Kikuchi Kazu 菊地和

Researcher Number	10638240
Other IDs	https://orcid.org/0000-0002-4681-4275
Affiliation (Current)	2025: 国立研究開発法人国立循環器病研究センター, 研究所, 部長
Affiliation (based on the past Project Information) *help	2024: 国立研究開発法人国立循環器病研究センター, 研究所, 部長 2020 – 2022: 国立研究開発法人国立循環器病研究センター, 研究所, 部長
Review Section/Research Field	Principal Investigator Medium-sized Section 53:Organ-based internal medicine and related fields / Basic Section 53020:Cardiology-related Except Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 心筋再生 / 心筋細胞脱分化 / 心筋細胞増殖 / 心臓再生 / 心不全 / マウス / ゼブラフィッシュ / 転写因子 / 増殖 / 脱分化 / 心筋細胞 … More Except Principal Investigator … More SVEP1 / 細胞外マトリックス / 心不全 Less

Elucidation of the roles of a new extracellular matrix protein SVEP1 in the pathogenesis of heart failure
- Principal Investigator
  
  坂田泰彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Integrative investigations of cardiac regeneration mechanismsPrincipal Investigator
- Principal Investigator
  
  菊地和
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  National Cardiovascular Center Research Institute
Elucidation of cardiomyocyte dedifferentiation and proliferation mechanismsPrincipal Investigator
- Principal Investigator
  
  Kikuchi Kazu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute

All 2023 2022 2021 2020

All Journal Article Presentation Patent

[Journal Article] Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish2023
- Author(s)
  Hiroyuki Nakajima, Hiroyuki Ishikawa, Takuya Yamamoto, Ayano Chiba, Hajime Fukui, Keisuke Sako, Moe Fukumoto, Kenny Mattonet, Hyouk-Bum Kwon, Subhra P Hui, Gergana D Dobreva, Kazu Kikuchi, Christian S M Helker, Didier Y R Stainier, Naoki Mochizuki
- Journal Title
  
  Developmental Cell
  
  Volume: 58 Issue: 3 Pages: 224-238
- DOI
  10.1016/j.devcel.2022.12.013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06764, KAKENHI-PROJECT-22K15156, KAKENHI-PROJECT-20H03683, KAKENHI-PROJECT-20K20532, KAKENHI-PROJECT-19H01022
[Journal Article] Rough and smooth variants of Mycobacterium abscessus are differentially controlled by host immunity during chronic infection of adult zebrafish2022
- Author(s)
  Kam Julia Y.、Hortle Elinor、Krogman Elizabeth、Warner Sherridan E.、Wright Kathryn、Luo Kaiming、Cheng Tina、Manuneedhi Cholan Pradeep、Kikuchi Kazu、Triccas James A.、Britton Warwick J.、Johansen Matt D.、Kremer Laurent、Oehlers Stefan H.
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 952-952
- DOI
  10.1038/s41467-022-28638-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03683
[Journal Article] Zebrafish <i>Heme Oxygenase 1a</i> Is Necessary for Normal Development and Macrophage Migration2022
- Author(s)
  Luo Kaiming、Ogawa Masahito、Ayer Anita、Britton Warwick J.、Stocker Roland、Kikuchi Kazu、Oehlers Stefan H.
- Journal Title
  
  Zebrafish
  
  Volume: 19 Issue: 1 Pages: 7-17
- DOI
  10.1089/zeb.2021.0058
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08144, KAKENHI-PROJECT-20H03683
[Journal Article] Haem oxygenase limits Mycobacterium marinum infection-induced detrimental ferrostatin-sensitive cell death in zebrafish2022
- Author(s)
  Luo Kaiming、Stocker Roland、Britton Warwick J.、Kikuchi Kazu、Oehlers Stefan H.
- Journal Title
  
  The FEBS Journal
  
  Volume: 289 Issue: 3 Pages: 671-681
- DOI
  10.1111/febs.16209
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03683
[Journal Article] Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration2022
- Author(s)
  Hui Subhra P.、Sugimoto Kotaro、Sheng Delicia Z.、Kikuchi Kazu
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 13 Pages: 952868-952868
- DOI
  10.3389/fimmu.2022.981000
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06950, KAKENHI-PROJECT-20H03683
[Journal Article] Kruppel-like factor 1 is a core cardiomyogenic trigger in zebrafish2021
- Author(s)
  Ogawa Masahito、Geng Fan-Suo、Humphreys David T.、Kristianto Esther、Sheng Delicia Z.、Hui Subhra P.、Zhang Yuxi、Sugimoto Kotaro、Nakayama Maki、Zheng Dawei、Hesselson Daniel、Hodson Mark P.、Bogdanovic Ozren、Kikuchi Kazu
- Journal Title
  
  Science
  
  Volume: 372 Issue: 6538 Pages: 201-205
- DOI
  10.1126/science.abe2762
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03683, KAKENHI-PROJECT-19K16615
[Journal Article] Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain2021
- Author(s)
  DGama Percival P...Kikuchi Kazu、Kizil Caghan、Yaksi Emre、Roy Sudipto、Jurisch-Yaksi Nathalie
- Journal Title
  
