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Togashi Yu  富樫 優

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… Alternative Names

TOGASHI YU  富樫 優

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Researcher Number 10710444
Other IDs
Affiliation (Current) 2022: 横浜市立大学, 医学部, 講師
Affiliation (based on the past Project Information) *help 2021 – 2022: 横浜市立大学, 医学部, 講師
2019 – 2020: 横浜市立大学, 医学部, 助教
2017 – 2018: 横浜市立大学, 附属病院, 助教
2014 – 2016: 横浜市立大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Metabolomics / Basic Section 54040:Metabolism and endocrinology-related
Except Principal Investigator
Metabolomics / Basic Section 54040:Metabolism and endocrinology-related
Keywords
Principal Investigator
膵β細胞 / 糖尿病 / 2型糖尿病 / インスリン抵抗性 / 再生 / 脂肪 / 脂肪肝 / 肝臓 / サルコペニア / 骨格筋 / プロテオミクス … More
Except Principal Investigator
… More 膵島 / グルコキナーゼ / 膵β細胞 / S100A8 / 糖尿病 / 糖 / ミトコンドリア / 膵島炎症 / インスリン / 糖脂肪毒性 / UCP2 Less
  • Research Projects

    (6 results)
  • Research Products

    (26 results)
  • Co-Researchers

    (12 People)
  •  リン酸化プロテオミクスによる膵切除後膵β細胞増殖機構の解明Principal Investigator

    • Principal Investigator
      富樫 優
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Yokohama City University
  •  Elucidation of pathogenesis and treatment of islet mitochondrial dysfunction and inflammation under glucolipotoxicity

    • Principal Investigator
      寺内 康夫
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Yokohama City University
  •  A novel sarcopenia model by insulin / IGF-1 receptor inhibitionPrincipal Investigator

    • Principal Investigator
      TOGASHI Yu
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Yokohama City University
  •  Fate determination of pancreatic beta cells by glucokinase activation

    • Principal Investigator
      Terauchi Yasuo
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Metabolomics
    • Research Institution
      Yokohama City University
  •  The mechanism of recovery after inhibition of insulin receptor and IGF-1 receptor in pancreatic beta cells, liver, adipose tissue.Principal Investigator

    • Principal Investigator
      TOGASHI Yu
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Metabolomics
    • Research Institution
      Yokohama City University
  •  The mechanism of pancreatic beta cell proliferation after a pancreatectomyPrincipal Investigator

    • Principal Investigator
      TOGASHI YU
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Metabolomics
    • Research Institution
      Yokohama City University

All 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

  • [Journal Article] ignaling between pancreatic β-cells and macrophages via S100 calcium-binding protein A8 exacerbates β-cell apoptosis and islet inflammation.2018

    • Author(s)
      Inoue H, Shirakawa J, Togashi Y, Tajima K, Okuyama T, Kyohara M, Tanaka Y, Saisho Y, Yamada T, Shibue K, Kulkarni RN, Terauchi Y
    • Journal Title

      Journal of Biological Chemistry

      Volume: 293 Pages: 5934-5946

    • DOI

      10.1074/jbc.m117.809228

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H04714, KAKENHI-PROJECT-16H05329, KAKENHI-PROJECT-18K16240, KAKENHI-PROJECT-17K16152
  • [Journal Article] Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets2017

    • Author(s)
      Okuyama T, Shirakawa J, Yanagisawa H, Kyohara M, Yamasaki S, Tajima K, Togashi Y, Terauchi Y.
    • Journal Title

      Scientific Reports

      Volume: 7(1) Pages: 2345-2345

    • DOI

      10.1038/s41598-017-02535-0

    • NAID

      120007134459

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05329, KAKENHI-PROJECT-17H06992
  • [Journal Article] Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets.2017

    • Author(s)
      Okuyama T, Shirakawa J, Yanagisawa H, Kyohara M, Yamasaki S, Tajima K, Togashi Y, Terauchi Y.
    • Journal Title

      Scientific Reports

      Volume: 印刷中

    • NAID

      120007134459

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05329
  • [Journal Article] Rapid recovery of adipose tissue atrophy, liver steatosis, and pancreatic β cells proliferation after dual inhibition of insulin and IGF-1 receptors.2017

    • Author(s)
      Tajima K, Shirakawa J, Togashi Y, Yamazaki S, Okuyama T, Kyohara M, Konishi H, Terauchi Y.
    • Journal Title

      Scientific Reports

      Volume: 7 Pages: 4119-4119

    • DOI

      10.1038/s41598-017-04304-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16152, KAKENHI-PROJECT-16H05329, KAKENHI-PROJECT-16K19542
  • [Journal Article] Serum quantitative proteomic analysis reveals soluble EGFR to be a marker of insulin resistance in male mice and humans2017

