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satoh michio  佐藤 道大

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Sato Michio  佐藤 道大

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Researcher Number 10629695
Other IDs
Affiliation (Current) 2022: 静岡県立大学, 薬学部, 講師
Affiliation (based on the past Project Information) *help 2017 – 2022: 静岡県立大学, 薬学部, 講師
Review Section/Research Field
Principal Investigator
Basic Section 47050:Environmental and natural pharmaceutical resources-related / Bioorganic chemistry
Except Principal Investigator
Medium-sized Section 38:Agricultural chemistry and related fields
Keywords
Principal Investigator
二次代謝産物 / 天然物生合成 / 標的分子 / ゲノムマイニング / 生合成 / ポリケタイド / 非リボソームペプチド / シトクロームP450 / X線結晶構造解析 / 酵素 … More / 抗生物質 / 微生物 / 自己耐性 / 標的タンパク質 / 糸状菌 … More
Except Principal Investigator
天然物 / 生合成 / Diels-Alder / 反応メカニズム / Diels-Alderase / 生合成酵素 / Diels-Alder反応 / 天然物生合成 / 酵素反応機構 / [4+2]環化反応 / spiro-carbon / monooxygenase / FAD / epoxidation / 天然物化学 / 酸化反応 / 計算化学 / コリバクチン / 大腸がん / がん化学予防法 Less
  • Research Projects

    (5 results)
  • Research Products

    (37 results)
  • Co-Researchers

    (11 People)
  •  Understanding a mechanism of an onset of colorectal cancer by colibactin and finding a inhibitor to the biosynthetic enzymes

    • Principal Investigator
      渡辺 賢二
    • Project Period (FY)
      2022 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 38:Agricultural chemistry and related fields
    • Research Institution
      University of Shizuoka
  •  Identification of target molecules based on self-resistance gene-directed genome miningPrincipal Investigator

    • Principal Investigator
      佐藤 道大
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47050:Environmental and natural pharmaceutical resources-related
    • Research Institution
      University of Shizuoka
  •  Compound discovery by target mining using potential target moleculesPrincipal Investigator

    • Principal Investigator
      SATO Michio
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47050:Environmental and natural pharmaceutical resources-related
    • Research Institution
      University of Shizuoka
  •  Integrating Computational and Experimental Approaches for New Paradigms in Molecule Synthesis

    • Principal Investigator
      Watanabe Kenji
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 38:Agricultural chemistry and related fields
    • Research Institution
      University of Shizuoka
  •  Biosynthetic study of oxaleimidesPrincipal Investigator

    • Principal Investigator
      Sato Michio
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Bioorganic chemistry
    • Research Institution
      University of Shizuoka

All 2021 2020 2019 2018 2017

All Journal Article Presentation

  • [Journal Article] Catalytic mechanism and endo-to-exo selectivity reversion of an octalin-forming natural Diels-Alderase2021

    • Author(s)
      Sato Michio、Kishimoto Shinji、Yokoyama Mamoru、Jamieson Cooper S.、Narita Kazuto、Maeda Naoya、Hara Kodai、Hashimoto Hiroshi、Tsunematsu Yuta、Houk Kendall N.、Tang Yi、Watanabe Kenji
    • Journal Title

      Nature Catalysis

      Volume: 4 Pages: 223-232

    • DOI

      10.1038/s41929-021-00577-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K05866, KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-20H03197, KAKENHI-PROJECT-17K07314, KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-19KK0150
  • [Journal Article] Biosynthesis of the Immunosuppressant FR9014832021

    • Author(s)
      Zhang Zhuan、Tamura Yui、Tang Mancheng、Qiao Tianzhang、Sato Michio、Otsu Yoshihiro、Sasamura Satoshi、Taniguchi Masatoshi、Watanabe Kenji、Tang Yi
    • Journal Title

      Journal of the American Chemical Society

      Volume: 143 Pages: 132-136

    • DOI

      10.1021/jacs.0c12352

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-19KK0150, KAKENHI-PLANNED-16H06449
  • [Journal Article] <i>o</i>-Anisidine Dimer, 2-Methoxy-<i>N</i><sup>4</sup>-(2-methoxyphenyl) Benzene-1,4-diamine, in Rat Urine Associated with Urinary bladder Carcinogenesis2021

