Mukai Yuji 向祐志

Researcher Number	10711830
Other IDs	https://orcid.org/0000-0001-5662-0418
Affiliation (based on the past Project Information) *help	2020 – 2023: 筑波大学, 附属病院, 病院講師 2018 – 2019: 北海道科学大学, 薬学部, 講師
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related
Keywords	Principal Investigator LC-MS/MS / TDM / dried blood spot / チロシンキナーゼ阻害薬 / BCR-ABL / Dried blood spots / chronic myeloid leukemia / BCR::ABL1 / VAMS / micro sampling … More / Dried plasma spot / Dried blood spot / キナーゼ阻害薬 / 分子標的薬 / dried plasma spot Less

Research Projects
(2 results)
Research Products
(23 results)

慢性骨髄性白血病患者を対象とした経口分子標的薬の来院不要な治療評価体制の構築Principal Investigator
- Principal Investigator
  
  向祐志
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Tsukuba
Development of simultaneous determination method of kinase inhibitors by means of dried blood spot sampling at homePrincipal Investigator
- Principal Investigator
  
  Mukai Yuji
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  University of Tsukuba
  Hokkaido University of Science

All 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Utilizing the dry spot method to monitor the concentrations of biologic agents in breast milk2023
- Author(s)
  Mukai Yuji、Doki Kosuke、Suzuki Yoshiharu、Homma Masato
- Journal Title
  
  British Journal of Clinical Pharmacology
  
  Volume: 90 Issue: 1 Pages: 368-369
- DOI
  10.1111/bcp.15929
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15313
[Journal Article] An Liquid Chromatography-Tandem Mass Spectrometry Method for the Simultaneous Determination of Afatinib, Alectinib, Ceritinib, Crizotinib, Dacomitinib, Erlotinib, Gefitinib, and Osimertinib in Human Serum2021
- Author(s)
  Mukai Yuji、Wakamoto Azusa、Hatsuyama Tae、Yoshida Tatsunari、Sato Hideki、Fujita Akihisa、Inotsume Nobuo、Toda Takaki
- Journal Title
  
  Therapeutic Drug Monitoring
  
  Volume: 43 Issue: 6 Pages: 772-779
- DOI
  10.1097/ftd.0000000000000895
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14988
[Journal Article] Effects of angiotensin II receptor blockers on serum levels of epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids in patients admitted to a cardiovascular center2021
- Author(s)
  Kato Yuka、Senda Asuna、Mukai Yuji、Yamashita Miki、Sasaoka Yuki、Hanada Minayo、Hongo Fuminori、Hirokami Mitsugu、Rane Anders、Inotsume Nobuo、Toda Takaki
- Journal Title
  
  European Journal of Clinical Pharmacology
  
  Volume: 77 Issue: 6 Pages: 887-894
- DOI
  10.1007/s00228-020-03061-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14988
[Journal Article] Simultaneous Quantification of BCR-ABL and Bruton's Tyrosine Kinase Inhibitors in Dried Plasma Spots and Its Application to Clinical Sample Analysis2021
- Author(s)
  Mukai Yuji、Yoshida Yuka、Yoshida Tatsunari、Kondo Takeshi、Inotsume Nobuo、Toda Takaki
- Journal Title
  
  Therapeutic Drug Monitoring
  
  Volume: 43 Issue: 3 Pages: 386-393
- DOI
  10.1097/ftd.0000000000000825
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14988
[Journal Article] Novel high-performance liquid chromatography-tandem mass spectrometry method for simultaneous quantification of BCR-ABL and Bruton’s tyrosine kinase inhibitors and their three active metabolites in human plasma2020
- Author(s)
  Mukai Yuji、Yoshida Tatsunari、Kondo Takeshi、Inotsume Nobuo、Toda Takaki
- Journal Title
  
  Journal of Chromatography B
  
  Volume: 1137 Pages: 121928-121928
- DOI
  10.1016/j.jchromb.2019.121928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14988
[Journal Article] Interior Temperature and Relative Humidity of an Envelope During Mail Transport by the Japan Post in the Summer2019
- Author(s)
  Mukai Yuji、Minami Rumiko、Doki Kosuke、Inotsume Nobuo、Toda Takaki
- Journal Title
  
