Takemoto Hiroyasu 武元宏泰

Researcher Number	10709249
Other IDs
Affiliation (Current)	2025: 京都府立医科大学, 医学(系)研究科(研究院), 准教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 京都府立医科大学, 医学(系)研究科(研究院), 准教授 2016 – 2021: 東京工業大学, 科学技術創成研究院, 助教 2015: 東京工業大学, 資源化学研究所, 助教
Review Section/Research Field	Principal Investigator Biomedical engineering/Biomaterial science and engineering / 0403:Biomedical engineering and related fields / Basic Section 90120:Biomaterials-related / Pharmaceutical Sciences and related fields Except Principal Investigator Medium-sized Section 90:Biomedical engineering and related fields / Physical pharmacy
Keywords	Principal Investigator 高分子 / バイオマテリアル / 生体高分子 / ベタイン / がん / 生体材料 / 高分子構造・物性 / 薬物送達システム / ドラッグデリバリーシステム / ナノ粒子 … More / pH応答性 / pH / 刺激応答材料 / 核酸 / 生体材料学 / 生体医工学 / 高分子科学 / 高分子化学 / 核酸医薬 … More Except Principal Investigator 高分子ミセル / ナノメディシン / タンパク質デリバリー / コア設計 / スマートシェル / 機能性ポリマー / DDS / 生理活性タンパク質 / ボロン酸 / タンニン酸 / がん標的化 / 生体適合性ポリマー / 薬物送達システム / 治療抵抗生がん / 光線力学治療 / イメージング / 治療抵抗性がん / ターゲティング / アミノ酸トランスポーター / 合成高分子 / ターティング / がん代謝 / がん細胞 Less

rational design of pH-responsive polyzwitterion for tumor-targeted drug vehiclePrincipal Investigator
- Principal Investigator
  
  武元宏泰
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Kyoto Prefectural University of Medicine
Functional polymer with regulated ionic behavior and the coated nanoparticles for penetration into tumorous deeper sitesPrincipal Investigator
- Principal Investigator
  
  武元宏泰
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0403:Biomedical engineering and related fields
- Research Institution
  Kyoto Prefectural University of Medicine
Development of smart polymeric micelles based on novel shell and core designs
- Principal Investigator
  
  NISHIYAMA Nobuhiro
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Tokyo Institute of Technology
Facilitated intracellular delivery of oligonucleotide based on the controlled electrostatic behavior of the polymerPrincipal Investigator
- Principal Investigator
  
  Takemoto Hiroyasu
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Pharmaceutical Sciences and related fields
- Research Institution
  Tokyo Institute of Technology
Functional polymer that recognizes tumorous pH for effective delivery of the coated nanoparticles to tumor tissuesPrincipal Investigator
- Principal Investigator
  
  Takemoto Hiroyasu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Tokyo Institute of Technology
Development of shell molecule for facilitated celluar internalization of the nanoparticle for tumor cellsPrincipal Investigator
- Principal Investigator
  
  Takemoto Hiroyasu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Tokyo Institute of Technology
Design of functional ligand molecules focused on specific metabolism of cancer cells and their applications for diagnosis and therapy
- Principal Investigator
  
  NISHIYAMA Nobuhiro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Tokyo Institute of Technology

All 2024 2023 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Patent

[Journal Article] Fine tuning of the net charge alternation of polyzwitterion surfaced lipid nanoparticles to enhance cellular uptake and membrane fusion potential2024
- Author(s)
  Homma Keitaro、Miura Yutaka、Kobayashi Motoaki、Chintrakulchai Wanphiwat、Toyoda Masahiro、Ogi Koichi、Michinishi Junya、Ohtake Tomoyuki、Honda Yuto、Nomoto Takahiro、Takemoto Hiroyasu、Nishiyama Nobuhiro
- Journal Title
  
  Science and Technology of Advanced Materials
  
  Volume: 25 Issue: 1 Pages: 2338785-2338785
- DOI
  10.1080/14686996.2024.2338785
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K19223, KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-22H00581
[Journal Article] pH-responsive polyzwitterion covered nanocarriers for DNA delivery2023
- Author(s)
  X. Shen, A. Dirisala, M. Toyoda, Y. Xiao, H. Guo, Y. Honda, T. Nomoto, H. Takemoto, Y. Miura, N. Nishiyama
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 360 Pages: 928-939
- DOI
  10.1016/j.jconrel.2023.07.038
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18322, KAKENHI-PROJECT-23K19223, KAKENHI-PROJECT-23K11841, KAKENHI-PROJECT-21K18062, KAKENHI-PROJECT-23H05451, KAKENHI-PROJECT-22H00581, KAKENHI-PROJECT-23K24177
[Journal Article] Fructose-functionalized polymers to enhance therapeutic potential of p-boronophenylalanine for neutron capture therapy2021
- Author(s)
  Nomoto Takahiro、Yao Ying、Inoue Yukiya、Suzuki Minoru、Kanamori Kaito、Takemoto Hiroyasu、Matsui Makoto、Tomoda Keishiro、Nishiyama Nobuhiro
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 332 Pages: 184-193
- DOI
  10.1016/j.jconrel.2021.02.021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K18383, KAKENHI-PROJECT-18H04163
[Journal Article] Systemically applicable glutamine-functionalized polymer exerting multivalent interaction with tumors overexpressing ASCT22021
- Author(s)
  Y. Honda, T. Nomoto, H. Takemoto, M. Matsui, K. Taniwaki, H. Guo, Y. Miura, N. Nishiyama
- Journal Title
  
  ACS Applied Bio Materials
  
  Volume: 4(10) Issue: 10 Pages: 7402-7407
- DOI
  10.1021/acsabm.1c00771
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K18322, KAKENHI-PROJECT-18H04163
[Journal Article] Sequentially self-assembled nanoreactor comprising tannic acid and phenylboronic acid-conjugated polymers inducing tumor-selective enzymatic activity2021
- Author(s)
  Y. Honda, T. Nomoto, M. Matsui, H. Takemoto, Y. Miura, N. Nishiyama
- Journal Title
  
  ACS Appl. Mater. Inter.
  