  Cell Reports
  
  Volume: 37 Issue: 1 Pages: 109775-109775
- DOI
  10.1016/j.celrep.2021.109775
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03683
[Journal Article] Cardiac resection injury in zebrafish2021
- Author(s)
  Delicia Z. Sheng, Dawei Zheng, Kazu Kikuchi
- Journal Title
  
  Methods Mol Biol
  
  Volume: 2158 Pages: 63-69
- DOI
  10.1007/978-1-0716-0668-1_6
- ISBN
  9781071606674, 9781071606681
- Data Source
  KAKENHI-PROJECT-20H03683
[Journal Article] Deep conservation of the enhancer regulatory code in animals2020
- Author(s)
  Emily S. Wong*, Dawei Zheng†, Siew Z. Tan†, Neil L. Bower, Victoria Garside, Gilles Vanwalleghem, Federico Gaiti, Ethan Scott, Benjamin M. Hogan, Kazu Kikuchi, Edwina McGlinn, Mathias Francois*‡, Bernard M. Degnan*‡ (*Corresponding author; †, ‡Contributed equally)
- Journal Title
  
  Science
  
  Volume: 370 Issue: 6517
- DOI
  10.1126/science.aax8137
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03683
[Journal Article] Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling2020
- Author(s)
  Catherine R. Cochrane, Vijesh Vaghjiani, Anette Szczepny, W. Samantha N. Jayasekara, Alvaro Gonzalez-Rajal, Kazu Kikuchi, Geoffrey W. McCaughan, Andrew Burgess, Daniel J. Gough, D. Neil Watkins, Jason E. Cain
- Journal Title
  
  J Clin Invest
  
  Volume: 130 Pages: 4006-4018
- DOI
  10.1172/jci132513
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03683
[Journal Article] A zebrafish functional genomics model to investigate the role of human A20 variants in vivo2020
- Author(s)
  Daniele Cultrone, Nathan W. Zammit, Eleanor Self, Benno Postert, Jeremy Z. R. Han, Jacqueline Bailey, Joanna Warren, David R. Croucher, Kazu Kikuchi, Ozren Bogdanovic, Tatyana Chtanova, Daniel Hesselson, Shane T. Grey
- Journal Title
  
  Sci Rep
  
  Volume: 10 Issue: 1 Pages: 19085-19085
- DOI
  10.1038/s41598-020-75917-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03683
[Journal Article] New function of zebrafish regulatory T cells in organ regeneration2020
- Author(s)
  Kazu Kikuchi
- Journal Title
  
