MOTOZONO CHIHIRO 本園千尋

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Motozono Chihiro 本園千尋

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Researcher Number	10642910
Other IDs
Affiliation (Current)	2025: 熊本大学, ヒトレトロウイルス学共同研究センター, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 熊本大学, ヒトレトロウイルス学共同研究センター, 准教授 2022: 熊本大学, 学内共同利用施設等, 講師 2019 – 2022: 熊本大学, ヒトレトロウイルス学共同研究センター, 講師 2017 – 2018: 大阪大学, 微生物病研究所, 助教 2016 – 2018: 九州大学, 医学研究院, 助教 2015: 近畿大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 49060:Virology-related / Basic Section 49070:Immunology-related / Immunology / Virology Except Principal Investigator Medium-sized Section 50:Oncology and related fields / Immunology / Experimental pathology
Keywords	Principal Investigator T細胞 / 免疫逃避 / 免疫受容体 / ワクチン / T細胞受容体 / 交差反応性 / SARS-CoV-2 / 抗原認識 / 新型コロナウイルス / 脂質 … More / 結核菌 / 抑制型受容体 / 感染症 / C型レクチン受容体 / 死細胞 / 免疫学 / レトロウイルス / ペプチドワクチン / ペプチド免疫 / ウイルス感染 … More Except Principal Investigator MR1 / 主要組織適合抗原 / 乳がん反応性 / MR1分子 / HLA非依存的 / T細胞受容体 / 粘膜免疫 / 肺粘膜 / CD8T細胞 / 免疫記憶 / 滞在型メモリー / インフルエンザウイルス / 感染防御 / 肺 / 組織滞在型 / メモリーCD8T細胞 / TLR / レトロウイルス誘発がん / 内在性レトロウイルス / ウイルス誘発がん / TLR7 / レトロウイルス / 中和抗体 / B細胞 Less

T cell receptor cross-reactivity and structural basis of virus immune escapePrincipal Investigator
- Principal Investigator
  
  本園千尋
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Kumamoto University
Development of immune regulation for emerging and re-emerging infectious diseases by human T cell cross-reactivityPrincipal Investigator
- Principal Investigator
  
  本園千尋
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Kumamoto University
Development of HLA-independent T cell receptor-T cell therapy for innovative immunological cancer therapy
- Principal Investigator
  
  岸裕幸
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  University of Toyama
Immune regulation by sensing endogenous lipid composition changes via inhibitory C-type lectin receptorPrincipal Investigator
- Principal Investigator
  
  Motozono Chihiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kumamoto University
Immune regulation by inhibitory immune receptors against MycobacteriaPrincipal Investigator
- Principal Investigator
  
  Motozono Chihiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
The requirement of B cell-intrinsic TLR7 for the protection of retrovirus-induced leuchemia
- Principal Investigator
  
  Sachiyo Kawahara
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Baika Women's University
  Kindai University
Mechanisms by which lung-resident memory CD8 T cells are maintained
- Principal Investigator
  
  TAKAMURA Shiki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Kindai University
Induction of vaccine-elicited T cell responses by non-natural amino acidsPrincipal Investigator
- Principal Investigator
  
  Motozono Chihiro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Kyushu University
  Kinki University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book Patent

[Book] 新型コロナウイルスの細胞性免疫からの逃避の可能性2022
- Author(s)
  本園千尋、上野貴将
- Total Pages
  51
- Publisher
  日本エイズ学会誌
- Data Source
  KAKENHI-PROJECT-23K24139
[Book] 次世代アジュバント開発のためのメカニズム解明と安全性評価2017
- Author(s)
  上地貴音、本園千尋
- Total Pages
  355
- Publisher
  シーエムシー出版
- Data Source
  KAKENHI-PROJECT-15K19116
[Book] THE LUNG perspectives2016
- Author(s)
  鳥越祥太, 本園千尋, 山﨑晶
- Total Pages
  120
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-15K19116
[Book] 臨床免疫・アレルギー科2016
- Author(s)
  今井崇史、高野智嗣、本園千尋、山崎晶
- Total Pages
  200
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-15K19116
[Journal Article] CD8+ T-cell memory induced by successive SARS-CoV-2 mRNA vaccinations is characterized by shifts in clonal dominance2024
- Author(s)
  H, Aoki., M, Kitabatake., H, Abe., P, Xu., M, Tsunoda., S, Shichino., A, Hara., N, Ouji- Sageshima., C, Motozono., T, Ito., K, Matsushima., and S, Ueha
- Journal Title
  
