Togashi Yu 富樫優

… Alternative Names

TOGASHI YU 富樫優

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Researcher Number	10710444
Other IDs
Affiliation (Current)	2025: 横浜市立大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2021 – 2024: 横浜市立大学, 医学部, 講師 2019 – 2020: 横浜市立大学, 医学部, 助教 2017 – 2018: 横浜市立大学, 附属病院, 助教 2014 – 2016: 横浜市立大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Metabolomics Except Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Metabolomics
Keywords	Principal Investigator 膵β細胞 / インスリン抵抗性 / 2型糖尿病 / 糖尿病 / プロテオミクス / 骨格筋 / サルコペニア / 肝臓 / 脂肪肝 / 脂肪 / 再生 … More Except Principal Investigator … More 糖尿病 / 膵β細胞 / 膵島 / AldB / UCP2 / インスリン / ミトコンドリア / S100A8 / グルコキナーゼ / アルドラーゼB / 糖脂肪毒性 / 膵島炎症 / TLR4 / Aldolase B / 糖 Less

機能的な膵β細胞量を増加させる「膵β細胞のhealthy expansion」の分子機構の解明
- Principal Investigator
  
  寺内康夫
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Yokohama City University
リン酸化プロテオミクスによる膵切除後膵β細胞増殖機構の解明Principal Investigator
- Principal Investigator
  
  富樫優
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Yokohama City University
Elucidation of pathogenesis and treatment of islet mitochondrial dysfunction and inflammation under glucolipotoxicity
- Principal Investigator
  
  TERAUCHI Yasuo
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Yokohama City University
A novel sarcopenia model by insulin / IGF-1 receptor inhibitionPrincipal Investigator
- Principal Investigator
  
  TOGASHI Yu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Yokohama City University
Fate determination of pancreatic beta cells by glucokinase activation
- Principal Investigator
  
  Terauchi Yasuo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Yokohama City University
The mechanism of recovery after inhibition of insulin receptor and IGF-1 receptor in pancreatic beta cells, liver, adipose tissue.Principal Investigator
- Principal Investigator
  
  TOGASHI Yu
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Yokohama City University
The mechanism of pancreatic beta cell proliferation after a pancreatectomyPrincipal Investigator
- Principal Investigator
  
  TOGASHI YU
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Yokohama City University

All 2023 2022 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Protective Effects of Imeglimin and Metformin Combination Therapy on β-Cells in db/db Male Mice2023
- Author(s)
  Nishiyama Kuniyuki、Ono Masato、Tsuno Takahiro、Inoue Ryota、Fukunaka Ayako、Okuyama Tomoko、Kyohara Mayu、Togashi Yu、Fukushima Setsuko、Atsumi Takuto、Sato Aoi、Tsurumoto Asuka、Sakai Chisato、Fujitani Yoshio、Terauchi Yasuo、Ito Shuichi、Shirakawa Jun
- Journal Title
  
  Endocrinology
  
  Volume: 164 Issue: 8
- DOI
  10.1210/endocr/bqad095
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-22H04801, KAKENHI-PROJECT-23K27652, KAKENHI-PROJECT-23K28014
[Journal Article] E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance.2022
- Author(s)
  Shirakawa J, Togashi Y, Basile G, Okuyama T, Inoue R, Fernandez M, Kyohara M, De Jesus DF, Goto N, Zhang W, Tsuno T, Kin T, Pan H, Dreyfuss JM, Shapiro AMJ, Yi P, Terauchi Y, Kulkarni RN.
- Journal Title
  
  Cell Rep.
  
  Volume: 41(1) Issue: 1 Pages: 111436-111436
- DOI
  10.1016/j.celrep.2022.111436
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03733, KAKENHI-PROJECT-20K08866
[Journal Article] Protective effects of S100A8 on sepsis mortality: Links to sepsis risk in obesity and diabetes.2022
- Author(s)
  Miyashita D, Inoue R, Tsuno T, Okuyama T, Kyohara M, Nakahashi-Oda C, Nishiyama K, Fukushima S, Inada Y, Togashi Y, Shibuya A, Terauchi Y, Shirakawa J.
- Journal Title
  