  Volume: 13(46) Issue: 46 Pages: 54850-54859
- DOI
  10.1021/acsami.1c20188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K18322, KAKENHI-PROJECT-18H04163
[Journal Article] Sequential Self-Assembly Using Tannic Acid and Phenylboronic Acid-Modified Copolymers for Potential Protein Delivery2020
- Author(s)
  Honda Yuto、Nomoto Takahiro、Matsui Makoto、Takemoto Hiroyasu、Kaihara Yuka、Miura Yutaka、Nishiyama Nobuhiro
- Journal Title
  
  Biomacromolecules
  
  Volume: 21 Issue: 9 Pages: 3826-3835
- DOI
  10.1021/acs.biomac.0c00903
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K18383, KAKENHI-PROJECT-18H04163
[Journal Article] Potential urinary monitoring of the enhanced permeability and retention effect using MMP-2-responsive poly(ethylene glycol) derivatives2020
- Author(s)
  X. Sun, T. Nomoto, H. Takemoto, M. Matsui, H. Guo, Y. Sun, Y. Miura, N. Nishiyama*
- Journal Title
  
  J. Control. Release
  
  Volume: 329 Pages: 513-523
- DOI
  10.1016/j.jconrel.2020.09.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H04163, KAKENHI-PROJECT-20K20196
[Journal Article] Poly(vinyl alcohol) boosting therapeutic potential of p-boronophenylalanine in neutron capture therapy by modulating metabolism2020
- Author(s)
  Nomoto Takahiro、Inoue Yukiya、Yao Ying、Suzuki Minoru、Kanamori Kaito、Takemoto Hiroyasu、Matsui Makoto、Tomoda Keishiro、Nishiyama Nobuhiro
- Journal Title
  
  Science Advances
  
  Volume: 6 Issue: 4
- DOI
  10.1126/sciadv.aaz1722
- NAID
  120006779811
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K18383, KAKENHI-PROJECT-18H04163, KAKENHI-PROJECT-17H04743
[Journal Article] Photodynamic therapy using LCST polymers exerting pH-responsive isothermal phase transition2020
- Author(s)
  S. Muttaqien, T. Nomoto*, X. Dou, H. Takemoto, M. Matsui, N. Nishiyama*
- Journal Title
  
  J. Control. Release
  
  Volume: 328 Pages: 608-616
- DOI
  10.1016/j.jconrel.2020.09.036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H04163, KAKENHI-PROJECT-20K20196
[Journal Article] Polymeric modification of gemcitabine via cyclic acetal linkage for enhanced anticancer potency with negligible side effects2020
- Author(s)
  Takemoto Hiroyasu、Inaba Takanori、Nomoto Takahiro、Matsui Makoto、Liu Xiaomeng、Toyoda Masahiro、Honda Yuto、Taniwaki Kaori、Yamada Naoki、Kim Junhyun、Tomoda Keishiro、Nishiyama Nobuhiro
- Journal Title
  
  Biomaterials
  
  Volume: 235 Pages: 119804-119804
- DOI
  10.1016/j.biomaterials.2020.119804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K18383, KAKENHI-PROJECT-19K20693, KAKENHI-PROJECT-18H04163, KAKENHI-PROJECT-17H04743, KAKENHI-PROJECT-18J01989, KAKENHI-PROJECT-18K09020
[Journal Article] Iron chelation cancer therapy using hydrophilic block copolymers conjugated with deferoxamine2020
- Author(s)
  K. Komoto, T. Nomoto*, S. Muttaqien, H. Takemoto, M. Matsui, Y. Miura, N. Nishiyama*
- Journal Title
  
  Cancer Sci.
  
  Volume: 112 Issue: 1 Pages: 410-421
- DOI
  10.1111/cas.14607
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H04163, KAKENHI-PROJECT-20K20196
[Journal Article] In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers2019
- Author(s)
  Watanabe Sumiyo、Hayashi Kotaro、Toh Kazuko、Kim Hyun Jin、Liu Xueying、Chaya Hiroyuki、Fukushima Shigeto、Katsushima Keisuke、Kondo Yutaka、Uchida Satoshi、Ogura Satomi、Nomoto Takahiro、et al.
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 1894-1894
- DOI
  10.1038/s41467-019-09856-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18383, KAKENHI-PROJECT-17KT0048, KAKENHI-PROJECT-19K12799, KAKENHI-PROJECT-17K20086, KAKENHI-PROJECT-18K18391, KAKENHI-PROJECT-17KK0102, KAKENHI-PROJECT-18H04163, KAKENHI-PROJECT-16H03178, KAKENHI-PROJECT-17H03582, KAKENHI-PROJECT-18H02797, KAKENHI-PROJECT-18H03529, KAKENHI-PROJECT-17H04743, KAKENHI-PROJECT-17K07234, KAKENHI-PROJECT-17H02098
[Journal Article] Pyruvate Responsiveness Based on α-Oxohydrazone Formation for Intracellular siRNA Release from Polyion Complex-Based Carriers2019
- Author(s)
  Takemoto Hiroyasu、Wang Chih-Ling、Nomoto Takahiro、Matsui Makoto、Tomoda Keishiro、Nishiyama Nobuhiro
- Journal Title
  
  Biomacromolecules
  
  Volume: 20 Issue: 6 Pages: 2305-2314
- DOI
  10.1021/acs.biomac.9b00261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K18383, KAKENHI-PROJECT-18H04163, KAKENHI-PROJECT-17H04743
[Journal Article] Effect of multiple cyclic RGD peptides on tumor accumulation and intratumoral distribution of IRDye 700DX-conjugated polymers2018
- Author(s)
  Dou Xuebo、Nomoto Takahiro、Takemoto Hiroyasu、Matsui Makoto、Tomoda Keishiro、Nishiyama Nobuhiro
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 8126-8126
- DOI
  10.1038/s41598-018-26593-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K18383, KAKENHI-PROJECT-18H04163, KAKENHI-PROJECT-17H04743, KAKENHI-PROJECT-16F16058, KAKENHI-PROJECT-16F16407
[Journal Article] An Ethylenediamine‐based Switch to Render the Polyzwitterion Cationic at Tumorous pH for Effective Tumor Accumulation of Coated Nanomaterials2018
- Author(s)
  Abdul-Hackam Ranneh, Hiroyasu Takemoto, Shunya Sakuma, Aziz Awaad, Takahiro Nomoto, Yuki Mochida, Makoto Matsui, Keishiro Tomoda, Mitsuru Naito, Nobuhiro Nishiyama
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 57 Issue: 18 Pages: 5057-5061
- DOI
  10.1002/anie.201801641
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K19481, KAKENHI-PROJECT-15H04635, KAKENHI-PROJECT-17H04743, KAKENHI-PROJECT-16F16058, KAKENHI-PROJECT-16K15104, KAKENHI-PROJECT-18H04163, KAKENHI-PROJECT-16F16407
[Journal Article] Poly(ethylene glycol)ーpoly(lysine) block copolymerーubenimex conjugate targets aminopeptidase N and exerts an antitumor effect in hepatocellular carcinoma stem cells2018
- Author(s)
  Toshiyama, R., Konno, M., Eguchi, H., Takemoto, H., Noda, T., Asai, A., Koseki, J., Haraguchi, N., Ueda, Y. Matsushita, K., Asukai, K., Ohashi, T., Iwagami, Y., Yamada, D., Sakai, D., Asaoka, T., Kudo, T., Kawamoto, K., Gotoh, K., Kobayashi, S., Satoh, T., Doki, Y., Nishiyama, N., Mori, M., Ishii, H.
- Journal Title
  
