Aibara Daisuke 藍原大甫

Researcher Number	10636567
Other IDs	https://orcid.org/0000-0003-3437-1531
Affiliation (Current)	2025: 福岡大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 福岡大学, 薬学部, 准教授 2021 – 2022: 福岡大学, 薬学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Basic Section 49030:Experimental pathology-related
Keywords	Principal Investigator 遺伝子発現制御 / PPAR / 核内受容体 / 脂肪肝 / MASLD / 糖尿病 / 肥満 / 脂質代謝 / 遺伝子発現調節 / OSBPL3 / NAFLD / MAFLD

新規脂肪制御因子 PDT1 を介した代謝機能不全関連脂肪肝の発症機構の解明Principal Investigator
- Principal Investigator
  
  藍原大甫
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Fukuoka University
Role of FLP1 in metabolic-related fatty liverPrincipal Investigator
- Principal Investigator
  
  Aibara Daisuke
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  Fukuoka University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Hepatocyte-specific CCAAT/enhancer binding protein α restricts liver fibrosis progression2024
- Author(s)
  Yan Tingting、Yan Nana、Xia Yangliu、Sawaswong Vorthon、Zhu Xinxin、Dias Henrique Bregolin、Aibara Daisuke、Takahashi Shogo、Hamada Keisuke、Saito Yoshifumi、Li Guangming、Liu Hui、Yan Hualong、Velenosi Thomas J.、Krausz Kristopher W.、Huang Jing、Kimura Shioko、Rotman Yaron、Qu Aijuan、Hao Haiping、Gonzalez Frank J.
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 134 Issue: 7
- DOI
  10.1172/jci166731
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15424
[Journal Article] Epigenetic Regulation of Gene Expression and Hepatocyte Proliferation by Nuclear Receptor PPARA2024
- Author(s)
  Aibara Daisuke
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 144 Issue: 2 Pages: 157-161
- DOI
  10.1248/yakushi.23-00176
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2024-02-01
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15424
[Journal Article] Transcriptional regulation of adipogenin expression in liver steatosis by hepatic peroxisome proliferator‐activated receptor gamma2023
- Author(s)
  Aibara Daisuke、Sakaguchi Ai、Matsusue Kimihiko
- Journal Title
  
  Genes to Cells
  
  Volume: 28 Issue: 8 Pages: 585-594
- DOI
  10.1111/gtc.13052
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07979, KAKENHI-PROJECT-21K15424
[Journal Article] Oxysterol-binding protein-like 3 is a novel target gene of peroxisome proliferator-activated receptor γ in fatty liver disease2023
- Author(s)
  Aibara Daisuke、Sakaguchi Ai、Matsusue Kimihiko
- Journal Title
  
  Molecular and Cellular Endocrinology
  
  Volume: 565 Pages: 111887-111887
- DOI
  10.1016/j.mce.2023.111887
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07979, KAKENHI-PROJECT-21K15424
[Journal Article] Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation2022
- Author(s)
  Aibara Daisuke、Takahashi Shogo、Yagai Tomoki、Kim Donghwan、Brocker Chad N.、Levi Moshe、Matsusue Kimihiko、Gonzalez Frank J.
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 5 Pages: 104196-104196
- DOI
  10.1016/j.isci.2022.104196
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16152, KAKENHI-PROJECT-21K15424
[Journal Article] Lipase family member N is a novel target gene for CCAAT/enhancer-binding protein α in type 2 diabetic model mouse liver2022
- Author(s)
  Aibara Daisuke、Matsuo Kohei、Matsusue Kimihiko
- Journal Title
  
