT-20K16967
[Presentation] 切除不能肝細胞癌に対するアテゾリズマブ＋ベバシズマブ治療における血中バイオマーカー探索2023
- Author(s)
  小田桐直志、Hoang Hai、武藤芳美、小谷晃平、元山宏行、小塚立蔵、川村悦史、萩原淳司、藤井英樹、打田佐和子、榎本大、河田則文
- Organizer
  第59回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-20K16967
[Presentation] Serum levels of circulating soluble B- and T- lymphocyte attenuator in unresectable hepatocellular carcinoma as a predictor of response to atezolizumab and bevacizumab2023
- Author(s)
  Naoshi Odagiri, Hoang Hai, Le Thi Thanh Thuy, Yoshimi Yukawa-Muto, Kohei Kotani, Hiroyuki Motoyama, Ritsuzo Kozuka, Etsushi Kawamura, Atsushi Hagihara, Hideki Fujii, Sawako Uchida-Kobayashi, Masaru Enomoto, and Norifumi Kawada
- Organizer
  AASLD 2023 THE Liver Meeting
- Data Source
  KAKENHI-PROJECT-23K15081
[Presentation] アテゾリズマブ＋ベバシズマブ併用療法施行中にPseudoprogressionを呈した切除不能肝細胞癌の1例2023
- Author(s)
  小田桐直志、榎本大、武藤芳美、小谷晃平、元山宏行、小塚立蔵、川村悦史、萩原淳司、藤井英樹、打田佐和子、河田則文
- Organizer
  第27回日本肝がん分子標的治療研究会
- Data Source
  KAKENHI-PROJECT-20K16967
[Presentation] 当院におけるがん遺伝子パネル検査の現状と課題2023
- Author(s)
  小田桐直志、石沢武彰、藤原靖弘、八代正和
- Organizer
  第119回　日本消化器病学会　近畿支部例会
- Data Source
  KAKENHI-PROJECT-23K15081
[Presentation] 2 次治療以降例に注目したアテゾリズマブ・ベバシズマブの有効性・安全性と治療中止後の後治療成績2022
- Author(s)
  小田桐直志、榎本大、武藤芳美、小谷晃平、元山宏行、小塚立蔵、川村悦史、萩原淳司、藤井英樹、打田佐和子、田守昭博、久保正二、河田則文
- Organizer
  第58回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-20K16967
[Presentation] 高齢肝細胞癌に対するアテゾリズマブ・ベバシズマブの有効性・安全性2022
- Author(s)
  小田桐直志、榎本大、武藤芳美、小谷晃平、元山宏行、川村悦史、萩原淳司、藤井英樹、打田佐和子、河田則文
- Organizer
  第24回日本高齢消化器病学会総会
- Data Source
  KAKENHI-PROJECT-20K16967
[Presentation] 75歳以上の高齢肝細胞癌に対するアテゾリズマブ・ベバシズマブの有効性と安全性2022
- Author(s)
  小田桐直志、榎本大、萩原淳司、河田則文
- Organizer
  日本消化器病学会近畿支部第117回例会
- Data Source
  KAKENHI-PROJECT-20K16967
[Presentation] Efficacy and safety of atezolizumab plus bevacizumab for advanced hepatocellular carcinoma2021
- Author(s)
  Naoshi Odagiri, Atsushi Hagihara, Kohei Kotani, Hiroyuki Motoyama, Ritsuzo Kozuka, Etsushi Kawamura, Hideki Fujii, Sawako Uchida, Masaru Enomoto, Akihiro Tamori, Shogo Tanaka, Ryosuke Amano, Shigekazu Takemura, Shoji Kubo , Norifumi Kawada
- Organizer
  JSH International Liver Conference 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16967
[Presentation] 当院における切除不能肝細胞癌に対するアテゾリズマブ・ベバシズマブ併用療法の初期投与経験2021
- Author(s)
  小田桐直志、萩原淳司、吉田香奈子、小谷晃平、元山宏行、小塚立蔵、木村健二郎、川村悦史、藤井英樹、打田佐和子、田中肖吾、天野良亮、榎本大、竹村茂一、田守昭博、久保正二、河田則文
- Organizer
  第24回　日本肝がん分子標的治療研究会
- Data Source
  KAKENHI-PROJECT-20K16967
[Presentation] 切除不能肝細胞癌に対する血管新生阻害剤の効果予測における可溶性免疫チェックポイント蛋白の有用性2021
- Author(s)
  小田桐直志、Minh Phuong Dong、Hai Hoang、Thanh Thuy Le Thi、小谷晃平、小塚立蔵、元山宏行、川村悦史、萩原淳司、藤井英樹、打田佐和子、榎本大、田守昭博、河田則文
- Organizer
  第57回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-20K16967
[Presentation] EARLY CHANGE IN THE PLASMA LEVELS OF CIRCULATING SOLUBLE IMMUNE CHECKPOINT PROTEINS IN ATIENTS WITH UNRESECTABLE HEPATOCELLULAR CARCINOMA TREATED BY LENVATINIB OR TRANSCATHETER ARTERIAL HEMOEMBOLIZATION2020
- Author(s)
  Odagiri, N; Enomoto, M; Hai, H; Le, TTT;Dong, MP; Suoh, M; Kotani, K; Hagihara,A; Uchida, S; Tamori, A; Kawada, N
- Organizer
  AASLD The Liver Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16967
[Presentation] 加齢関連肝疾患における肝星細胞の理解2020
- Author(s)
  小田桐直志、松原勤、河田則文
- Organizer
  第56回　日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K23951
[Presentation] Putative role of ERK1/2 signaling of senescent human hepatic stellate cells in hepatocellular carcinoma derived from liver cirrhosis.2019
- Author(s)
  Naoshi Odagiri
- Organizer
  JSH International Liver Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K23951
[]

