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Kodama Takahiro  小玉 尚宏

… Alternative Names

Takahiro Kodama  小玉 尚宏

小玉 尚宏  コダマ タカヒロ

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Researcher Number 10623275
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-6250-1324
Affiliation (Current) 2025: 大阪大学, 大学院医学系研究科, 助教
Affiliation (based on the past Project Information) *help 2022 – 2024: 大阪大学, 大学院医学系研究科, 助教
2017 – 2021: 大阪大学, 医学系研究科, 助教
2017: 大阪大学, 医学部附属病院, その他
2012: 大阪大学, 医学部附属病院, 医員
Review Section/Research Field
Principal Investigator
Basic Section 53010:Gastroenterology-related / Gastroenterology / Medium-sized Section 53:Organ-based internal medicine and related fields
Except Principal Investigator
Basic Section 53010:Gastroenterology-related / Medium-sized Section 53:Organ-based internal medicine and related fields / Gastroenterology
Keywords
Principal Investigator
肝細胞癌 / スクリーニング / トランスポゾン / NASH / CRISPR / 遺伝子スクリーニング / 肝癌 / がん微小環境 / Regnase-1 / 胆管癌 … More / 膵癌 / T細胞疲弊 / マウスモデル / HBV / NK細胞 / マクロファージ / インターフェロン / シングルセル解析 / モデルマウス / 免疫疲弊 / T細胞 / B型肝炎 / プール型ライブラリー / ドライバー遺伝子 / HCC / Traf3 / 肝内胆管癌 / がん抑制遺伝子 / CRISPR/Cas / EMT / 肝細胞がん / 脱分化 / Pten / Sav1 / ノックアウトマウス / Hippo経路 / 肝繊維化 / CTGF … More
Except Principal Investigator
膵癌 / 肝癌 / 癌微小環境 / 肝細胞癌 / 脂肪肝 / 慢性炎症 / 多核球系骨髄由来免疫抑制細胞 / リキッドバイオプシー / ベバシズマブ / アテゾリズマブ / ctDNA / cfDNA / IL-6 / 複合免疫療法 / TNF-alfa / ノックアウトマウス / オートファジー / 慢性膵炎 / TNF-α / マウス / CIRPSR/Cas / 単一細胞解析 / 遺伝子導入 / レンチウイルス / エレクトロポレーション / 転移 / マウスモデル / シングルセル解析 / HLA / 免疫逃避 / 肝転移 / 肝がん / バイオマーカー / 癌免疫療法 / 免疫学的解析 / ゲノム・トランスクリプトーム解析 / ドライバー遺伝子 / 腫瘍免疫 / 免疫細胞 / 酸化ストレス / βカテニン / 遺伝子変異 / 癌免疫 / 癌ゲノム / 動物モデル / 膵前癌病変 / 膵癌進展 / 膵発癌 / 高血糖状態 / 糖尿病 Less
  • Research Projects

    (12 results)
  • Research Products

    (134 results)
  • Co-Researchers

    (10 People)
  •  多層オミクスを起点とした肝代謝異常と再生不全をつなぐ分子機序の解明

    • Principal Investigator
      巽 智秀
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Osaka University
  •  A mechanism of cholangiopancreatic cancer ecosystem via intercellular network through dysregulated inflammation.Principal Investigator

    • Principal Investigator
      小玉 尚宏
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Osaka University
  •  Mechanisms of cancer cell clonal expansion via phenotypic and spatial diversity in the cancer microenvironment.

    • Principal Investigator
      Takehara Tetsuo
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 53:Organ-based internal medicine and related fields
    • Research Institution
      Osaka University
  •  Elucidation of HBV Survival Strategy by Inducing Host Immune Exhaustion Using Innovative Animal ModelsPrincipal Investigator

    • Principal Investigator
      Kodama Takahiro
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 53:Organ-based internal medicine and related fields
    • Research Institution
      Osaka University
  •  Building personalised pharmacotherapy for liver cancer based on driver gene abnormalities.

    • Principal Investigator
      Tatsumi Tomohide
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Osaka University
  •  The effect of elevated TNF-alfa on the pathogenesis of chronic pancreatitis

    • Principal Investigator
      Shigekawa Minoru
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Osaka University
  •  Discovery of cancer genes driving NASH-HCC for personalized therapyPrincipal Investigator

    • Principal Investigator
      Kodama Takahiro
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 53010:Gastroenterology-related
    • Research Institution
      Osaka University
  •  Elucidation of the mechanism of pancreatic cancer metastasis using single cell analysis technology and innovative mouse models

    • Principal Investigator
      Takehara Tetsuo
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 53:Organ-based internal medicine and related fields
    • Research Institution
      Osaka University
  •  Discovery of HCC progression-related cancer genes through in vivo forward genetic screenPrincipal Investigator

    • Principal Investigator
      Takahiro Kodama
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  The effect of insulin insufficiency and/or insulin resistance on pancreatic carcinogenesis and progression

    • Principal Investigator
      Shigekawa Minoru
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  Development of genetically-defined hepatocarcinogenesis animal model and establishment of personalized cancer immunotherapy

    • Principal Investigator
      Tatsumi Tomohide
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University
  •  肝細胞CTGFによる肝線維化・肝発癌制御機構の解明Principal Investigator

    • Principal Investigator
      小玉 尚宏
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Osaka University

All 2024 2023 2022 2021 2020 2019 2018 2017 2012

All Journal Article Presentation Book Patent

  • [Book] Hepatobiliary Cancers and Immunology. In: Gershwin M.E., M. Vierling J., Tanaka A., P. Manns M. (eds) Liver Immunology.2020

    • Author(s)
      Kodama T., Takehara T.
    • Total Pages
      620
    • Publisher
      Springer
    • ISBN
      9783030517090
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Journal Article] Clinical factors associated with the therapeutic efficacy of atezolizumab plus bevacizumab in patients with unresectable hepatocellular carcinoma: A multicenter prospective observational study2024

    • Author(s)
      Kai M, Hikita H, Kazuki M, Tahata Y, Shinkai K, Doi A, Ohkawa K, Miyazaki M, Ishida H, Matsumoto K, Nozaki Y, Yakushijin T, Sakamori R, Kaneko A, Iio S, Nawa T, Kakita N, Morishita N, Hiramatsu N, Usui T, Imanaka K, Doi Y, Sakakibara M, Yoshida Y, Oze T, Kodama T, Tatsumi T, Takehara T.
    • Journal Title

      PLOS ONE

      Volume: 19 Issue: 1 Pages: e0294590-e0294590

    • DOI

      10.1371/journal.pone.0294590

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K15068, KAKENHI-PROJECT-21K07894
  • [Journal Article] Molecular genealogy of metabolic associated HCC2024

    • Author(s)
      Kodama Takahiro,Takehara Tetsuo
    • Journal Title

      Seminars in Liver Disease

      Volume: in press Issue: 02 Pages: 147-158

    • DOI

      10.1055/a-2289-2298

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K27584
  • [Journal Article] Genome‐wide loss‐of‐function genetic screen identifies INSIG2 as the vulnerability of hepatitis B virus‐integrated hepatoma cells2024

    • Author(s)
      Fukuoka Makoto、Kodama Takahiro、Murai Kazuhiro、Hikita Hayato、Sometani Emi、Sung Jihyun、Shimoda Akiyoshi、Shigeno Satoshi、Motooka Daisuke、Nishio Akira、Furuta Kunimaro、Tatsumi Tomohide、Yusa Kosuke、Takehara Tetsuo
    • Journal Title

      Cancer Science

      Volume: 115 Issue: 3 Pages: 859-870

    • DOI

      10.1111/cas.16070

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K27584
  • [Journal Article] Regnase-1 downregulation promotes pancreatic cancer through myeloid-derived suppressor cell-mediated evasion of anticancer immunity2023