  Oncogene
  
  Volume: 38 Issue: 2 Pages: 244-260
- DOI
  10.1038/s41388-018-0406-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16355, KAKENHI-PROJECT-18K16356, KAKENHI-PROJECT-18KK0251, KAKENHI-PROJECT-18H04163, KAKENHI-PROJECT-17H04282, KAKENHI-PROJECT-16F16058, KAKENHI-PROJECT-17K19698, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06279
[Journal Article] Poly(N-isopropylacrylamide)-Based Polymer-Inducing Isothermal Hydrophilic-to-Hydrophobic Phase Transition via Detachment of Hydrophilic Acid-Labile Moiety2018
- Author(s)
  Muttaqien Sjaikhurrizal El、Nomoto Takahiro、Takemoto Hiroyasu、Matsui Makoto、Tomoda Keishiro、Nishiyama Nobuhiro
- Journal Title
  
  Biomacromolecules
  
  Volume: 20 Issue: 4 Pages: 1493-1504
- DOI
  10.1021/acs.biomac.8b01465
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K18383, KAKENHI-PROJECT-17H04743, KAKENHI-PROJECT-16F16058, KAKENHI-PROJECT-16F16407, KAKENHI-PROJECT-18H04163
[Journal Article] Utility of the 2-nitrobenzenesulfonamide group as a chemical linker for enhanced extracellular stability and cytosolic cleavage in siRNA-conjugated polymer systems2017
- Author(s)
  C. H. Huang, H. Takemoto, T. Nomoto, K. Tomoda, M. Matsui, N. Nishiyama
- Journal Title
  
  ChemMedChem
  
  Volume: 12 Issue: 1 Pages: 19-22
- DOI
  10.1002/cmdc.201600488
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16F16058, KAKENHI-PROJECT-16F16407, KAKENHI-PROJECT-15K16331, KAKENHI-PROJECT-15H04635, KAKENHI-PROJECT-16K15104
[Journal Article] Engineering Tumour Cell-Binding Synthetic Polymers with Sensing Dense Transporters Associated with Aberrant Glutamine Metabolism2017
- Author(s)
  Yamada Naoki、Honda Yuto、Takemoto Hiroyasu、Nomoto Takahiro、Matsui Makoto、Tomoda Keishiro、Konno Masamitsu、Ishii Hideshi、Mori Masaki、Nishiyama Nobuhiro
- Journal Title
  
  Sci. Rep.
  
  Volume: 7 Issue: 1 Pages: 6077-6077
- DOI
  10.1038/s41598-017-06438-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19698, KAKENHI-PROJECT-15H04635, KAKENHI-PROJECT-17H04282, KAKENHI-PROJECT-16F16058, KAKENHI-PROJECT-16F16407, KAKENHI-PROJECT-16J10727, KAKENHI-PROJECT-16K15104, KAKENHI-PROJECT-16K15615
[Journal Article] Multilayered polyion complexes with dissolvable silica layer covered by controlling densities of cRGD-conjugated PEG chains for cancer-targeted siRNA delivery.2017
- Author(s)
  M. Naito, R. Azuma, H. Takemoto, M. Hori, N. Yoshinaga, S. Osawa, R. Kamegawa, H. -J. Kim, T. Ishii, N. Nishiyama, K. Miyata, K. Kataoka
- Journal Title
  
  J. Biomater. Sci. Polym.
  
  Volume: 28 Issue: 10-12 Pages: 1109-1123
- DOI
  10.1080/09205063.2017.1301775
- Description
  【掲載確定】 in press
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25000006, KAKENHI-PROJECT-15H04635, KAKENHI-PROJECT-16F16058, KAKENHI-PROJECT-16F16407, KAKENHI-PROJECT-16K15104, KAKENHI-PROJECT-25282141
[Journal Article] Functional polymer-based siRNA delivery carrier that recognizes site-specific biosignals2017
- Author(s)
  Hiroyasu Takemoto, Nobuhiro Nishiyama
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 267 Pages: 90-99
- DOI
  10.1016/j.jconrel.2017.09.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19481, KAKENHI-PROJECT-15H04635, KAKENHI-PROJECT-17H04743, KAKENHI-PROJECT-16F16058, KAKENHI-PROJECT-16F16407, KAKENHI-PROJECT-16K15104
[Journal Article] Influence of RNA strand rigidity on polyion complex formation with block catiomers.2016
- Author(s)
  K. Hayashi, H. Chaya, S. Fukushima, S. Watanabe, H. Takemoto, K. Osada, N. Nishiyama, K. Miyata, K. Kataoka
- Journal Title
  
  Macromol. Rapid Commun.
  
  Volume: 37 Issue: 6 Pages: 486-493
- DOI
  10.1002/marc.201500661
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16331, KAKENHI-PROJECT-14J10626, KAKENHI-PROJECT-24659411, KAKENHI-PROJECT-25000006, KAKENHI-PROJECT-25282141
[Journal Article] siRNA-loaded polyion complex micelle decorated with charge-conversional polymer tuned to undergo stepwise response to intra-tumoral and intra-endosomal pHs for exerting enhanced RNAi efficacy.2016
- Author(s)
  M. Tangsangasaksri, H. Takemoto, M. Naito, Y. Maeda, D. Sueyoshi, H. -J. Kim, Y. Miura, J. -Y. Ahn, R. Azuma, N. Nishiyama, K. Miyata, K. Kataoka
- Journal Title
  
  Biomacromolecules
  
  Volume: 17 Issue: 1 Pages: 246-255
- DOI
  10.1021/acs.biomac.5b01334
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16331, KAKENHI-PROJECT-24689051, KAKENHI-PROJECT-25282141
[Journal Article] Artificial Control of Gene Silencing Activity Based on siRNA Conjugation with Polymeric Molecule Having Coil Globule Transition Behavior2016
- Author(s)
  Noor Faizah Che Harun, Hiroyasu Takemoto, Takahiro Nomoto, Keishiro Tomoda, Makoto Matsui, and Nobuhiro Nishiyama
- Journal Title
  
  Bioconjugate Chemistry
  
  Volume: 27 Issue: 9 Pages: 1961-1964
- DOI
  10.1021/acs.bioconjchem.6b00322
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K16331, KAKENHI-PROJECT-15H04635, KAKENHI-PROJECT-16K15104
[Journal Article] Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity2015
- Author(s)
  H. Gao, H. Takemoto, Q. Chen, M. Naito, H. Uchida, X. Liu, K. Miyata, K. Kataoka
- Journal Title
  