  Curr Opin Immunol
  
  Volume: 63 Pages: 7-13
- DOI
  10.1016/j.coi.2019.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03683
[Patent] KLF induced cardiomyogenesis2022
- Inventor(s)
  Kazu Kikuchi, Masahito Ogawa
- Industrial Property Rights Holder
  Kazu Kikuchi, Masahito Ogawa
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-20H03683
[Patent] KLF induced cardiomyogenesis2022
- Inventor(s)
  Kazu Kikuchi, Masahito Ogawa
- Industrial Property Rights Holder
  Kazu Kikuchi, Masahito Ogawa
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-20H03683
[Patent] KLF induced cardiomyogenesis2022
- Inventor(s)
  Kazu Kikuchi, Masahito Ogawa
- Industrial Property Rights Holder
  Kazu Kikuchi, Masahito Ogawa
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-20H03683
[Patent] KLF induced cardiomyogenesis2022
- Inventor(s)
  Kazu Kikuchi, Masahito Ogawa
- Industrial Property Rights Holder
  Kazu Kikuchi, Masahito Ogawa
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-20H03683
[Patent] KLF induced cardiomyogenesis2022
- Inventor(s)
  Kazu Kikuchi, Masahito Ogawa
- Industrial Property Rights Holder
  Kazu Kikuchi, Masahito Ogawa
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-20H03683
[Patent] KLF induced cardiomyogenesis2022
- Inventor(s)
  Kazu Kikuchi, Masahito Ogawa
- Industrial Property Rights Holder
  Kazu Kikuchi, Masahito Ogawa
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-20H03683
[Patent] KLF induced cardiomyogenesis2022
- Inventor(s)
  Kazu Kikuchi, Masahito Ogawa
- Industrial Property Rights Holder
  Kazu Kikuchi, Masahito Ogawa
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-20H03683
[Patent] KLF induced cardiomyogenesis2022
- Inventor(s)
  Kazu Kikuchi, Masahito Ogawa
- Industrial Property Rights Holder
  Kazu Kikuchi, Masahito Ogawa
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-20H03683
[Patent] KLF INDUCED CARDIOMYOGENESIS2020
- Inventor(s)
  Kazu Kikuchi, Masahito Ogawa
- Industrial Property Rights Holder
  Kazu Kikuchi, Masahito Ogawa
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Acquisition Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-20H03683
[Presentation] Klf1 regulates cardiomyocyte state transitions that are essential for heart regeneration in zebrafish2023
- Author(s)
  Kazu Kikuchi
- Organizer
  RIKEN BDR Symposium 2023: Transitions in Biological Systems
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03683
[Presentation] 心筋細胞の自己再生機序2022
- Author(s)
  菊地和
- Organizer
  Cardio Research Conference
- Invited
- Data Source
  KAKENHI-PROJECT-20H03683
[Presentation] Cell-cell communication during cardiomyocyte renewal2022
- Author(s)
  Kazu Kikuchi
- Organizer
  ISRB Regeneration Around the World
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03683
[Presentation] 心筋再生研究と透明魚研究2022
- Author(s)
  菊地和
- Organizer
  第一回関西共創の場オールスター最先端セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-20H03683
[Presentation] 心筋再生の基礎研究と透明魚研究の進展2022
- Author(s)
  菊地和
- Organizer
  大阪大学CoMIT Omics Centerセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-20H03683
[Presentation] Non-cell autonomous effects of cardiomyocyte renewal2022
- Author(s)
  Kazu Kikuchi
- Organizer
  The 17th International Zebrafish Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03683
[Presentation] Induction of adult cardiomyocyte renewal by Klf12022
- Author(s)
  Kazu Kikuchi
- Organizer
  EMBO Workshop: The Molecular and Cellular Basis of Regeneration and Tissue Repair
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03683
[Presentation] Induction of cardiomyocyte renewal in adult hearts2021
- Author(s)
  Kazu Kikuchi
- Organizer
  Japan Circulation Society together with WCC 2021
- Invited
- Data Source
  KAKENHI-PROJECT-20H03683
[Presentation] Klf1-mediated mechanisms for cardiomyocyte renewal2021
- Author(s)
  菊地　和
- Organizer
  ZDM14: Zebrafish Disease Models Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03683
[Presentation] 心筋細胞の自己再生機序2021
- Author(s)
  菊地　和
- Organizer
  Cardio Research Conference
- Invited
- Data Source
  KAKENHI-PROJECT-20H03683
[Presentation] Induction of cardiomyocyte renewal in adult hearts2021
- Author(s)
  菊地　和
- Organizer
  The 85th Annual Scientific Meeting of the Japanese Circulation Society/JCS together with WCC 2021
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03683
[Presentation] 心筋再生研究の新展開2021
- Author(s)
  菊地　和
- Organizer
  30th Cardiovascular Metabolism and Aging Conference
- Invited
- Data Source
  KAKENHI-PROJECT-20H03683
[Presentation] Klf1-induced mechanisms for adult cardiomyocyte renewal2021
- Author(s)
  菊地　和
- Organizer
  The 5th Japanese Circulation Society Council Forum on Basic Cardiovascular Research
- Invited
- Data Source
  KAKENHI-PROJECT-20H03683
[Presentation] Regulation of cardiomyocyte dedifferentiation and proliferation by Klf12021
- Author(s)
  菊地　和
- Organizer
  The 27th Japanese Medaka and Zebrafish Meeting
- Invited
- Data Source
  KAKENHI-PROJECT-20H03683
[Presentation] Induction of cardiomyocyte renewal in adult hearts2020
- Author(s)
  Kazu Kikuchi
- Organizer
  International Zebrafish Society Webinar, Zebrafish Cardiac Regeneration
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03683

1. 大谷健太郎 (50470191)

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2. 坂田泰彦 (90379206)

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3. 富松航佑 (00614926)

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4. 北井豪 (10470204)

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5. 竹田浩之 (40609393)

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6. 畠山金太 (60325735)

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7. 長崎正朗 (90396862)

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8. 伊藤慎 (20796560)

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9. 小川真仁 (00898009)

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10. 安藤康史 (10736010)

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11. 渡邉裕介 (20562333)

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12. 望月直樹 (30311426)

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13. FUKUI Hajime

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14. 杉本幸太郎

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Kikuchi Kazu 菊地 和

Research Projects

Research Products

Co-Researchers

Elucidation of the roles of a new extracellular matrix protein SVEP1 in the pathogenesis of heart failure

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Integrative investigations of cardiac regeneration mechanismsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of cardiomyocyte dedifferentiation and proliferation mechanismsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rough and smooth variants of Mycobacterium abscessus are differentially controlled by host immunity during chronic infection of adult zebrafish2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Zebrafish <i>Heme Oxygenase 1a</i> Is Necessary for Normal Development and Macrophage Migration2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Haem oxygenase limits Mycobacterium marinum infection-induced detrimental ferrostatin-sensitive cell death in zebrafish2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Kruppel-like factor 1 is a core cardiomyogenic trigger in zebrafish2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Diversity and function of motile ciliated cell types within ependymal lineages of the zebrafish brain2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cardiac resection injury in zebrafish2021

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Deep conservation of the enhancer regulatory code in animals2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Trp53 and Rb1 regulate autophagy and ligand-dependent Hedgehog signaling2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A zebrafish functional genomics model to investigate the role of human A20 variants in vivo2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] New function of zebrafish regulatory T cells in organ regeneration2020

Author(s)

Kikuchi Kazu 菊地和