  Cell reports
  
  Volume: 43 Issue: 3 Pages: 113887-113902
- DOI
  10.1016/j.celrep.2024.113887
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0277, KAKENHI-PROJECT-21K07246, KAKENHI-PLANNED-22H05064, KAKENHI-PROJECT-23K24139
[Journal Article] HIV-Tocky system to visualize proviral expression dynamics2024
- Author(s)
  O, Reda., K, Monde., K, Sugata., A, Rahman., W, Sakhor., SA, Rajib., SN, Sithi., BJY, Tan., K, Niimura., C, Motozono., K, Maeda., M, Ono., H, Takeuchi and Y, Satou. 4.巻 7
- Journal Title
  
  Communications biology
  
  Volume: 7 Issue: 1 Pages: 334-350
- DOI
  10.1038/s42003-024-06025-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0277, KAKENHI-PROJECT-21K08494, KAKENHI-PROJECT-23K24139
[Journal Article] Association of Clostridium butyricum Therapy Using the Live Bacterial Product CBM588 with the Survival of Patients with Lung Cancer Receiving Chemoimmunotherapy Combinations2023
- Author(s)
  Tomiya Y, Sakata S, Imamura K, Iyama S, Jodai T, et al.
- Journal Title
  
  Cancers
  
  Volume: 16 Issue: 1 Pages: 47-47
- DOI
  10.3390/cancers16010047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16449, KAKENHI-PROJECT-22KK0277, KAKENHI-PROJECT-22K08256, KAKENHI-PROJECT-21K08494, KAKENHI-PROJECT-18K15928, KAKENHI-PROJECT-21H02788, KAKENHI-PROJECT-23K24139
[Journal Article] Evaluation of Neutralizing Activity against Omicron Subvariants in BA.5 Breakthrough Infection and Three-Dose Vaccination Using a Novel Chemiluminescence-Based, Virus-Mediated Cytopathic Assay2023
- Author(s)
  Toyoda Mako、Tan Toong Seng、Motozono Chihiro、Barabona Godfrey、Yonekawa Akiko、Shimono Nobuyuki、Minami Rumi、Nagasaki Yoji、Miyashita Yusuke、Oshiumi Hiroyuki、Nakamura Kimitoshi、Matsushita Shuzo、Kuwata Takeo、Ueno Takamasa
- Journal Title
  
  Microbiology Spectrum
  
  Volume: 11 Issue: 4 Pages: 00660-23
- DOI
  10.1128/spectrum.00660-23
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KJ1775, KAKENHI-PROJECT-22KK0277, KAKENHI-PROJECT-22K07089, KAKENHI-PROJECT-21K05989, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-23K24139, KAKENHI-PROJECT-23K24378, KAKENHI-PROJECT-23K27640
[Journal Article] Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b2022
- Author(s)
  Shibata Kensuke、Motozono Chihiro、Nagae Masamichi、Shimizu Takashi、Ishikawa Eri、Motooka Daisuke、Okuzaki Daisuke、Izumi Yoshihiro、Takahashi Masatomo、Fujimori Nao、Wing James B.、Hayano Takahide、Asai Yoshiyuki、Bamba Takeshi、Ogawa Yoshihiro、Furutani-Seiki Makoto、Shirai Mutsunori、Yamasaki Sho
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 6948-6948
- DOI
  10.1038/s41467-022-34802-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07539, KAKENHI-PROJECT-22K18924, KAKENHI-PLANNED-22H05183, KAKENHI-PLANNED-22H05185, KAKENHI-PROJECT-20H00505, KAKENHI-PROJECT-20K06575, KAKENHI-PROJECT-23K23151, KAKENHI-PROJECT-23K24139
[Journal Article] Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 Spike2022
- Author(s)
  Tan Toong Seng、Toyoda Mako、Ode Hirotaka、Barabona Godfrey、Hamana Hiroshi、Kitamatsu Mizuki、Kishi Hiroyuki、Motozono Chihiro、Iwatani Yasumasa、Ueno Takamasa
- Journal Title
  