    • Author(s)
      Okabe J, Kodama T, Sato Y, Shigeno S, Matsumae T, Daiku K, Sato K, Yoshioka T, Shigekawa M, Higashiguchi M, Kobayashi S, Hikita H, Tatsumi T, Okamoto T, Satoh T, Eguchi H, Akira S, Takehara T.
    • Journal Title

      J Exp Clin Cancer Res

      Volume: 9;42 Issue: 1 Pages: 262-262

    • DOI

      10.1186/s13046-023-02831-w

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K18260, KAKENHI-PROJECT-22K19527, KAKENHI-ORGANIZER-22H05060, KAKENHI-PLANNED-22H05061, KAKENHI-PROJECT-20H05693, KAKENHI-PROJECT-23K27584
  • [Journal Article] Thrombospondin-2 as a Predictive Biomarker for Hepatocellular Carcinoma after Hepatitis C Virus Elimination by Direct-Acting Antiviral2023

    • Author(s)
      Matsumae Takayuki、Kodama Takahiro、Tahata Yuki、Oshita Masahide、Hiramatsu Naoki、Morishita Naoki、Ohkawa Kazuyoshi、Hijioka Taizo、Sakakibara Mitsuru、Doi Yoshinori、Kakita Naruyasu、Yakushijin Takayuki、Sakamori Ryotaro、Hikita Hayato、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cancers

      Volume: 15 Issue: 2 Pages: 463-463

    • DOI

      10.3390/cancers15020463

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Journal Article] The impact of the COVID‐19 pandemic on hepatocellular carcinoma diagnosis and treatment in Japan: A multicenter collaborative observational study2023

    • Author(s)
      Murai Kazuhiro、Hikita Hayato、Kodama Takahiro、Kaibori Masaki、Nishimura Yuki、Tatsumi Tomohide、Yamada Tomomi、Kanto Tatsuya、Mochida Satoshi、Takehara Tetsuo
    • Journal Title

      Hepatology Research

      Volume: in press Issue: 5 Pages: 439-450

    • DOI

      10.1111/hepr.13990

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Journal Article] STAT3 is Activated by CTGF-mediated Tumor-stroma Cross Talk to Promote HCC Progression2023

    • Author(s)
      Makino Yuki、Hikita Hayato、Kato Seiya、Sugiyama Masaya、Shigekawa Minoru、Sakamoto Tatsuya、Sasaki Yoichi、Murai Kazuhiro、Sakane Sadatsugu、Kodama Takahiro、Sakamori Ryotaro、Kobayashi Shogo、Eguchi Hidetoshi、Takemura Nobuyuki、Kokudo Norihiro、Yokoi Hideki、Mukoyama Masashi、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cellular and Molecular Gastroenterology and Hepatology

      Volume: 15 Issue: 1 Pages: 99-119

    • DOI

      10.1016/j.jcmgh.2022.09.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-20K08307, KAKENHI-PROJECT-20K08633
  • [Journal Article] The absence of warfarin treatment and situs inversus are associated with the occurrence of hepatocellular carcinoma after Fontan surgery2022

    • Author(s)
      Sakamori Ryotaro、Yamada Ryoko、Tahata Yuki、Kodama Takahiro、Hikita Hayato、Tatsumi Tomohide、Yamada Tomomi、Takehara Tetsuo
    • Journal Title

      Journal of Gastroenterology

      Volume: 57 Issue: 2 Pages: 111-119

    • DOI

      10.1007/s00535-021-01842-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Journal Article] Interleukin-6 Is a Circulating Prognostic Biomarker for Hepatocellular Carcinoma Patients Treated with Combined Immunotherapy2022

    • Author(s)
      Myojin Yuta、Kodama Takahiro、Sakamori Ryotaro、Maesaka Kazuki、Matsumae Takayuki、Tahata Yuki、Yamada Ryoko、Hikita Hayato、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cancers

      Volume: 14 Issue: 4 Pages: 883-883

    • DOI

      10.3390/cancers14040883

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-21K07894
  • [Journal Article] Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma2022

    • Author(s)
      Murai Hiroki、Kodama Takahiro、Maesaka Kazuki、Tanaka Satoshi、Mita Eiji、Ohkawa Kazuyoshi、Hikita Hayato、Sakamori Ryotaro、Tatsumi Tomohide、Eguchi Hidetoshi、Morii Eiichi、Takehara Tetsuo
    • Journal Title

      Hepatology

      Volume: 77 Issue: 1 Pages: 77-91

    • DOI

      10.1002/hep.32573

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K07894, KAKENHI-PROJECT-22K07173, KAKENHI-PROJECT-22H04925, KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-19K07426, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-19K08372
  • [Journal Article] Circulating Cell-Free DNA Profiling Predicts the Therapeutic Outcome in Advanced Hepatocellular Carcinoma Patients Treated with Combination Immunotherapy2022

    • Author(s)
      Matsumae Takayuki、Kodama Takahiro、Myojin Yuta、Maesaka Kazuki、Nakabori Tasuku、Ohkawa Kazuyoshi、Miyazaki Masanori、Tanaka Satoshi、Mita Eiji、Tawara Seiichi、Yakushijin Takayuki、Nozaki Yasutoshi、Hagiwara Hideki、Tahata Yuki、Yamada Ryoko、Hikita Hayato、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cancers

      Volume: 14 Issue: 14 Pages: 3367-3367

    • DOI

      10.3390/cancers14143367

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07894, KAKENHI-PROJECT-20H03661
  • [Journal Article] TNF receptor-related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase-mediated hepatocyte transdifferentiation2022

    • Author(s)
      Shiode Yuto、Kodama Takahiro、Shigeno Satoshi、Murai Kazuhiro、Tanaka Satoshi、Newberg Justin Y.、Kondo Jumpei、Kobayashi Shogo、Yamada Ryoko、Hikita Hayato、Sakamori Ryotaro、Suemizu Hiroshi、Tatsumi Tomohide、Eguchi Hidetoshi、Jenkins Nancy A.、Copeland Neal G.、Takehara Tetsuo
    • Journal Title

      Hepatology

      Volume: - Issue: 2 Pages: 395-410

    • DOI

      10.1002/hep.32317

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K15998, KAKENHI-PROJECT-20H03661
  • [Journal Article] Inhibition of nonhomologous end joining‐mediated <scp>DNA</scp> repair enhances <scp>anti‐HBV CRISPR</scp> therapy2022

    • Author(s)
      Murai Kazuhiro、Kodama Takahiro、Hikita Hayato、Shimoda Akiyoshi、Fukuoka Makoto、Fukutomi Keisuke、Shigeno Satoshi、Shiode Yuto、Motooka Daisuke、Higuchi Yuichiro、Miyakawa Kei、Suemizu Hiroshi、Ryo Akihide、Tahata Yuki、Makino Yuki、Yamada Ryoko、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Hepatology Communications

      Volume: 6 Issue: 9 Pages: 2474-2487

    • DOI

      10.1002/hep4.2014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22K19528
  • [Journal Article] Constitutive Activation of the Tumor Suppressor p53 in Hepatocytes Paradoxically Promotes Non-Cell Autonomous Liver Carcinogenesis2022

    • Author(s)
      Makino Yuki、Hikita Hayato、Fukumoto Kenji、Sung Ji Hyun、Sakano Yoshihiro、Murai Kazuhiro、Sakane Sadatsugu、Kodama Takahiro、Sakamori Ryotaro、Kondo Jumpei、Kobayashi Shogo、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cancer Research

      Volume: 82 Issue: 16 Pages: 2860-2873

    • DOI

      10.1158/0008-5472.can-21-4390

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-21H02903
  • [Journal Article] Liver-related events after direct-acting antiviral therapy in patients with hepatitis C virus-associated cirrhosis2022

    • Author(s)
      Tahata Y, Hikita H, Mochida S, Enomoto N, Kawada N, Kurosaki M, Ido A, Miki D, Yoshiji H, Takikawa Y, Sakamori R, Hiasa Y, Nakao K, Kato N, Ueno Y, Yatsuhashi H, Itoh Y, Tateishi R, Suda G, Takami T, Nakamoto Y, Asahina Y, et al.
    • Journal Title

      Journal of Gastroenterology

      Volume: 57 Issue: 2 Pages: 120-132

    • DOI

      10.1007/s00535-021-01845-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K08415, KAKENHI-PROJECT-19K08458, KAKENHI-PROJECT-21K07909, KAKENHI-PROJECT-19H03635, KAKENHI-PROJECT-19H03637, KAKENHI-PROJECT-21H02896, KAKENHI-PROJECT-17K09435, KAKENHI-PROJECT-20K08314, KAKENHI-PROJECT-21K07894, KAKENHI-PROJECT-21K19476, KAKENHI-PROJECT-23K24315
  • [Journal Article] Prediction Model for Intrahepatic Distant Recurrence After Radiofrequency Ablation for Primary Hepatocellular Carcinoma 2cm or Smaller2022

    • Author(s)
      Takigawa Atsuo、Sakamori Ryotaro、Tahata Yuki、Yoshioka Teppei、Yamada Ryoko、Kodama Takahiro、Hikita Hayato、Yakushijin Takayuki、Ohkawa Kazuyoshi、Hiramatsu Naoki、Mita Eiji、Hagiwara Hideki、Ito Toshifmi、Imai Yasuharu、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Digestive Diseases and Sciences

      Volume: in press Issue: 12 Pages: 5704-5711

    • DOI

      10.1007/s10620-022-07455-2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Journal Article] Pentraxin 3 is an adipose tissue‐related serum marker for pancreatic cancer cachexia predicting subsequent muscle mass and visceral fat loss2022

    • Author(s)
      Sato Katsuhiko、Hikita Hayato、Shigekawa Minoru、Kato Seiya、Sasaki Yoichi、Shinkai Kazuma、Fukuoka Makoto、Kudo Shinnosuke、Sato Yu、Fukumoto Kenji、Shirai Kumiko、Myojin Yuta、Sakane Sadatsugu、Murai Kazuhiro、Yoshioka Teppei、Nishio Akira、Kodama Takahiro、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cancer Science

      Volume: 113 Issue: 12 Pages: 4311-4326

    • DOI

      10.1111/cas.15569

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K19527, KAKENHI-PROJECT-22K16043
  • [Journal Article] Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma2021

    • Author(s)
      Kodama Michiko、Shimura Hiroko、Tien Jean C.、Newberg Justin Y.、Kodama Takahiro、Wei Zhubo、Rangel Roberto、Yoshihara Kosuke、Kuruma Airi、Nakae Aya、Hashimoto Kae、Sawada Kenjiro、Kimura Tadashi、Jenkins Nancy A.、Copeland Neal G.
    • Journal Title

      Cancer Research

      Volume: 81 Issue: 21 Pages: 5413-5424

    • DOI

      10.1158/0008-5472.can-21-0356

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-20K09617, KAKENHI-PROJECT-16H06279
  • [Journal Article] Serum growth differentiation factor 15 predicts hepatocellular carcinoma occurrence after hepatitis C virus elimination2021

    • Author(s)
      Myojin Yuta、Hikita Hayato、Tahata Yuki、Doi Akira、、Kodama Takahiro、Hagiwara Hideki、Imai Yasuharu、Hiramatsu Naoki、Tamura Shinji、Yamamoto Keiji、Ohkawa Kazuyoshi、Hijioka Taizo、Fukui Hiroyuki、Doi Yoshinori、Yamada Yukinori、Yakushijin Takayuki、Mita Eiji、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Alimentary Pharmacology &amp; Therapeutics

      Volume: 55 Issue: 4 Pages: 422-433

    • DOI

      10.1111/apt.16691

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Journal Article] Sequential administration of XPO1 and ATR inhibitors enhances therapeutic response in TP53-mutated colorectal cancer2021

    • Author(s)
      Inoue A, Robinson FS, Minelli R, Tomihara H, Rizi BS, Rose JL, Kodama T, Srinivasan S, , Stephan C, Giuliani V, Deem AK, Shingu T, Deribe YL, Menter DG, Heffernan TP, Viale A, Bristow CA, Kopetz S, Draetta GF, Genovese G, Carugo A
    • Journal Title

      Gastroenterology

      Volume: in press Issue: 1 Pages: 196-210

    • DOI

      10.1053/j.gastro.2021.03.022

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Journal Article] Transcriptomics Identify Thrombospondin-2 as a Biomarker for Nonalcoholic Steatohepatitis and Advanced Liver Fibrosis2021

    • Author(s)
      Kozumi K, Kodama T, Murai H, Sakane S, Govaere O, Cockell S, Motooka D, Kakita N, Yamada Y, Kondo Y, Tahata Y, Yamada R, Hikita H, Sakamori R, Kamada Y, Daly KA, Anstee MQ, Tatsumi T, Morii E, Takehara T
    • Journal Title

      Hepatology

      Volume: 74(5) Issue: 5 Pages: 2452-2466

    • DOI

      10.1002/hep.31995

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08374, KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-20K08383
  • [Journal Article] Hepatitis C virus modulates signal peptide peptidase to alter host protein processing.2021

    • Author(s)
      11.Hirano J, Yoshio S, Sakai Y, Songling L, Suzuki T, Itoh Y, Zhang H, Chen DV, Haga S, Oomori H, Kodama T, Maeda Y, Ono Y, Takahashi Y, Standley DM, Yamamoto M, Moriishi K, Moriya K, Kanto T, Takehara T, Koike K, Matsuura Y, Okamoto T.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 118(22) Issue: 22 Pages: 2026184118-2026184118

    • DOI

      10.1073/pnas.2026184118

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03479, KAKENHI-PROJECT-20H03495, KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-21K08020
  • [Journal Article] Persistent hepatocyte apoptosis promotes tumorigenesis from diethylnitrosamine-transformed hepatocytes through increased oxidative stress, independent of compensatory liver regeneration2021

    • Author(s)
      Nozaki Y, Hikita H, Tanaka S, Fukumoto K, Urabe M, Sato K, Myojin Y, Doi A, Murai K, Sakane S, Saito Y, Kodama T, Sakamori R, Tatsumi T, Takehara T.
    • Journal Title

      Sci Rep

      Volume: 11 Issue: 1 Pages: 3363-3363

    • DOI

      10.1038/s41598-021-83082-7

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08307, KAKENHI-PROJECT-18H02795, KAKENHI-PROJECT-20H03661
  • [Journal Article] White Adipose Tissue Autophagy and Adipose-Liver Crosstalk Exacerbate Nonalcoholic Fatty Liver Disease in Mice2021

    • Author(s)
      Sakane Sadatsugu、Hikita Hayato、Shirai Kumiko、Myojin Yuta、Sasaki Youichi、Kudo Shinnosuke、Fukumoto Kenji、Mizutani Naoki、Tahata Yuki、Makino Yuki、Yamada Ryoko、Kodama Takahiro、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cellular and Molecular Gastroenterology and Hepatology

      Volume: 12 Issue: 5 Pages: 1683-1699

    • DOI

      10.1016/j.jcmgh.2021.07.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-20K08307
  • [Journal Article] Dysregulation of PI3K and Hippo signaling pathways synergistically induces chronic pancreatitis via CTGF upregulation2021

    • Author(s)
      Tamura Takeshi、Kodama Takahiro、Sato Katsuhiko、Murai Kazuhiro、Yoshioka Teppei、Shigekawa Minoru、Yamada Ryoko、Hikita Hayato、Sakamori Ryotaro、Akita Hirofumi、Eguchi Hidetoshi、Johnson Randy L.、Yokoi Hideki、Mukoyama Masashi、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Journal of Clinical Investigation

