• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Kawakami Takahisa  川上 貴久

ORCIDConnect your ORCID iD *help
Researcher Number 10722093
Affiliation (Current) 2025: 杏林大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2019 – 2023: 杏林大学, 医学部, 講師
2018 – 2019: 杏林大学, 医学部, 学内講師
2014 – 2017: 東京大学, 医学部附属病院, 助教
Review Section/Research Field
Principal Investigator
Basic Section 53040:Nephrology-related / Kidney internal medicine
Except Principal Investigator
Kidney internal medicine / Neo-Gerontology
Keywords
Principal Investigator
慢性腎臓病 / 炎症 / マクロファージ / 低酸素 / 急性腎障害 / HMGB1 / DAMP / 尿細管間質 / 慢性炎症 / 敗血症 … More / PHD / 2-デオキシグルコース / 代謝リプログラミング / アポトーシス / NF-κB / 尿細管間質傷害 / Mint3 / 解糖系 / 尿細管細胞 / 慢性腎臓病新規治療 / TRPV4 … More
Except Principal Investigator
慢性腎臓病 / 低酸素 / HIF / エピゲノム / 尿細管上皮細胞 / 小胞体ストレス / SASP / 細胞周期停止 / アポトーシス / D-セリン / D-アミノ酸 / 近位尿細管上皮細胞 / 腎臓老化 / 蛋白尿 / 糖尿病性腎臓病 / 肥満関連腎症 / PHD阻害薬 / プロリン水酸化酵素 / 蛋白質恒常性 / 腎臓病態生理 / 尿細管間質障害 / 尿細管老化 / metabolism / kidney / kidney fibrosis / Mitochondrial function / Fatty acid oxidation / ATF6 / Endoplasmic reticulum / UPR / Energy metabolism / Chronic kidney disease / エピジェネティック / 線維化 / エピジェネティックス / 低酸素応答 / エピジェネティクス / エネルギー代謝 / 腎不全 / HIF / 酸化ストレス / microRNA 205 / microRNA / 尿毒素 / 糸球体腎炎 / アセチル化蛋白 / アクチン重合 / 糸球体濾過量 / アクチン細胞骨格 / cortactin / アセチル化 / SIRT1 / ポドサイト / 糖尿病性腎症 / 翻訳後修飾 / TGF-β1 / 高グルコース / 細胞骨格 / 糸球体足細胞 Less
  • Research Projects

    (10 results)
  • Research Products

    (10 results)
  • Co-Researchers

    (14 People)
  •  Investigation of pathophysiology of tubulointerstitial inflammation in kidney diseases from the viewpoint of an inflammation trigger, DAMPPrincipal Investigator

    • Principal Investigator
      川上 貴久
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Kyorin University
  •  Development of a novel therapy for kidney diseases targeting the hypoxia sensor PHD in macrophagesPrincipal Investigator

    • Principal Investigator
      Kawakami Takahisa
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Kyorin University
  •  Therapeutic intervention of CKD targeting cellular oxygen sensors

    • Principal Investigator
      Tanaka Tetsuhiro
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      The University of Tokyo
  •  Development of novel therapeutic approaches targeting ATF6-mediated metabolic alteration

    • Principal Investigator
      饒 梓明
    • Project Period (FY)
      2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      The University of Tokyo
  •  Development of Novel Therapy for Renal Diseases Targeting Macrophage Metabolic ReprogrammingPrincipal Investigator

    • Principal Investigator
      Kawakami Takahisa
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Kyorin University
      The University of Tokyo
  •  Pathophysiological role of D-amino acid on proteostasis in the kidney

    • Principal Investigator
      Reiko Inagi
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Kidney internal medicine
    • Research Institution
      The University of Tokyo
  •  Mechanisms of maintenance of podocyte cytoskeletal structure against metabolic stress associated with diabetes and Development of novel therapeutic strategies

    • Principal Investigator
      WADA Takehiko
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokai University
  •  Epigenetic regulation of endoplasmic reticulum stress signal in aging of kidney

    • Principal Investigator
      Inagi Reiko
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neo-Gerontology
    • Research Institution
      The University of Tokyo
  •  Metabolic Reprogramming and Hypoxic Memory in Kidney Disease

    • Principal Investigator
      Nangaku Masaomi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Kidney internal medicine
    • Research Institution
      The University of Tokyo
  •  Research for developing a novel therapy for renal diseases targeting TRPV4Principal Investigator

    • Principal Investigator
      Kawakami Takahisa
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Kidney internal medicine
    • Research Institution
      The University of Tokyo

All 2017 2015

All Journal Article Presentation

  • [Journal Article] Vascular adhesion protein-1 enhances neutrophil infiltration by generation of hydrogen peroxide in renal ischemia/reperfusion injury2017