  iScience
  
  Volume: 25(12) Issue: 12 Pages: 105662-105662
- DOI
  10.1016/j.isci.2022.105662
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03733, KAKENHI-PROJECT-20K08866
[Journal Article] Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER2022
- Author(s)
  Inoue Ryota、Tsuno Takahiro、Togashi Yu、Okuyama Tomoko、Sato Aoi、Nishiyama Kuniyuki、Kyohara Mayu、Li Jinghe、Fukushima Setsuko、Kin Tatsuya、Miyashita Daisuke、Shiba Yusuke、Atobe Yoshitoshi、Kiyonari Hiroshi、Bando Kana、Shapiro A.M. James、Funakoshi Kengo、Kulkarni Rohit N.、Terauchi Yasuo、Shirakawa Jun
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 7 Pages: 104603-104603
- DOI
  10.1016/j.isci.2022.104603
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K21247, KAKENHI-PROJECT-20H03733, KAKENHI-PROJECT-20K08866
[Journal Article] Signaling between pancreatic beta-cells and macrophages via S100 calcium-binding protein A8 exacerbates beta-cell apoptosis and islet inflammation.2018
- Author(s)
  Inoue H, Shirakawa J, Togashi Y, Tajima K, Okuyama T, Kyohara M, Tanaka Y, Saisho Y, Yamada T, Shibue K, Kulkarni RN, Terauchi Y
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 293 Issue: 16 Pages: 5934-5946
- DOI
  10.1074/jbc.m117.809228
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04714, KAKENHI-PROJECT-16H05329, KAKENHI-PROJECT-18K16240, KAKENHI-PROJECT-17K16152
[Journal Article] Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets.2017
- Author(s)
  Okuyama T, Shirakawa J, Yanagisawa H, Kyohara M, Yamasaki S, Tajima K, Togashi Y, Terauchi Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 7(1) Issue: 1 Pages: 2345-2345
- DOI
  10.1038/s41598-017-02535-0
- NAID
  120007134459
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05329, KAKENHI-PROJECT-17H06992
[Journal Article] Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets.2017
- Author(s)
  Okuyama T, Shirakawa J, Yanagisawa H, Kyohara M, Yamasaki S, Tajima K, Togashi Y, Terauchi Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中
- NAID
  120007134459
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05329
[Journal Article] Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-9062017
- Author(s)
  Tajima K, Shirakawa J, Togashi Y, Yamazaki S, Okuyama T, Kyohara M, Konishi H, Terauchi Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 4119-4119
- DOI
  10.1038/s41598-017-04304-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16152, KAKENHI-PROJECT-16H05329, KAKENHI-PROJECT-16K19542
[Journal Article] Serum quantitative proteomic analysis reveals soluble EGFR to be a marker of insulin resistance in male mice and humans.2017
- Author(s)
  Kyohara M, Shirakawa J, Okuyama T, Kimura A, Togashi Y, Tajima K, Hirano H, Terauchi Y.
- Journal Title
  
  Endocrinology
  
  Volume: 158(12) Issue: 12 Pages: 4152-4164
- DOI
  10.1210/en.2017-00339
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05329, KAKENHI-PROJECT-15K19028
[Journal Article] Rapid recovery of adipose tissue atrophy, liver steatosis, and pancreatic β cells proliferation after dual inhibition of insulin and IGF-1 receptors.2017
- Author(s)
  Tajima K, Shirakawa J, Togashi Y, Yamasaki S, Okuyama T, Kyohara M, Konishi H, Terauchi Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05329
[Journal Article] Evaluation of blood glucose meters for measuring mouse blood glucose levels.2016
- Author(s)
  Togashi Y, Shirakawa J, Okuyama T, Kyohara M, Yamazaki S, Miyazawa A, Suzuki T, Hamada M, Terauchi Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 25465-25465
- DOI
  10.1038/srep25465
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05329
[Journal Article] Using miglitol at 30 min before meal is effective in hyperinsulinemic hypoglycemia after a total gastrectomy2014
- Author(s)
  Shirakawa J, Murohashi Y, Okazaki N, Yamazaki S, Tamura T, Okuyama T, Togashi Y, Terauchi Y.
- Journal Title
  
  Endocr J
  
  Volume: 61 Issue: 11 Pages: 1115-1123
- DOI
  10.1507/endocrj.EJ14-0290
- NAID
  130004677955
- ISSN
  0918-8959, 1348-4540
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860754, KAKENHI-PROJECT-26860698
[Journal Article] Metoformin prevents liver tumorigenesis induced by high-fat diet in C57Bl/6 mice.2014
- Author(s)
  Tajima K, Nakamurar A, Shirakawa J, Togashi Y, Orime K, Sato K, Inoue H, Kaji M, Sakamoto E, Ito Y, Aoki K, Nagashima Y, Atsumi T, Terauchi Y.
- Journal Title
  
  Am J Physiol Endocrinol Metab
  
  Volume: 305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860698
[Journal Article] β cell proliferation after a partial pancreatectomy is independent of IRS-2 in mice.2014
- Author(s)
  Togashi Y, Shirakawa J, Orime K, Kaji M, Sakamoto E, Tajima K, Inoue H, Nakamura A, Tochino Y, Goshima Y, Shimomura I, Terauchi Y.
- Journal Title
  
  Endocrinology
  
  Volume: 155 Issue: 5 Pages: 1643-52
- DOI
  10.1210/en.2013-1796
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591316, KAKENHI-PROJECT-25670435, KAKENHI-PROJECT-25860754, KAKENHI-PROJECT-26860698
[Presentation] 膵β細胞におけるUCP2発現上昇の意義の検討2018
- Author(s)
  井上亮太、白川　純、富樫　優、寺内　康夫．
- Organizer
  第61回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] Functional role and mechanism of UCP2 upregulation in pancreatic β cells2018
- Author(s)
  Ryota Inoue, Jun Shirakawa, Yu Togashi, Yasuo Terauchi
- Organizer
  78th American Diabetes Association (ADA) meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] グルコースおよびインスリンシグナルの変動に伴う膵島UCP2発現の検討．2018
- Author(s)
  井上亮太、白川　純、富樫　優、寺内　康夫．
- Organizer
  第32回日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] 膵β細胞増殖モデルマウスを用いた糖尿病研究2017
- Author(s)
  富樫優、白川純、田島一樹、寺内康夫
- Organizer
  第31回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  はまぎんホール（神奈川県横浜市）
- Year and Date
  2017-02-10
- Invited
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] メトホルミンは、インスリン抵抗性とは独立して、膵β細胞に保護的に作用する2017
- Author(s)
  田島一樹、白川純、富樫優、寺内康夫
- Organizer
  第31回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  はまぎんホール（神奈川県横浜市）
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] OSI-906投与マウスモデルにおけるDPP-4阻害薬およびSGLT-2阻害薬の膵β細胞、肝臓、脂肪組織へ効果2017
- Author(s)
  市川大河、山崎伸悟、白川純、田島一樹、奥山朋子、山崎俊介、富樫優、寺内康夫
- Organizer
  第31回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  はまぎんホール（神奈川県横浜市）
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] ムスカリニックアゴニストによる膵β細胞増殖機構の解析2017
- Author(s)
  伊藤譲、田島一樹、富樫優、寺内康夫
- Organizer
  第31回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  はまぎんホール（神奈川県横浜市）
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] S100A8を介した膵島とマクロファージの相互作用による膵島炎症惹起機構の解明2016
- Author(s)
  井上英昭、白川純、折目和基、田島一樹、富樫優、京原麻由、奥山朋子、吉田瑛子、山崎俊介、小西裕美、寺内康夫
- Organizer
  第59回日本糖尿病学会年次学術総会
- Place of Presentation
  京都国際会館（京都府）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] 膵部分切除マウスによる新規膵β細胞増殖シグナルの探索2016
- Author(s)
  富樫　優、白川　純、田島　一樹、折目和基、寺内　康夫
- Organizer
  第30回日本糖尿病・肥満動物学会.
- Place of Presentation
  大宮ソニックシティホール（埼玉県さいたま市）
- Year and Date
  2016-03-11
- Data Source
  KAKENHI-PROJECT-26860698
[Presentation] 簡易血糖測定器を用いたマウスの血糖測定の評価2016
- Author(s)
  富樫　優、白川　純、鈴木　崇文、宮沢　あゆみ、浜田　麻里、寺内　康夫
- Organizer
  第59回日本糖尿病学会年次学術総会
- Place of Presentation
  京都国際会館（京都府）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] A mouse model of acute reversible lipodystrophy with dual inhibition of insulin and IGF-1 receptors.2016
- Author(s)
  Kazuki Tajima, Jun Shirakawa, Yu Togashi, Yasuo Terauchi
- Organizer
  American Diabetes Association (ADA) 76th Scientific sessions.
- Place of Presentation
  NewOrleans,USA
- Year and Date
  2016-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19542
[Presentation] A Mouse of Model of Acute Reversible Lipodystrophy with Dual Inhibition of Insulin and IGF-1 Receptors.2016
- Author(s)
  Tajima K, Shirakawa J, Togashi Y, Terauchi Y.
- Organizer
  76th American Diabetes Association (ADA) meeting
- Place of Presentation
  New Orleans，USA
- Year and Date
  2016-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] メトホルミンによる膵β細胞保護作用の検討2016
- Author(s)
  田島一樹、白川　純、富樫　優、折目和基、寺内康夫
- Organizer
  日本臨床分子医学会
- Place of Presentation
  東京国際フォーラム（東京都）
- Year and Date
  2016-04-15
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] 膵部分切除マウスによる膵β細胞増殖シグナルの探索2015
- Author(s)
  富樫　優、白川　純、奥山　朋子、吉田　瑛子、京原　麻由、山崎　俊介、井上　英昭、折目　和基、伊藤　譲、寺内　康夫
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  海峡メッセ下関（山口県下関市）
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26860698
[Presentation] 膵部分切除マウスによる新規膵β細胞増殖シグナルの探索
- Author(s)
  富樫　優、白川　純、田島　一樹、山崎　俊介、小西　裕美、寺内　康夫
- Organizer
  第58回日本糖尿病学会年次学術集会
- Place of Presentation
  海峡メッセ下関（山口県下関市）
- Year and Date
  2015-05-21 – 2015-05-23
- Data Source
  KAKENHI-PROJECT-26860698
[Presentation] 膵部分切除マウスにおける膵β細胞増殖機構の解明
- Author(s)
  富樫　優、白川　純、折目和基、田島一樹、井上英昭、坂本絵里、梶美津代、寺内康夫
- Organizer
  第57回日本糖尿病学会年次学術集会
- Place of Presentation
  大阪国際会議場（大阪府大阪市）
- Year and Date
  2014-05-22 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-26860698

1. Terauchi Yasuo (40359609)

# of Collaborated Projects: 7 results

# of Collaborated Products: 25 results
2. 白川純 (70625532)

# of Collaborated Projects: 6 results

# of Collaborated Products: 23 results
3. Tajima Kazuki (00725236)

# of Collaborated Projects: 4 results

# of Collaborated Products: 17 results
4. 奥山朋子 (90806928)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. 京原麻由 (20828545)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. ORIME Kazuki

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
7. 伊藤譲 (00512980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. FUKUNAKA Ayako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. YAMADA koji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. NAKAMURA Akinobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 山田健人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 伊藤讓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Togashi Yu 富樫 優

TOGASHI YU 富樫 優

Research Projects

Research Products

Co-Researchers

機能的な膵β細胞量を増加させる「膵β細胞のhealthy expansion」の分子機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

リン酸化プロテオミクスによる膵切除後膵β細胞増殖機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of pathogenesis and treatment of islet mitochondrial dysfunction and inflammation under glucolipotoxicity

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel sarcopenia model by insulin / IGF-1 receptor inhibitionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Fate determination of pancreatic beta cells by glucokinase activation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism of recovery after inhibition of insulin receptor and IGF-1 receptor in pancreatic beta cells, liver, adipose tissue.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism of pancreatic beta cell proliferation after a pancreatectomyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Protective Effects of Imeglimin and Metformin Combination Therapy on β-Cells in db/db Male Mice2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] E2F1 transcription factor mediates a link between fat and islets to promote β cell proliferation in response to acute insulin resistance.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protective effects of S100A8 on sepsis mortality: Links to sepsis risk in obesity and diabetes.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Uncoupling protein 2 and aldolase B impact insulin release by modulating mitochondrial function and Ca2+ release from the ER2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Signaling between pancreatic beta-cells and macrophages via S100 calcium-binding protein A8 exacerbates beta-cell apoptosis and islet inflammation.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets.2017

Author(s)

Togashi Yu 富樫優

TOGASHI YU 富樫優