      Volume: 131 Issue: 13

    • DOI

      10.1172/jci143414

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-20K08611, KAKENHI-PROJECT-20K08633
  • [Journal Article] Prediction model for hepatocellular carcinoma occurrence in patients with hepatitis C in the era of direct‐acting anti‐virals2021

    • Author(s)
      Tahata Yuki、Sakamori Ryotaro、Yamada Ryoko、Kodama Takahiro、Hikita Hayato、Tatsumi Tomohide、Takehara Tetsuo、the Osaka Liver Forum
    • Journal Title

      Alimentary Pharmacology &amp; Therapeutics

      Volume: 54 Issue: 10 Pages: 1340-1349

    • DOI

      10.1111/apt.16632

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07894, KAKENHI-PROJECT-20K16956
  • [Journal Article] Hepatic Stellate Cells in Hepatocellular Carcinoma Promote Tumor Growth Via Growth Differentiation Factor 15 Production2021

    • Author(s)
      Myojin Y, Hikita H, Sugiyama M, Sasaki Y, Fukumoto K, Sakane S, Makino Y, Takemura N, Yamada R, Shigekawa M, Kodama T, Sakamori R, Kobayashi S, Tatsumi T, Suemizu H, Eguchi H, Kokudo N, Mizokami M, Takehara T.
    • Journal Title

      Gastroenterology .

      Volume: 160 Issue: 5 Pages: 1741-1754

    • DOI

      10.1053/j.gastro.2020.12.015

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08307, KAKENHI-PROJECT-18H02795, KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-19K17489
  • [Journal Article] Efficacy of Ramucirumab <i>Versus</i> Sorafenib as Subsequent Treatment for Hepatocellular Carcinoma2021

    • Author(s)
      MAESAKA KAZUKI、SAKAMORI RYOTARO、YAMADA RYOKO、TAHATA YUKI、OHKAWA KAZUYOSHI、OSHITA MASAHIDE、TAMURA SHINJI、HAGIWARA HIDEKI、MITA EIJI、YAKUSHIJIN TAKAYUKI、INADA MASAMI、KODAMA TAKAHIRO、HIKITA HAYATO、TATSUMI TOMOHIDE、TAKEHARA TETSUO
    • Journal Title

      Anticancer Research

      Volume: 41 Issue: 4 Pages: 2187-2192

    • DOI

      10.21873/anticanres.14993

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Journal Article] Gab1 in livers with persistent hepatocyte apoptosis has an antiapoptotic effect and reduces chronic liver injury, fibrosis and tumorigenesis2021

    • Author(s)
      Mizutani N, Hikita H, Saito Y, Myojin Y, Sato K, Urabe M, Kurahashi T, Shiode Y, Sakane S, Murai K, Nozaki Y, Kodama T, Sakamori R, Yoshida Y, Tatsumi T, Takehara T.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol.

      Volume: in press Issue: 6 Pages: G958-G968

    • DOI

      10.1152/ajpgi.00370.2020

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K08307, KAKENHI-PROJECT-18H02795, KAKENHI-PROJECT-20H03661
  • [Journal Article] Hyperprogressive disease in patients with unresectable hepatocellular carcinoma receiving atezolizumab plus bevacizumab therapy2021

    • Author(s)
      Maesaka Kazuki、Sakamori Ryotaro、Yamada Ryoko、Tahata Yuki、Imai Yasuharu、Ohkawa Kazuyoshi、Miyazaki Masanori、Mita Eiji、Ito Toshifumi、Hagiwara Hideki、Yakushijin Takayuki、Kodama Takahiro、Hikita Hayato、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Hepatology Research

      Volume: 52 Issue: 3 Pages: 298-307

    • DOI

      10.1111/hepr.13741

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Journal Article] Risk Factors for Pancreatic Cancer and the Necessity of Long-Term Surveillance in Patients With Pancreatic Cystic Lesions2020

    • Author(s)
      Yoshioka Teppei、Shigekawa Minoru、Ikezawa Kenji、Tamura Takeshi、Sato Katsuhiko、Urabe Makiko、Sueyoshi Hironari、Yamai Takuo、Suda Takahiro、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Pancreas

      Volume: 49 Issue: 4 Pages: 552-560

    • DOI

      10.1097/mpa.0000000000001521

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K19546
  • [Journal Article] ST6GAL1 Is a Novel Serum Biomarker for Lenvatinib-Susceptible FGF19-Driven Hepatocellular Carcinoma2020

    • Author(s)
      Myojin Yuta、Kodama Takahiro、Maesaka Kazuki、Motooka Daisuke、Sato Yu、Tanaka Satoshi、Abe Yuichi、Ohkawa Kazuyoshi、Mita Eiji、Hayashi Yoshito、Hikita Hayato、Sakamori Ryotaro、Tatsumi Tomohide、Taguchi Ayumu、Eguchi Hidetoshi、Takehara Tetsuo
    • Journal Title

      Clinical Cancer Research

      Volume: 27 Issue: 4 Pages: 1150-1161

    • DOI

      10.1158/1078-0432.ccr-20-3382

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-19K17489
  • [Journal Article] Endoscopic biliary stenting as the risk factor for cholangitis after endoscopic ultrasound in patients with biliary strictures2020

    • Author(s)
      Ikezawa Kenji、Shigekawa Minoru、Yamai Takuo、Suda Takahiro、Kegasawa Tadashi、Yoshioka Teppei、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: in press Issue: 5 Pages: 1263-1266

    • DOI

      10.1111/jgh.15264

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K19546
  • [Journal Article] Hepatocellular carcinoma occurrence does not differ between interferon‐based and interferon‐free treatment with liver histological assessment2020

    • Author(s)
      Tahata Yuki、Sakamori Ryotaro、Urabe Ayako、Yamada Ryoko、Ohkawa Kazuyoshi、Hiramatsu Naoki、Hagiwara Hideki、Oshita Masahide、Hijioka Taizo、Tamura Shinji、Imai Yasuharu、Kodama Takahiro、Hikita Hayato、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Hepatology Research

      Volume: 50 Issue: 3 Pages: 313-320

    • DOI

      10.1111/hepr.13454

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04160
  • [Journal Article] Forkhead Box M1 Transcription Factor Drives Liver Inflammation Linking to Hepatocarcinogenesis in Mice2020

    • Author(s)
      Kurahashi Tomohide、Yoshida Yuichi、Ogura Satoshi、Egawa Mayumi、Furuta Kunimaro、Hikita Hayato、Kodama Takahiro、Sakamori Ryotaro、Kiso Shinichi、Kamada Yoshihiro、Wang I-Ching、Eguchi Hidetoshi、Morii Eiichi、Doki Yuichiro、Mori Masaki、Kalinichenko Vladimir V.、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cellular and Molecular Gastroenterology and Hepatology

      Volume: 9 Issue: 3 Pages: 425-446

    • DOI

      10.1016/j.jcmgh.2019.10.008

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04160, KAKENHI-PROJECT-18H02795, KAKENHI-PROJECT-17K09422, KAKENHI-PROJECT-17K09424
  • [Journal Article] Hyperglycemia enhances pancreatic cancer progression accompanied by elevations in phosphorylated STAT3 and MYC levels2020

    • Author(s)
      Sato Katsuhiko、Hikita Hayato、Myojin Yuta、Fukumoto Kenji、Murai Kazuhiro、Sakane Sadatsugu、Tamura Takeshi、Yamai Takuo、Nozaki Yasutoshi、Yoshioka Teppei、Kodama Takahiro、Shigekawa Minoru、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 7 Pages: e0235573-e0235573

    • DOI

      10.1371/journal.pone.0235573

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K19546
  • [Journal Article] Hypovascular hepatic nodules as a predictive factor for transcatheter arterial chemoembolization refractoriness in hepatocellular carcinoma2019

    • Author(s)
      Maesaka Kazuki、Sakamori Ryotaro、Yamada Ryoko、Tahata Yuki、Urabe Ayako、Shigekawa Minoru、Kodama Takahiro、Hikita Hayato、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Hepatology Research

