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MOTOZONO CHIHIRO  本園 千尋

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Motozono Chihiro  本園 千尋

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Researcher Number 10642910
Other IDs
Affiliation (Current) 2023: 熊本大学, ヒトレトロウイルス学共同研究センター, 准教授
Affiliation (based on the past Project Information) *help 2023: 熊本大学, ヒトレトロウイルス学共同研究センター, 准教授
2022: 熊本大学, 学内共同利用施設等, 講師
2019 – 2022: 熊本大学, ヒトレトロウイルス学共同研究センター, 講師
2017 – 2018: 大阪大学, 微生物病研究所, 助教
2016 – 2018: 九州大学, 医学研究院, 助教
2015: 近畿大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 49060:Virology-related / Basic Section 49070:Immunology-related / Immunology / Virology
Except Principal Investigator
Medium-sized Section 50:Oncology and related fields / Immunology / Experimental pathology
Keywords
Principal Investigator
T細胞 / 免疫逃避 / 免疫受容体 / 新型コロナウイルス / ワクチン / SARS-CoV-2 / 脂質 / 結核菌 / 抑制型受容体 / 感染症 … More / C型レクチン受容体 / 死細胞 / 免疫学 / レトロウイルス / ペプチドワクチン / ペプチド免疫 / ウイルス感染 … More
Except Principal Investigator
MR1 / HLA非依存的 / T細胞受容体 / 主要組織適合抗原 / 粘膜免疫 / 肺粘膜 / CD8T細胞 / 免疫記憶 / 滞在型メモリー / インフルエンザウイルス / 感染防御 / 肺 / 組織滞在型 / メモリーCD8T細胞 / TLR / レトロウイルス誘発がん / 内在性レトロウイルス / ウイルス誘発がん / TLR7 / レトロウイルス / 中和抗体 / B細胞 Less
  • Research Projects

    (8 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (14 People)
  •  T cell receptor cross-reactivity and structural basis of virus immune escapePrincipal Investigator

    • Principal Investigator
      本園 千尋
    • Project Period (FY)
      2023 – 2024
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      Kumamoto University
  •  Development of immune regulation for emerging and re-emerging infectious diseases by human T cell cross-reactivityPrincipal Investigator

    • Principal Investigator
      本園 千尋
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      Kumamoto University
  •  Development of HLA-independent T cell receptor-T cell therapy for innovative immunological cancer therapy

    • Principal Investigator
      岸 裕幸
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 50:Oncology and related fields
    • Research Institution
      University of Toyama
  •  Immune regulation by sensing endogenous lipid composition changes via inhibitory C-type lectin receptorPrincipal Investigator

    • Principal Investigator
      Motozono Chihiro
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Kumamoto University
  •  Immune regulation by inhibitory immune receptors against MycobacteriaPrincipal Investigator

    • Principal Investigator
      Motozono Chihiro
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Immunology
    • Research Institution
      Osaka University
  •  The requirement of B cell-intrinsic TLR7 for the protection of retrovirus-induced leuchemia

    • Principal Investigator
      Sachiyo Kawahara
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Baika Women's University
      Kindai University
  •  Mechanisms by which lung-resident memory CD8 T cells are maintained

    • Principal Investigator
      TAKAMURA Shiki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Kindai University
  •  Induction of vaccine-elicited T cell responses by non-natural amino acidsPrincipal Investigator

    • Principal Investigator
      Motozono Chihiro
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Virology
    • Research Institution
      Kyushu University
      Kinki University

All 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book

  • [Book] 次世代アジュバント開発のためのメカニズム解明と安全性評価2017

    • Author(s)
      上地貴音、本園千尋
    • Total Pages
      355
    • Publisher
      シーエムシー出版
    • Data Source
      KAKENHI-PROJECT-15K19116
  • [Book] THE LUNG perspectives2016

    • Author(s)
      鳥越祥太, 本園千尋, 山﨑晶
    • Total Pages
      120
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-15K19116
  • [Book] 臨床免疫・アレルギー科2016

    • Author(s)
      今井崇史、高野智嗣、本園千尋、山崎晶
    • Total Pages
      200
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-15K19116
  • [Journal Article] The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance2022