  Endocr J
  
  Volume: 69 Issue: 5 Pages: 567-575
- DOI
  10.1507/endocrj.EJ21-0465
- NAID
  130008144911
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15424
[Journal Article] Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis2021
- Author(s)
  Qing Wu, Lulu Sun, Xiaomin Hu, Xuemei Wang, Feng Xu, Bo Chen, Xianyi Liang, Jialin Xia, Pengcheng Wang, Daisuke Aibara , Shaofei Zhang, Guangyi Zeng, Chuyu Yun, Yu Yan, Yicheng Zhu, Michael Bustin, Shuyang Zhang, Frank J. Gonzalez and Changtao Jiang
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 131(9) Issue: 9 Pages: 142865-142865
- DOI
  10.1172/jci142865
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15424
[Journal Article] Feedback repression of PPARα signaling by Let-7 microRNA2021
- Author(s)
  Yagai Tomoki、Yan Tingting、Luo Yuhong、Takahashi Shogo、Aibara Daisuke、Kim Donghwan、Brocker Chad N.、Levi Moshe、Motohashi Hozumi、Gonzalez Frank J.
- Journal Title
  
  Cell Reports
  
  Volume: 36 Issue: 6 Pages: 109506-109506
- DOI
  10.1016/j.celrep.2021.109506
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16152, KAKENHI-PROJECT-21K15424
[Presentation] 脂肪肝における adipogenin 遺伝子の発現制御－C/EBPα の関与－2024
- Author(s)
  藍原大甫, 税所佑太, 坂口愛, 松尾康平, 松末公彦
- Organizer
  日本薬学会第 144 年会
- Data Source
  KAKENHI-PROJECT-21K15424
[Presentation] 脂肪肝における Gpnmb 遺伝子の PPARγ による発現制御－肝臓の脂肪蓄積における新規シグナル伝達経路－2023
- Author(s)
  浅田健人, 藍原大甫, 平井貴壮, 坂口愛, 松尾康平, 松末公彦
- Organizer
  日本薬学会第 143 年会
- Data Source
  KAKENHI-PROJECT-21K15424
[Presentation] 脂肪肝で高発現する adipogenin 遺伝子の PPARγ による発現調節機構2023
- Author(s)
  藍原大甫, 中野明日香, 橋本楓乃, 坂口愛, 松尾康平, 松末公彦
- Organizer
  日本薬学会第 143 年会
- Data Source
  KAKENHI-PROJECT-21K15424
[Presentation] 肝 PPARγ の新規標的遺伝子 Gpnmb の発現制御メカニズム2023
- Author(s)
  藍原大甫, 浅田健人, 坂口愛, 松尾康平, 松末公彦
- Organizer
  第 40 回日本薬学会九州山口支部大会
- Data Source
  KAKENHI-PROJECT-21K15424
[Presentation] Transcriptional regulation of the Osbpl3 gene by PPARγ in the fatty liver disease2023
- Author(s)
  Daisuke Aibara, Ai Sakaguchi, Kimihiko Matsusue
- Organizer
  2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics [2023 ICCP450/JSSX]
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15424
[Presentation] 脂肪肝における Adig 遺伝子の発現解析－PPARγ による発現制御－2023
- Author(s)
  藍原大甫, 中野明日香, 橋本楓乃, 坂口愛, 松尾康平, 松末公彦
- Organizer
  フォーラム 2023：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-21K15424
[Presentation] 肝 PPARγ の新規標的遺伝子 Osbpl3 の発現制御メカニズム2022
- Author(s)
  藍原大甫, 高田紘佑, 橋本楓乃, 坂口愛, 松尾康平, 松末公彦
- Organizer
  第 39 回日本薬学会九州山口支部大会
- Data Source
  KAKENHI-PROJECT-21K15424
[Presentation] 核内受容体によるエピジェネティックな遺伝子発現制御を介した生体調節機構に関する研究2022
- Author(s)
  藍原大甫
- Organizer
  第 39 回日本薬学会九州山口支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K15424
[Presentation] 2 型糖尿病モデルマウスの脂肪肝における Lipn 遺伝子の発現制御 -C/EBPα の関与-2022
- Author(s)
  藍原大甫、光本悠華、高木美空、松尾康平、松末公彦
- Organizer
  日本薬学会第 142 年会
- Data Source
  KAKENHI-PROJECT-21K15424
[Presentation] 脂肪肝で高発現する adipogenin 遺伝子の PPARγ による発現調節機構2022
- Author(s)
  藍原大甫, 中野明日香, 橋本楓乃, 坂口愛, 松尾康平, 松末公彦
- Organizer
  日本薬学会第 143 年会
- Data Source
  KAKENHI-PROJECT-21K15424
[Presentation] 脂肪肝で高発現する Osbpl3 遺伝子の PPARγ による発現調節機構2022
- Author(s)
  藍原大甫, 高田紘佑, 橋本楓乃, 坂口愛, 松尾康平, 松末公彦
- Organizer
  フォーラム 2022 衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-21K15424
[Presentation] 脂肪肝における Gpnmb 遺伝子の PPARγ による発現制御－肝臓の脂肪蓄積における新規シグナル伝達経路－2022
- Author(s)
  浅田健人, 藍原大甫, 平井貴壮, 坂口愛, 松尾康平, 松末公彦
- Organizer
  日本薬学会第 143 年会
- Data Source
  KAKENHI-PROJECT-21K15424
[Presentation] 肝 C/EBPα の新規標的遺伝子 Lipn の発現調節機構2021
- Author(s)
  藍原大甫、光本悠華、松尾康平、松末公彦
- Organizer
  第 38 回日本薬学会九州山口支部大会
- Data Source
  KAKENHI-PROJECT-21K15424

