Fujino Naoya 藤野直也

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FUJINO Naoya 藤野直也

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Researcher Number	10633670
Other IDs	https://orcid.org/0000-0003-3174-2632
Affiliation (Current)	2025: 東北大学, 大学病院, 助教
Affiliation (based on the past Project Information) *help	2017 – 2023: 東北大学, 大学病院, 助教 2016: 東北大学, 東北メディカル・メガバンク機構, 非常勤講師 2012 – 2013: 東北大学, 医学(系)研究科(研究院), 非常勤講師
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Respiratory organ internal medicine Except Principal Investigator Basic Section 55040:Respiratory surgery-related
Keywords	Principal Investigator 慢性閉塞性肺疾患 / 組織幹細胞 / COPD / Axl受容体チロシンキナーゼ / 炎症 / 気道上皮細胞 / 肺胞マクロファージ / マクロファージ / クロスプレゼンテーション / 細胞間相互作用 … More / ストレス応答機構 / 肺胞上皮II型細胞 / 幹細胞 / 肺胞II型上皮細胞 / 肺胞上皮細胞 / 喘息 / 気道上皮炎症制御 / Axlキナーゼ / アポトーシス細胞認識 / 基底細胞 / 好酸球性気道炎症 / 重症喘息 / 発現制御 / 再生医学 / シグナル伝達 / 細胞・組織 / 受容体チロシンキナーゼ / リモデリング / 気道上皮 / microRNA / II型肺胞上皮細胞 / 肺胞上皮前駆細胞 / 修復 / 上皮間葉移行 / マイクロRNA / 肺上皮前駆細胞 / 分化 / 自己複製 … More Except Principal Investigator マイクロアレイ / 慢性拒絶反応 / マウス / 高齢 / RNAシークエンス / 加齢 / 肺水腫 / RNAシーケンス / 高齢ドナー / 虚血・再灌流傷害 / 肺移植 Less

慢性閉塞性肺疾患における新規病原性肺胞マクロファージの同定と機能解析Principal Investigator
- Principal Investigator
  
  藤野直也
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Tohoku University
Molecular mechanisms on how alveolar epithelial cells respond to exogenous stress in COPDPrincipal Investigator
- Principal Investigator
  
  Fujino Naoya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Tohoku University
Why is prognosis of lung transplant recipient from elderly donors poor? –Elucidation of mechanisms and establishment of therapeutic intervention strategy-
- Principal Investigator
  
  Okada Yoshinori
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Tohoku University
Apototic cell-induced supression of inflammation in the airwayPrincipal Investigator
- Principal Investigator
  
  Fujino Naoya
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Tohoku University
Investigation of Axl receptor tyrosine kinase in COPD airwaysPrincipal Investigator
- Principal Investigator
  
  Fujino Naoya
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University
Identification of microRNAs that regulate differentiation of human lung progenitor cellsPrincipal Investigator
- Principal Investigator
  
  FUJINO Naoya
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Tohoku University

All 2024 2022 2021 2020 2019 2017 2013 2012

All Journal Article Presentation

[Journal Article] Identification of Siglec-1-negative alveolar macrophages with pro-inflammatory phenotypes in chronic obstructive pulmonary disease2024
- Author(s)
  Saito Takuya、Fujino Naoya、Kyogoku Yorihiko、Yamada Mitsuhiro、Okutomo Koji、Ono Yoshinao、Konno Shuichi、Endo Takuto、Itakura Koji、Matsumoto Shuichiro、Sano Hirohito、Aizawa Hiroyuki、Numakura Tadahisa、Onodera Katsuhiro、Okada Yoshinori、Hussell Tracy、Ichinose Masakazu、Sugiura Hisatoshi
- Journal Title
  
  American Journal of Physiology-Lung Cellular and Molecular Physiology
  
  Volume: - Issue: 6 Pages: L672-L686
- DOI
  10.1152/ajplung.00303.2023
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16160, KAKENHI-PROJECT-23K07619
[Journal Article] Increased 　LHX9 expression in alveolar epitherial type 2 cells of patients with chronic obstructive pulmonary disease.2022
- Author(s)
  Okutomo K. Fujino N, Yamada M, Saito T,Ono Y,Okada Y, Ichinose M, Sugiura H
- Journal Title
  
  Respir Investig.
  