  Journal of Virology
  
  Volume: 96 Issue: 20
- DOI
  10.1128/jvi.01162-22
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0148, KAKENHI-PROJECT-21H02966, KAKENHI-PROJECT-23K24139, KAKENHI-PROJECT-23K24144, KAKENHI-PROJECT-23K24378
[Journal Article] The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance2022
- Author(s)
  Kimura Izumi、Kosugi Yusuke、Wu Jiaqi、other 17 authors、Saito Akatsuki、Nakagawa So、Sato Kei
- Journal Title
  
  Cell Reports
  
  Volume: 38 Issue: 2 Pages: 110218-110218
- DOI
  10.1016/j.celrep.2021.110218
- NAID
  120007183813
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06382, KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-18H02662, KAKENHI-PROJECT-19J20488, KAKENHI-PROJECT-21K07060, KAKENHI-PROJECT-18KK0447, KAKENHI-PROJECT-22KJ0809, KAKENHI-PROJECT-22KJ2159, KAKENHI-PROJECT-18H05279
[Journal Article] The SARS-CoV-2 Omicron BA.1 spike G446S mutation potentiates antiviral T-cell recognition2022
- Author(s)
  Motozono C, Toyoda M, Tan TS, Hamana H, Goto Y, Aritsu Y, Miyashita Y, Oshiumi H, Nakamura K, Okada S, Udaka K, Kitamatsu M, Kishi H, Ueno T
- Journal Title
  
  Nat Commun
  
  Volume: 13 Issue: 1 Pages: 5440-5440
- DOI
  10.1038/s41467-022-33068-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K18261, KAKENHI-PROJECT-22KK0148, KAKENHI-PROJECT-21H02966, KAKENHI-PROJECT-23K24139, KAKENHI-PROJECT-23K24378
[Journal Article] Trehalose diamide glycolipids augment antigen-specific antibody responses in a Mincle-dependent manner.2021
- Author(s)
  Lynch, AT., Motozono, C., Foster, AJ., Kodar, K., Dangerfield, EM., Yamasaki, S., Wedlock, DN., Timmer, MSM., Stocker, BL.
- Journal Title
  
  Bioorg Chem.
  
  Volume: 110 Pages: 104747-104747
- DOI
  10.1016/j.bioorg.2021.104747
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-19H00922, KAKENHI-PROJECT-20H00505
[Journal Article] Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-192021
- Author(s)
  Kaku Y, Kuwata T, Zahid HM, Hashiguchi T, Noda T, Kuramoto N, Biswas S, Matsumoto K, Shimizu M, Kawanami Y, Shimura K, Onishi C, Muramoto Y, Suzuki T, Sasaki J, Nagasaki Y, Minami R, Motozono C, Toyoda M, Takahashi H, Kishi H, Fujii K, Tatsuke T, Ikeda T, Maeda Y, Ueno T, Koyanagi Y, Iwagoe H, Matsushita S.
- Journal Title
  
  Cell Reports
  
  Volume: 36 Issue: 2 Pages: 109385-109385
- DOI
  10.1016/j.celrep.2021.109385
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06401, KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-19K08932, KAKENHI-PROJECT-20K20596, KAKENHI-PLANNED-20H05773
[Journal Article] SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity2021
- Author(s)
  Motozono Chihiro、Toyoda Mako、Zahradnik Jiri、Saito Akatsuki、Other 19 authors、Ikeda Terumasa、Nakagawa So、Ueno Takamasa、Sato Kei
- Journal Title
  