  Chemical Communications
  
  Volume: 51 Issue: 15 Pages: 3158-3161
- DOI
  10.1039/c4cc09859e
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25000006, KAKENHI-PROJECT-15K16331
[Patent] グルタミントランスポーターと多価結合することができるリガンド, 及び当該リガンドを含む組成物2017
- Inventor(s)
  西山伸宏、武元宏泰、野本貴大、他7名
- Industrial Property Rights Holder
  東京工業大学, 大阪大学
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-15H04635
[Patent] ｐＨ応答性ポリマー及び薬物送達システム2017
- Inventor(s)
  武元宏泰　他5名
- Industrial Property Rights Holder
  武元宏泰　他5名
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Overseas
- Data Source
  KAKENHI-PROJECT-17H04743
[Patent] ｐＨ応答性ポリマー及び薬物送達システム2016
- Inventor(s)
  武元宏泰　他5名
- Industrial Property Rights Holder
  武元宏泰　他5名
- Industrial Property Rights Type
  特許
- Filing Date
  2016-12-15
- Data Source
  KAKENHI-PROJECT-15K16331
[Patent] グルタミントランスポーターと多価結合することができるリガンド, 及び当該リガンドを含む組成物2016
- Inventor(s)
  西山伸宏, 武元宏泰, 野本貴大, 友田敬士郎, 松井誠他
- Industrial Property Rights Holder
  東京工業大学, 大阪大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-161774
- Filing Date
  2016-08-22
- Data Source
  KAKENHI-PROJECT-15H04635
[Presentation] 生体内刺激応答性高分子の開発とがん送達への展開2023
- Author(s)
  武元宏泰
- Organizer
  第11回　9大学化学会
- Invited
- Data Source
  KAKENHI-PROJECT-23K19223
[Presentation] Iron chelation cancer therapy using functional polymers targeting tumors2020
- Author(s)
  Kana Komoto, Takahiro Nomoto, Hiroyasu Takemoto, Matsui Makoto, Yutaka Miura, Nobuhiro Nishiyama
- Organizer
  International Symposium on Biomedical Materials for Drug/Gene Delivery, Alumni House, University of Utah, UT, USA
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] The development of polyzwitterion that responds to tumorous pH for effective delivery of nanomaterials to the deeper site in the tumor tissue2020
- Author(s)
  Hiroyasu Takemoto, Aziz Awaad, Takahiro Nomoto, Makoto Matsui, Yutaka Miura, Nobuhiro Nishiyama
- Organizer
  ACS Spring 2020 National Meeting & Expo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04743
[Presentation] Poly(vinyl alcohol) for enhancing therapeutic effects of p-boronophenylalanine in neutron capture therapy2020
- Author(s)
  Takahiro Nomoto, Yukiya Inoue, Ying Yao, Minoru Suzuki, Kaito Kanamori, Hiroyasu Takemoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyama
- Organizer
  International Symposium on Biomedical Materials for Drug/Gene Delivery, Alumni House, University of Utah, UT, USA
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 高濃度ビタミンC療法の治療効果向上を指向した高分子鉄キレート剤2020
- Author(s)
  Guo Haochen,野本貴大, 河本花奈, ムツタキンシャイクリザルエル, ソンショウギョウ, 武元宏泰, 松井誠, 三浦裕, 西山伸宏
- Organizer
  第69回高分子討論会(オンライン開催)
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 環状アセタール構造を介したゲムシタビンのポリアミノ酸への導入と薬効増大および副作用低減2020
- Author(s)
  武元宏泰, 野本貴大, 松井誠, 三浦裕, 西山伸宏
- Organizer
  第69回高分子学会年次大会(オンライン開催)
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] Effect of polymeric iron-chelators on high-dose vitamin C therapy2020
- Author(s)
  Guo Haochen, 野本貴大, 河本花奈,ムツタキンシャイクリザルエル, ソンショウギョウ, 武元宏泰, 松井誠, 三浦裕, 西山伸宏
- Organizer
  第36回日本DDS学会学術大会(オンライン開催)
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 腫瘍内pH応答性の獲得を目指した高分子ベタイン内の両イオン性基の種類・間隔の検討2020
- Author(s)
  豊田真広, 武元宏泰, 野本貴大, 松井誠, 三浦裕, 西山伸宏
- Organizer
  第69回高分子討論会(オンライン開催)
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 中性子捕捉療法におけるボロノフェニルアラニンの治療効果を向上する機能性高分子の開発2020
- Author(s)
  野本貴大, 井上透矢, Yao Ying, 鈴木実, 金盛開人, 小成田翔, 武元宏泰, 松井誠, 西山伸宏
- Organizer
  第69回高分子討論会(オンライン開催)
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] がん鉄キレート療法のための効率的な除鉄を実現する機能性高分子の開発2020
- Author(s)
  河本花奈, 野本貴大, Sjaikhurrizal El Muttaqien, 武元宏泰, 松井誠, 三浦裕, 西山伸宏
- Organizer
  第69回高分子討論会(オンライン開催)
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 環状アセタール構造に基づくゲムシタビン担持型高分子の開発とその機能評価および副作用低減2020
- Author(s)
  武元宏泰, 稲葉高徳, 野本貴大, 松井誠, 三浦裕, 西山伸宏
- Organizer
  第36回日本DDS学会学術大会(オンライン開催)
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] Development of intracellular pH- responsive protein delivery system utilizing boronic acid-conjugated polymer and tannic acid2020
- Author(s)
  Yuto Honda, Takahiro Nomoto, Makoto Matsui, Hiroyasu Takemoto, Yuka Kaihara, Yutaka Miura, Nobuhiro Nishiyama
- Organizer
  International Symposium on Biomedical Materials for Drug/Gene Delivery, Alumni House, University of Utah, UT, USA
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] Development of a versatile drug delivery system using tannic acid and boronic acid-conjugated polymer2020
- Author(s)
  I Dewa Agung Panji Dwipayana, Yuto Honda, Takahiro Nomoto, Hiroyasu Takemoto, Makoto Matsui, Yutaka Miura, Nobuhiro Nishiyama
- Organizer
  第69回高分子討論会(オンライン開催)
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 骨折治癒促進効果を有するDDS 医薬品の創製2020
- Author(s)
  松井誠, 海原悠可, 武元宏泰, 野本貴大, 三浦裕, 西山伸宏
- Organizer
  第36回日本DDS学会学術大会(オンライン開催)
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 高分子修飾によるsiRNA周囲の空間支配と薬理機構制御2020
- Author(s)
  武元宏泰, 野本貴大, 松井誠, 三浦裕, 西山伸宏
- Organizer
  第69回高分子討論会(オンライン開催)
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 高分子ベタイン内のイオン性基の種類・間隔の制御と腫瘍内pH応答性への展開2020
- Author(s)
  豊田真広, 武元宏泰, 野本貴大, 松井誠, 三浦裕, 西山伸宏
- Organizer
  第69回高分子学会年次大会(オンライン開催)
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] ASO-PEG結合体の開発と単分子ASO内包キャリアへの展開2020
- Author(s)
  SUN Yudi, 武元宏泰, 野本貴大, 松井誠, 三浦裕, 西山伸宏
- Organizer
  第36回日本DDS学会学術大会(オンライン開催)
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] ASO-分岐PEG結合体を内包する小分子キャリアの開発および機能評価2020
- Author(s)
  Sun Yudi, 武元宏泰, 野本貴大, 松井誠, 三浦裕, 西山伸宏
- Organizer
  第69回高分子討論会(オンライン開催)
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 腫瘍内pH応答性高分子ベタイン内のイオン性基間距離の検討2019
- Author(s)
  豊田真広、武元宏泰、野本貴大、松井誠、西山伸宏
- Organizer
  第68回高分子学会年次大会、大阪府立国際会議場、大阪
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] ボロン酸導入高分子とタンニン酸を用いた細胞内環境応答タンパク質送達システムの構築2019
- Author(s)
  本田雄士、野本貴大、松井誠、武元宏泰、海原悠可、三浦裕、西山伸宏
- Organizer
  第41回日本バイオマテリアル学会大会、つくば国際会議場、つくば
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 生体適合性高分子とボロノフェニルアラニンから構成される中性子捕捉療法用代謝制御型ホウ素送達システム2019
- Author(s)
  野本貴大、井上透矢、Yao Ying、金盛開人、鈴木実、武元宏泰、松井誠、西山伸宏
- Organizer
  第41回日本バイオマテリアル学会大会、つくば国際会議場、つくば
