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Takizawa Hitoshi  滝澤 仁

ORCIDConnect your ORCID iD *help
Researcher Number 10630866
Other IDs
Affiliation (Current) 2025: 熊本大学, 国際先端医学研究機構, 特定事業教員(教授)
Affiliation (based on the past Project Information) *help 2017 – 2024: 熊本大学, 国際先端医学研究機構, 特別招聘教授
2015 – 2017: 熊本大学, 国際先端医学研究機構, 特別招聘准教授
2016: 熊本大学, 学内共同利用施設等, その他
Review Section/Research Field
Principal Investigator
Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Basic Section 54010:Hematology and medical oncology-related / Basic Section 54010:Hematology and medical oncology-related / Hematology / Biological Sciences / Hematology / Medium-sized Section 52:General internal medicine and related fields
Except Principal Investigator
Basic Section 50010:Tumor biology-related / Hematology
Keywords
Principal Investigator
造血幹細胞 / 炎症 / クローナル造血 / 間葉系ストローマ細胞 / 骨髄ニッチ / 造血ニッチ / 赤血球造血 / inflammation / clonal hematopoiesis / Inflammation … More / Leukemia / Tracing / Lineage / Hematopoiesis / Clonal / 免疫記憶 / 自然免疫シグナル / 骨髄造血 / 遊走 / 老化 / 腸管炎症 / 造血前駆細胞 / 間葉系幹細胞 / ヒト化マウス、造血幹細胞、骨髄ニッチ、白血病 / 造血幹細胞ニッチ / ヒト化マウス / 移植・再生医療 / 造血幹細胞、炎症、感染 / 炎症ストレス / Toll-like receptor / 感染 … More
Except Principal Investigator
シングルセル / ゲノミクス / ゲノム編集 / ヒト患者腫瘍組織移植モデル / BCR-ABL1 / B前駆細胞型急性リンパ性白血病 / メタボロミクス / PDX / IKZF1 / BCP-ALL / リンパ腫 / 発がん機序 / 点突然変異 / がん遺伝子 / シグナル伝達 / B細胞 / 遺伝子変異 / 悪性リンパ腫 / 造血幹細胞 / 血液内科学 / 血液内科 Less
  • Research Projects

    (16 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (17 People)
  •  Understanding brain dysfunction caused by clonal hematopoiesisPrincipal Investigator

    • Principal Investigator
      滝澤 仁
    • Project Period (FY)
      2024 – 2025
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
    • Research Institution
      Kumamoto University
  •  IKZF1変異によるB前駆細胞型急性リンパ性白血病悪性化の機序

    • Principal Investigator
      吉田 年美
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Kumamoto University
  •  造血幹細胞における自然免疫記憶の形成と維持Principal Investigator

    • Principal Investigator
      滝澤 仁
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for JSPS Fellows
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Kumamoto University
  •  tRNA修飾異常を起点とした赤血球プロテオスタシスの破綻Principal Investigator

    • Principal Investigator
      滝澤 仁
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
    • Research Institution
      Kumamoto University
  •  Mechanism underlying initiation of bone marrow hematopoiesis in neonatePrincipal Investigator

    • Principal Investigator
      Takizawa Hitoshi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Kumamoto University
  •  Modulation of immune memory in blood stem cell toward effective host defensePrincipal Investigator

    • Principal Investigator
      Takizawa Hitoshi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
    • Review Section
      Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
    • Research Institution
      Kumamoto University
  •  Investigating the mechanisms of B cell lymphomagenesis driven by MYD88 and CD79B mutations

    • Principal Investigator
      Horikawa Keisuke
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 50010:Tumor biology-related
    • Research Institution
      Kumamoto University
  •  Understanding of hematopoietic stem cell trafficking across developmental hematopoietic organsPrincipal Investigator

    • Principal Investigator
      TAKIZAWA Hitoshi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Kumamoto University
  •  Inflammation induced emergence and evolution of clonal hematopoiesisPrincipal Investigator

    • Principal Investigator
      Takizawa Hitoshi
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Kumamoto University
  •  Role of inflammation in initiation and progression of clonal hematopoiesisHost Researcher