    • Author(s)
      Kyohara M, Shirakawa J, Okuyama T, Kimura A, Togashi Y, Tajima K, Hirano H, Terauchi Y.
    • Journal Title

      Endocrinology

      Volume: 158(12) Pages: 4152-4164

    • DOI

      10.1210/en.2017-00339

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05329, KAKENHI-PROJECT-15K19028
  • [Journal Article] Rapid recovery of adipose tissue atrophy, liver steatosis, and pancreatic β cells proliferation after dual inhibition of insulin and IGF-1 receptors.2017

    • Author(s)
      Tajima K, Shirakawa J, Togashi Y, Yamasaki S, Okuyama T, Kyohara M, Konishi H, Terauchi Y.
    • Journal Title

      Scientific Reports

      Volume: 印刷中

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05329
  • [Journal Article] Evaluation of blood glucose meters for measuring mouse blood glucose levels.2016

    • Author(s)
      Togashi Y, Shirakawa J, Okuyama T, Kyohara M, Yamazaki S, Miyazawa A, Suzuki T, Hamada M, Terauchi Y.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 25465-25465

    • DOI

      10.1038/srep25465

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05329
  • [Journal Article] Metoformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 mice.2014

    • Author(s)
      Tajima K, Nakamurar A, Shirakawa J, Togashi Y, Orime K, Sato K, Inoue H, Kaji M, Sakamoto E, Ito Y, Aoki K, Nagashima Y, Atsumi T, Terauchi Y.
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 305

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26860698
  • [Journal Article] Using miglitol at 30 min before meal is effective in hyperinsulinemic hypoglycemia after a total gastrectomy2014

    • Author(s)
      Shirakawa J, Murohashi Y, Okazaki N, Yamazaki S, Tamura T, Okuyama T, Togashi Y, Terauchi Y.
    • Journal Title

      Endocrine Journal

      Volume: 61 Issue: 11 Pages: 1115-1123

    • DOI

      10.1507/endocrj.ej14-0290

      10.1507/endocrj.EJ14-0290

    • NAID

      130004677955

    • ISSN
      0918-8959, 1348-4540
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25860754, KAKENHI-PROJECT-26860698
  • [Journal Article] β-Cell proliferation after a partial pancreatectomy is independent of IRS-2 in mice.2014

    • Author(s)
      Togashi Y, Shirakawa J, Orime K, Kaji M, Sakamoto E, Tajima K, Inoue H, Nakamura A, Tochino Y, Goshima Y, Shimomura I, Terauchi Y.
    • Journal Title

      Endocrinology

      Volume: 155 Pages: 1643-52

    • DOI

      10.1210/en.2013-1796

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-23591316, KAKENHI-PROJECT-25670435, KAKENHI-PROJECT-25860754, KAKENHI-PROJECT-26860698
  • [Presentation] 膵β細胞におけるUCP2発現上昇の意義の検討2018

    • Author(s)
      井上 亮太、白川 純、富樫 優、寺内 康夫.
    • Organizer
      第61回日本糖尿病学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-16H05329
  • [Presentation] Functional role and mechanism of UCP2 upregulation in pancreatic β cells2018

    • Author(s)
      Ryota Inoue, Jun Shirakawa, Yu Togashi, Yasuo Terauchi
    • Organizer
      78th American Diabetes Association (ADA) meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05329
  • [Presentation] グルコースおよびインスリンシグナルの変動に伴う膵島UCP2発現の検討.2018

    • Author(s)
      井上 亮太、白川 純、富樫 優、寺内 康夫.
    • Organizer
      第32回日本糖尿病・肥満動物学会年次学術集会
    • Data Source
      KAKENHI-PROJECT-16H05329
  • [Presentation] 膵β細胞増殖モデルマウスを用いた糖尿病研究2017

    • Author(s)
      富樫優、白川純、田島一樹、寺内康夫
    • Organizer
      第31回日本糖尿病・肥満動物学会年次学術集会
    • Place of Presentation
      はまぎんホール(神奈川県横浜市)
    • Year and Date
      2017-02-10
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05329
  • [Presentation] メトホルミンは、インスリン抵抗性とは独立して、膵β細胞に保護的に作用する2017

    • Author(s)
      田島一樹、白川純、富樫優、寺内康夫
    • Organizer
      第31回日本糖尿病・肥満動物学会年次学術集会
    • Place of Presentation
      はまぎんホール(神奈川県横浜市)
    • Year and Date
      2017-02-10
    • Data Source
      KAKENHI-PROJECT-16H05329
  • [Presentation] OSI-906投与マウスモデルにおけるDPP-4阻害薬およびSGLT-2阻害薬の膵β細胞、肝臓、脂肪組織へ効果2017