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 腫瘍 pH 応答性高分子ベタインの開発とナノ粒子のがん送達への展開2019
- Author(s)
  武元宏泰、アワードアジズ、野本貴大、松井誠、西山伸宏
- Organizer
  第35回日本DDS学会学術集会、パシフィコ横浜、横浜
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] がん細胞の高密度グルタミントランスポーターを標的として選択的な相互作用を示す機能性高分子の開発2019
- Author(s)
  本田雄士、山田直生、武元宏泰、野本貴大、松井誠、友田敬士郎、西山伸宏
- Organizer
  第68回高分子学会年次大会、大阪府立国際会議場、大阪
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 糖修飾高分子とホウ素薬物から構成される薬物送達システムの開発2019
- Author(s)
  金盛開人、野本貴大、鈴木実、武元宏泰、松井誠、西山伸宏
- Organizer
  第68回高分子学会年次大会、大阪府立国際会議場、大阪
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 生体適合性高分子とp-boronophenylalanineから構成されるホウ素送達システムの開発と構成高分子の物性が体内動態と治療効果に与える影響に関する考察2019
- Author(s)
  野本貴大、井上透矢、Yao Ying、金盛開人、鈴木実、武元宏泰、松井誠、友田敬士郎、西山伸宏
- Organizer
  第16回日本中性子捕捉療法学会、京都大学宇治キャンパス、京都
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] Polyzwitterion comprising 1,2-diaminoethane that recognizes tumorous pH for effective delivery of the coated nanoparticles2019
- Author(s)
  Hiroyasu Takemoto, Nobuhiro Nishiyama
- Organizer
  ICBZM2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04743
[Presentation] Metabolism-controlled boron delivery systems composed of biocompatible polymers and boronophenylalanine for neutron capture therapy2019
- Author(s)
  Takahiro Nomoto, Yukiya Inoue, Ying Yao, Minoru Suzuki, Kaito Kanamori, Hiroyasu Takemoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyama
- Organizer
  he ACS Spring 2019 National Meeting, Orange County Convention Center, FL, USA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] がん治療のための効率的な生体内の除鉄を実現する機能性高分子の開発2019
- Author(s)
  河本花奈、野本貴大、武元宏泰、松井誠、三浦裕、西山伸宏
- Organizer
  第41回日本バイオマテリアル学会大会、つくば国際会議場、つくば
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 温度応答性高分子-siRNA結合体とのポリイオンコンプレックス形成と外部刺激によるsiRNA の薬効制御2019
- Author(s)
  小野寺彩、武元宏泰、野本貴大、友田敬士郎、松井誠、西山伸宏
- Organizer
  第35回日本DDS学会学術集会、パシフィコ横浜、横浜
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] ボロン酸エステルを利用したホウ素薬物送達キャリアの開発2019
- Author(s)
  金盛開人、野本貴大、鈴木実、武元宏泰、松井誠、西山伸宏
- Organizer
  第35回日本DDS学会学術集会、パシフィコ横浜、横浜
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 腫瘍内低pH環境に応答して親水-疎水相転移挙動を示す高分子コンジュゲート型光増感剤2019
- Author(s)
  野本貴大、Sjaikhurrizal El Muttaqien、武元宏泰、松井誠、西山伸宏
- Organizer
  PhotoDynamic Medicine 2019 (PDM2019)、ホテルグランドヒル市ヶ谷、東京
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] がん細胞の高密度グルタミントランスポーターと選択的な相互作用を示す機能性高分子の開発2019
- Author(s)
  本田雄士、山田直生、武元宏泰、野本貴大、松井誠、友田敬士郎、西山伸宏
- Organizer
  第68回高分子討論会、福井大学文京キャンパス、福井
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 環状アセタール構造に基づくゲムシタビンの高分子修飾と制がん効果増大及び副作用低減2019
- Author(s)
  武元宏泰、稲葉高徳、野本貴大、松井誠、三浦裕、西山伸宏
- Organizer
  第41回日本バイオマテリアル学会大会、つくば国際会議場、つくば
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] Photosensitizer delivery to tumor cells and tumor-associated vasculature using functional polymers2019
- Author(s)
  Takahiro Nomoto, Xuebo Dou, Hiroyasu Takemoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyama
- Organizer
  7th International ALA and Prophyrin Symposium (IAPS7)、北海道大学、札幌
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] ポリイオンコンプレックスを利用した温度応答性高分子-siRNA結合体の細胞内導入と外部刺激によるsiRNAの生物活性制御2019
- Author(s)
  小野寺彩、武元宏泰、野本貴大、友田敬士郎、松井誠、西山伸宏
- Organizer
  第68回高分子学会年次大会、大阪府立国際会議場、大阪
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 薬物送達技術を応用した新規骨折治療法の開発2019
- Author(s)
  松井誠、海原悠可、武元宏泰、野本貴大、西山伸宏
- Organizer
  第35回日本DDS学会学術集会、パシフィコ横浜、横浜
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 温度応答性高分子-siRNA結合体の合成と外部刺激によるsiRNAの生物活性制御2019
- Author(s)
  小野寺彩、武元宏泰、野本貴大、松井誠、三浦裕、西山伸宏
- Organizer
  第68回高分子討論会、福井大学文京キャンパス、福井
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 腫瘍pH応答性高分子べタインの開発とナノ粒子のがん送達への展開2019
- Author(s)
  武元宏泰,Awaad Aziz,Ranneh Abdul-Hackam,野本貴大,松井誠,三浦裕,西山伸宏
- Organizer
  第35回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-17H04743
[Presentation] 腫瘍内pH応答性高分子ベタインの設計と被覆ナノ粒子への展開2019
- Author(s)
  武元宏泰,Awaad Aziz,Ranneh Abdul-Hackam,野本貴大,松井誠,三浦裕,西山伸宏
- Organizer
  第68回高分子学会討論会
- Invited
- Data Source
  KAKENHI-PROJECT-17H04743
[Presentation] 腫瘍内pH応答性高分子ベタインの設計と被覆ナノ粒子への展開2019
- Author(s)
  武元宏泰、アワードアジズ、ラネーアブドゥルハカム、野本貴大、松井誠、三浦裕、西山伸宏
- Organizer
  第68回高分子討論会、福井大学文京キャンパス、福井
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] がん治療を指向した生体内鉄イオンをキレートする機能性高分子の開発2019
- Author(s)
  河本花奈、野本貴大、武元宏泰、松井誠、西山伸宏
- Organizer
  第35回日本DDS学会学術集会、パシフィコ横浜、横浜
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] Enhanced tumor-targeted delivery of p-boronophenylalanine using fructose-functionalized polymers for boron neutron capture therapy2018
- Author(s)
  Ying Yao, Takahiro Nomoto, Yukiya Inoue, Minoru Suzuki, Makoto Matsui, Hiroyasu Takemoto, Keishiro Tomoda, Nobuhiro Nishiyama
- Organizer
  18th International Congress on Neutron Capture Therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] Development of gemcitabine-conjugated poly(amino acid) and its evaluation using pancreatic tumor model2018
- Author(s)
  劉暁夢, 武元宏泰, 野本貴大, 松井誠, 友田敬士郎, 西山伸宏
- Organizer
  第67回高分子討論会
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] Metabolism-controlled boron delivery systems composed of boronophenylalanine and functional polymers for neutron capture therapy2018
- Author(s)
  Takahiro Nomoto, Yukiya Inoue, Ying Yao, Minoru Suzuki, Kaito Kanamori, Hiroyasu Takemoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyama
- Organizer
  The 12th SPSJ International Polymer Conference (IPC2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] Bioresponsive Polyzwitterion that Recognizes Tumorous pH for a Construction of Tumor-Targeted Carriers2018
- Author(s)
  Hiroyasu Takemoto
- Organizer
  The 35th International Conference of Photopolymer Science and Technology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04743
[Presentation] Ethylenediamine-based polyzwitterion that becomes cationic at tumorous pH for effective tumor accumulation of the coated nanomaterials2018
- Author(s)
  Hiroyasu Takemoto, Abdul-Hackam Ranneh, Takahiro Nomoto, Makoto Matsui, Nobuhiro Nishiyama
- Organizer
  The 12th SPSJ International Polymer Conference (IPC2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04743