    • Author(s)
      Kobayashi Takuma、Toyoda Takeshi、Tajima Yuya、Kishimoto Shinji、Tsunematsu Yuta、Sato Michio、Matsushita Kohei、Yamada Takanori、Shimamura Yuko、Masuda Shuichi、Ochiai Masako、Ogawa Kumiko、Watanabe Kenji、Takamura-Enya Takeji、Totsuka Yukari、Wakabayashi Keiji、Miyoshi Noriyuki
    • Journal Title

      Chemical Research in Toxicology

      Volume: 34 Pages: 912-919

    • DOI

      10.1021/acs.chemrestox.0c00536

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-20K10452, KAKENHI-PROJECT-19H02898, KAKENHI-PROJECT-19K12344, KAKENHI-PROJECT-20H04109
  • [Journal Article] ディールス-アルダラーゼとはどういった酵素なのか2021

    • Author(s)
      佐藤道大, 渡辺賢二
    • Journal Title

      化学

      Volume: 2 Pages: 72-73

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19KK0150
  • [Journal Article] Biosynthesis of triacsin featuring an N-hydroxytriazene pharmacophore2021

    • Author(s)
      Del Rio Flores Antonio、Twigg Frederick F.、Du Yongle、Cai Wenlong、Aguirre Daniel Q.、Sato Michio、Dror Moriel J.、Narayanamoorthy Maanasa、Geng Jiaxin、Zill Nicholas A.、Zhai Rui、Zhang Wenjun
    • Journal Title

      Nature Chemical Biology

      Volume: 17 Pages: 1305-1313

    • DOI

      10.1038/s41589-021-00895-3

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07136
  • [Journal Article] Isolation of New Colibactin Metabolites from Wild-Type Escherichia coli and In Situ Trapping of a Mature Colibactin Derivative2021

    • Author(s)
      Zhou Tao、Hirayama Yuichiro、Tsunematsu Yuta、Suzuki Nanami、Tanaka Seiji、Uchiyama Nahoko、Goda Yukihiro、Yoshikawa Yuko、Iwashita Yuji、Sato Michio、Miyoshi Noriyuki、Mutoh Michihiro、Ishikawa Hideki、Sugimura Haruhiko、Wakabayashi Keiji、Watanabe Kenji
    • Journal Title

      Journal of the American Chemical Society

      Volume: 143 Pages: 5526-5533

    • DOI

      10.1021/jacs.1c01495

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-19H02898
  • [Journal Article] Association between dietary intake and the prevalence of tumourigenic bacteria in the gut microbiota of middle-aged Japanese adults2020

    • Author(s)
      Watanabe Daiki、Murakami Haruka、Ohno Harumi、Tanisawa Kumpei、Konishi Kana、Tsunematsu Yuta、Sato Michio、Miyoshi Noriyuki、Wakabayashi Keiji、Watanabe Kenji、Miyachi Motohiko
    • Journal Title

      Sci Rep

      Volume: 10 Pages: 15221-15221

    • DOI

      10.1038/s41598-020-72245-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-19K20207, KAKENHI-PROJECT-19H04065
  • [Journal Article] Characterization of Colibactin-Producing <i>Escherichia coli</i> Isolated from Japanese Patients with Colorectal Cancer2020

    • Author(s)
      Yoshikawa Yuko、Tsunematsu Yuta、Matsuzaki Nobuo、Hirayama Yuichiro、Higashiguchi Fumi、Sato Michio、Iwashita Yuji、Miyoshi Noriyuki、Mutoh Michihiro、Ishikawa Hideki、Sugimura Haruhiko、Wakabayashi Keiji、Watanabe Kenji
    • Journal Title

      Jpn J Infect Dis

      Volume: 73 Issue: 6 Pages: 437-442

    • DOI

      10.7883/yoken.jjid.2020.066

      10.7883/yoken.JJID.2020.066

    • NAID

      130007942237

    • ISSN
      1344-6304, 1884-2836
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-17K08841
  • [Journal Article] A new class of dimeric product isolated from the fungus Chaetomium globosum: evaluation of chemical structure and biological activity2020