  Cell Host & Microbe
  
  Volume: 29 Issue: 7 Pages: 1124-1136
- DOI
  10.1016/j.chom.2021.06.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06382, KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-18H02662, KAKENHI-PROJECT-21H02736, KAKENHI-PROJECT-19J01713, KAKENHI-PROJECT-19J20488, KAKENHI-PROJECT-20K15767, KAKENHI-PROJECT-18KK0447
[Journal Article] In vivo delivery of an exogenous molecule into murine T lymphocytes using a lymphatic drug delivery system combined with sonoporation.2020
- Author(s)
  Kato S, Shirai Y, Motozono C, Kanzaki H, Mori S, Kodama T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: - Issue: 4 Pages: 1025-1031
- DOI
  10.1016/j.bbrc.2020.02.174
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22941, KAKENHI-PROJECT-19K16622, KAKENHI-PROJECT-17H00865, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-18H03544
[Journal Article] The effects of 5‐OP‐RU stereochemistry on its stability and MAIT‐MR1 axis2020
- Author(s)
  Matsuoka Takuro、Motozono Chihiro、Hattori Akira、Kakeya Hideaki、Yamasaki Sho、Oishi Shinya、Ohno Hiroaki、Inuki Shinsuke
- Journal Title
  
  ChemBioChem
  
  Volume: 22 Issue: 4 Pages: 672-678
- DOI
  10.1002/cbic.202000466
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K06938, KAKENHI-PLANNED-17H06401, KAKENHI-PUBLICLY-20H04773, KAKENHI-PROJECT-19K07623
[Journal Article] Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands2020
- Author(s)
  Braganza Chriselle D.、Motozono Chihiro、Sonoda Koh-Hei、Yamasaki Sho、Shibata Kensuke、Timmer Mattie S. M.、Stocker Bridget L.
- Journal Title
  
  Chemical Communications
  
  Volume: in press Issue: 39 Pages: 529-5294
- DOI
  10.1039/d0cc00247j
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04087, KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-20K07539, KAKENHI-PROJECT-20H00505
[Journal Article] Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ+CD8αα+ T cells.2019
- Author(s)
  Ishifune C, Tsukumo S, Maekawa Y, Hozumi K, Chung D, Motozono C, Yamasaki S, Nakano H, Yasutomo K.
- Journal Title
  
  PLoS Biology
  
  Volume: - Issue: 5 Pages: e3000262-e3000262
- DOI
  10.1371/journal.pbio.3000262
- NAID
  120006812006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-26110003, KAKENHI-PROJECT-17H04069, KAKENHI-PROJECT-17K19533, KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-18K15191, KAKENHI-PROJECT-17H04087
[Journal Article] Interstitial-resident memory CD8+ T cells sustain frontline epithelial memory in the lung.2019
- Author(s)
  Takamura, S., Kato, S., Motozono, C., Shimaoka, T., Ueha, S., Matsuo, K., Miyauchi, K., Masumoto, T., Katsushima, A., Nakayama, T., Tomura, M., Matsushima, K., Kubo, M. & Miyazawa, M.
- Journal Title
  
  J Exp Med.
  
  Volume: 216 Issue: 12 Pages: 2736-2747
- DOI
  10.1084/jem.20190557
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-19K16622, KAKENHI-PLANNED-17H06392, KAKENHI-PROJECT-19H03481, KAKENHI-PROJECT-19H03491, KAKENHI-PROJECT-16H06276
[Journal Article] The effect of MR1 ligand glycol-analogues on mucosal-associated invariant T (MAIT) cell activation.2019
- Author(s)
  Braganza, CD., Shibata, K., Fujiwara, A., Motozono, C., Sonoda, KH., Yamasaki, S., Stocker, BL., Timmer, MSM.
- Journal Title
  
  Org Biomol Chem.
  
  Volume: 17 Issue: 40 Pages: 8992-9000
- DOI
  10.1039/c9ob01436e
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-19K08424, KAKENHI-PROJECT-17H04087, KAKENHI-PROJECT-16H06276
[Journal Article] Dectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity2017
- Author(s)
  Takano, T., Motozono, C., Imai, T., Sonoda, KH., Nakanishi, Y., Yamasaki, S
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 292 Pages: 16933-16941
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15730
[Journal Article] Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance.2016
- Author(s)
  Takamura, S., H. Yagi, Y. Hakata, C. Motozono, S. R. McMaster, T. Masumoto, M. Fujisawa, T. Chikaishi, J. Komeda, J. Itoh, M. Umemura, A. Kyusai, M. Tomura, T. Nakayama, D. L. Woodland, J. E. Kohlmeier, and M. Miyazawa
- Journal Title
  
  The Journal of Experimental Medicine
  
  Volume: 213 Issue: 13 Pages: 3057-3073
- DOI
  10.1084/jem.20160938
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01268, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-16H05199, KAKENHI-PROJECT-15K19116, KAKENHI-PROJECT-16K08409, KAKENHI-PROJECT-16K08821, KAKENHI-PROJECT-16K08850
[Journal Article] Clonotypically similar hybrid αβ TCRs can exhibit markedly different surface expression, antigen specificity and cross-reactivity2015
- Author(s)
  Chihiro Motozono, John S Bridgeman, David A Price, Andrew K. Sewell and Takamasa Ueno
- Journal Title
  
  Clinical & Experimental Immunology
  
  Volume: 180 Pages: 560-570
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19116
[Journal Article] Distortion of the MHC class I binding groove to accommodate an insulin-derived 10-mer peptide2015
- Author(s)
  Chihiro Motozono, James A. Pearson, Evy De Leenheer, Pierre J. Rizkallah, Konrad Beck, Andrew Trimby, Andrew K. Sewell, F. Susan Wong and David K. Cole
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 290 Pages: 18924-18933
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19116
[Patent] ヌクレオカプシド由来抗原ペプチド、核酸、ベクター、医薬組成物、HLA/ 抗原ペプチド複合体、およびT細胞の検出方法2022
- Inventor(s)
  本園千尋、上野貴将、後藤由比古、岸裕幸、浜名洋
- Industrial Property Rights Holder
  本園千尋、上野貴将、後藤由比古、岸裕幸、浜名洋
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2022-166518
- Filing Date
  2022
- Data Source
  KAKENHI-PROJECT-23K24139
[Presentation] 新型コロナウイルス変異株に対するT細胞の抗原認識機構2024
- Author(s)
  本園千尋
- Organizer
  集え、多分野研究者!」感染症キャンプ in 宮崎
- Invited
- Data Source
  KAKENHI-PROJECT-22KK0277
[Presentation] The SARS-CoV-2 Omicron BA.1 spike G446S potentiates antiviral T cell immunity2024
- Author(s)
  C, Motozono., A, Wall., M, Toyoda., H, Hamana., K, Udaka., PJ, Rizkallah., H, Kishi., AK. Sewell., T, Ueno.
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24139
[Presentation] 新型コロナウイルス変異株に対するT細胞の抗原認識機構2024
- Author(s)
  本園千尋
- Organizer
  集え、多分野研究者!」感染症キャンプ in 宮崎
- Invited
- Data Source
  KAKENHI-PROJECT-23K24139
[Presentation] The SARS-CoV-2 Omicron BA.1 spike G446S potentiates antiviral T cell immunity2024
- Author(s)
  C, Motozono., A, Wall., M, Toyoda., H, Hamana., K, Udaka., PJ, Rizkallah., H, Kishi., AK. Sewell., T, Ueno.
- Organizer
  第52回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-22KK0277
[Presentation] HLA-C-restricted CTLs specific for SARS-CoV-2 nucleocapsid display potent antiviral activity across viral variants and are maintained as a long-lived memory cells2023
- Author(s)
  Yoshihiko Goto, Mako Toyoda, Toong Seng Tan, Hiroshi Hamana, Takeshi Nakama, Hanyu Li, Yoshiki Aritsu, Mizuki Kitamatsu, Hiroyuki Kishi, Yusuke Tomita, Takuro Sakagami, Takamasa Ueno and Chihiro Motozono
- Organizer
  The 24th Kumamoto AIDS Seminar
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18261
[Presentation] Cross-reactivity of HLA-A*24:02-restricted T-cell receptors towards SARS-CoV-2 mutations2023
- Author(s)
  Takeshi Nakama, Aaron Wall, Hiroshi Hamana, Huanyu Li, Yoshihiko Goto, Yoshiki Aritsu, Mako Toyoda, Toong Seng Tan, Mizuki Kitamatsu, Keiko Udaka, Pierre J Rizkallah, Hiroyuki Kishi, Andrew K. Sewell, Takamasa Ueno, Chihiro Motozono
- Organizer
  The 24th Kumamoto AIDS Seminar
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18261
[Presentation] SARS-CoV-2抗原変異に対するHLA-A*24:02拘束性T細胞受容体の交差反応性2023
- Author(s)
  仲摩健、浜名洋、Huanyu Li、後藤由比古、有津由樹、豊田真子、Toong Seng Tan、北松瑞生、宇高恵子、岸裕幸、上野貴将、本園千尋
- Organizer
  第70回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-21K18261
[Presentation] Mechanism of widespread SARS-CoV-2 spike escape from HLA-A*24:02 restricted T cell receptors2023
- Author(s)
  Chihiro Motozono
- Organizer
  Oxford-Kumamoto Universities Joint Annual Symposium 2023
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24139
[Presentation] The SARS-CoV-2 Omicron BA.1 spike G446S potentiates antiviral T cell immunity2022
- Author(s)
  Motozono C, Toyoda M, Hamana H, Udaka K, Kishi H, Ueno T
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24139
[Presentation] 新型コロナウイルスOmicron BA.1株のG446S変異はT細胞の抗ウイルス活性を増強する2022
- Author(s)
  本園千尋、豊田真子、Toong Seng Tan、浜名洋、後藤由比古、仲摩健、山本紫穂、有津良樹、北松瑞生、宇高恵子、岸裕幸、上野貴将
- Organizer
  第36回日本エイズ学会学術集会
- Data Source
  KAKENHI-PROJECT-23K24139
[Presentation] 新型コロナウイルスOmicron BA.1株のG446S変異はT細胞の抗ウイルス活性を増強する2022
- Author(s)
  本園千尋、豊田真子、Toong Seng Tan、浜名洋、後藤由比古、仲摩健、有津良樹、北松瑞生、宇高恵子、岸裕幸、上野貴将
- Organizer
  第69回日本ウイルス学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24139
[Presentation] The SARS-CoV-2 Omicron BA.1 spike G446S mutation potentiates antiviral T cell recognition2022
- Author(s)
  Motozono, C., Toyoda M., Tan TS., Hamana H., Goto Y., Nakama T., Yamamoto S., Aritsu Y., Udaka K., Kitamatsu M., Kishi H., Ueno, T
- Organizer
  23rd Kumamoto AIDS seminar
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24139
[Presentation] SARS-CoV-2 Omicron BA.1 spike G446S potentiates HLA-A*24:02-restricted T cell immunity2022
- Author(s)
  Motozono, C., Toyoda M., Tan TS., Hamana H., Goto Y., Nakama T., Aritsu Y., Udaka K., Kitamatsu M., Kishi H., Ueno, T.
- Organizer
  Keystone symposia (Respiratory Viruses and Viral Immunity)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K24139
[Presentation] SARS-CoV-2 spike L452R and Y453F variants confer escape from immunodominant HLA-A24-restricted T cell recognition2021
- Author(s)
  Motozono C, Hamana H, Udaka K, Kishi H, Ueno T
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07623
[Presentation] フローサイトメトリーを基盤とした新型コロナウイルス特異的T細胞の検出と機能解析2021
- Author(s)
  本園千尋，Isaac Ngare，上野貴将
- Organizer
  第31回日本サイトメトリー学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07623
[Presentation] 新型コロナウイルス L452R変異はHLA-A24拘束性T細胞の認識から逃避する2021
- Author(s)
  本園千尋、浜名洋、Isaac Ngare、豊田真子、Toong Seng Ta、宇高恵子、岸裕幸、佐藤佳、上野貴将
- Organizer
  第68回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07623
[Presentation] 抑制型免疫受容体が内因性脂質変化を感知して誘導する免疫応答制御2020
- Author(s)
  本園　千尋、鳥越　祥太、西村　直矢、森田　真也、宮本　智文、山﨑　晶
- Organizer
  第36回日本DDS会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07623
[Presentation] Capturing and identification of MR1-binding molecules using unfolded MR1 protein.2019
- Author(s)
  C. Motozono, HS. Ismanto, K. Shibata, and S. Yamasaki.
- Organizer
  The 48th Annual Meeting of the Japanese Society for Immunology, December 11-13, 2019, Shizuoka, Japan
- Data Source
  KAKENHI-PROJECT-19K07623
[Presentation] Recognition of phospholipids on dead cells via inhibitory C-type lectin receptor.2018
- Author(s)
  C. Motozono, T. Shimane, S. Torigoe, N. Nishimura, and S. Yamasaki.
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17K15730
[Presentation] Dectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity.2018
- Author(s)
  C. Motozono, T. Takano, T. Imai, K. Sonoda and S. Yamasaki.
- Organizer
  第91回日本生化学学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K15730
[Presentation] FATE DETERMINATION WITH A SELECTED EPITOPE FACILITATES FOLLICULAR HELPER T CELL DIFFERENTIATION AND PROTECTION AGAINST ACUTE RETROVIRAL INFECTION.2018
- Author(s)
  Shigeki Kato, Chihiro Motozono, Sachiyo Kawahara and Masaaki Miyazawa
- Organizer
  30th International Workshop on Retroviral Pathogenesis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08749
[Presentation] Vaccine-elicited preferential induction of polyfunctional Th cells is associated with protection against acute retroviral infection2016
- Author(s)
  C. Motozono, S. Tsuji-Kawahara, S. Takamura, M. Miyazawa
- Organizer
  International congress of Immunolgy
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19116
[Presentation] Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance2016
- Author(s)
  高村史記、八木秀樹、本園千尋、戸村道夫、中山俊憲、宮澤正顯
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K08850
[Presentation] B cell-intrinsic TLR7 signaling is required to prevent the generation of recombinant viruses following retrovirus infection2015
- Author(s)
  Tsuji-Kawahara Sachiyo, Kawasaki Yuri, Motozono Chihiro, Takamura Shiki, Miyazawa Masaaki
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター　（札幌）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K19116
[Presentation] Vaccine-elicited preferential induction of germinal center follicular helper T cells is associated with protection against retroviral infection2015
- Author(s)
  Chihiro Motozono, Sachiyo Tsuji-Kawahara, Shiki Takamura, Hideo Yagita, M. Miyazawa
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター　（札幌）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K19116