[Presentation] Metabolism-controlled boron delivery systems composed of p-boronophenylalanine and poly(vinyl alcohol)2018
- Author(s)
  Takahiro Nomoto, Yukiya Inoue, Ying Yao, Minoru Suzuki, Hiroyasu Takemoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyama
- Organizer
  18th International Congress on Neutron Capture Therapy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] Ethylenediamine-based betaine structure switches the neutral net charge of polyzwitterion into cationic at tumorous pH toward effective tumor accumulation of the coated nanomaterials2018
- Author(s)
  Hiroyasu Takemoto, Abduhl Hackam Ranneh, Takahiro Nomoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyama
- Organizer
  256th ACS National Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] Tumor cell-targeting glutamine-derived polymer that can interact with high density glutamine transporter based on aberrant glutamine metabolism2018
- Author(s)
  本田雄士, 山田直生, 武元宏泰, 野本貴大, 松井誠, 友田敬士郎, 西山伸宏
- Organizer
  The 12th SPSJ International Polymer Conference (IPC2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] Size-regulated siRNA carriers from small complex loading single siRNA molecule for systemic delivery to tumor tissue2018
- Author(s)
  Hiroyasu Takemoto, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka
- Organizer
  第77回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K19481
[Presentation] Tumor-targeted delivery of BPA using functional polymers for boron neutron capture therapy2018
- Author(s)
  Yao Ying, 野本貴大, 井上透矢, 鈴木実, 松井誠, 武元宏泰, 友田敬士郎, 西山伸宏
- Organizer
  第34回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 精密合成ポリビニルアルコールによるボロノフェニルアラニンの治療効果向上2018
- Author(s)
  野本貴大, 井上透矢, Yao Ying, 鈴木実, 金盛開人, 武元宏泰, 松井誠, 友田敬士郎, 西山伸宏
- Organizer
  第15回日本中性子捕捉療法学会学術大会
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] Ethylenediamine-based betaine structure switches the neutral net charge of polyzwitterion into cationic at tumorous pH toward effective tumor accumulation of the coated nanomaterials2018
- Author(s)
  Hiroyasu Takemoto, Abduhl Hackam Ranneh, Takahiro Nomoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyama
- Organizer
  256th ACS National Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04743
[Presentation] グルタミン代謝が亢進したがん細胞の高密度グルタミントランスポーターを認識してアフィニティを示す機能性高分子2018
- Author(s)
  本田雄士, 山田直生, 武元宏泰, 野本貴大, 松井誠, 友田敬士郎, 西山伸宏
- Organizer
  第67回高分子討論会
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] Novel design of pH-responsive polymer for targeting acidic microenvironment of tumor2018
- Author(s)
  Sjaikhurrizal El Muttaqien, Takahiro Nomoto, Hiroyasu Takemoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyama
- Organizer
  256th ACS National Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 腫瘍内環境を認識する高分子べタインの開発とナノ粒子の効率的な腫瘍集積への展開2018
- Author(s)
  武元宏泰, Ranneh Abdul-Hackam, 野本貴大, 松井誠, 友田敬士郎, 持田祐希, 内藤瑞, 西山伸宏
- Organizer
  第67回高分子年次大会
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] Ethylenediamine-based polyzwitterion that becomes cationic at tumorous pH for effective tumor accumulation of the coated nanomaterials2018
- Author(s)
  Hiroyasu Takemoto, Abdul-Hackam Ranneh, Takahiro Nomoto, Makoto Matsui, Nobuhiro Nishiyama
- Organizer
  The 12th SPSJ International Polymer Conference (IPC2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] IRDye 700DXの腫瘍内分布を制御する環状RGD担持高分子コンジュゲートによる光線力学効果の検討2018
- Author(s)
  野本貴大, Dou Xuebo, 武元宏泰, 松井誠, 友田敬士郎, 西山伸宏
- Organizer
  第34回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] Development of poly(amino acid)-based carrier that loads gemcitabine via reversible linkage and its evaluation using pancreatic cancer model2018
- Author(s)
  劉暁夢, 武元宏泰, 野本貴大, 松井誠, 友田敬士郎, 西山伸宏
- Organizer
  The 12th SPSJ International Polymer Conference (IPC2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04163
[Presentation] 腫瘍指向性ステルス高分子の開発とDDSへの応用-ベタイン構造内アニオン性基の影響-2017
- Author(s)
  左久間隼矢、Abdul-Hackam RANNEH, 武元宏泰、野本貴大、松井誠、友田敬士郎、西山伸宏
- Organizer
  第66回高分子討論会
- Data Source
  KAKENHI-PROJECT-17K19481
[Presentation] 2-Nitrobenzenesulfonamide group as a chemical linker with highly selective cleavability in response to intracellular redox system for a construction of siRNA-polymer conjugate2017
- Author(s)
  Hiroyasu Takemoto, Huang Chih-Hao, Takahiro Nomoto, Keishiro Tomoda, Makoto Matsui, Nobuhiro Nishiyama
- Organizer
  253rd American Chemical Society National Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04635
[Presentation] Novel design of glutamine-derived polymer with a high affinity to cancer cells based on aberrant glutamine metabolism2017
- Author(s)
  Yuto Honda, Naoki Yamada, Hiroyasu Takemoto, Takahiro Nomoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyama
- Organizer
  253rd American Chemical Society National Meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04635
[Presentation] Development of stealth shell based on polycarboxybetaine structure tuned to selectively interact with cells in tumor extracellular acidic pH2017
- Author(s)
  Abdul-Hackam Ranneh, Hiroyasu Takemoto, Takahiro Nomoto, Makoto Matsui, Keishiro Tomoda, Nobohiro Nishiyama
- Organizer
  日本薬学会第１３７年会
- Place of Presentation
  宮城県仙台市
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K16331
[Presentation] 腫瘍指向性ステルス高分子の開発とDDS への応用-ベタイン構造内アニオン性基の影響-2017
- Author(s)
  左久間隼矢、Abdul-Hackam RANNEH, 武元宏泰、野本貴大、松井誠、友田敬士郎、西山伸宏
- Organizer
  第66回高分子討論会
- Data Source
  KAKENHI-PROJECT-15H04635
[Presentation] ミトコンドリア呼吸鎖阻害剤を腫瘍組織に送達するための高分子ミセルの開発2017
- Author(s)
  劉暁夢、武元宏泰・野本貴大・松井誠・友田敬士郎・西山伸宏
- Organizer
  第66回高分子年次大会
- Data Source
  KAKENHI-PROJECT-15H04635
[Presentation] 2-Nitrobenzenesulfonamide group as a redox-sensitive linker for a construction of polymer-siRNA conjugate system2017
- Author(s)
  Hiroyasu Takemoto, Chih Hao Huang, Takahiro Nomoto, Keishiro Tomoda, Makoto Matsui, Nobuhiro Nishiyama
- Organizer
  第66回高分子年次大会
- Data Source
  KAKENHI-PROJECT-15H04635
[Presentation] 光増感剤結合型高分子における多岐環状ＲＧＤペプチドの腫瘍集積性と腫瘍内分布への効果の検討2017