    • Author(s)
      Sarmales-Murga Christopher、Akaoka Fumito、Sato Michio、Takanishi Jun、Mino Takashi、Miyoshi Noriyuki、Watanabe Kenji
    • Journal Title

      The Journal of Antibiotics

      Volume: 73 Pages: 320-323

    • DOI

      10.1038/s41429-020-0281-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-19K07136
  • [Journal Article] Specialized Flavoprotein Promotes Sulfur Migration and Spiroaminal Formation in Aspirochlorine Biosynthesis2020

    • Author(s)
      Tsunematsu Yuta、Maeda Naoya、Sato Michio、Hara Kodai、Hashimoto Hiroshi、Watanabe Kenji、Hertweck Christian
    • Journal Title

      Journal of the American Chemical Society

      Volume: 143 Pages: 206-213

    • DOI

      10.1021/jacs.0c08879

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-19KK0150, KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-20H03197, KAKENHI-PROJECT-17K07314
  • [Journal Article] Elevated levels of proinflammatory volatile metabolites in feces of high fat diet fed KK-Ay mice.2020

    • Author(s)
      Uchikawa Misaki、Kato Mai、Nagata Akika、Sanada Shunsuke、Yoshikawa Yuto、Tsunematsu Yuta、Sato Michio、Suzuki Takuji、Hashidume Tsutomu、Watanabe Kenji、Yoshikawa Yuko、Miyoshi Noriyuki
    • Journal Title

      Scientific Reports

      Volume: 10 Pages: 1-11

    • DOI

      10.1038/s41598-020-62541-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H03041, KAKENHI-PROJECT-18K11123, KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-17K08841
  • [Journal Article] ディールス-アルダラーゼとはどういった酵素なのか?2020

    • Author(s)
      佐藤道大、渡辺賢二
    • Journal Title

      化学

      Volume: 76 Pages: 72-73

    • Data Source
      KAKENHI-PROJECT-19KK0150
  • [Journal Article] Genotyping of a gene cluster for production of colibactin and in vitro genotoxicity analysis of Escherichia coli strains obtained from the Japan Collection of Microorganisms.2020

    • Author(s)
      Kawanishi Masanobu、Shimohara Chiaki、Oda Yoshimitsu、Hisatomi Yuuta、Tsunematsu Yuta、Sato Michio、Hirayama Yuichiro、Miyoshi Noriyuki、Iwashita Yuji、Yoshikawa Yuko、Sugimura Haruhiko、Mutoh Michihiro、Ishikawa Hideki、Wakabayashi Keiji、Yagi Takashi、Watanabe Kenji
    • Journal Title

      Genes and Environment

      Volume: 42 Pages: 12-12

    • DOI

      10.1186/s41021-020-00149-z

    • NAID

      120006843780

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18J02190, KAKENHI-PROJECT-19K07136, KAKENHI-PROJECT-20K05866, KAKENHI-PROJECT-19H02898, KAKENHI-PROJECT-17K08841
  • [Journal Article] Biosynthesis of lagopodins in mushroom involves a complex network of oxidation reactions.2019

    • Author(s)
      Masuya Takahiro、Tsunematsu Yuta、Hirayama Yuichiro、Sato Michio、Noguchi Hiroshi、Nakazawa Takehito、Watanabe Kenji
    • Journal Title

      Organic and Biomolecular Chemistry

      Volume: 17 Pages: 234-239

    • DOI

      10.1039/c8ob02814a

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-16H06449, KAKENHI-PROJECT-16H05840, KAKENHI-PROJECT-17H07002, KAKENHI-PROJECT-17K15265
  • [Journal Article] Identifying the Biosynthetic Gene Cluster for Triacsins with an N-Hydroxytriazene Moiety.2019

    • Author(s)
      Twigg FF, Cai W, Huang W, Liu J, Sato M, Perez TJ, Geng J, Dror MJ, Montanez I, Tong TL, Lee H, Zhang W.
    • Journal Title

      ChemBioChem

      Volume: 20 Pages: 1145-1149

    • DOI

      10.1002/cbic.201800762

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H07002
  • [Presentation] Diels-Alderaseのジアステレオ選択性および生成物阻害回避メカニズムの解明2021

    • Author(s)
      佐藤道大、岸本真治、Cooper S. Jamiesonc、原幸大、橋本博、恒松雄太、Houk N. Kendall、Yi Tang、渡辺賢二
    • Organizer
      第62回天然有機化合物討論会
    • Data Source
      KAKENHI-PROJECT-19KK0150
  • [Presentation] 酵素的[4+2]環化付加反応の分子機構の解明2021

    • Author(s)
      佐藤道大
    • Organizer
      日本農芸化学会2021年度大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K07136
  • [Presentation] FR901483産生菌におけるに対する自己耐性機構の解明2021

    • Author(s)
      中原実玖,田村優衣,佐藤道大,原幸大,橋本博,Tang Yi,渡辺賢二
    • Organizer
      日本生薬学会第67年会
    • Data Source
      KAKENHI-PROJECT-19K07136
  • [Presentation] 共生型子嚢菌Pyrenula sp.に由来するpyrenulic acid類の生合成研究2021

    • Author(s)
      伊藤 優衣、佐藤 道大、籠浦 倫美、恒松 雄太、竹仲 由希子、棚橋 孝雄、渡辺 賢二
    • Organizer
      日本農芸化学会2021年度大会
    • Data Source
      KAKENHI-PROJECT-19K07136
  • [Presentation] 微生物が制御するDiels-Alder反応2021

    • Author(s)
      佐藤道大
    • Organizer
      日本農芸化学会中部支部 第191回例会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K07136
  • [Presentation] Cladobotryum属真菌が生産するFR901483に対する自己耐性機構の解明2021

    • Author(s)
      中原実玖,田村優衣,佐藤道大,原幸大,橋本博,Tang Yi,渡辺賢二
    • Organizer
      第23回天然薬物の開発と応用シンポジウム
    • Data Source
      KAKENHI-PROJECT-19K07136
  • [Presentation] Diels-Alderaseのジアステレオ選択性および生成物阻害回避メカニズムの解明2020

    • Author(s)
      佐藤 道大、岸本 真治、Cooper S. Jamieson、原 幸大、橋本 博、恒松 雄太、Houk N. Kendall、Yi Tang、渡辺 賢二
    • Organizer
      第 62 回 天然有機化合物討論会
    • Data Source
      KAKENHI-PROJECT-19K07136
  • [Presentation] 免疫抑制活性物質FR901483の生合成研究2020

    • Author(s)
      田村優依, 佐藤道大, 谷口昌要, 笹村智司, 大津嘉弘, 永井浩二, 渡辺賢二
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-19K07136
  • [Presentation] 酵素的Diels-Alder反応におけるジアステレオ選択性の制御機構2020

    • Author(s)
      佐藤道大, 岸本真治, Jamieson Cooper, 成田一仁, 前田直哉, 原幸大, 橋本博, 恒松雄太, Houk N. Kendall, Yi Tang, 渡辺賢二
    • Organizer
      日本薬学会第140年会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19KK0150
  • [Presentation] Diels-Alderase のジアステレオ選択性および生成物阻害回避メカニズムの解明2020

    • Author(s)
      佐藤道大, 岸本真治, Cooper S. Jamieson, 原幸大, 橋本博, 恒松雄太, Houk N. Kendall, Yi Tang, 渡辺賢二
    • Organizer
      第62回天然有機化合物討論会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19KK0150
  • [Presentation] 免疫抑制活性物質FR901483の生合成研究2020

    • Author(s)
      田村優依, 佐藤道大, 谷口昌要, 笹村智司, 大津嘉弘, 永井浩二, 渡辺賢二
    • Organizer
      日本農芸化学会2019年度大会
    • Data Source
      KAKENHI-PROJECT-19K07136
  • [Presentation] Diels-Alderase CghA の全容解明2020

    • Author(s)
      岸本真治, 佐藤道大, Jamieson Cooper, 横山葵, 成田一仁, 前田直哉, 恒松雄太, 原幸大, 橋本博, Houk Kendall N., 渡辺賢二
    • Organizer
      日本農芸化学会2020年度大会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19KK0150
  • [Presentation] 共生型子嚢菌Pyrenula sp.由来pyrenulic acid類の生合成研究2019

