Ikoma Takeharu 生駒丈晴

… Alternative Names

IKOMA Takeharu 生駒丈晴

Less

Researcher Number	10638290
Other IDs
Affiliation (Current)	2025: 神奈川歯科大学, 歯学部, 特任講師
Affiliation (based on the past Project Information) *help	2021 – 2022: 神奈川歯科大学, 歯学部, 助教 2015 – 2020: 神奈川歯科大学, 大学院歯学研究科, 助教 2014 – 2015: 神奈川歯科大学, 歯学研究科(研究院), 助教 2013: 神奈川歯科大学, 歯学部附属病院, その他
Review Section/Research Field	Principal Investigator Surgical dentistry / Basic Section 57060:Surgical dentistry-related Except Principal Investigator Surgical dentistry
Keywords	Principal Investigator サイトカイン / CXCL14 / 血管新生抑制 / BRAK / BOSS/GPRC5B / ケトン食 / BOSS / GPRC5B / 扁平上皮癌 / 頭頸部扁平上皮癌 … More / VEGF / 血管新生 / 抗腫瘍効果 / 血管新生阻害 / 細胞分化 / 転写因子 … More Except Principal Investigator セツキシマブ / メチル化異常 / 頭頸部癌 / メチル化 / 頭頚部癌 / BRAK / CXCL14 Less

Introduction of a ketogenic diet to head and neck squamous cell carcinoma focusing on the cell membrane energy sensor GPRC5BPrincipal Investigator
- Principal Investigator
  
  Ikoma Takeharu
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Kanagawa Dental College
Clinical significance of CXCL14, a cytokine that normalizes cancer neovascularizationPrincipal Investigator
- Principal Investigator
  
  Ikoma Takeharu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kanagawa Dental College
Clinical application of BRAK that is anti-angiogenic agentPrincipal Investigator
- Principal Investigator
  
  Ikoma Takeharu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kanagawa Dental College
Elucidation of Epigenetics in Head and Neck Squamous Cell Carcinoma.
- Principal Investigator
  
  Kubota Eiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kanagawa Dental College
Search of transcription factor for BRAK by using new method in Head and neck carcinomaPrincipal Investigator
- Principal Investigator
  
  IKOMA Takeharu
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Kanagawa Dental College

All 2023 2021 2019 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] GPRC5B (G protein-coupled receptor class C group 5 member B) suppresses glucose starvation-induced apoptosis in head-and-neck squamous cell carcinoma2023
- Author(s)
  Kanamori K, Ozawa S, Iwabuchi H, Ikoma T, Suzuki K, Tanaka K, Yoshimura-Sawai N, Abe T, Kato Y, Hata R-I, Kobayashi M
- Journal Title
  
  Biomed. Res.
  
  Volume: 44 Issue: 1 Pages: 1-7
- DOI
  10.2220/biomedres.44.1
- ISSN
  0388-6107, 1880-313X
- Year and Date
  2023-01-25
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10074, KAKENHI-PROJECT-20K10091, KAKENHI-PROJECT-22K09929, KAKENHI-PROJECT-22K10135, KAKENHI-PROJECT-20K10193, KAKENHI-PROJECT-21K21101, KAKENHI-PROJECT-23K09344
[Journal Article] C-X-C Motif Chemokine Ligand 14 is a Unique Multifunctional Regulator of Tumor Progression. International Journal of Molecular2019
- Author(s)
  Xiao-Yan Yang,Shigeyuki Ozawa, Yasumasa Kato, Yojiro Maehata, Kazuhito Izukuri1, Takeharu Ikoma, Keisuke Kanamori, Tetsu Akasaka, Kenji Suzuki, Hiroshi Iwabuchi, Shun-Ichi Kurata, Iyoko Katoh,, Takashi Sakurai, Tohru Kiyono, Ryu-Ichiro Hata
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Issue: 8 Pages: 1872-1872
- DOI
  10.3390/ijms20081872
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11707, KAKENHI-PROJECT-17K17112, KAKENHI-PROJECT-19K10074, KAKENHI-PROJECT-19K10080, KAKENHI-PROJECT-17K11860
[Journal Article] Expression of the chemokine CXCL14 and cetuximab-dependent tumour suppression in head and neck squamous cell carcinoma.2016
- Author(s)
  Kondo T, Ozawa S, Ikoma T, Yang XY, Kanamori K, Suzuki K, Iwabuchi H, Maehata Y, Miyamoto C, Taguchi T, Kiyono T, Kubota E, Hata RI
- Journal Title
  
  Oncogenesis
  
  Volume: 5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K20567
[Journal Article] Fasudil, a Rho kinase inhibitor, suppresses tumor growth by inducing CXCL14/BRAK in head and neck squamous cell carcinoma.2014
- Author(s)
  Miyamoto C1, Maehata Y, Motohashi K, Ozawa S, Ikoma T, Hidaka K, Wada-Takahashi S, Takahashi SS, Yoshino F, Yoshida A, Kubota E, Hata R, Lee MC.
- Journal Title
  
  Biomedical Research
  
  Volume: 35 Pages: 381-388
- NAID
  130004903867
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25861982
[Journal Article] Fasudil, a Rho kinase inhibitor, suppresses tumor growth by inducing CXCL14/BRAK in head and neck squamous cell carcinoma2014
- Author(s)
  Chihiro MIYAMOTO, Yojiro MAEHATA, Kazuhiko MOTOHASHI, Shigeyuki OZAWA, Takeharu IKOMA, Kouki HIDAKA, Satoko WADA-TAKAHASHI, Shun-Suke TAKAHASHI, Fumihiko YOSHINO, Ayaka YOSHIDA, Eiro KUBOTA, Ryu-Ichiro HATA, Masaichi-Chang-il LEE
- Journal Title
  