- Author(s)
  Dou Xuebo、野本貴大、武元宏泰、松井誠、友田敬士郎、西山伸宏
- Organizer
  第66回高分子討論会
- Data Source
  KAKENHI-PROJECT-15H04635
[Presentation] 2-Nitrobenzenesulfonamide group that responds to intracellular redox potential with enhanced photostability for a construction of polymer-siRNA conjugate system2017
- Author(s)
  Hiroyasu Takemoto, Huang Chih-Hao, Takahiro Nomoto, Keishiro Tomoda, Makoto Matsui, Nobuhiro Nishiyama
- Organizer
  The 34th International Conference of Photopolymer Science and Technology (ICPST-34)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04635
[Presentation] Design of synthetic polymer toward achieving a selective high affinity to tumor cells by interacting with dense glutaminolysis-related transporters2017
- Author(s)
  Naoki Yamada, Yuto Honda, Hiroyasu Takemoto, Takahiro Nomoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyamam
- Organizer
  第66回高分子年次大会
- Data Source
  KAKENHI-PROJECT-15H04635
[Presentation] がん代謝に着想した表層にグルタミンを有する高分子ミセル型薬物送達システムの開発2017
- Author(s)
  真貝太規、山田直生, 武元宏泰, 野本貴大, 松井誠, 友田敬士郎, 西山伸宏
- Organizer
  第66回高分子討論会
- Data Source
  KAKENHI-PROJECT-15H04635
[Presentation] がん特異的代謝に着想した外殻にグルタミンを有する高分子ミセルの開発2017
- Author(s)
  真貝太規、山田直生、武元宏泰、野本貴大、松井誠、友田敬士郎、西山伸宏
- Organizer
  第66回高分子年次大会
- Data Source
  KAKENHI-PROJECT-15H04635
[Presentation] がん選択的に相互作用するグルタミン担持高分子の創製と機能評価,2017
- Author(s)
  山田直生, 本田雄士，武元宏泰，野本貴大，松井誠，友田敬士郎，西山伸宏
- Organizer
  第39回日本バイオマテリアル学会大会
- Data Source
  KAKENHI-PROJECT-15H04635
[Presentation] 腫瘍内pHに応答する双性イオン型ポリマーの設計とDDS応用-ベタイン内アニオン性基の影響-2017
- Author(s)
  左久間隼矢、Abdul-Hackam RANNEH, 武元宏泰、野本貴大、松井誠、友田敬士郎、西山伸宏
- Organizer
  第66回高分子年次大会
- Data Source
  KAKENHI-PROJECT-17K19481
[Presentation] 2-Nitrobenzenesulfonamide group that allows highly selective cleavage in intracellular redox system and the application for a construction of siRNA-polymer conjugate2017
- Author(s)
  Hiroyasu Takemoto, Takahiro Nomoto, Keishiro Tomoda, Makoto Matsui, Nobuhiro Nishiyama
- Organizer
  14th US-JAPAN Symposium on Drug Delivery Systems
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04635
[Presentation] ゲムシタビンのポリアミノ酸への可逆的担持に基づく消化器毒性低減及び制がん効果向上2017
- Author(s)
  武元宏泰, 稲葉高徳, 野本貴大, 松井誠, 友田敬士郎, 西山伸宏
- Organizer
  第33回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-15H04635
[Presentation] 腫瘍内pHに応答する双性イオン型ポリマーの設計とDDS応用-ベタイン内アニオン性基の影響-2017
- Author(s)
  左久間隼矢、Abdul-Hackam RANNEH, 武元宏泰、野本貴大、松井誠、友田敬士郎、西山伸宏
- Organizer
  第66回高分子年次大会
- Data Source
  KAKENHI-PROJECT-15H04635
[Presentation] 糖骨格を有する制がん剤のポリアミノ酸への可逆的担持と薬効向上及び消化器毒性低減2017
- Author(s)
  武元宏泰、稲葉高徳、野本貴大、松井誠、友田敬士郎、西山伸宏
- Organizer
  第66回高分子討論会
- Data Source
  KAKENHI-PROJECT-15H04635
[Presentation] 2-Nitrobenzenesulfonamide group as a chemical linker with highly selective cleavability in response to intracellular redox system for a construction of siRNA-polymer conjugate2017
- Author(s)
  Hiroyasu Takemoto, Huang Chih-Hao, Takahiro Nomoto, Keishiro Tomoda, Makoto Matsui, Nobuhiro Nishiyama
- Organizer
  253rd American Chemical Society National Meeting & Exposition
- Place of Presentation
  San Francisco, CA, USA
- Year and Date
  2017-04-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16331
[Presentation] Glutamine-functionalized polymer for tumor-selective high affinity by sensing dense glutamine transporters associated with aberrant metabolism2017
- Author(s)
  Naoki Yamada, Naoki Yamada, Yuto Honda, Hiroyasu Takemoto, Takahiro Nomoto, Makoto Matsui, Keishiro Tomoda, Nobuhiro Nishiyama
- Organizer
  14th US-JAPAN Symposium on Drug Delivery Systems
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04635
[Presentation] 2-nitrobenzensulfonamide groups as a chemical linker with enhanced extracellular stability and redox-sensitive cleavability for siRNA-conjugated polymer system2016
- Author(s)
  Patrick Huang, Hiroyasu Takemoto, Takahiro Nomoto, Nobuhiro Nishiyama
- Organizer
  The 11th SPSJ International Polymer Conference (IPC2016)
- Place of Presentation
  福岡県福岡市
- Year and Date
  2016-12-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16331
[Presentation] Development of thermoresponsive polymer-siRNA conjugates for controlled RNAi activity2016
- Author(s)
  Noor Faizah Binti Che Harun, Hiroyasu Takemoto, Takahiro Nomoto, Nobuhiro Nishiyama
- Organizer
  第６５回高分子学会年次大会
- Place of Presentation
  兵庫県神戸市
- Year and Date
  2016-05-25
- Data Source
  KAKENHI-PROJECT-15K16331
[Presentation] Development of siRNA-conjugated polymer with coil-globule transition behavior for an artificially controlled gene silencing activity2016
- Author(s)
  Noor Faizah Binti Che Harun, Hiroyasu Takemoto, Takahiro Nomoto, Nobuhiro Nishiyama
- Organizer
  第６５回高分子討論会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2016-09-14
- Data Source
  KAKENHI-PROJECT-15K16331
[Presentation] Artificial control of siRNA bioactivity based on the phase transition behavior of the conjugated polymeric molecule2016
- Author(s)
  Noor Faizah Binti Che Harun, Hiroyasu Takemoto, Takahiro Nomoto, Nobuhiro Nishiyama
- Organizer
  The 11th SPSJ International Polymer Conference (IPC2016)
- Place of Presentation
  福岡県福岡市
- Year and Date
  2016-12-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16331
[Presentation] Accelerated Polymer-siRNA Conjugation Based On Freezing-Thawing Treatment2015
- Author(s)
  Hiroyasu Takemoto, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka
- Organizer
  The 11th International Conference on Advanced Polymers via Macromolecular Engineering (APME 2015)
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16331
[Presentation] 酸性pH応答性高分子を表層に搭載した高分子ミセルの構築とsiRNAデリバリーへの応用2015
- Author(s)
  武元　宏泰、宮田　完二郎、タンサガサクスリ　モンティラ、内藤　瑞、前田　芳周、キム　ヒュンジン、西山　伸宏、片岡　一則
- Organizer
  第64回高分子学会年次大会
- Place of Presentation
  北海道札幌市
- Year and Date
  2015-05-27
- Data Source
  KAKENHI-PROJECT-15K16331
[Presentation] PIC型siRNAデリバリーに向けたポリカチオン側鎖構造の改変と細胞内動態制御への展開2015
- Author(s)
  武元　宏泰、Gao Hui、宮田　完二郎、西山　伸宏、片岡　一則
- Organizer
  第31回日本DDS学会学術集会
- Place of Presentation
  東京都新宿区
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-15K16331