    • Author(s)
      市川大河、山崎伸悟、白川純、田島一樹、奥山朋子、山崎俊介、富樫優、寺内康夫
    • Organizer
      第31回日本糖尿病・肥満動物学会年次学術集会
    • Place of Presentation
      はまぎんホール(神奈川県横浜市)
    • Year and Date
      2017-02-10
    • Data Source
      KAKENHI-PROJECT-16H05329
  • [Presentation] ムスカリニックアゴニストによる膵β細胞増殖機構の解析2017

    • Author(s)
      伊藤譲、田島一樹、富樫優、寺内康夫
    • Organizer
      第31回日本糖尿病・肥満動物学会年次学術集会
    • Place of Presentation
      はまぎんホール(神奈川県横浜市)
    • Year and Date
      2017-02-10
    • Data Source
      KAKENHI-PROJECT-16H05329
  • [Presentation] S100A8を介した膵島とマクロファージの相互作用による膵島炎症惹起機構の解明2016

    • Author(s)
      井上英昭、白川純、折目和基、田島一樹、富樫優、京原麻由、奥山朋子、吉田瑛子、山崎俊介、小西裕美、寺内康夫
    • Organizer
      第59回日本糖尿病学会年次学術総会
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-16H05329
  • [Presentation] 膵部分切除マウスによる新規膵β細胞増殖シグナルの探索2016

    • Author(s)
      富樫 優、白川 純、田島 一樹、折目和基、寺内 康夫
    • Organizer
      第30回日本糖尿病・肥満動物学会.
    • Place of Presentation
      大宮ソニックシティホール(埼玉県さいたま市)
    • Year and Date
      2016-03-11
    • Data Source
      KAKENHI-PROJECT-26860698
  • [Presentation] 簡易血糖測定器を用いたマウスの血糖測定の評価2016

    • Author(s)
      富樫 優、白川 純、鈴木 崇文、宮沢 あゆみ、浜田 麻里、寺内 康夫
    • Organizer
      第59回日本糖尿病学会年次学術総会
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2016-05-19
    • Data Source
      KAKENHI-PROJECT-16H05329
  • [Presentation] A mouse model of acute reversible lipodystrophy with dual inhibition of insulin and IGF-1 receptors.2016

    • Author(s)
      Kazuki Tajima, Jun Shirakawa, Yu Togashi, Yasuo Terauchi
    • Organizer
      American Diabetes Association (ADA) 76th Scientific sessions.
    • Place of Presentation
      NewOrleans,USA
    • Year and Date
      2016-06-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K19542
  • [Presentation] A Mouse of Model of Acute Reversible Lipodystrophy with Dual Inhibition of Insulin and IGF-1 Receptors.2016

    • Author(s)
      Tajima K, Shirakawa J, Togashi Y, Terauchi Y.
    • Organizer
      76th American Diabetes Association (ADA) meeting
    • Place of Presentation
      New Orleans,USA
    • Year and Date
      2016-06-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05329
  • [Presentation] メトホルミンによる膵β細胞保護作用の検討2016

    • Author(s)
      田島一樹、白川 純、富樫 優、折目和基、寺内康夫
    • Organizer
      日本臨床分子医学会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2016-04-15
    • Data Source
      KAKENHI-PROJECT-16H05329
  • [Presentation] 膵部分切除マウスによる膵β細胞増殖シグナルの探索2015

    • Author(s)
      富樫 優、白川 純、奥山 朋子、吉田 瑛子、京原 麻由、山崎 俊介、井上 英昭、折目 和基、伊藤 譲、寺内 康夫
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      海峡メッセ下関(山口県下関市)
    • Year and Date
      2015-05-21
    • Data Source
      KAKENHI-PROJECT-26860698
  • [Presentation] 膵部分切除マウスによる新規膵β細胞増殖シグナルの探索

    • Author(s)
      富樫 優、白川 純、田島 一樹、山崎 俊介、小西 裕美、寺内 康夫
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      海峡メッセ下関(山口県下関市)
    • Year and Date
      2015-05-21 – 2015-05-23
    • Data Source
      KAKENHI-PROJECT-26860698
  • [Presentation] 膵部分切除マウスにおける膵β細胞増殖機構の解明

    • Author(s)
      富樫 優、白川 純、折目和基、田島一樹、井上英昭、坂本絵里、梶美津代、寺内康夫
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2014-05-22 – 2014-05-24
    • Data Source
      KAKENHI-PROJECT-26860698
  • 1.  Terauchi Yasuo (40359609)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 28 results
  • 2.  白川 純 (70625532)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 28 results
  • 3.  Tajima Kazuki (00725236)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 20 results
  • 4.  奥山 朋子 (90806928)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 5.  ORIME Kazuki
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 5 results
  • 6.  伊藤 譲 (00512980)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  京原 麻由 (20828545)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  YAMADA koji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  NAKAMURA Akinobu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  山田 健人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  木村 鮎子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  伊藤 讓
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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