      Volume: 50 Issue: 3 Pages: 365-373

    • DOI

      10.1111/hepr.13446

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04160
  • [Journal Article] MRTFB suppresses colorectal cancer development through regulating SPDL1 and MCAM2019

    • Author(s)
      Kodama Takahiro、Marian Teresa A.、Lee Hubert、Kodama Michiko、Li Jian、Parmacek Michael S.、Jenkins Nancy A.、Copeland Neal G.、Wei Zhubo
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 116 Issue: 47 Pages: 23625-23635

    • DOI

      10.1073/pnas.1910413116

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Journal Article] Soluble UL16-binding protein 2 is associated with a poor prognosis in pancreatic cancer patients2019

    • Author(s)
      Kegasawa Tadashi、Tatsumi Tomohide、Yoshioka Teppei、Suda Takahiro、Ikezawa Kenji、Nakabori Tasuku、Yamada Ryoko、Kodama Takahiro、Shigekawa Minoru、Hikita Hayato、Sakamori Ryotaro、Takehara Tetsuo
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 517 Issue: 1 Pages: 84-88

    • DOI

      10.1016/j.bbrc.2019.07.020

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04160, KAKENHI-PROJECT-17K09424
  • [Journal Article] CRISPR Loss-of-Function Screen Identifies the Hippo Signaling Pathway as the Mediator of Regorafenib Efficacy in Hepatocellular Carcinoma2019

    • Author(s)
      Suemura Shigeki、Kodama Takahiro、Myojin Yuta、Yamada Ryoko、Shigekawa Minoru、Hikita Hayato、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cancers

      Volume: 11 Issue: 9 Pages: 1362-1362

    • DOI

      10.3390/cancers11091362

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04160, KAKENHI-PROJECT-17K09422, KAKENHI-PROJECT-17K09424
  • [Journal Article] CTGF Mediates Tumor?Stroma Interactions between Hepatoma Cells and Hepatic Stellate Cells to Accelerate HCC Progression2018

    • Author(s)
      Makino Yuki、Hikita Hayato、Kodama Takahiro、Shigekawa Minoru、Yamada Ryoko、Sakamori Ryotaro、Eguchi Hidetoshi、Morii Eiichi、Yokoi Hideki、Mukoyama Masashi、Hiroshi Suemizu、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cancer Research

      Volume: 78 Issue: 17 Pages: 4902-4914

    • DOI

      10.1158/0008-5472.can-17-3844

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K09422, KAKENHI-PROJECT-17K15943
  • [Journal Article] Immunological responses against hepatitis B virus in human peripheral blood mononuclear cell-engrafted mice2018

    • Author(s)
      Aono Satoshi、Tatsumi Tomohide、Yoshioka Teppei、Tawara Seiichi、Nishio Akira、Onishi Yoshiki、Fukutomi Keisuke、Nakabori Tasuku、Kodama Takahiro、Shigekawa Minoru、Hikita Hayato、Sakamori Ryotaro、Takahashi Takeshi、Suemizu Hiroshi、Takehara Tetsuo
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 503 Issue: 3 Pages: 1457-1464

    • DOI

      10.1016/j.bbrc.2018.07.063

    • Data Source
      KAKENHI-PROJECT-17H04160
  • [Journal Article] Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis2018

    • Author(s)
      Kodama Takahiro、Yi Jing、Newberg Justin Y.、Tien Jean C.、Wu Hao、Finegold Milton J.、Kodama Michiko、Wei Zhubo、Tamura Takeshi、Takehara Tetsuo、Johnson Randy L.、Jenkins Nancy A.、Copeland Neal G.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 115 Issue: 44

    • DOI

      10.1073/pnas.1808968115

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Journal Article] DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-β signaling pathway2018

    • Author(s)
      Saito Yoshinobu、Hikita Hayato、Nozaki Yasutoshi、Kai Yugo、Makino Yuki、Nakabori Tasuku、Tanaka Satoshi、Yamada Ryoko、Shigekawa Minoru、Kodama Takahiro、Sakamori Ryotaro、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Cell Death & Differentiation

      Volume: 26 Issue: 3 Pages: 470-486

    • DOI

      10.1038/s41418-018-0131-6

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09422, KAKENHI-PUBLICLY-17H05508, KAKENHI-PROJECT-18H02795, KAKENHI-PROJECT-17K09423
  • [Journal Article] CEACAM1 Is Associated With the Suppression of Natural Killer Cell Function in Patients With Chronic Hepatitis C2018

    • Author(s)
      Suda Takahiro、Tatsumi Tomohide、Nishio Akira、Kegasawa Tadashi、Yoshioka Teppei、Yamada Ryoko、Furuta Kunimaro、Kodama Takahiro、Shigekawa Minoru、Hikita Hayato、Sakamori Ryotaro、Fukuhara Takasuke、Matsuura Yoshiharu、Takehara Tetsuo
    • Journal Title

      Hepatology Communications

      Volume: 2 Issue: 10 Pages: 1247-1258

    • DOI

      10.1002/hep4.1240

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04160
  • [Journal Article] Interferon-α suppresses hepatitis B virus enhancer II activity via the protein kinase C pathway2012

    • Author(s)
      Nawa T, Kodama T, et al.
    • Journal Title

      Virology

      Volume: 432 Pages: 452-459

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590971
  • [Journal Article] Bak deficiency inhibits liver carcinogenesis : a causal link between apoptosis and carcinogenesis2012

    • Author(s)
      Hikita H, Kodama T, et al.
    • Journal Title

      Journal of Hepatology

      Volume: 57 Pages: 92-100

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590971
  • [Journal Article] Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistages2012

    • Author(s)
      Kodama T, et al.
    • Journal Title

      Cell Death and Differentiation

      Volume: (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590971
  • [Patent] 免疫チェックポイント阻害剤に対する感受性の検査方法2022

    • Inventor(s)
      小玉尚宏、村井大毅、竹原徹郎
    • Industrial Property Rights Holder
      小玉尚宏、村井大毅、竹原徹郎
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2022-074111
    • Filing Date
      2022
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Patent] 成熟肝細胞の分化転換抑制用組成物2021

    • Inventor(s)
      小玉尚宏、塩出悠登、竹原徹郎
    • Industrial Property Rights Holder
      小玉尚宏、塩出悠登、竹原徹郎
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-135496
    • Filing Date
      2021
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Patent] 癌に関連する新規バイオマーカー2020

    • Inventor(s)
      小玉尚宏、明神悠太、竹原徹郎
    • Industrial Property Rights Holder
      小玉尚宏、明神悠太、竹原徹郎
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-165604
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] 癌免疫微小環境解析による進行肝細胞癌の複合免疫療法効果予測2023

    • Author(s)
      山本修平、小玉尚宏、竹原徹郎
    • Organizer
      第59回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Presentation] 肝微小環境におけるクロストークを介した肝内胆管癌発症機構2023

    • Author(s)
      小玉尚宏、佐藤 悠、疋田 隼人、巽 智秀、竹原 徹郎
    • Organizer
      第37回肝類洞壁細胞研究会
    • Data Source
      KAKENHI-PROJECT-23K27584
  • [Presentation] 炎症制御分子 Regnase-1 を介した膵がん発症・進展機構の解明2023

    • Author(s)
      岡部 純弥、小玉尚宏、竹原 徹郎
    • Organizer
      第54回日本膵臓学会大会
    • Data Source
      KAKENHI-PROJECT-22K19527
  • [Presentation] 肝細胞癌に対する複合免疫療法効果予測バイオマーカー探索2023

    • Author(s)
      小玉尚宏、西尾 啓、竹原 徹郎
    • Organizer
      第109回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Presentation] 炎症制御分子 Regnase-1 を介した膵がん発症・進展機構の解明2023