1. NISHIYAMA Nobuhiro (10372385)

# of Collaborated Projects: 2 results

# of Collaborated Products: 71 results
2. 野本貴大 (00734732)

# of Collaborated Projects: 2 results

# of Collaborated Products: 77 results
3. AOKI Ichio (10319519)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. MIYATA Kanjiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. MIURA Yutaka

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
6. HIDESHI Ishii

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. MORI masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. ISHII Takehiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 片岡一則

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 内田智士

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 松井誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 今野雅允

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 浅井歩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takemoto Hiroyasu 武元 宏泰

Research Projects

Research Products

Co-Researchers

rational design of pH-responsive polyzwitterion for tumor-targeted drug vehiclePrincipal Investigator

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Functional polymer with regulated ionic behavior and the coated nanoparticles for penetration into tumorous deeper sitesPrincipal Investigator

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Development of smart polymeric micelles based on novel shell and core designs

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Facilitated intracellular delivery of oligonucleotide based on the controlled electrostatic behavior of the polymerPrincipal Investigator

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Functional polymer that recognizes tumorous pH for effective delivery of the coated nanoparticles to tumor tissuesPrincipal Investigator

Principal Investigator

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Development of shell molecule for facilitated celluar internalization of the nanoparticle for tumor cellsPrincipal Investigator

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Design of functional ligand molecules focused on specific metabolism of cancer cells and their applications for diagnosis and therapy

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[Journal Article] Fine tuning of the net charge alternation of polyzwitterion surfaced lipid nanoparticles to enhance cellular uptake and membrane fusion potential2024

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[Journal Article] pH-responsive polyzwitterion covered nanocarriers for DNA delivery2023

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[Journal Article] Fructose-functionalized polymers to enhance therapeutic potential of p-boronophenylalanine for neutron capture therapy2021

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[Journal Article] Systemically applicable glutamine-functionalized polymer exerting multivalent interaction with tumors overexpressing ASCT22021

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[Journal Article] Sequentially self-assembled nanoreactor comprising tannic acid and phenylboronic acid-conjugated polymers inducing tumor-selective enzymatic activity2021

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[Journal Article] Sequential Self-Assembly Using Tannic Acid and Phenylboronic Acid-Modified Copolymers for Potential Protein Delivery2020

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[Journal Article] Potential urinary monitoring of the enhanced permeability and retention effect using MMP-2-responsive poly(ethylene glycol) derivatives2020

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Takemoto Hiroyasu 武元宏泰