    • Principal Investigator
      滝澤 仁
    • Host Researcher
      滝澤 仁
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for JSPS Fellows
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Kumamoto University
  •  Mechanism of stem cell aging induced by inflammatory stressPrincipal Investigator

    • Principal Investigator
      滝澤 仁
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kumamoto University
  •  understanding of leukemic niche signal to establish niche-targeting thearpyPrincipal Investigator

    • Principal Investigator
      滝澤 仁
    • Project Period (FY)
      2017
    • Research Category
      Grant-in-Aid for JSPS Fellows
    • Research Field
      Hematology
    • Research Institution
      Kumamoto University
  •  Reconstiution of functional artificail bone marrow niche via induction of mesenchymal stromal cell divisionPrincipal Investigator

    • Principal Investigator
      Takizawa Hitoshi
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Hematology
    • Research Institution
      Kumamoto University
  •  炎症性因子による造血幹細胞老化のメカニズムPrincipal Investigator

    • Principal Investigator
      滝澤 仁
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kumamoto University
  •  Analysis of normal and malignant hematopoietic niche using nove bone marrow humanized micePrincipal Investigator

    • Principal Investigator
      Takizawa Hitoshi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Hematology
    • Research Institution
      Kumamoto University
  •  Induction of self-renewal in single hematopoietic stem cells

    • Principal Investigator
      Ema Hideo
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Kumamoto University
      Keio University

All 2023 2022 2019 2018 2017 2016 2015

All Journal Article Presentation Book

  • [Book] 炎症に対する造血幹細胞応答2016

    • Author(s)
      滝澤 仁
    • Publisher
      日本血液学会 臨床血液
    • Data Source
      KAKENHI-PUBLICLY-15H01519
  • [Book] Humanized Mice for HIV Research2015

    • Author(s)
      Kovtonyuk LV, Takizawa H.
    • Total Pages
      538
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-15H05669
  • [Journal Article] Inflammation Regulates Haematopoietic Stem Cells and Their Niche2022

    • Author(s)
      Ho Nicole Pui-Yu、Takizawa Hitoshi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 3 Pages: 1125-1125

    • DOI

      10.3390/ijms23031125

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21KK0150
  • [Journal Article] Hlf expression marks the developmental pathway for hematopoietic stem cells but not for erythroid-myeloid progenitors2019

    • Author(s)
      Yokomizo T*, Watanabe N, Umemoto T, Matsuo J, Harai R, Kihara Y, Nakamura E, Tada N, Sato T, Takaku T, Shimono A, Takizawa H, Nakagata N, Mori S, Kurokawa M, Tenen DG, Osato M, Suda T
    • Journal Title

      J Exp Med

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18H02843
  • [Journal Article] Development of the Hematopoietic System: Role of Inflammatory Factors2019

    • Author(s)
      Hayashi Y#, Sezaki M#, Takizawa H*
    • Journal Title

      Wiley Interdiscip Rev Dev Biol

      Volume: 27 Issue: 4

    • DOI

      10.1002/wdev.341

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-17H05651, KAKENHI-PROJECT-18H02843, KAKENHI-PROJECT-18J20690, KAKENHI-PROJECT-18K16091
  • [Journal Article] 炎症と造血”Inflammation and early hematopoiesis2018

    • Author(s)
      滝澤 仁、林 慶和
    • Journal Title

      臨床血液

      Volume: 59 Pages: 1955-1961

    • Data Source
      KAKENHI-PUBLICLY-17H05651
  • [Journal Article] Engineered humanized bone organs maintain human hematopoiesis in vivo2018

    • Author(s)
      Kristin Fritsch; Sebastien;bastien Pigeot; Xiaomin Feng; Paul E Bourgine; Timm Schroeder; Ivan Martin; Markus Manz; Hitoshi Takizawa
    • Journal Title

      Experimental Hematology

      Volume: 印刷中

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17F17424
  • [Journal Article] Engineered humanized bone organs maintain human hematopoiesis in vivo,2018