  Biomedical Research
  
  Volume: 35 Pages: 381-388
- NAID
  130004903867
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293414
[Presentation] 糖尿病原因遺伝子GPRC5Bはグルコース飢餓によって誘導される頭頚部扁平上皮癌細胞のアポトーシスを抑制する2021
- Author(s)
  金森慶亮、小澤重幸、生駒丈晴、鈴木健司、田中香衣、沢井奈津子、小関理恵子、岩渕博史、安部貴大
- Organizer
  NPO法人日本口腔科学会
- Data Source
  KAKENHI-PROJECT-20K10193
[Presentation] エネルギーセンサーGPRC5Bは頭頚部扁平上皮癌細胞の無糖培養下での細胞死を抑制する2019
- Author(s)
  金森慶亮, 小澤重幸, 生駒丈晴, 鈴木健司, 岩渕博史, 小林優
- Organizer
  第64回日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-17K11860
[Presentation] Is chemokine CXCL14, a multi-step tumor suppressor, a differentiation regulator of squamous epithelial cells ?2016
- Author(s)
  T. Ikoma, X. Yang, S. Ozawa, Y. Maehata, R. Hata
- Organizer
  歯科基礎医学会
- Place of Presentation
  札幌
- Year and Date
  2016-08-25
- Data Source
  KAKENHI-PROJECT-15K20567
[Presentation] Expression of the chemokine CXCL14 is a predictive biomarker for Cetuximab-dependent tumor supression.2015
- Author(s)
  生駒　丈晴
- Organizer
  歯科基礎医学会
- Place of Presentation
  新潟
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-15K20567
[Presentation] セツキシマブによる抗腫瘍性ケモカインBRAKの発現上昇メカニズムの解明2013
- Author(s)
  小澤重幸、近藤忠稚、生駒丈晴、鈴木健司、久保田英朗
- Organizer
  日本口腔外科学会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-25861982
[Presentation] CXCL14のメチル化異常に着目したセツキシマブの抗腫瘍効果判定のための基礎研究
- Author(s)
  近藤忠稚、小澤重幸、生駒丈晴、鈴木健司、久保田英朗
- Organizer
  日本口腔外科学会総会・学術大会
- Place of Presentation
  千葉　(幕張メッセ)
- Year and Date
  2014-10-17 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-25861982
[Presentation] CXCL14のメチル化異常に着目したセツキシマブの抗腫瘍効果判定のための基礎研究
- Author(s)
  近藤忠稚、小澤重幸、生駒丈晴、鈴木健司、久保田英朗
- Organizer
  日本口腔外科学会総会・学術大会
- Place of Presentation
  千葉　(幕張メッセ)
- Year and Date
  2014-10-17 – 2014-10-19
- Data Source
  KAKENHI-PROJECT-25293414

1. OZAWA SHIGEYUKI (40434394)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. Kubota Eiro (50170030)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. KONDO TADANORI (00587727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. SUZUKI KENJI (80350536)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. MAEHATA YOUJIRO (80410009)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. 小林優 (00162024)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 畑隆一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ikoma Takeharu 生駒 丈晴

IKOMA Takeharu 生駒 丈晴

Research Projects

Research Products

Co-Researchers

Introduction of a ketogenic diet to head and neck squamous cell carcinoma focusing on the cell membrane energy sensor GPRC5BPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clinical significance of CXCL14, a cytokine that normalizes cancer neovascularizationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clinical application of BRAK that is anti-angiogenic agentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of Epigenetics in Head and Neck Squamous Cell Carcinoma.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Search of transcription factor for BRAK by using new method in Head and neck carcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] GPRC5B (G protein-coupled receptor class C group 5 member B) suppresses glucose starvation-induced apoptosis in head-and-neck squamous cell carcinoma2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] C-X-C Motif Chemokine Ligand 14 is a Unique Multifunctional Regulator of Tumor Progression. International Journal of Molecular2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Expression of the chemokine CXCL14 and cetuximab-dependent tumour suppression in head and neck squamous cell carcinoma.2016

Author(s)

Journal Title

Data Source

[Journal Article] Fasudil, a Rho kinase inhibitor, suppresses tumor growth by inducing CXCL14/BRAK in head and neck squamous cell carcinoma.2014

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Fasudil, a Rho kinase inhibitor, suppresses tumor growth by inducing CXCL14/BRAK in head and neck squamous cell carcinoma2014

Author(s)

Journal Title

NAID

Data Source

[Presentation] 糖尿病原因遺伝子GPRC5Bはグルコース飢餓によって誘導される頭頚部扁平上皮癌細胞のアポトーシスを抑制する2021

Author(s)

Organizer

Data Source

[Presentation] エネルギーセンサーGPRC5Bは頭頚部扁平上皮癌細胞の無糖培養下での細胞死を抑制する2019

Author(s)

Organizer

Data Source

[Presentation] Is chemokine CXCL14, a multi-step tumor suppressor, a differentiation regulator of squamous epithelial cells ?2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Expression of the chemokine CXCL14 is a predictive biomarker for Cetuximab-dependent tumor supression.2015

Author(s)

Organizer

Place of Presentation

Ikoma Takeharu 生駒丈晴

IKOMA Takeharu 生駒丈晴