  Volume: 60 Issue: 1 Pages: 119-128
- DOI
  10.1016/j.resinv.2021.08.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03684, KAKENHI-PROJECT-20K08558
[Journal Article] Triple versus LAMA/LABA combination therapy for Japanese patients with COPD: A systematic review and meta-analysis2022
- Author(s)
  Koarai Akira、Yamada Mitsuhiro、Ichikawa Tomohiro、Fujino Naoya、Kawayama Tomotaka、Sugiura Hisatoshi
- Journal Title
  
  Respiratory Investigation
  
  Volume: 60 Issue: 1 Pages: 90-98
- DOI
  10.1016/j.resinv.2021.04.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03684, KAKENHI-PROJECT-20K08558
[Journal Article] Decreased expression of airway epithelial Axl is associated with eosinophilic inflammation in severe asthma2022
- Author(s)
  Itakura Koji、Fujino Naoya、Kamide Yosuke、Saito Ikuo、Yamada Mitsuhiro、Okutomo Koji、Tsukita Yoko、Saito Takuya、Ichikawa Tomohiro、Numakura Tadahisa、Kyogoku Yorihiko、Aizawa Hiroyuki、Ono Yoshinao、Matsumoto Shuichiro、Hussell Tracy、Taniguchi Masami、Ichinose Masakazu、Sugiura Hisatoshi
- Journal Title
  
  Allergol. Int.
  
  Volume: 71 Issue: 3 Pages: 383-394
- DOI
  10.1016/j.alit.2022.02.010
- ISSN
  1323-8930, 1440-1592
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16160, KAKENHI-PROJECT-20H03684, KAKENHI-PROJECT-20K08558
[Journal Article] Axl kinase drives immune checkpoint and chemokine signalling pathways in lung adenocarcinomas2019
- Author(s)
  Tsukita Yoko、Fujino Naoya、Miyauchi Eisaku、Saito Ryoko、Fujishima Fumiyoshi、Itakura Koji、Kyogoku Yorihiko、Okutomo Koji、Yamada Mitsuhiro、Okazaki Tatsuma、Sugiura Hisatoshi、Inoue Akira、Okada Yoshinori、Ichinose Masakazu
- Journal Title
  
  Molecular Cancer
  
  Volume: 18 Issue: 1 Pages: 24-24
- DOI
  10.1186/s12943-019-0953-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K21266, KAKENHI-PROJECT-18K08134, KAKENHI-PROJECT-17H04149, KAKENHI-PROJECT-17H04180, KAKENHI-PROJECT-17K19785, KAKENHI-PROJECT-18K15942
[Journal Article] Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases2019
- Author(s)
  Fujino Naoya、Brand Oliver J.、Morgan David J.、Fujimori Toshifumi、Grabiec Aleksander M.、Jagger Christopher P.、Maciewicz Rose A.、Yamada Mitsuhiro、Itakura Koji、Sugiura Hisatoshi、Ichinose Masakazu、Hussell Tracy
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 216 Issue: 9 Pages: 2184-2201
- DOI
  10.1084/jem.20171978
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08134, KAKENHI-PROJECT-17H04180, KAKENHI-PROJECT-18K15942
[Journal Article] Increased severity of H1N1 pandemic influenza virus infection in alveolar type II cells from patients with pulmonary fibrosis2013
- Author(s)
  Fujino N, Kubo H, Ota C, Suzuki T, Takahashi T, Yamada M, Suzuki S, Kondo T, Nagatomi R, Tando Y, Yamaya M
- Journal Title
  
  J Infect Dis
  
  Volume: 207 Pages: 692-692
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890016
[Journal Article] Gene expression profiles of alveolar type II cells of chronic obstructive pulmonary disease: A case-control study2012
- Author(s)
  Fujino N, Ota C, Takahashi T, Suzuki T, Suzuki S, Yamada M, Nagatomi R, Kondo T, Yamaya M, Kubo H
- Journal Title
  