    • Author(s)
      1.Fritsch K, Pigeot S, Bourgine PE, Feng X, Schroeder T, Martin I, Manz MG, Takizawa H
    • Journal Title

      Experimental Hematology

      Volume: 61 Pages: 45-51.e5

    • DOI

      10.1016/j.exphem.2018.01.004

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05669, KAKENHI-PROJECT-16K15504
  • [Journal Article] Inflamm-Aging of hematopoiesis, hematopoietic stem cells, bone marrow microenvironment.2016

    • Author(s)
      Kovtonyuk LV, Fritsch K, Feng X, Manz MG, Takizawa H
    • Journal Title

      Frontiers in Immunology

      Volume: 14 Pages: 502-502

    • DOI

      10.3389/fimmu.2016.00502

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01519
  • [Journal Article] Enhanced thrombopoietin but not G-CSF receptor stimulation induces self-renewing hematopoietic stem cell divisions in vivo.2016

    • Author(s)
      Kovtonyuk LV, Markus G. Manz, Takizawa H
    • Journal Title

      Blood

      Volume: 0 Pages: 0-0

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01519
  • [Presentation] Erythroblast differentiation driven by mitochondrial translation2023

    • Author(s)
      Hitoshi Takizawa
    • Organizer
      Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies Symposium
    • Invited
    • Data Source
      KAKENHI-PROJECT-22K19548
  • [Presentation] Terminal erythroid differentiation is regulated by mitochondrial translation via maintenance of iron homeostasis2022

    • Author(s)
      Tatsuya Morishima, Md. Fakruddin, Takeshi Masuda, Yuxin Wang, Vivien A. C. Schoonenberg, Falk Butter, Yuichiro Arima, Kazuhito Tomizawa, Fan-Yan Wei, Toshio Suda, Hitoshi Takizawa
    • Organizer
      The 64th ASH Annual Meeting and Exposition
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K19548
  • [Presentation] Mitochondrial tRNA modification regulates erythroid differentiation by maintaining iron homeostasis2022

    • Author(s)
      Tatsuya Morishima, Md. Fakruddin, Takeshi Masuda, Yuxin Wang, Vivien A. C. Schoonenberg, Falk Butter, Yuichiro Arima, Kazuhito Tomizawa, Fan-Yan Wei, Toshio Suda, Hitoshi Takizawa
    • Organizer
      The 84th Annual Meeting of Japanese Society of Hematology
    • Data Source
      KAKENHI-PROJECT-22K19548
  • [Presentation] Innate Immune Signal-Regulated Hematopoiesis2019

    • Author(s)
      Hitoshi Takizawa
    • Organizer
      61st ASH annual meeting
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19520
  • [Presentation] Microbial signal instructs early hematopoiesis upon intestinal tissue damage2019

    • Author(s)
      Yoshikazu Hayashi, Maiko Sezaki, Sumit Sheoran, Tatsuya Morishima1, Gaku Nakato, Shinji Fukuda, Hitoshi Takizawa
    • Organizer
      48th Annual Scientific Meeting of International Society of Experimental Hematology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19520
  • [Presentation] EARLY HEMATOPOIESIS TRANSLATES MICROBIAL SIGNALS TO INTESTINAL TISSUE REPAIR2019

    • Author(s)
      Hitoshi Takizawa
    • Organizer
      24th Congress of European Hematology Association
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19520
  • [Presentation] Taurine Modification of Mitochondrial tRNAs is Indispensable for Fetal Erythroid Differentiation2019

    • Author(s)
      Md. Fakruddin, Hitoshi Takizawa
    • Organizer
      第81回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-18F18408
  • [Presentation] Engineered human bone organ maintains hematopoietic stem cell and hematopoiesis2018

    • Author(s)
      Hitoshi Takizawa
    • Organizer
      JSPS-NUS joint symposium
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H05669
  • [Presentation] CyTof-driven discovery for hematopoietic stem cell biology2018

    • Author(s)
      Hitoshi Takizawa
    • Organizer
      CyTOF User Meeting
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-17H05651
  • [Presentation] 炎症と造血制御(Inflammation and hematopoietic regulation)2018