    • Author(s)
      佐藤道大、籠浦倫美、恒松雄太、竹仲由希子、棚橋孝雄、渡辺賢二
    • Organizer
      日本農芸化学会2019年度大会(東京)
    • Data Source
      KAKENHI-PROJECT-17H07002
  • [Presentation] 共生型子嚢菌Pyrenula sp.由来pyrenulic acid類の生合成研究2019

    • Author(s)
      佐藤道大、籠浦倫美、恒松雄太、竹仲由希子、棚橋孝雄、渡辺賢二
    • Organizer
      日本薬学会第139年会(千葉)
    • Data Source
      KAKENHI-PROJECT-17H07002
  • [Presentation] 立体選択的反応機構の解明を目指したDiels-Alder反応を触媒するCghAの基質合成研究2018

    • Author(s)
      成田一仁、岸本真治、横山葵、恒松 雄太、佐藤 道大、渡辺賢二
    • Organizer
      日本薬学会東海支部合同学術大会2018
    • Data Source
      KAKENHI-PROJECT-17H07002
  • [Presentation] 酵素-生成物複合体を用いたCghAの立体選択的反応機構の解明2018

    • Author(s)
      横山葵、佐藤 道大、前田 直哉、恒松 雄太、原 幸大、橋本 博、渡辺 賢二
    • Organizer
      日本薬学会東海支部合同学術大会2018
    • Data Source
      KAKENHI-PROJECT-17H07002
  • [Presentation] 共生型子嚢菌Pyrenula sp.に由来するPyrenulic acid類の生合成遺伝子の同定2018

    • Author(s)
      籠浦倫美、佐藤道大、恒松雄太、竹仲由希子、棚橋孝雄、渡辺賢二
    • Organizer
      日本生薬学会第65回年会(広島)
    • Data Source
      KAKENHI-PROJECT-17H07002
  • [Presentation] 大腸がんリスク因子物質コリバクチンの生産菌検出に関する化学的研究2018

    • Author(s)
      平山裕一郎、松崎信生、玉舟亮太、恒松雄太、佐藤道大、吉川悠、三好規之、岩下雄二、椙村春彦、若林敬二、武藤倫弘、石川秀樹、渡辺賢二
    • Organizer
      がん予防学術大会2018高松
    • Data Source
      KAKENHI-PROJECT-17H07002
  • [Presentation] Expanding the Scope of Biosynthetic Cooperativity Between Polyketide Megasynthases Through Genome Mining2018

    • Author(s)
      Michio Sato, Yi Tang, Kenji Watanabe
    • Organizer
      30th International Symposium on the Chemistry of Natural Products and the 10th International Congress on Biodiversity (ISCNP30 & ICOB10)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H07002
  • [Presentation] 糸状菌由来azaphilone系天然物cochliodone Aの生合成研究2018

    • Author(s)
      赤岡史人、高西潤、佐藤道大、三野孝、渡辺賢二
    • Organizer
      日本生薬学会第65回年会(広島)
    • Data Source
      KAKENHI-PROJECT-17H07002
  • [Presentation] 糸状菌ポリケタイド合成酵素によるイミド含有天然物の生合成2017

    • Author(s)
      佐藤道大, Jacob E. Dander, Neil K. Garg, Yi Tang, 渡辺賢二
    • Organizer
      第59回 天然有機化合物討論会
    • Data Source
      KAKENHI-PROJECT-17H07002
  • [Presentation] BIOSYNTHETIC COOPERATIVITY BETWEEN FUNGAL POLYKETIDE MEGASYNTHASES REVEALED THROUGH GENOME MINING2017

    • Author(s)
      Michio Sato, Kenji Watanabe, Yi Tang
    • Organizer
      IUMS2017(国際微生物学連合2017会議)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H07002
  • 1.  Watanabe Kenji (50360938)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 15 results
  • 2.  岸本 真治 (40814330)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 3.  恒松 雄太 (30629697)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 13 results
  • 4.  MIYOSHI Noriyuki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 5.  YOSHIKAWA Yuko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 6.  TAKAMURA Takeji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 7.  野口 博司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  橋本 博
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 9.  原 幸大
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 10.  谷澤 薫平
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  鈴木 拓史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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