1. 松原三佐子(佐藤三佐子)

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 松原勤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 萩原淳司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Odagiri Naoshi 小田桐 直志

Research Projects

Research Products

Co-Researchers

肝星細胞老化関連分泌因子IL-8が肝がん治療効果に与える分子機序の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of senescence-associated secretory factor-induced liver cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

functional analysis of senescence-associated secretory factors from human hepatic stellate cells in liver cancer microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] A case of hepatocellular carcinoma with “pseudoprogression” followed by complete response to atezolizumab plus bevacizumab2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 肝線維化進展の分子機序、血中肝線維化マーカー2022

Author(s)

Journal Title

Data Source

[Journal Article] Anti-fibrotic treatments for chronic liver diseases: the present and the future2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical significance of circulating soluble immune checkpoint proteins in sorafenib-treated patients with advanced hepatocellular carcinoma.2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] 切除不能肝細胞癌に対するアテゾリズマブ＋ベバシズマブ治療における血中バイオマーカー探索2023

Author(s)

Organizer

Data Source

[Presentation] 切除不能肝細胞癌に対するアテゾリズマブ+ベバシズマブ治療における予後予測マーカーとしてのGlypican-3の有用性2023

Author(s)

Organizer

Data Source

[Presentation] Serum levels of circulating soluble B- and T- lymphocyte attenuator in unresectable hepatocellular carcinoma as a predictor of response to atezolizumab and bevacizumab2023

Author(s)

Organizer

Data Source

[Presentation] 切除不能肝細胞癌に対するアテゾリズマブ+ベバシズマブ治療における予後予測マーカーとしてのGlypican-3の有用性2023

Author(s)

Organizer

Data Source

[Presentation] 当院におけるアテゾリズマブ・ベバシズマブ早期中止例の検討2023

Author(s)

Organizer

Data Source

[Presentation] 当院におけるアテゾリズマブ・ベバシズマブ早期中止例の検討2023

Author(s)

Organizer

Data Source

[Presentation] 当院におけるがん遺伝子パネル検査の現状と課題2023

Author(s)

Organizer

Data Source

[Presentation] 切除不能肝細胞癌に対するアテゾリズマブ＋ベバシズマブ治療における血中バイオマーカー探索2023

Author(s)

Organizer

Data Source

[Presentation] Serum levels of circulating soluble B- and T- lymphocyte attenuator in unresectable hepatocellular carcinoma as a predictor of response to atezolizumab and bevacizumab2023

Author(s)

Organizer

Data Source

[Presentation] アテゾリズマブ＋ベバシズマブ併用療法施行中にPseudoprogressionを呈した切除不能肝細胞癌の1例2023

Author(s)

Organizer

Odagiri Naoshi 小田桐直志

[Presentation] 2 次治療以降例に注目したアテゾリズマブ・ベバシズマブの有効性・安全性と治療中止後の後治療成績2022

[Presentation] 高齢肝細胞癌に対するアテゾリズマブ・ベバシズマブの有効性・安全性2022

[Presentation] 75歳以上の高齢肝細胞癌に対するアテゾリズマブ・ベバシズマブの有効性と安全性2022