  Therapeutic Drug Monitoring
  
  Volume: 41 Issue: 5 Pages: 628-633
- DOI
  10.1097/ftd.0000000000000653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14988
[Presentation] Dried blood spotsに基づくTDM2023
- Author(s)
  向　祐志
- Organizer
  第39回日本TDM学会・学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15313
[Presentation] Venetoclax PK adjusted by Ven duration affected neutropenia after Ven-AzaC for AML2023
- Author(s)
  Kanaya M, Mukai Y, Kobayashi M, Kajikawa S, Yokoyama E, Izumiyama K, Saito M, Morioka M, Mori A, Yoshimoto G, Chi SG, Minami Y, Homma M, Kondo T
- Organizer
  第85回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-22K15313
[Presentation] 乾燥血液スポットを用いたチロシンキナーゼ阻害薬の治療薬物モニタリング（第1報）：クリニカルバリデーション2023
- Author(s)
  向祐志、近藤健、吉田達成、戸田貴大、土岐浩介、本間真人
- Organizer
  第44回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-22K15313
[Presentation] 白血病治療に用いられる分子標的薬のTDM2023
- Author(s)
  向　祐志
- Organizer
  第39回日本TDM学会・学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15313
[Presentation] Dried blood spotsを用いたチロシンキナーゼ阻害薬の来院不要なTDM体制の構築を目指して2022
- Author(s)
  向　祐志
- Organizer
  第38回日本TDM学会・学術大会
- Data Source
  KAKENHI-PROJECT-22K15313
[Presentation] 出産前後にエルロチニブ及びその代謝物の血中濃度測定を行った妊娠症例2022
- Author(s)
  大神　正宏、向　祐志、會田　有香、鈴木　嘉治、関根　郁夫、本間　真人
- Organizer
  第38回日本TDM学会・学術大会
- Data Source
  KAKENHI-PROJECT-22K15313
[Presentation] BCR-ABLチロシンキナーゼ阻害薬を対象とした乾燥ろ紙血血漿中薬物濃度換算式の導出2021
- Author(s)
  向　祐志、吉田　達成、三浦　淳、近藤　健、猪爪　信夫、戸田　貴大
- Organizer
  第37回日本TDM学会・学術大会
- Data Source
  KAKENHI-PROJECT-18K14988
[Presentation] 上皮成長因子受容体チロシンキナーゼ阻害薬および未分化リンパ腫キナーゼ阻害薬の血清中濃度一斉分析法の開発2020
- Author(s)
  向　祐志、吉田　達成、猪爪　信夫、戸田　貴大
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K14988
[Presentation] BCR-ABLおよびブルトン型チロシンキナーゼ阻害薬の乾燥ろ紙血中薬物濃度一斉分析法の確立とその臨床適用2020
- Author(s)
  向　祐志、近藤　健、吉田　達成、三浦　淳、猪爪　信夫、戸田　貴大
- Organizer
  第41回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-18K14988
[Presentation] 造血器腫瘍に用いられるキナーゼ阻害薬および活性代謝物の血漿中濃度一斉分析法の開発2019
- Author(s)
  向　祐志、吉田　達成、猪爪　信夫、戸田　貴大
- Organizer
  第36回日本TDM学会・学術大会
- Data Source
  KAKENHI-PROJECT-18K14988
[Presentation] カペシタビンとワルファリンの薬物相互作用モデリングと凝固能推移シミュレーション2019
- Author(s)
  作間　脩平、戸田　貴大、向　祐志、猪爪　信夫
- Organizer
  第40回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-18K14988
[Presentation] 造血器腫瘍に用いられるキナーゼ阻害薬の血漿中濃度同時定量法：線形性に関するバリデーション2019
- Author(s)
  向　祐志、小林　隼人、河原　弥生、齊藤　この実、吉田　達成、猪爪　信夫、戸田　貴大
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K14988
[Presentation] Effects of angiotensin II receptor blockers on serum levels of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids2018
- Author(s)
  Toda T, Kato Y, Senda A, Mukai Y, Yamashita M, Hanada M, Komazawa H, Tojima K, Hongo F, Hirokami M, Rane A, Inotsume N
- Organizer
  The 16th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14988
[Presentation] フィルグラスチムの先行バイオ医薬品とバイオ後続品の臨床的同等性評価2018
- Author(s)
  平田　萌、新沼　芳文、大熊　実季、平手　大輔、山下　美妃、向　祐志、猪爪　信夫、戸田　貴大、本郷　文教
- Organizer
  第38回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-18K14988
[Presentation] Pharmacokinetics of ritodrine in pregnant women and their neonates2018
- Author(s)
  Soma M, Konda A, Sasaki Y, Mishima T, Keira M, Yoshida H, Mukai Y, Toda T, Inotsume N
- Organizer
  The 18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14988
[Presentation] 血液腫瘍に用いられるキナーゼ阻害薬の血漿中濃度同時定量法：線形性に関するバリデーション2018
- Author(s)
  向　祐志、吉田　壘、猪爪　信夫、戸田　貴大
- Organizer
  第35回日本TDM学会・学術大会
- Data Source
  KAKENHI-PROJECT-18K14988
[Presentation] Detection of exogenous anabolic androgenic steroids in drugs-of-abuse urine samples with UHPLC-HRMS after enzymatic hydrolysis and direct injection2018
- Author(s)
  Masquelier M, Lofgren H, Dubedout A, Mukai Y, Ericsson M
- Organizer
  The 36th Cologne Workshop on Dope Analysis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14988