    • Author(s)
      Kimura Izumi、Kosugi Yusuke、Wu Jiaqi、other 17 authors、Saito Akatsuki、Nakagawa So、Sato Kei
    • Journal Title

      Cell Reports

      Volume: 38 Issue: 2 Pages: 110218-110218

    • DOI

      10.1016/j.celrep.2021.110218

    • NAID

      120007183813

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06382, KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-18H02662, KAKENHI-PROJECT-19J20488, KAKENHI-PROJECT-21K07060, KAKENHI-PROJECT-18KK0447
  • [Journal Article] Trehalose diamide glycolipids augment antigen-specific antibody responses in a Mincle-dependent manner.2021

    • Author(s)
      Lynch, AT., Motozono, C., Foster, AJ., Kodar, K., Dangerfield, EM., Yamasaki, S., Wedlock, DN., Timmer, MSM., Stocker, BL.
    • Journal Title

      Bioorg Chem.

      Volume: 110 Pages: 104747-104747

    • DOI

      10.1016/j.bioorg.2021.104747

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-19H00922, KAKENHI-PROJECT-20H00505
  • [Journal Article] Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-192021

    • Author(s)
      Kaku Y, Kuwata T, Zahid HM, Hashiguchi T, Noda T, Kuramoto N, Biswas S, Matsumoto K, Shimizu M, Kawanami Y, Shimura K, Onishi C, Muramoto Y, Suzuki T, Sasaki J, Nagasaki Y, Minami R, Motozono C, Toyoda M, Takahashi H, Kishi H, Fujii K, Tatsuke T, Ikeda T, Maeda Y, Ueno T, Koyanagi Y, Iwagoe H, Matsushita S.
    • Journal Title

      Cell Reports

      Volume: 36 Issue: 2 Pages: 109385-109385

    • DOI

      10.1016/j.celrep.2021.109385

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K06401, KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-21H02970, KAKENHI-PROJECT-19K08932, KAKENHI-PROJECT-20K20596
  • [Journal Article] SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity2021

    • Author(s)
      Motozono Chihiro、Toyoda Mako、Zahradnik Jiri、Saito Akatsuki、Other 19 authors、Ikeda Terumasa、Nakagawa So、Ueno Takamasa、Sato Kei
    • Journal Title

      Cell Host & Microbe

      Volume: 29 Issue: 7 Pages: 1124-1136

    • DOI

      10.1016/j.chom.2021.06.006

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K06382, KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-18H02662, KAKENHI-PROJECT-21H02736, KAKENHI-PROJECT-19J01713, KAKENHI-PROJECT-19J20488, KAKENHI-PROJECT-20K15767, KAKENHI-PROJECT-18KK0447
  • [Journal Article] In vivo delivery of an exogenous molecule into murine T lymphocytes using a lymphatic drug delivery system combined with sonoporation.2020

    • Author(s)
      Kato S, Shirai Y, Motozono C, Kanzaki H, Mori S, Kodama T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: - Issue: 4 Pages: 1025-1031

    • DOI

      10.1016/j.bbrc.2020.02.174

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K22941, KAKENHI-PROJECT-19K16622, KAKENHI-PROJECT-17H00865, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-18H03544
  • [Journal Article] The effects of 5‐OP‐RU stereochemistry on its stability and MAIT‐MR1 axis2020

    • Author(s)
      Matsuoka Takuro、Motozono Chihiro、Hattori Akira、Kakeya Hideaki、Yamasaki Sho、Oishi Shinya、Ohno Hiroaki、Inuki Shinsuke
    • Journal Title

      ChemBioChem

      Volume: 22 Issue: 4 Pages: 672-678

    • DOI

      10.1002/cbic.202000466

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K06938, KAKENHI-PLANNED-17H06401, KAKENHI-PUBLICLY-20H04773, KAKENHI-PROJECT-19K07623
  • [Journal Article] Agonistic or antagonistic mucosal-associated invariant T (MAIT) cell activity is determined by the 6-alkylamino substituent on uracil MR1 ligands2020

    • Author(s)
      Braganza Chriselle D.、Motozono Chihiro、Sonoda Koh-Hei、Yamasaki Sho、Shibata Kensuke、Timmer Mattie S. M.、Stocker Bridget L.
    • Journal Title

      Chemical Communications

      Volume: in press Issue: 39 Pages: 529-5294

    • DOI

      10.1039/d0cc00247j

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04087, KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-20K07539, KAKENHI-PROJECT-20H00505
  • [Journal Article] Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ+CD8αα+ T cells.2019

    • Author(s)
      Ishifune C, Tsukumo S, Maekawa Y, Hozumi K, Chung D, Motozono C, Yamasaki S, Nakano H, Yasutomo K.
    • Journal Title

      PLoS Biology

      Volume: - Issue: 5 Pages: e3000262-e3000262

    • DOI

      10.1371/journal.pbio.3000262

    • NAID

      120006812006

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26110003, KAKENHI-PROJECT-17H04069, KAKENHI-PROJECT-17K19533, KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-18K15191, KAKENHI-PROJECT-17H04087
  • [Journal Article] Interstitial-resident memory CD8+ T cells sustain frontline epithelial memory in the lung.2019

    • Author(s)
      Takamura, S., Kato, S., Motozono, C., Shimaoka, T., Ueha, S., Matsuo, K., Miyauchi, K., Masumoto, T., Katsushima, A., Nakayama, T., Tomura, M., Matsushima, K., Kubo, M. & Miyazawa, M.
    • Journal Title

      J Exp Med.

      Volume: 216 Issue: 12 Pages: 2736-2747

    • DOI

      10.1084/jem.20190557

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-19K16622, KAKENHI-PLANNED-17H06392, KAKENHI-PROJECT-19H03481, KAKENHI-PROJECT-19H03491, KAKENHI-PROJECT-16H06276
  • [Journal Article] The effect of MR1 ligand glycol-analogues on mucosal-associated invariant T (MAIT) cell activation.2019

    • Author(s)
      Braganza, CD., Shibata, K., Fujiwara, A., Motozono, C., Sonoda, KH., Yamasaki, S., Stocker, BL., Timmer, MSM.
    • Journal Title

      Org Biomol Chem.

      Volume: 17 Issue: 40 Pages: 8992-9000

    • DOI

      10.1039/c9ob01436e

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07623, KAKENHI-PROJECT-19K08424, KAKENHI-PROJECT-17H04087, KAKENHI-PROJECT-16H06276
  • [Journal Article] Dectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity2017

    • Author(s)
      Takano, T., Motozono, C., Imai, T., Sonoda, KH., Nakanishi, Y., Yamasaki, S
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 292 Pages: 16933-16941

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K15730
  • [Journal Article] Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance.2016

    • Author(s)
      Takamura, S., H. Yagi, Y. Hakata, C. Motozono, S. R. McMaster, T. Masumoto, M. Fujisawa, T. Chikaishi, J. Komeda, J. Itoh, M. Umemura, A. Kyusai, M. Tomura, T. Nakayama, D. L. Woodland, J. E. Kohlmeier, and M. Miyazawa
    • Journal Title

      The Journal of Experimental Medicine

      Volume: 213 Issue: 13 Pages: 3057-3073

    • DOI

      10.1084/jem.20160938

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01268, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-16H05199, KAKENHI-PROJECT-15K19116, KAKENHI-PROJECT-16K08409, KAKENHI-PROJECT-16K08821, KAKENHI-PROJECT-16K08850
  • [Journal Article] Clonotypically similar hybrid αβ TCRs can exhibit markedly different surface expression, antigen specificity and cross-reactivity2015

    • Author(s)
      Chihiro Motozono, John S Bridgeman, David A Price, Andrew K. Sewell and Takamasa Ueno
    • Journal Title

      Clinical & Experimental Immunology

      Volume: 180 Pages: 560-570

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19116
  • [Journal Article] Distortion of the MHC class I binding groove to accommodate an insulin-derived 10-mer peptide2015

    • Author(s)
      Chihiro Motozono, James A. Pearson, Evy De Leenheer, Pierre J. Rizkallah, Konrad Beck, Andrew Trimby, Andrew K. Sewell, F. Susan Wong and David K. Cole
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 290 Pages: 18924-18933

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19116
  • [Presentation] SARS-CoV-2 spike L452R and Y453F variants confer escape from immunodominant HLA-A24-restricted T cell recognition2021