1. 谷貝知樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 松末公彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Aibara Daisuke 藍原 大甫

Research Projects

Research Products

Co-Researchers

新規脂肪制御因子 PDT1 を介した代謝機能不全関連脂肪肝の発症機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of FLP1 in metabolic-related fatty liverPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Hepatocyte-specific CCAAT/enhancer binding protein α restricts liver fibrosis progression2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epigenetic Regulation of Gene Expression and Hepatocyte Proliferation by Nuclear Receptor PPARA2024

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Transcriptional regulation of adipogenin expression in liver steatosis by hepatic peroxisome proliferator‐activated receptor gamma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oxysterol-binding protein-like 3 is a novel target gene of peroxisome proliferator-activated receptor γ in fatty liver disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lipase family member N is a novel target gene for CCAAT/enhancer-binding protein α in type 2 diabetic model mouse liver2022

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Feedback repression of PPARα signaling by Let-7 microRNA2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] 脂肪肝における adipogenin 遺伝子の発現制御 －C/EBPα の関与－2024

Author(s)

Organizer

Data Source

[Presentation] 脂肪肝における Gpnmb 遺伝子の PPARγ による発現制御 －肝臓の脂肪蓄積における新規シグナル伝達経路－2023

Author(s)

Organizer

Data Source

[Presentation] 脂肪肝で高発現する adipogenin 遺伝子の PPARγ による発現調節機構2023

Author(s)

Organizer

Data Source

[Presentation] 肝 PPARγ の新規標的遺伝子 Gpnmb の発現制御メカニズム2023

Author(s)

Organizer

Data Source

[Presentation] Transcriptional regulation of the Osbpl3 gene by PPARγ in the fatty liver disease2023

Author(s)

Aibara Daisuke 藍原大甫

[Presentation] 脂肪肝における adipogenin 遺伝子の発現制御－C/EBPα の関与－2024

[Presentation] 脂肪肝における Gpnmb 遺伝子の PPARγ による発現制御－肝臓の脂肪蓄積における新規シグナル伝達経路－2023

[Presentation] 脂肪肝における Adig 遺伝子の発現解析－PPARγ による発現制御－2023

[Presentation] 脂肪肝における Gpnmb 遺伝子の PPARγ による発現制御－肝臓の脂肪蓄積における新規シグナル伝達経路－2022