    • Author(s)
      岡部 純弥、小玉尚宏、竹原 徹郎
    • Organizer
      第54回日本膵臓学会大会
    • Data Source
      KAKENHI-PROJECT-23K27584
  • [Presentation] Regnase-1と腫瘍促進性炎症細胞の相互作用を介した新規肝内胆管癌発症機構の解明2023

    • Author(s)
      佐藤悠、小玉尚宏、竹原徹郎
    • Organizer
      第59回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-23K27584
  • [Presentation] 転写後制御因子Regnase-1の肝内胆管癌発症への関与2023

    • Author(s)
      佐藤悠、小玉尚宏、疋田隼人、巽智秀、竹原徹郎
    • Organizer
      第82回日本癌学会
    • Data Source
      KAKENHI-PROJECT-23K27584
  • [Presentation] Immunokinetic Analysis Predicts Efficacy of Combination Immunotherapy for Advanced Hepatocellular Carcinoma2023

    • Author(s)
      Takahiro Kodama, Shuhei Yamamoto, Akira Nishio, Kazuki Maesaka, Akira Doi, Yuki Tahata, Hayato Hikita, Tomohide Tatsumi, Tetsuro Takehara
    • Organizer
      APASL Oncology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Presentation] A novel mechanism of driving intrahepatic cholangiocarcinoma2023

    • Author(s)
      小玉尚宏
    • Organizer
      37th Meeting of the USJCMSP Hepatitis Panel.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K27584
  • [Presentation] A novel mechanism of driving intrahepatic cholangiocarcinoma2023

    • Author(s)
      小玉尚宏
    • Organizer
      37th Meeting of the USJCMSP Hepatitis Panel.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19527
  • [Presentation] Regnase-1 dysfunction promotes intrahepatic cholangiocarcinoma development via myeloid cell-mediated hepatocyte transdiffentiation2023

    • Author(s)
      Yu Sato, Takahiro Kodama, Shuhei Yamamoto, Hayato Hikita, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      The Liver meeting(AALSD 2023)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K27584
  • [Presentation] マルチオミクス解析による非B非C肝癌の分子免疫分類の構築2022

    • Author(s)
      村井大毅 小玉尚宏 竹原徹郎
    • Organizer
      第58回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] 肝細胞癌に対するアテゾリズマブ+ベバシズマブ併用療法の治療効果予測バイオマーカー としてのIL-6の有用性2022

    • Author(s)
      松前高幸、小玉尚宏、阪森亮太郎、前阪和城、野﨑泰俊、俵誠一、田中聡司、宮﨑昌典、澤井良之、藥師神崇行、大川和良、三田英治、萩原秀紀、今井康陽、田畑優貴、山田涼子、疋田隼人、巽智秀、竹原徹郎
    • Organizer
      第26回日本肝がん分子標的治療研究会
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Presentation] CRISPR/Cas9によるHBVゲノム切断とDNA 修復経路阻害併用によるB型肝炎根治を目指した新規HBV治療の開発2022

    • Author(s)
      村井一裕, 小玉尚宏, 竹原徹郎
    • Organizer
      JDDW2022
    • Data Source
      KAKENHI-PROJECT-22K19528
  • [Presentation] Olaparib enhances the anti-viral effect of CRISPR/Cas9 therapy targeting HBV genome via NHEJ-mediated DNA repair machinery2022

    • Author(s)
      Kazuhiro Murai, Takahiro Kodama, Hayato Hikita, Emi Sometani, Jihyun Sung, Akiyoshi Shimoda, Makoto Fukuoka, Satoshi Shigeno, Yuki Tahata, Akira Nishio, Ryoko Yamada, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      AASLD The Liver Meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19528
  • [Presentation] Multiomics profiling identifies the link between intratumoral steatosis and immune-exhausted immunotherapy-susceptible tumor immune microenvironment in HCC2022

    • Author(s)
      Takahiro Kodama, Hiroki Murai, Tetsuo Takehara
    • Organizer
      APASL Oncology 2022
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] Intratumoral steatosis is an imaging biomarker for immunotherapy-susceptibility in HCC2022

    • Author(s)
      村井大毅 小玉尚宏 竹原徹郎
    • Organizer
      第81回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] 免疫系を保持した新規B型慢性肝炎モデルマウスを用いたTLR7アゴニストの治療効果の検討2022

    • Author(s)
      滋野 聡、小玉 尚宏、竹原 徹郎
    • Organizer
      第58回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-22K19528
  • [Presentation] マルチオミクス解析による非B非C型肝癌の腫瘍免疫微小環境解析2022

    • Author(s)
      村井大毅 小玉尚宏 竹原徹郎
    • Organizer
      JDDW2022
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] MRI is an imaging biomarker to diagnose steatotic HCC susceptible to combination immunotherapy for advanced HCC patients2022

    • Author(s)
      Hiroki Murai, Takahiro Kodama,Tetsuo Takehara
    • Organizer
      AASLD The Liver Meeting
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] B型肝炎根治を目指したCRISPR/Cas9によるウイルスゲノム切断とDNA 修復経路阻害併用療法の開発2022

    • Author(s)
      村井一裕、小玉尚宏、竹原徹郎
    • Organizer
      第58回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-22K19528
  • [Presentation] 免疫系を保持する新規B型慢性肝炎モデルマウスの作成と免疫応答解析2022

    • Author(s)
      滋野 聡、小玉 尚宏、村井 一裕、山田 涼子、疋田 隼人、阪森 亮太郎、巽 智秀、竹原 徹郎
    • Organizer
      第59回日本消化器免疫学会総会
    • Data Source
      KAKENHI-PROJECT-22K19528
  • [Presentation] 肝細胞癌に対するアテゾリズマブ+ベバシズマブ併用療法における、リキッドバイオプシーを用いた治療効果予測2022

    • Author(s)
      小玉 尚宏、巽 智秀、竹原 徹郎
    • Organizer
      第58回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Presentation] Understanding of tumor immune microenvironment in non-viral HCC through multi-omics and spatial transcriptomics2022

    • Author(s)
      小玉尚宏
    • Organizer
      JDDW2022
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] 個別化医療を目指したがんゲノム・トランスクリプトーム解析による肝細胞癌層別化の試み2022

    • Author(s)
      村井大毅 小玉尚宏 竹原徹郎
    • Organizer
      第108回消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] Traf3による分化転換を介した肝内胆管癌発症機構の解明2021

    • Author(s)
      塩出悠登、小玉 尚宏、竹原徹郎
    • Organizer
      第57回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] マウス生体内トランスポゾン挿入変異スクリーニングによる胆管がん発症機構の解明2021

    • Author(s)
      小玉 尚宏、塩出悠登、竹原徹郎
    • Organizer
      第94回日本生化学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] TRAF3 inactivation promotes intrahepatic cholangiocarcinoma development via NIK-mediated hepatocyte transdifferentiation2021

    • Author(s)
      Yuto Shiode, Takahiro Kodama, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      AASLD The Liver Meeting 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] Multi-omics解析による非B非C肝癌の分子・免疫学的プロファイリング2021

    • Author(s)
      村井大毅、小玉 尚宏、竹原徹郎
    • Organizer
      第57回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] Biomarker-driven precision medicine for hepatocellular carcinoma2021

    • Author(s)
      Takahiro Kodama, Yuta Myojin, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      第80回日本癌学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] 切除不能肝細胞癌に対するアテゾリズマブ/ベバシズマブ併用療法の初期治療成績2021

    • Author(s)
      前阪 和城、阪森 亮太郎、山田 涼子、田畑 優貴、小玉 尚宏、疋田 隼人、今井 康陽、尾下 正秀、大川 和良、三田 英治、伊藤 敏文、萩原 秀紀、藥師神 崇行、巽 智秀、竹原 徹郎
    • Organizer
      第24回日本肝癌分子標的治療研究会
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Presentation] 肝細胞癌薬物療法効果予測バイオマーカーとしての血清ST6GAL1の有用性2021