  BMJ Open
  
  Volume: 2 Issue: 6 Pages: e001553-e001553
- DOI
  10.1136/bmjopen-2012-001553
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390163, KAKENHI-PROJECT-23890020, KAKENHI-PROJECT-24890016
[Presentation] 1細胞RNAシークエンスを用いたCOPD肺胞マクロファージにおける炎症性サブセットの同定2024
- Author(s)
  齋藤拓矢, 藤野直也, 今野周一, 小野祥直, 遠藤卓人, 松本周一郎, 山田充啓, 杉浦久敏
- Organizer
  第64回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-23K07619
[Presentation] COPD患者におけるCCR5+Siglec-1－肺胞マクロファージの増加は重症度と相関する2024
- Author(s)
  今野周一，藤野直也，齋藤拓矢，小野祥直，遠藤卓人，鈴木眞奈美, 松本周一郎，佐野寛仁, 京極自彦, 相澤洋之, 山充啓，杉浦久敏
- Organizer
  第64回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-23K07619
[Presentation] dsDNA刺激誘導性インターフェロン産生に与えるタバコ煙の影響の検討2022
- Author(s)
  相澤洋之, 小荒井晃, 沼倉忠久, 市川朋宏, 藤野直也, 山田充啓, 杉浦久敏
- Organizer
  第62回日本呼吸器学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08558
[Presentation] 慢性閉塞性肺疾患の増悪における肺胞マクロファージのSiglec-1発現低下2021
- Author(s)
  齋藤拓矢，藤野直也，京極自彦，山田充啓，杉浦久敏
- Organizer
  第61回　日本呼吸器学会学術集会
- Data Source
  KAKENHI-PROJECT-20K08558
[Presentation] Siglec-1-negative Alveolar Macrophages May Represent Pro-inflammatory Phenotypes And Are Associated With COPD Exacerbation2021
- Author(s)
  Takuya Saito, Naoya Fujino, Yorihiko Kyogoku, Koji Okutomo, Mitsuhiro Yamada, Hisatoshi Sugiura
- Organizer
  ATS 2021 International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08558
[Presentation] Sialic Acid-binding Immunoglobulin-type Lectin1 (Siglec1) Is Important For Bacterial Engulfment By Alveolar Macrophages And Is Down- regulated In COPD Patients2020
- Author(s)
  N. Fujino, A. Tanno, M. Yamada, H. Sugiura, T. Hirano, R. Tanaka, H. Sano, M. Ichinose
- Organizer
  American Thoracic Society 2020 International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08558
[Presentation] Axl receptor tyrosine kinase suppresses eosinophilic airway inflammation in allergen-induced asthma2019
- Author(s)
  Koji Itakura, Naoya Fujino, Mitsuhiro Yamada, Yosuke Kamide, Ikuo Saito, Hisatoshi Sugiura, Masami Taniguchi, Masakazu Ichinose
- Organizer
  American Thoracic Society International Conference 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15942
[Presentation] Negative regulation of eosinophilic inflammation by Axl receptor tyrosine kinase in a house-dust mite-induced asthma model2019
- Author(s)
  Koji Itakura, Naoya Fujino, Mitsuhiro Yamada, Yosuke Kamide, Ikuo Saito, Hisatoshi Sugiura, Masami Taniguchi, Masakazu Ichinose
- Organizer
  第68回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-18K15942
[Presentation] Axl受容体チロシンキナーゼによる重症喘息の好酸球性気道炎症制御機構2019
- Author(s)
  板倉康司，藤野直也，山田充啓，上出庸介，齋藤生朗, 杉浦久敏，谷口正実，一ノ瀬正和
- Organizer
  第59回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-18K15942
[Presentation] Sensing of Apoptotic Cells Via Axl Kinase Triggers Cell Cycle Re-Entry of Airway Basal Cells in Mice2017
- Author(s)
  Fujino N, Fujimori T, Grabiec AM, Maciewicz RA, Hussell T
- Organizer
  Annual Congress of American Thoracic Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06641

1. Okada Yoshinori (90323104)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 松田安史 (00455833)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 大河内眞也 (40375035)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 大石久 (60451580)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 野田雅史 (70400356)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 兼平雅彦 (90374941)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 早坂一希 (40964739)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SUGIURA Hisatoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. 突田容子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 京極自彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 山田充啓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 久保裕司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fujino Naoya 藤野 直也

FUJINO Naoya 藤野 直也

Research Projects

Research Products

Co-Researchers

慢性閉塞性肺疾患における新規病原性肺胞マクロファージの同定と機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms on how alveolar epithelial cells respond to exogenous stress in COPDPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Why is prognosis of lung transplant recipient from elderly donors poor? &#8211;Elucidation of mechanisms and establishment of therapeutic intervention strategy-

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Apototic cell-induced supression of inflammation in the airwayPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of Axl receptor tyrosine kinase in COPD airwaysPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of microRNAs that regulate differentiation of human lung progenitor cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Identification of Siglec-1-negative alveolar macrophages with pro-inflammatory phenotypes in chronic obstructive pulmonary disease2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased LHX9 expression in alveolar epitherial type 2 cells of patients with chronic obstructive pulmonary disease.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Triple versus LAMA/LABA combination therapy for Japanese patients with COPD: A systematic review and meta-analysis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Decreased expression of airway epithelial Axl is associated with eosinophilic inflammation in severe asthma2022

Author(s)

Journal Title

DOI

ISSN

Language

Data Source

[Journal Article] Axl kinase drives immune checkpoint and chemokine signalling pathways in lung adenocarcinomas2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sensing of apoptotic cells through Axl causes lung basal cell proliferation in inflammatory diseases2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased severity of H1N1 pandemic influenza virus infection in alveolar type II cells from patients with pulmonary fibrosis2013

Author(s)

Journal Title

Data Source

[Journal Article] Gene expression profiles of alveolar type II cells of chronic obstructive pulmonary disease: A case-control study2012

Author(s)

Journal Title

Fujino Naoya 藤野直也

FUJINO Naoya 藤野直也

Why is prognosis of lung transplant recipient from elderly donors poor? –Elucidation of mechanisms and establishment of therapeutic intervention strategy-

[Journal Article] Increased 　LHX9 expression in alveolar epitherial type 2 cells of patients with chronic obstructive pulmonary disease.2022