1. 宮澤正顯 (60167757)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. Sachiyo Kawahara (60297629)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. TAKAMURA Shiki (90528564)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 岸裕幸 (60186210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. TOMURA Michio

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. FUKUYAMA Satoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SHBATA Kensuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 小玉哲也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 山崎晶

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 坂田晋也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. BARABONA GODFREY

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 上野貴将

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 齊藤暁

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
14. 村本裕紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 井貫晋輔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 宮澤正顕

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
17. 中野裕康

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 辻佐智代

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MOTOZONO CHIHIRO 本園 千尋

Motozono Chihiro 本園 千尋

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T cell receptor cross-reactivity and structural basis of virus immune escapePrincipal Investigator

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Development of immune regulation for emerging and re-emerging infectious diseases by human T cell cross-reactivityPrincipal Investigator

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Development of HLA-independent T cell receptor-T cell therapy for innovative immunological cancer therapy

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Immune regulation by sensing endogenous lipid composition changes via inhibitory C-type lectin receptorPrincipal Investigator

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Immune regulation by inhibitory immune receptors against MycobacteriaPrincipal Investigator

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The requirement of B cell-intrinsic TLR7 for the protection of retrovirus-induced leuchemia

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Mechanisms by which lung-resident memory CD8 T cells are maintained

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Induction of vaccine-elicited T cell responses by non-natural amino acidsPrincipal Investigator

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[Book] 新型コロナウイルスの細胞性免疫からの逃避の可能性2022

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[Book] 次世代アジュバント開発のためのメカニズム解明と安全性評価2017

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[Book] THE LUNG perspectives2016

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[Book] 臨床免疫・アレルギー科2016

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[Journal Article] CD8+ T-cell memory induced by successive SARS-CoV-2 mRNA vaccinations is characterized by shifts in clonal dominance2024

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[Journal Article] HIV-Tocky system to visualize proviral expression dynamics2024

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MOTOZONO CHIHIRO 本園千尋

Motozono Chihiro 本園千尋