Kyotani Yoji 京谷陽司

… Alternative Names

京谷陽司キョウタニヨウジ

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Researcher Number	10706534
Other IDs
Affiliation (Current)	2025: 奈良県立医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2020 – 2022: 奈良県立医科大学, 医学部, 助教 2014 – 2018: 奈良県立医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Pathological medical chemistry Except Principal Investigator Basic Section 47040:Pharmacology-related / General pharmacology
Keywords	Principal Investigator 間歇的低酸素 / インターロイキン-6 / 睡眠時無呼吸 / シクロオキシゲナーゼ / Epiregulin / Intermittent hypoxia / エピレグリン / 血管平滑筋細胞 / 間歇的低酸素症 / 睡眠時無呼吸症候群 … More / interleukin-6 / epiregulin / vascular smooth muscle / Obstructive sleep apnea … More Except Principal Investigator MAPキナーゼ / 分子機構 / 伸展負荷 / 細胞死 / 血管平滑筋細胞 / 動脈解離 / 進展負荷 / 血管平滑筋細胞死 / Nr4a / アンジオテンシンＩＩ受容体拮抗薬 / カルシウム拮抗薬 / ケモカイン Less

Investigation of the role of Nr4a in cyclic mechanical stretch-induced vascular smooth muscle cell death and the development of preventive drugs for aortic dissection
- Principal Investigator
  
  Yoshizumi Masanori
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Nara Medical University
Establishment of prophylaxis and clarification of the development and the progression mechanisms of obstructive sleep apnea induced-cardiovascular diseasesPrincipal Investigator
- Principal Investigator
  
  Kyotani Yoji
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nara Medical University
Investigation of cyclic mechanical stretch-inducued vasular smooth muscle cell death and the development of prevention strategies of aortic dissection
- Principal Investigator
  
  Yoshizumi Masanori
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  Nara Medical University
Investigation of the pathogenesis and progression of cardiovascular diseases in patients with obstructive sleep apneaPrincipal Investigator
- Principal Investigator
  
  Kyotani Yoji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nara Medical University

All 2023 2022 2021 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Intermittent Hypoxia Induces Expression of Epiregulin mRNA via Upregulation of Interleukin-6 in Human Coronary Artery Smooth Muscle Cells2018
- Author(s)
  YOJI KYOTANI, JING ZHAO, ASAKO ITAYA-HIRONAKA, AKIYO YAMAUCHI, SUMIYO SAKURAMOTO-TSUCHIDA, MAI MAKINO, SHIN TAKASAWA, MASANORI YOSHIZUMI
- Journal Title
  
  Diabetes
  
  Volume: 67 Issue: Supplement_1
- DOI
  10.2337/db18-472-p
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19058
[Journal Article] Intermittent hypoxia-induced epiregulin expression by IL-6 production in human coronary artery smooth muscle cells.2018
- Author(s)
  Kyotani Y, Itaya-Hironaka A, Yamauchi A, Sakuramoto-Tsuchida S, Makino M, Takasawa S, Yoshizumi M.
- Journal Title
  
  FEBS Open Bio
  
  Volume: 8 Issue: 5 Pages: 868-876
- DOI
  10.1002/2211-5463.12430
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19058
[Journal Article] Endothelin-1(1-31) causes the migration of vascular smooth muscle cells through endothelin ETA receptor2016
- Author(s)
  Yoji Kyotani, Jing Zhao, Kentaro Ozawa, Takahiro nakagawa,Francesco A. Bolstad, Masanori Yoshizumi
- Journal Title
  
  Brit. J. Pharmaceut. Res.
  
  Volume: 13 Issue: 6 Pages: 1-7
- DOI
  10.9734/bjpr/2016/29824
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460345
[Journal Article] Olmesartan inhibits cultured rat aortic smooth muscle cell death induced by cyclic mechanical stretch through the inhibition of the c-Jun N-terminal kinase and p38 signaling pathways2015
- Author(s)
  Satoyasu Ito, Kentaro Ozawa, Jing Zhao, Yoji Kyotani, Kosuke Nagayama, Masanori Yoshizumi
- Journal Title
  
  Journal of Pharmacological Sciences
  
  Volume: 127 Issue: 1 Pages: 69-74
- DOI
  10.1016/j.jphs.2014.11.002
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460345, KAKENHI-PROJECT-26461277, KAKENHI-PROJECT-26860217
[Journal Article] Exendin-4 Prevents Vascular Smooth Muscle Cell Proliferation and Migration by Angiotensin II via the Inhibition of ERK1/2 and JNK Signaling Pathways2015
- Author(s)
  Kosuke Nagayama, Yoji Kyotani, Jing Zhao, Satoyasu Ito, Kentaro Ozawa, Francesco A. Bolstad, Masanori Yoshizumi
- Journal Title
  
  Plos One
  
  Volume: 10 Issue: 9 Pages: e0137960-e0137960
- DOI
  10.1371/journal.pone.0137960
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460345, KAKENHI-PROJECT-26461277, KAKENHI-PROJECT-26860217
[Journal Article] Azelnidipine inhibits cultured rat vascular smooth muscle cell death induced by cyclic mechanical stretch2014
- Author(s)
  Jing Zhao, Kentaro Ozawa, Yoji Kyotani, Kosuke Nagayama, Satoyasu Ito, Akira T Komatsubara, Yuichi Tsuji, Masanori Yoshizumi
- Journal Title
  
  PloS One
  
  Volume: 9 Issue: 7 Pages: e102813-e102813
- DOI
  10.1371/journal.pone.0102813
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460345, KAKENHI-PROJECT-26461277, KAKENHI-PROJECT-26860217
[Presentation] 急激な高血圧を模した伸展刺激による血管平滑筋細胞死における転写因子NR4A1の役割について2023
- Author(s)
  趙晶、中平毅一、京谷陽司、吉栖正典
- Organizer
  第32回　日本循環薬理学会
- Data Source
  KAKENHI-PROJECT-20K07073
[Presentation] 進展負荷によるラット血管平滑筋細胞死に対してNR4A1は防御的に作用する2022
- Author(s)
  趙晶、中平毅一、京谷陽司、吉栖正典
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07073
[Presentation] 転写因子 NR4A1は伸展負荷による血管平滑筋細胞死を抑制する2021
- Author(s)
  趙晶、中平毅一、京谷陽司、吉栖正典
- Organizer
  第31回日本循環薬理学会
- Data Source
  KAKENHI-PROJECT-20K07073
[Presentation] 急激な進展負荷によるラット血管平滑筋細胞死におけるNR4A1の保護作用について2021
- Author(s)
  趙晶、中平毅一、京谷陽司、吉栖正典
- Organizer
  第140回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-20K07073
[Presentation] Intermittent hypoxia-induced cell proliferation via upregulations of interleukin-6 and epiregulin2018
- Author(s)
  Yoji Kyotani, Jing Zhao, Asako Itaya-Hironaka, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Mai Makino, Shin Takasawa, Masanori Yoshizumi
- Organizer
  18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19058
[Presentation] Intermittent Hypoxia Induces Expression of Epiregulin mRNA via Upregulation of Interleukin-6 in Human Coronary Artery Smooth Muscle Cells2018
- Author(s)
  Yoji Kyotani, Jing Zhao, Asako Itaya-Hironaka, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Mai Makino, Shin Takasawa, Masanori Yoshizumi
- Organizer
  78th American Diabetes Association Scientific Sessions
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19058
[Presentation] Intermittent hypoxia-induced cell proliferation via upregulations of interleukin-6 and epiregulin2018
- Author(s)
  Yoji Kyotani, Jing Zhao, Asako Itaya-Hironaka, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Mai Makino, Shin Takasawa, Masanori Yoshizumi
- Organizer
  18th World Congress of Basic and Clinical Pharmacology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19058
[Presentation] 伸展負荷によるラット血管平滑筋細胞死に対するケモカインの保護作用2017
- Author(s)
  趙晶、小澤健太郎、京谷陽司、吉栖正典
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール
- Year and Date
  2017-03-15
- Data Source
  KAKENHI-PROJECT-26460345
[Presentation] 伸展刺激に対する血管平滑筋細胞応答と動脈硬化2017
- Author(s)
  吉栖正典、趙晶、小澤健太郎、京谷陽司
- Organizer
  第90回日本薬理学会年会
- Place of Presentation
  長崎ブリックホール
- Year and Date
  2017-03-15
- Invited
- Data Source
  KAKENHI-PROJECT-26460345
[Presentation] 間歇的低酸素暴露によるインターロイキン-6の発現増加を介した上皮成長因子の遺伝子発現2017
- Author(s)
  京谷陽司、趙晶、高沢伸、吉栖正典
- Organizer
  第131回日本薬理学会近畿部会
- Data Source
  KAKENHI-PROJECT-16K19058
[Presentation] Intermittent hypoxia induces epiregulin mRNA expression through the increase of interleukin-6 in human coronary artery smooth muscle cells2017
- Author(s)
  Y. Kyotani, A. Hironaka, A. Yamauchi, S. Tsuchida,M. Makino, S. Takasawa, M. Yoshizumi
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K19058
[Presentation] Chemokine inhibition of mechanical stretch-induced vascular smooth muscle cell death2016
- Author(s)
  趙晶、小澤健太郎、京谷陽司、長山功佑、吉栖正典
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-26460345
[Presentation] GLP-1 analogueであるExendin-4はアンジオテンシンＩＩによる血管平滑筋細胞の増殖と遊走を抑制する2016
- Author(s)
  吉栖正典、長山　功佑、京谷　陽司、趙　晶、伊藤　都裕、小澤　健太郎
- Organizer
  第45回日本心脈管作動物質学会
- Place of Presentation
  阿波観光ホテル
- Year and Date
  2016-02-05
- Data Source
  KAKENHI-PROJECT-26460345
[Presentation] 周期性の低酸素負荷または伸展負荷に対する血管平滑筋細胞応答と動脈硬化2016
- Author(s)
  京谷陽司、高沢伸、趙昌、小澤健太郎、吉栖正典
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜　会議センター
- Year and Date
  2016-03-09
- Data Source
  KAKENHI-PROJECT-26860217
[Presentation] Underlining mechanisms for arteriosclerosis in intermittent hypoxia or biomechanical stretch2016
- Author(s)
  京谷　陽司、高澤　伸、趙　晶、小澤　健太郎、吉栖　正典
- Organizer
  第89回日本薬理学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-09
- Invited
- Data Source
  KAKENHI-PROJECT-26460345
[Presentation] 伸展負荷による血管平滑筋細胞死に対するケモカインの抑制作用2015
- Author(s)
  趙晶、小澤健太郎、京谷陽司、長山功佑、吉栖正典
- Organizer
  第２５回　日本循環薬理学会
- Place of Presentation
  東大寺総合文化センター
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-26460345
[Presentation] アンギオテンシンＩＩによる血管平滑筋細胞の増殖と遊走に対するGLP-1 analogueのExendin-4の抑制効果2015
- Author(s)
  長山　功佑、京谷　陽司、趙　晶、伊藤　都裕、小澤　健太郎、吉栖　正典
- Organizer
  第２５回　日本循環薬理学会
- Place of Presentation
  東大寺総合文化センター
- Year and Date
  2015-12-04
- Data Source
  KAKENHI-PROJECT-26460345
[Presentation] オルメサルタンはJNK、p38のリン酸化を阻害することにより伸展刺激による細胞死を抑制する2014
- Author(s)
  伊藤都裕、趙晶、京谷陽司、長山功佑、辻優一、小澤健太郎、吉栖正典
- Organizer
  第125回日本薬理学会近畿部会
- Place of Presentation
  岡山コンベンションセンター
- Year and Date
  2014-06-20
- Data Source
  KAKENHI-PROJECT-26460345
[Presentation] 蛍光タンパク質を使った一酸化窒素アッセイ系の確立
- Author(s)
  小澤　健太郎、辻　優一、趙　晶、伊藤　都裕、長山　功佑、京谷　陽司、吉栖　正典
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26460345
[Presentation] オルメサルタンは、JNK及びp38シグナル経路を抑制する事で、周期的機械的伸展による培養大動脈平滑筋細胞死を抑制する
- Author(s)
  伊藤都裕、小澤健太郎、趙晶、京谷陽司、長山功佑、吉栖正典
- Organizer
  第88回日本薬理学会年会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-03-18 – 2015-03-20
- Data Source
  KAKENHI-PROJECT-26460345
[Presentation] Sleep apnea syndrome as an emerging risk factor for type 2 diabetes and atherosclerosis: evidence and underlying mechanism
- Author(s)
  Yoji Kyotani, Hiroyo Ota, Asako Itaya-Hironaka, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Jing Zhao, Kosuke Nagayama, Kentaro Ozawa, Shin Takasawa, Hiroshi Kimura, Masanori Yoshizumi
- Organizer
  9th Metabolic Syndrome, Type 2 Diabetes and Atherosclerosis Congress
- Place of Presentation
  Kyoto International Conference Center
- Year and Date
  2014-09-12 – 2014-09-14
- Data Source
  KAKENHI-PROJECT-26860217
[Presentation] 一酸化窒素による脱分極ミトコンドリアの分解の制御機構
- Author(s)
  小澤　健太郎、趙　晶、京谷　陽司、伊藤　都裕、長山　功佑、辻　優一、吉栖　正典
- Organizer
  第37回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-11 – 2014-09-13
- Data Source
  KAKENHI-PROJECT-26460345
[Presentation] Sleep apnea Syndrome as an emerging risk factor for type 2 diabetes and atherosclerosis: evidence and underlying mechanism
- Author(s)
  Yoji Kyotani, Hiroko Ota, Asako Itaya-Hironaka, Akiyo Yamauchi, Sumiyo Sakuramoto-Tsuchida, Jing Zhao, Kosuke nagayama, Kentaro Ozawa, Shin Takasawa, Hiroshi Kimura, Masanori Yoshizumi
- Organizer
  9th Metabolic Syndrome, Type 2 diabetes and Aterosclerosis Congress
- Place of Presentation
  京都国際会議場
- Year and Date
  2014-09-12 – 2014-09-14
- Data Source
  KAKENHI-PROJECT-26460345

1. Yoshizumi Masanori (60294667)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
2. 趙晶 (60804466)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
3. 小澤健太郎 (80507393)

# of Collaborated Projects: 1 results

# of Collaborated Products: 16 results
4. 中平毅一 (80844414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. TAKASAWA Shin

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

Kyotani Yoji 京谷 陽司

京谷 陽司 キョウタニ ヨウジ

Research Projects

Research Products

Co-Researchers

Investigation of the role of Nr4a in cyclic mechanical stretch-induced vascular smooth muscle cell death and the development of preventive drugs for aortic dissection

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of prophylaxis and clarification of the development and the progression mechanisms of obstructive sleep apnea induced-cardiovascular diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of cyclic mechanical stretch-inducued vasular smooth muscle cell death and the development of prevention strategies of aortic dissection

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Investigation of the pathogenesis and progression of cardiovascular diseases in patients with obstructive sleep apneaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Intermittent Hypoxia Induces Expression of Epiregulin mRNA via Upregulation of Interleukin-6 in Human Coronary Artery Smooth Muscle Cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intermittent hypoxia-induced epiregulin expression by IL-6 production in human coronary artery smooth muscle cells.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Endothelin-1(1-31) causes the migration of vascular smooth muscle cells through endothelin ETA receptor2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Olmesartan inhibits cultured rat aortic smooth muscle cell death induced by cyclic mechanical stretch through the inhibition of the c-Jun N-terminal kinase and p38 signaling pathways2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Exendin-4 Prevents Vascular Smooth Muscle Cell Proliferation and Migration by Angiotensin II via the Inhibition of ERK1/2 and JNK Signaling Pathways2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Azelnidipine inhibits cultured rat vascular smooth muscle cell death induced by cyclic mechanical stretch2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] 急激な高血圧を模した伸展刺激による血管平滑筋細胞死における転写因子NR4A1の役割について2023

Author(s)

Organizer

Data Source

[Presentation] 進展負荷によるラット血管平滑筋細胞死に対してNR4A1は防御的に作用する2022

Author(s)

Organizer

Data Source

[Presentation] 転写因子 NR4A1は伸展負荷による血管平滑筋細胞死を抑制する2021

Author(s)

Organizer

Data Source

[Presentation] 急激な進展負荷によるラット血管平滑筋細胞死におけるNR4A1の保護作用について2021

Author(s)

Organizer

Data Source

[Presentation] Intermittent hypoxia-induced cell proliferation via upregulations of interleukin-6 and epiregulin2018

Author(s)

Organizer

Data Source

[Presentation] Intermittent Hypoxia Induces Expression of Epiregulin mRNA via Upregulation of Interleukin-6 in Human Coronary Artery Smooth Muscle Cells2018

Kyotani Yoji 京谷陽司

京谷陽司キョウタニヨウジ