    • Author(s)
      Hitoshi Takizawa
    • Organizer
      The 80th Annual Meeting of the Japanese Society of Hematology
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05651
  • [Presentation] Gut inflammatory stress impacts early hematopoiesis2018

    • Author(s)
      Yoshikazu Hayashi and Hitoshi Takizawa
    • Organizer
      JSPS-NUS joint symposium
    • Data Source
      KAKENHI-PUBLICLY-17H05651
  • [Presentation] 感染における造血制御とその機能変容2018

    • Author(s)
      Hitoshi Takizawa
    • Organizer
      The 36th Annual Meeting of The Japanese Society for Bone and Mineral Research
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05651
  • [Presentation] Humanization of bone marrow niche for better maintenance of human hematopoiesis in xenograft model2017

    • Author(s)
      Xiaomin Feng1 Kristin Fritsch, Sebastien Pigeot, Yuichiro Arima, Koichi Nishiyama, Ivan Martin, Markus G. Manz, Hitoshi Takizawa
    • Organizer
      Japanese society of hematology
    • Data Source
      KAKENHI-PROJECT-16K15504
  • [Presentation] Humanization of bone marrow niche for better maintenance of human hematopoiesis in xenograft model2017

    • Author(s)
      Xiaomin Feng, Kristin Fritsch, Sebastien Pigeot, Yuichiro Arima, Koichi Nishiyama, Ivan Martin, Markus G. Manz, Hitoshi Takizawa
    • Organizer
      Japanese society of hematology
    • Data Source
      KAKENHI-PROJECT-15H05669
  • [Presentation] Impact of inflammatory stress on early hematopoiesis2017

    • Author(s)
      Yoshikazu Hayashi and Hitoshi Takizawa
    • Organizer
      Japanese soceity for immunology
    • Data Source
      KAKENHI-PUBLICLY-17H05651
  • [Presentation] Humanization of bone marrow niche for better maintenance of human hematopoiesis in xenograft model2017

    • Author(s)
      Xiaomin Feng, Kristin Fritsch, Sebastien Pigeot, Yuichiro Arima, Koichi Nishiyama, Ivan Martin, Markus G. Manz, Hitoshi Takizawa
    • Organizer
      日本血液学会
    • Place of Presentation
      東京
    • Year and Date
      2017-10-20
    • Data Source
      KAKENHI-PROJECT-17F17424
  • [Presentation] Impact of Inflammation in Hematopoietic Stem Cell Behavior2016

    • Author(s)
      Hitoshi Takizawa
    • Organizer
      JSPS-NUS symposium
    • Place of Presentation
      Singapore
    • Year and Date
      2016-01-14
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01519
  • [Presentation] Hematopoietic Stem Cell Response to Inflammation2015

    • Author(s)
      Hitoshi Takizawa
    • Organizer
      77th Annual Meeting of Japanese Society of Hematology
    • Place of Presentation
      Kanazawa, Japan
    • Year and Date
      2015-11-16
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-15H01519
  • [Presentation] its HDirect Activation of TLR4-TRIF-ROS-p38 Pathways Limematopoietic Stem Cell Fitness2015

    • Author(s)
      Hitoshi Takizawa
    • Organizer
      13th Stem Cell Symposium
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2015-05-29
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01519
  • 1.  FAKRUDDIN MD.
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 2.  Ema Hideo (50344445)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  Fumio Arai (90365403)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  Ryuji Yokokawa (10411216)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  Horikawa Keisuke (60313095)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  黒滝 大翼 (10568455)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  波江野 洋 (70706754)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  HO Pui・Yu (40888385)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 9.  山下 真幸 (80588038)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  河合 麻友 (50942687)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  吉田 年美 (80639154)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  FAKRUDDIN MD (20816475)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 13.  山下 貴之 (40466321)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  森嶋 達也 (40421375)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 15.  増田 豪 (70383940)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 16.  FENG XIAOMIN
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 17.  HO PUI YU
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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