    • Author(s)
      Motozono C, Hamana H, Udaka K, Kishi H, Ueno T
    • Organizer
      第50回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07623
  • [Presentation] フローサイトメトリーを基盤とした新型コロナウイルス特異的T細胞の検出と機能解析2021

    • Author(s)
      本園千尋,Isaac Ngare,上野貴将
    • Organizer
      第31回日本サイトメトリー学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07623
  • [Presentation] 新型コロナウイルス L452R変異はHLA-A24拘束性T細胞の認識から逃避する2021

    • Author(s)
      本園千尋、浜名洋、Isaac Ngare、豊田真子、Toong Seng Ta、宇高恵子、岸裕幸、佐藤佳、上野貴将
    • Organizer
      第68回 日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07623
  • [Presentation] 抑制型免疫受容体が内因性脂質変化を感知して誘導する免疫応答制御2020

    • Author(s)
      本園 千尋、鳥越 祥太、西村 直矢、森田 真也、宮本 智文、山﨑 晶
    • Organizer
      第36回 日本DDS会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K07623
  • [Presentation] Capturing and identification of MR1-binding molecules using unfolded MR1 protein.2019

    • Author(s)
      C. Motozono, HS. Ismanto, K. Shibata, and S. Yamasaki.
    • Organizer
      The 48th Annual Meeting of the Japanese Society for Immunology, December 11-13, 2019, Shizuoka, Japan
    • Data Source
      KAKENHI-PROJECT-19K07623
  • [Presentation] Recognition of phospholipids on dead cells via inhibitory C-type lectin receptor.2018

    • Author(s)
      C. Motozono, T. Shimane, S. Torigoe, N. Nishimura, and S. Yamasaki.
    • Organizer
      第47回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K15730
  • [Presentation] Dectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity.2018

    • Author(s)
      C. Motozono, T. Takano, T. Imai, K. Sonoda and S. Yamasaki.
    • Organizer
      第91回日本生化学学会大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K15730
  • [Presentation] FATE DETERMINATION WITH A SELECTED EPITOPE FACILITATES FOLLICULAR HELPER T CELL DIFFERENTIATION AND PROTECTION AGAINST ACUTE RETROVIRAL INFECTION.2018

    • Author(s)
      Shigeki Kato, Chihiro Motozono, Sachiyo Kawahara and Masaaki Miyazawa
    • Organizer
      30th International Workshop on Retroviral Pathogenesis
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08749
  • [Presentation] Vaccine-elicited preferential induction of polyfunctional Th cells is associated with protection against acute retroviral infection2016

    • Author(s)
      C. Motozono, S. Tsuji-Kawahara, S. Takamura, M. Miyazawa
    • Organizer
      International congress of Immunolgy
    • Place of Presentation
      Melbourne, Australia
    • Year and Date
      2016-08-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19116
  • [Presentation] Specific niches for lung-resident memory CD8+ T cells at the site of tissue regeneration enable CD69-independent maintenance2016

    • Author(s)
      高村史記、八木秀樹、本園千尋、戸村道夫、中山俊憲、宮澤正顯
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-16K08850
  • [Presentation] B cell-intrinsic TLR7 signaling is required to prevent the generation of recombinant viruses following retrovirus infection2015

    • Author(s)
      Tsuji-Kawahara Sachiyo, Kawasaki Yuri, Motozono Chihiro, Takamura Shiki, Miyazawa Masaaki
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター (札幌)
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-15K19116
  • [Presentation] Vaccine-elicited preferential induction of germinal center follicular helper T cells is associated with protection against retroviral infection2015

    • Author(s)
      Chihiro Motozono, Sachiyo Tsuji-Kawahara, Shiki Takamura, Hideo Yagita, M. Miyazawa
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター (札幌)
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-15K19116
  • 1.  宮澤 正顯 (60167757)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 2.  Sachiyo Kawahara (60297629)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  TAKAMURA Shiki (90528564)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  岸 裕幸 (60186210)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  TOMURA Michio
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 6.  FUKUYAMA Satoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  小玉 哲也
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 8.  齊藤 暁
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 9.  村本 裕紀子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  井貫 晋輔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  宮澤 正顕
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 12.  中野 裕康
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  辻 佐智代
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  山崎 晶
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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