    • Author(s)
      Tanaka S, Tanaka T, Kawakami T, Takano H, Sugahara M, Saito H, Higashijima Y, Yamaguchi J, Inagi R, Nangaku M
    • Journal Title

      Kidney Int

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09247
  • [Journal Article] Vascular adhesion protein-1 enhances neutrophil infiltration by generation of hydrogen peroxide in renal ischemia/reperfusion injury.2017

    • Author(s)
      Tanaka S, Tanaka T, Kawakami T, Takano H, Sugahara M, Saito H, Higashijima Y, Yamaguchi J, Inagi R, Nangaku M.
    • Journal Title

      Kidney Int

      Volume: 印刷中 Issue: 1 Pages: 154-164

    • DOI

      10.1016/j.kint.2017.01.014

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-15H04835, KAKENHI-PROJECT-26461215, KAKENHI-PROJECT-15KT0088, KAKENHI-PROJECT-16K15465, KAKENHI-PROJECT-17K15991, KAKENHI-PROJECT-17J07088, KAKENHI-PROJECT-15K09247
  • [Journal Article] D-serine, a novel uremic toxin, induces senescence in human renal tubular cells via GCN2 activation.2017

    • Author(s)
      Okada A, Nangaku M, Jao TM, Maekawa H, Ishimono Y, Kawakami T, Inagi R.
    • Journal Title

      Sci Rep.

      Volume: 7 Issue: 1 Pages: 11168-11168

    • DOI

      10.1038/s41598-017-11049-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05280, KAKENHI-PROJECT-15K09247, KAKENHI-PROJECT-15KT0088, KAKENHI-PROJECT-16K15465
  • [Presentation] Inhibition of Glycolysis Attenuates Ischemia-Reperfusion Injury via Metabolic and Redox Changes in Proximal Tubular Cells2017

    • Author(s)
      Shinohara A, Kawakami T, Nangaku M.
    • Organizer
      The 51st Annual Meeting of the American Society of Nephrology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04835
  • [Presentation] D-Serine, a Novel Uremic Toxin, Induces Senescence in Human Renal Tubular Cells via GCN2 Activation.2017

    • Author(s)
      Okada A, Jao TM, Maekawa H, Ishimoto Y, Kawakami T, Nangaku M, Inagi R.
    • Organizer
      Kidney Week 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15465
  • [Presentation] Inhibition of Glycolysis Attenuates Ischemia-Reperfusion Injury via Metabolic and Redox Changes in Proximal Tubular Cells2017

    • Author(s)
      Akinari Shinohara, Takahisa Kawakami, Masaomi Nangaku
    • Organizer
      Kidney Week 2017, American Society of Nephrology
    • Data Source
      KAKENHI-PROJECT-16K09605
  • [Presentation] D-Serine, a Novel Uremic Toxin, Induces Senescence in Human Renal Tubular Cells via GCN2 Activation.2017

    • Author(s)
      Okada A, Jao TM, Maekawa H, Ishimoto Y, Kawakami T, Nangaku M, Inagi R.
    • Organizer
      Kidney Week 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15KT0088
  • [Presentation] Inhibition of Glycolysis attenuates ischemia-reperfusion injury via metabolic and redox changes in proximal tubular cells.2017

    • Author(s)
      Shinohara A, Kawakami T, Nangaku M
    • Organizer
      Kidney Week 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09247
  • [Presentation] D-Serine, a novel uremic toxin, induces senescence in human renal tubular cells via GCN2 activation2017

    • Author(s)
      Okada A, Jao TM, Maekawa H, Ishimoto Y, Kawakami T, Nangaku M, Inagi R
    • Organizer
      Kidney Week 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09247
  • [Presentation] 臍帯血移植御に認めた巣状糸球体硬化症に対しLDLアフェレシスが奏功した一例2015

    • Author(s)
      菅原有佳、亀井亮佑、本田謙次郎、伊藤麻里江、鈴木淳司、片桐大輔、林玲匡、新谷祐加子、中村元信、川上貴久、和田健彦、藤乗嗣泰、南学正臣
    • Organizer
      第45回日本腎臓学会東部学術大会
    • Place of Presentation
      東京ミッドタウンホール&カンファレンス(東京都港区)
    • Year and Date
      2015-10-02
    • Data Source
      KAKENHI-PROJECT-15K09247
  • 1.  Inagi Reiko (50232509)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 5 results
  • 2.  Nangaku Masaomi (90311620)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 9 results
  • 3.  Tanaka Tetsuhiro (90508079)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 1 results
  • 4.  加藤 秀樹 (90625237)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  WADA Takehiko (90447409)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 6.  正路 久美 (00439423)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  要 伸也 (60224581)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  三村 維真理 (00727084)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  饒 梓明 (30772446)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  吉田 瑶子 (90649443)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  Shinohara Akinari
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  Nasu Kahori
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  ISHIMOTO Yu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 14.  OKADA Akira
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi