Shigeta Keisuke 茂田啓介

… Alternative Names

SHIGETA KEISUKE 茂田啓介

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Researcher Number	10649875
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 訪問研究員
Affiliation (based on the past Project Information) *help	2021 – 2023: 慶應義塾大学, 医学部(信濃町), 訪問研究員 2017 – 2018: 慶應義塾大学, 医学部(信濃町), 助教
Review Section/Research Field	Principal Investigator Basic Section 56030:Urology-related / 0901:Oncology and related fields / Urology Except Principal Investigator Basic Section 56030:Urology-related / Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Keywords	Principal Investigator 膀胱癌 / 尿路上皮癌 / 抗癌剤耐性 / 進展系統樹 / 分子サブタイプ / 尿路上皮癌分子サブタイプ / p53 / CK20 / 腎盂尿管癌 / P53 … More / FGFR3 / CK2０ / CK5/6 / 膀胱内再発 / 上部尿路上皮癌 / 抗癌剤耐性尿路上皮癌 / ペントースリン酸回路 / グルタミン / メタボローム解析 / 嫌気解糖系 / イソクエン酸デヒドロゲナーゼ / IDH2 / 代謝リプログラミング / 腫瘍学 / ROS産生 / CD44v9 / MUC1C / MUC1阻害剤 / CDDP耐性 / 薬剤排出性トランスポーター / MUC1C蛋白 … More Except Principal Investigator CD163 / CD68 / urothelial carcinoma / UTUC / Immune microenvironment / FGFR3 / CD8 / CD204 / 免疫逃避機構 / 代謝リプログラミング / 薬剤耐性 / 尿路上皮癌 Less

Elucidation of tumor development mechanism by immune escape mechanism through metabolic reprogramming of anticancer drug-resistant cancer
- Principal Investigator
  
  小坂威雄
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
- Research Institution
  Keio University
Basic research focusing on correlation between tumor associated macrophage and peripheral monocyte count
- Principal Investigator
  
  北岡壮太郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Keio University
Profiling the Molecular Characteristics and Transitions Through Upper Tract Tumor Origin, Bladder Recurrence, and Muscle Invasive Bladder Progression in Upper Tract Urothelial CarcinomaPrincipal Investigator
- Principal Investigator
  
  Shigeta Keisuke
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Keio University
New Treatment Strategy for Chemoresistant Urothelial Carcinoma Regarding of Metabolic ReprogrammingPrincipal Investigator
- Principal Investigator
  
  SHIGETA KEISUKE
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Keio University
MUC1C Oncoprotein Contributes to Acquiring Cisplatin Resistance in Urothelial Carcinoma CellsPrincipal Investigator
- Principal Investigator
  
  Shigeta Keisuke
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Urology
- Research Institution
  Keio University

All 2024 2023 2022 2021 2019 2018 2017

All Journal Article Presentation

[Journal Article] Profiling Fibroblast Growth Factor Receptor 3 Expression Based on the Immune Microenvironment in Upper Tract Urothelial Carcinoma2024
- Author(s)
  Shigeta Keisuke、Matsumoto Kazuhiro、Kitaoka Sotaro、Omura Minami、Umeda Kota、Arita Yuki、Mikami Shuji、Fukumoto Keishiro、Yasumizu Yota、Tanaka Nobuyuki、Takeda Toshikazu、Morita Shinya、Kosaka Takeo、Mizuno Ryuichi、Hara Satoshi、Oya Mototsugu
- Journal Title
  
  European Urology Oncology
  
  Volume: NA Issue: 6 Pages: 1338-1349
- DOI
  10.1016/j.euo.2024.01.013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18344
[Journal Article] Vasohibin-1 Expression Can Predict Pathological Complete Remission of Advanced Bladder Cancer with Neoadjuvant Chemotherapy2024
- Author(s)
  Omura Minami、Kosaka Takeo、Kobayashi Hiroaki、Shigeta Keisuke、Matsumoto Kazuhiro、Hara Satoshi、Kikuchi Eiji、Mikami Shuji、Saya Hideyuki、Sato Yasufumi、Oya Mototsugu
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 31 Issue: 5 Pages: 2951-2958
- DOI
  10.1245/s10434-024-15009-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18344
[Journal Article] IDH2 stabilizes HIF‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer2023
- Author(s)
  Shigeta Keisuke、Hasegawa Masanori、Hishiki Takako、Naito Yoshiko、Baba Yuto、Mikami Shuji、Matsumoto Kazuhiro、Mizuno Ryuichi、Miyajima Akira、Kikuchi Eiji、Saya Hideyuki、Kosaka Takeo、Oya Mototsugu
- Journal Title
  
  The EMBO Journal
  
  Volume: 42 Issue: 4 Pages: 1-27
- DOI
  10.15252/embj.2022110620
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03817, KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-21K19579, KAKENHI-PROJECT-21K20811
[Journal Article] Does neoadjuvant chemotherapy have therapeutic benefit for node-positive upper tract urothelial carcinoma? Results of a multi-center cohort study2022
- Author(s)
  Shigeta Keisuke、Matsumoto Kazuhiro、Ogihara Koichiro、Murakami Tetsushi、Anno Tadatsugu、Umeda Kota、Izawa Mizuki、Baba Yuto、Sanjo Tansei、Shojo Kazunori、Tanaka Nobuyuki、Takeda Toshikazu、Morita Shinya、Kosaka Takeo、Mizuno Ryuichi、Arita Yuki、Akita Hirotaka、Jinzaki Masahiro、Kikuchi Eiji、Oya Mototsugu
- Journal Title
  
  Urologic Oncology: Seminars and Original Investigations
  
  Volume: 40 Issue: 3 Pages: 19-26
- DOI
  10.1016/j.urolonc.2021.07.029
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20811, KAKENHI-PROJECT-21K16757, KAKENHI-PROJECT-22K16809
[Journal Article] Profiling the Biological Characteristics and Transitions through Upper Tract Tumor Origin, Bladder Recurrence, and Muscle-Invasive Bladder Progression in Upper Tract Urothelial Carcinoma2022
- Author(s)
  Shigeta Keisuke、Matsumoto Kazuhiro、Tanaka Nobuyuki、Mikami Shuji、Kosaka Takeo、Yasumizu Yota、Takeda Toshikazu、Mizuno Ryuichi、Kikuchi Eiji、Oya Mototsugu
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 9 Pages: 5154-5154
- DOI
  10.3390/ijms23095154
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-22K16809
[Journal Article] Evaluating the Oncological Outcomes of Pure Laparoscopic Radical Nephroureterectomy Performed for Upper-Tract Urothelial Carcinoma Patients: A Multicenter Cohort Study Adjusted by Propensity Score Matching2021
- Author(s)
  Shigeta Keisuke、Matsumoto Kazuhiro、Takeda Toshikazu、Hattori Seiya、Kaneko Gou、Matsushima Masashi、Abe Takayuki、Tanaka Nobuyuki、Mizuno Ryuichi、Asanuma Hiroshi、Kikuchi Eiji、Oya Mototsugu
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 28 Issue: 1 Pages: 465-473
- DOI
  10.1245/s10434-020-09046-9
- Data Source
  KAKENHI-PROJECT-21K20811
[Journal Article] The clinicopathological characteristics of muscle‐invasive bladder recurrence in upper tract urothelial carcinoma2021
- Author(s)
  Shigeta Keisuke、Matsumoto Kazuhiro、Ogihara Koichiro、Murakami Tetsushi、Anno Tadatsugu、Umeda Kota、Izawa Mizuki、Baba Yuto、Sanjo Tansei、Shojo Kazunori、Tanaka Nobuyuki、Takeda Toshikazu、Kosaka Takeo、Mizuno Ryuichi、Mikami Shuji、Kikuchi Eiji、Oya Mototsugu
- Journal Title
  
  Cancer Science
  
  Volume: 112 Issue: 3 Pages: 1084-1094
- DOI
  10.1111/cas.14782
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07468, KAKENHI-PROJECT-22K16809
[Journal Article] The Over Time Conditional Survival of Intravesical Recurrence in Upper Tract Urothelial Carcinoma.2017
- Author(s)
  Shigeta K, Kikuchi E, Hagiwara M, Ando T, Mizuno R, Abe T, Mikami S, Miyajima A, Nakagawa K, Oya M.
- Journal Title
  
  Journal of Urology
  
  Volume: 198 Pages: 1278-1285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16815
[Presentation] 尿路上皮癌分子サブタイプ（ CK5/6, CK20, FGFR3, p53）分類に基づいた腎盂尿管癌術後膀胱内再発および進展系統樹の作成2023
- Author(s)
  茂田啓介　松本一宏　安水洋太　田中伸之武田利和　森田伸也　小坂威雄　水野隆一　浅沼宏　大家基嗣
- Organizer
  第１０９回日本泌尿器科科学会総会
- Data Source
  KAKENHI-PROJECT-22K16809
[Presentation] 尿路上皮癌分子サブタイプ（ CK5/6, CK20, FGFR3, p53）分類に基づいた腎盂尿管癌術後膀胱内再発および進展系統樹の作成2022
- Author(s)
  茂田啓介　松本一宏　安水洋太　田中伸之武田利和　森田伸也　小坂威雄　水野隆一　浅沼宏　大家基嗣
- Organizer
  第109回　日本泌尿器学科総会
- Data Source
  KAKENHI-PROJECT-22K16809
[Presentation] 尿路上皮癌細胞における細胞内代謝リプログラミング機構と抗癌剤耐性機序との関連2022
- Author(s)
  Keisuke Shigeta, Eiji Kikuchi1, Masanori Hasegawa, Kazuhiro Matsumoto, Takeo Kosaka, Ryuichi Mizuno, Akira Miyajima, Mototsugu Oya
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K20811
[Presentation] Isocitrate dehydrogenase 2 Regulates Intracellular Metabolic Reprogramming in Chemo-resistant Urothelial Carcinoma2022
- Author(s)
  Shigeta K, Hasegawa M, Kosaka T, Matsumoto K, Mizuno R, Miyajima A, Kikuchi E, Oya M
- Organizer
  36th EAU Annual Congress, 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20811
[Presentation] Isocitrate dehydrogenase 2 Regulates Intracellular Metabolic Reprogramming in Chemo-resistant Urothelial Carcinoma2021
- Author(s)
  Shigeta K, Hasegawa M, Kosaka T, Matsumoto K, Mizuno R, Miyajima A, Kikuchi E, Oya M
- Organizer
  36th EAU Annual Congress, 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20811
[Presentation] Gemcitabine Resistant Urothelial Cancer Cell may Acquire Cross Resistance to Cisplatin via Intracelluar Metabolic Reprogramming2021
- Author(s)
  Shigeta K, Kikuchi E, Hasegawa M, Matsumoto K, Kosaka T, Mizuno R, Mikami S, Oya M
- Organizer
  35th EAU Annual Congress, 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20811
[Presentation] Gemcitabine Resistant Urothelial Carcinoma Acquires Cross Resistance to Cisplatin by Altering Intracellular Metabolism2021
- Author(s)
  Shigeta K, Kikuchi E, Hasegawa M, Matsumoto K, Kosaka T, Mizuno R, Mikami S, Oya M
- Organizer
  第79回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-21K20811
[Presentation] ゲムシタビン耐性膀胱癌は癌蛋白MUC1Cを介してシスプラチン耐性への交差耐性を獲得する2019
- Author(s)
  茂田啓介
- Organizer
  第107回泌尿器科学会総会
- Data Source
  KAKENHI-PROJECT-17K16815
[Presentation] MUC1C Oncoprotein Contributes to Acquiring Cisplatin and Gemcitabine Resistance in Urothelial Carcinoma Cells2018
- Author(s)
  茂田啓介
- Organizer
  第77回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16815
[Presentation] Prolonged Pneumoperitoneum Time Is an Independent Risk Factor for Intravesical Recurrence After Laparoscopic Radical Nephroureterectomy in Upper Tract Urothelial Carcinoma.2018
- Author(s)
  茂田啓介
- Organizer
  第56回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16815
[Presentation] Efficacy of Chemotherapy Administration in Elderly Patients with Metastatic Upper Tract Urothelial Carcinoma after Radical Nephroureterectomy2017
- Author(s)
  Keisuke Shigeta
- Organizer
  American Urological Association Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16815

1. 小坂威雄 (30445407)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 北岡壮太郎 (90936387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 森田伸也 (10365364)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 松本一宏 (80366153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TANAKA Nobuyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 三上修治

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. 大家基嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 水野隆一

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Shigeta Keisuke 茂田 啓介

SHIGETA KEISUKE 茂田 啓介

Research Projects

Research Products

Co-Researchers

Elucidation of tumor development mechanism by immune escape mechanism through metabolic reprogramming of anticancer drug-resistant cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Basic research focusing on correlation between tumor associated macrophage and peripheral monocyte count

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Profiling the Molecular Characteristics and Transitions Through Upper Tract Tumor Origin, Bladder Recurrence, and Muscle Invasive Bladder Progression in Upper Tract Urothelial CarcinomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New Treatment Strategy for Chemoresistant Urothelial Carcinoma Regarding of Metabolic ReprogrammingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

MUC1C Oncoprotein Contributes to Acquiring Cisplatin Resistance in Urothelial Carcinoma CellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Profiling Fibroblast Growth Factor Receptor 3 Expression Based on the Immune Microenvironment in Upper Tract Urothelial Carcinoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vasohibin-1 Expression Can Predict Pathological Complete Remission of Advanced Bladder Cancer with Neoadjuvant Chemotherapy2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] IDH2 stabilizes HIF‐1α‐induced metabolic reprogramming and promotes chemoresistance in urothelial cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Does neoadjuvant chemotherapy have therapeutic benefit for node-positive upper tract urothelial carcinoma? Results of a multi-center cohort study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Profiling the Biological Characteristics and Transitions through Upper Tract Tumor Origin, Bladder Recurrence, and Muscle-Invasive Bladder Progression in Upper Tract Urothelial Carcinoma2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluating the Oncological Outcomes of Pure Laparoscopic Radical Nephroureterectomy Performed for Upper-Tract Urothelial Carcinoma Patients: A Multicenter Cohort Study Adjusted by Propensity Score Matching2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The clinicopathological characteristics of muscle‐invasive bladder recurrence in upper tract urothelial carcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Over Time Conditional Survival of Intravesical Recurrence in Upper Tract Urothelial Carcinoma.2017

Author(s)

Journal Title

Data Source

[Presentation] 尿路上皮癌分子サブタイプ（ CK5/6, CK20, FGFR3, p53）分類に基づいた腎盂尿管癌術後膀胱内再発および進展系統樹の作成2023

Author(s)

Organizer

Data Source

[Presentation] 尿路上皮癌分子サブタイプ（ CK5/6, CK20, FGFR3, p53）分類に基づいた腎盂尿管癌術後膀胱内再発および進展系統樹の作成2022

Author(s)

Shigeta Keisuke 茂田啓介

SHIGETA KEISUKE 茂田啓介