    • Author(s)
      小玉 尚宏、巽 智秀、竹原 徹郎
    • Organizer
      第57回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Presentation] 肝細胞癌薬物療法効果予測バイオマーカーとしての血清ST6GAL1の有用性2021

    • Author(s)
      小玉 尚宏、巽 智秀、竹原 徹郎
    • Organizer
      第57回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] 進行肝細胞癌に対するラムシルマブとソラフェニブの比較検討:多施設共同研究2021

    • Author(s)
      前阪 和城、阪森 亮太郎、山田 涼子、田畑 優貴、小玉 尚宏、疋田 隼人、大川 和良、尾下 正秀、田村 信司、萩原 秀紀、三田 英治、藥師神 崇行、稲田 正己、巽 智秀、竹原 徹郎
    • Organizer
      第57回日本肝癌研究会
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Presentation] Molecular and immunological profiling for biomarker discovery in NAFLD-HCC2021

    • Author(s)
      Takahiro Kodama, Hiroki Murai, Tetsuo Takehara
    • Organizer
      第25回日本肝臓学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] Serum ST6GAL1 is a novel biomarker for predicting efficacy of tyrosine kinase inhibitors in hepatocellular carcinoma by detecting FGF19 expressing tumor2021

    • Author(s)
      Yuta Myojin, Takahiro Kodama, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      AACR ANNUAL MEETING 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Presentation] Discovery of non-viral Hepatocellular Carcinoma Immunomolecular Subtype through Cancer Genome and Transcriptome Analysis2021

    • Author(s)
      Hiroki Murai, Takahiro Kodama, Tetsuo Takehara
    • Organizer
      第25回日本肝臓学会大会
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] Biomarker-driven precision medicine for hepatocellular carcinoma2021

    • Author(s)
      Takahiro Kodama, Yuta Myojin, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      第80回日本癌学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-21K07894
  • [Presentation] Serum ST6GAL1 is a novel biomarker for predicting efficacy of tyrosine kinase inhibitors in hepatocellular carcinoma by detecting FGF19 expressing tumor2021

    • Author(s)
      Yuta Myojin, Takahiro Kodama, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      AACR ANNUAL MEETING 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] Multiomics profiling identifies the pro-tumoral immune networks in the steatotic tumor microenvironment in non-viral hepatocellular carcinoma2021

    • Author(s)
      Hiroki Murai, Takahiro Kodama, Tetsuo Takehara
    • Organizer
      AASLD The Liver Meeting 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] 炎症制御分子Regnase-1を介した膵癌発症機構の解明2020

    • Author(s)
      岡部純弥、小玉尚宏、竹原徹郎
    • Organizer
      JDDW2020
    • Data Source
      KAKENHI-PROJECT-18K19546
  • [Presentation] 非B非C肝細胞癌の臨床的および分子生物学的特徴と予後に関する検討2020

    • Author(s)
      村井大毅、小玉尚宏、竹原徹郎
    • Organizer
      第56回日本肝癌研究会
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] プール型CRISPRライブラリーを用いたNASH新規治療標的分子の網羅的探索2020

    • Author(s)
      明神悠太、小玉尚宏、竹原徹郎
    • Organizer
      第56回肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] 非B非C肝癌の臨床的特徴とNAFLDからの肝癌発症早期診断マーカーの検討2020

    • Author(s)
      村井大毅、小玉尚宏、竹原徹郎
    • Organizer
      第56回肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] Serum ST6GAL1 is a novel biomarker for predicting efficacy of tyrosine kinase inhibitors in hepatocellular carcinoma2020

    • Author(s)
      Yuta Myojin, Takahiro Kodama, Kazuki Maesaka, Yu Sato, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      The Liver Meeting Digital Experience (TLMdX)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] Molecular and immunological profiling of non-viral hepatocellular carcinoma through multi-omics approach2020

    • Author(s)
      Hiroki Murai, Takahiro Kodama, Shoichiro Tange, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      The Liver Meeting Digital Experience (TLMdX)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] 非B非C肝細胞癌の背景肝疾患別臨床的及び分子生物学的特徴の検討2020

    • Author(s)
      村井大毅、小玉尚宏、竹原徹郎
    • Organizer
      第106回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] Identification and functional analysis of UBE2D3, a novel tumor suppressor gene of hepatocellular carcinoma2020

    • Author(s)
      Hiroki Murai, Takahiro Kodama, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      The Liver Meeting Digital Experience (TLMdX)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] 慢性膵炎におけるHippo/PI3K経路の調節不全と治療標的としての可能性2020

    • Author(s)
      田村猛、小玉尚宏、吉岡鉄平、重川稔、疋田隼人、阪森亮太郎、秋田裕史、江口英利、巽智秀、竹原徹郎
    • Organizer
      第51回日本膵臓学会大会
    • Data Source
      KAKENHI-PROJECT-18K19546
  • [Presentation] Genome-wide pooled CRISPR library screen identifies genetic mediators of hepatocyte lipotoxicity2020

    • Author(s)
      Takahiro Kodama, Yuta Myojin, Tetsuo Takehara
    • Organizer
      第24回日本肝臓学会大会
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] Hepatic stellate cell autophagy promotes HCC progression via GDF152020

    • Author(s)
      Yuta Myojin, Hayato Hikita, Masaya Sugiyama, Takahiro Kodama, Yuki Makino, Ryoko Yamada, Tasuku Nakabori, Ryotaro Sakamori, Tomohide Tatsumi, Masashi Mizokami, Tetsuo Takehara
    • Organizer
      The Digital International Liver Congress of the European Association for the Study of the Liver (EASL)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20H03661
  • [Presentation] プール型CRISPRライブラリースクリーニングによる肝がんレゴラフェニブ効果予測マーカーの探索2020

    • Author(s)
      小玉尚宏、末村茂樹、疋田隼人、阪森亮太郎、巽智秀、竹原徹郎
    • Organizer
      第21回日本肝がん分子標的治療研究会
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] In vivo rapid genetic screen of efficacy biomarker for multi-kinase inhibitors in hepatocellular carcinoma2019

    • Author(s)
      Takahiro Kodama, Yuta Myojin, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      JDDW2019
    • Data Source
      KAKENHI-PROJECT-17H04160
  • [Presentation] High-throughput discovery of liver cancer genes by forward genetic screens in mice2019

    • Author(s)
      Takahiro Kodama, Tetsuo Takehara
    • Organizer
      APPLE2019
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] In vivo oncogene library screen of predictive biomarkers for multi-kinase inhibitors in hepatocellular carcinoma2019

    • Author(s)
      小玉尚宏、明神悠太、山田涼子、疋田隼人、阪森亮太郎、巽智秀、竹原徹郎
    • Organizer
      第55回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] 肝細胞癌に対するレンバチニブの初期治療成績2019

    • Author(s)
      前阪和城、阪森亮太郎、山田涼子、中堀 輔、重川 稔、小玉尚宏、疋田隼人、巽 智秀、竹原徹郎
    • Organizer
      第20回日本肝がん分子標的治療研究会
    • Data Source
      KAKENHI-PROJECT-17H04160
  • [Presentation] THE RELATIONSHIP BETWEEN OBSERVATION INTERVAL AND PROGNOSIS IN PANCREATIC CANCER ASSOCIATED WITH PANCREATIC CYSTIC LESIONS2019

    • Author(s)
      Teppei Yoshioka, Minoru Shigekawa, Yu Sato, Junya Okabe, Takeshi Tamura, Katsuhiko Sato, Makiko Urabe, Takuo Yamai, Takahiro Suda, Ryoko Yamada, Takahiro Kodama, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi and Tetsuo Takehara
    • Organizer
      Digestive Disease Week (DDW2019)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19546
  • [Presentation] 肝臓におけるHippo/PI3K経路の制御異常はNASH進展と肝癌発症を促進する2019

    • Author(s)
      小玉 尚宏、疋田 隼人、竹原 徹郎
    • Organizer
      第55回日本肝臓学会総会
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] In vivo rapid genetic screen of efficacy biomarkers for multi-kinase inhibitors in Hepatocellular carcinoma2019

    • Author(s)
      Takahiro Kodama , Yuta Myojin , Hayato Hikita , Ryotaro Sakamori , Tomohide Tatsumi , Tetsuo Takehara
    • Organizer
      JDDW 2019
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] Whole-genome Sleeping Beauty mutagenesis screens identify the Hippo pathway as the driver of NAFLD-related hepatocellular carcinoma2019

    • Author(s)
      T Kodama, J Yi, J.Y. Newberg, J.C. Tien, H Wu, M.J. Finegold, M Kodama, T Tamura, R.L. Johnson, N.A. Jenkins, T Takehara, N.G. Copeland
    • Organizer
      11th AACR-JCA Joint Conference on Breakthrough in Cancer Reserch
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] CRISPR loss-of-function screen identifies the Hippo pathway as the potential efficacy biomarker of regorafenib in HCC2019

    • Author(s)
      Takahiro Kodama, Shigeki Suemura, Yuta Myojin, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      第78回日本癌学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] 生体内forward genetic screenによる肝がんドライバー遺伝子の網羅的探索2019

    • Author(s)
      小玉尚宏、巽 智秀、竹原徹郎
    • Organizer
      第105回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-17H04160
  • [Presentation] 肝細胞癌においてHippo経路はレゴラフェニブの治療効果を修飾する2019

    • Author(s)
      小玉尚宏、末村茂樹、疋田隼人、阪森亮太郎、巽智秀、竹原徹郎
    • Organizer
      第55回日本肝癌研究会
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] 生体内forward genetic screenによる肝がんドライバー遺伝子の網羅的探索2019

    • Author(s)
      小玉 尚宏、巽 智秀、竹原 徹郎
    • Organizer
      第105回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] CRISPR LOSS-OF-FUNCTION SCREEN IDENTIFIES THE HIPPO SIGNALLING PATHWAY AS THE MEDIATOR OF REGORAFENIB EFFICACY IN HEPATOCELLULAR CARCINOMA2019

    • Author(s)
      Takahiro Kodama, Shigeki Suemura, Yuta Myojin, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
    • Organizer
      AASLD The Liver Meeting 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] NASH肝発がんにおけるHippo経路の意義と治療標的としての有用性2018

    • Author(s)
      小玉 尚宏, 阪森 亮太郎, 竹原 徹郎
    • Organizer
      第54回日本肝臓学会大会
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] 肝がんにおける新規癌抑制遺伝子RNF125の同定と機能解析2018

    • Author(s)
      小玉 尚宏, 末村 茂樹, 村井 大毅, 疋田 隼人, 阪森 亮太郎, 巽 智秀, 竹原 徹郎
    • Organizer
      第54回日本肝臓学会大会
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] プール型全ゲノムCRISPR/Casライブラリーを用いた肝癌新規癌抑制遺伝子とソラフェニブ感受性因子探索2018

    • Author(s)
      小玉 尚宏、疋田 隼人, 阪森 亮太郎, 巽 智秀, 竹原 徹郎
    • Organizer
      第54回日本肝臓学会大会
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] トランスポゾンスクリーニングを用いたNASH由来肝癌ドライバー遺伝子の網羅的探索2018

    • Author(s)
      小玉 尚宏, 巽 智秀, 竹原 徹郎
    • Organizer
      第104回日本消化器病学会総会
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] Forward genetic screens of genes determining the efficacy of molecular target therapy in hepatocellular carcinoma2018

    • Author(s)
      小玉 尚宏, 明神 悠太、疋田 隼人、阪森 亮太郎, 竹原 徹郎
    • Organizer
      第77回日本癌学会大会
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] Whole-genome Sleeping Beauty mutagenesis screens identify the Hippo pathway as the driver of NAFLD-related hepatocellular carcinoma2018

    • Author(s)
      Takahiro Kodama, Jing Yi, Justin Y. Newberg, Hao Wu, Milton J. Finegold, Takeshi Tamura, Tetsuo Takehara, Randy L. Johnson, Nancy A. Jenkins, Neal G. Copeland
    • Organizer
      The Liver Meeting 2018 in AASLD
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] Hippo経路の破綻は脂肪性肝疾患からの肝癌発症のドライバーである2017

    • Author(s)
      小玉尚宏、巽智秀、竹原徹郎
    • Organizer
      JDDW2017
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] Two-step in vivo forward genetic screens in mice discover and validate novel tumor suppressor genes in HCC2017

    • Author(s)
      Takahiro Kodama, Tetsuo Takehara
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K09422
  • [Presentation] 肝細胞p53による肝線維化誘導機構の解析2012

    • Author(s)
      小玉尚宏、他
    • Organizer
      第48回日本肝臓学会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2012-06-08
    • Data Source
      KAKENHI-PROJECT-24590971
  • [Presentation] 肝細胞のアポトーシスによる酸化ストレス発生と肝発癌2012

    • Author(s)
      疋田隼人、小玉尚宏、他
    • Organizer
      第48回日本肝臓学会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2012-06-07
    • Data Source
      KAKENHI-PROJECT-24590971
  • [Presentation] Bid and Bim are essential regulators involving the intrinsic pathway of apoptosis in hepatocytes in the absence of antiapoptotic Bcl-2 family proteins2012

    • Author(s)
      小玉尚宏、他
    • Organizer
      Digestive Disease Week 2012
    • Place of Presentation
      米国サンディエゴ市
    • Year and Date
      2012-05-22
    • Data Source
      KAKENHI-PROJECT-24590971
  • [Presentation] 肝細胞アポトーシス持続による肝発癌誘導は抗酸化剤で抑制される2012

    • Author(s)
      疋田隼人、小玉尚宏、他
    • Organizer
      第19回肝細胞研究会
    • Place of Presentation
      北海道札幌市
    • Year and Date
      2012-06-29
    • Data Source
      KAKENHI-PROJECT-24590971
  • [Presentation] 自己免疫性肝炎におけるNKT細胞の関与2012

    • Author(s)
      西尾久美子、小玉尚宏、他
    • Organizer
      第48回日本肝臓学会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2012-06-07
    • Data Source
      KAKENHI-PROJECT-24590971
  • [Presentation] ミトコンドリア介在性アポトーシスによる成熟肝細胞の恒常性制御機構の解明2012

    • Author(s)
      小玉尚宏、他
    • Organizer
      第48回日本肝臓学会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2012-06-07
    • Data Source
      KAKENHI-PROJECT-24590971
  • [Presentation] C型肝炎における肝メチル化の定量的評価2012

    • Author(s)
      清水聡、小玉尚宏、他
    • Organizer
      第48回日本肝臓学会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2012-06-08
    • Data Source
      KAKENHI-PROJECT-24590971
  • [Presentation] Ras経路が活性化されている肝細胞癌においてSTAT3シグナルは有用な治療ターゲットとなりうる2012

    • Author(s)
      重川稔、小玉尚宏、他
    • Organizer
      第48回日本肝臓学会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2012-06-07
    • Data Source
      KAKENHI-PROJECT-24590971
  • [Presentation] 抗てんかん薬カルバマゼピンによる肝切除後肝再生促進機構の解析2012

    • Author(s)
      川口司、小玉尚宏、他
    • Organizer
      第48回日本肝臓学会
    • Place of Presentation
      石川県金沢市
    • Year and Date
      2012-06-07
    • Data Source
      KAKENHI-PROJECT-24590971
  • 1.  Tatsumi Tomohide (20397699)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 43 results
  • 2.  疋田 隼人 (20623044)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 24 results
  • 3.  Takehara Tetsuo (70335355)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 8 results
  • 4.  Shigekawa Minoru (00625436)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  阪森 亮太郎 (10644685)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 12 results
  • 6.  SATOH Takashi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  KONDO Yasuteru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  ASAHINA Yasuhiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  松浦 善治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  塩出 悠登
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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