Mukai Yuji 向 祐志

Research Projects

Research Products

慢性骨髄性白血病患者を対象とした経口分子標的薬の来院不要な治療評価体制の構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of simultaneous determination method of kinase inhibitors by means of dried blood spot sampling at homePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Utilizing the dry spot method to monitor the concentrations of biologic agents in breast milk2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An Liquid Chromatography-Tandem Mass Spectrometry Method for the Simultaneous Determination of Afatinib, Alectinib, Ceritinib, Crizotinib, Dacomitinib, Erlotinib, Gefitinib, and Osimertinib in Human Serum2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of angiotensin II receptor blockers on serum levels of epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids in patients admitted to a cardiovascular center2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Simultaneous Quantification of BCR-ABL and Bruton's Tyrosine Kinase Inhibitors in Dried Plasma Spots and Its Application to Clinical Sample Analysis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel high-performance liquid chromatography-tandem mass spectrometry method for simultaneous quantification of BCR-ABL and Bruton’s tyrosine kinase inhibitors and their three active metabolites in human plasma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Interior Temperature and Relative Humidity of an Envelope During Mail Transport by the Japan Post in the Summer2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Dried blood spotsに基づくTDM2023

Author(s)

Organizer

Data Source

[Presentation] Venetoclax PK adjusted by Ven duration affected neutropenia after Ven-AzaC for AML2023

Author(s)

Organizer

Data Source

[Presentation] 乾燥血液スポットを用いたチロシンキナーゼ阻害薬の治療薬物モニタリング（第1報）：クリニカルバリデーション2023

Author(s)

Organizer

Data Source

[Presentation] 白血病治療に用いられる分子標的薬のTDM2023

Author(s)

Organizer

Data Source

[Presentation] Dried blood spotsを用いたチロシンキナーゼ阻害薬の来院不要なTDM体制の構築を目指して2022

Author(s)

Organizer

Data Source

[Presentation] 出産前後にエルロチニブ及びその代謝物の血中濃度測定を行った妊娠症例2022

Author(s)

Organizer

Data Source

[Presentation] BCR-ABLチロシンキナーゼ阻害薬を対象とした乾燥ろ紙血 血漿中薬物濃度換算式の導出2021

Author(s)

Organizer

Data Source

[Presentation] 上皮成長因子受容体チロシンキナーゼ阻害薬および未分化リンパ腫キナーゼ阻害薬の血清中濃度一斉分析法の開発2020

Author(s)

Organizer

Data Source

[Presentation] BCR-ABLおよびブルトン型チロシンキナーゼ阻害薬の乾燥ろ紙血中薬物濃度一斉分析法の確立とその臨床適用2020

Author(s)

Organizer

Mukai Yuji 向祐志

[Presentation] BCR-ABLチロシンキナーゼ阻害薬を対象とした乾燥ろ紙血血漿中薬物濃度換算式の導出2021