Hayashi Takeru 林剛瑠

Researcher Number	10722209
Other IDs
Affiliation (Current)	2025: 公益財団法人微生物化学研究会, 微生物化学研究所, 主任研究員
Affiliation (based on the past Project Information) *help	2022 – 2024: 公益財団法人微生物化学研究会, 微生物化学研究所, 主任研究員 2016 – 2021: 東京大学, 大学院医学系研究科(医学部), 助教 2014 – 2015: 東京大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 49050:Bacteriology-related / Bacteriology (including mycology) / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords	Principal Investigator CagA / ピロリ菌 / 胃がん / 化合物スクリーニング / がん / 胃発がん / 分子標的薬 / SHP1/2 / 分子標的阻害剤 / SHP2 … More / 抗がん剤 / 新規創薬 / トランスレーショナルリサーチ / 感染症 / 阻害剤探索 / がんタンパク質 / ヘリコバクター・ピロリ / タンパク質複合体機能解析 / タンパク質複合体構造解析 / ピロリ菌感染 / 構造-機能解析 / 細胞内シグナル撹乱 Less

チロシンホスファターゼSHP1/2を標的とした新規の作用機序を有する低分子阻害剤の開発Principal Investigator
- Principal Investigator
  
  林剛瑠
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Microbial Chemistry Research Foundation
Research on drug discovery targeting the molecular mechanism of gastric carcinogenesis caused by H. pylori infectionPrincipal Investigator
- Principal Investigator
  
  Hayashi Takeru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  Microbial Chemistry Research Foundation
  The University of Tokyo
Structure-function analysis for the induction of pathogenic signaling by H. pylori CagA oncoproteinPrincipal Investigator
- Principal Investigator
  
  Hayashi Takeru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49050:Bacteriology-related
- Research Institution
  The University of Tokyo
Exploring the small molecule inhibitors that specifically block the intracellular signal perturbation induced by Helicobacter pylori CagA oncoproteinPrincipal Investigator
- Principal Investigator
  
  Hayashi Takeru
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  The University of Tokyo
Structural and functional analysis of the mechanism underlying perturbation of Csk by Helicobacter pylori virulence factor CagAPrincipal Investigator
- Principal Investigator
  
  Hayashi Takeru
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  The University of Tokyo

All 2022 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation Book

[Book] Photon Factory Highlights 20172018
- Author(s)
  Takeru Hayashi, Miki Senda, Nobuhiro Suzuki, Toshiya Senda, Masanori Hatakeyama
- Total Pages
  2
- Publisher
  High Energy Accelerator Research Organization (KEK)
- Data Source
  KAKENHI-PROJECT-18K07105
[Book] 実験医学増刊2014
- Author(s)
  千田俊哉、千田美紀、林剛瑠、畠山昌則
- Total Pages
  5
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-26860284
[Journal Article] Kinase Activity of PAR1b, Which Mediates Nuclear Translocation of the BRCA1 Tumor Suppressor, Is Potentiated by Nucleic Acid-Mediated PAR1b Multimerization2022
- Author(s)
  Hiroko Nishikawa, Priscillia Christiany, Takeru Hayashi, Hisashi Iizasa, Hironori Yoshiyama, Masanori Hatakeyama
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 12 Pages: 6634-6634
- DOI
  10.3390/ijms23126634
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07019, KAKENHI-PROJECT-21K07054, KAKENHI-PROJECT-22K07101, KAKENHI-PROJECT-21H04804
[Journal Article] Alternative splicing reverses the cell-intrinsic and cell-extrinsic pro-oncogenic potentials of YAP12020
- Author(s)
  Chi Ben, Xiaojing Wu, Atsushi Takahashi-Kanemitsu, Christopher Takaya Knight, Takeru Hayashi, Masanori Hatakeyama
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 295 Issue: 41 Pages: 13965-13980
- DOI
  10.1074/jbc.ra120.013820
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K05945, KAKENHI-PROJECT-16H06373, KAKENHI-PROJECT-18K07105
[Journal Article] ピロリ菌の遺伝子多型と胃がん発症リスクを結びつける分子構造解析2019
- Author(s)
  林剛瑠
- Journal Title
  
  日本ペプチド学会ニュースレター
  
  Volume: 112 Pages: 5-9
- Open Access
- Data Source
  KAKENHI-PROJECT-18K07105
[Journal Article] Evaluating the origin and virulence of a Helicobacter pylori cagApositive strain isolated from a non-human primate2018
- Author(s)
  Kana Hashi, Chihiro Imai, Koji Yahara, Kamrunnesa Tahmina, Takeru Hayashi, Takeshi Azuma, Takako Miyabe-Nishiwaki, Hideyuki Sato, Masao Matsuoka, Sachi Niimi, Munehiro Okamoto, Masanori Hatakeyama
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 15981-15981
- DOI
  10.1038/s41598-018-34425-4
- NAID
  120006539613
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07105, KAKENHI-PROJECT-18KK0204, KAKENHI-PROJECT-16H06373, KAKENHI-PROJECT-17H04666
[Journal Article] Differential mechanisms for SHP2 binding and activation are exploited by geographically distinct Helicobacter pylori CagA Oncoproteins.2017
- Author(s)
  Hayashi, H., Senda, M., Suzuki, N., Nishikawa, H., Ben, C., Tang, C., Nagase, L., Inoue, K., Senda, T. and Hatakeyama, M.
- Journal Title
  
  Cell Rep
  
  Volume: 20 Issue: 12 Pages: 2876-2890
- DOI
  10.1016/j.celrep.2017.08.080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06373, KAKENHI-PROJECT-16K15273, KAKENHI-PROJECT-16K19121
[Journal Article] Host SHP1 phosphatase antagonizes Helicobacter pylori CagA and can be downregulated by EBV.2016
- Author(s)
  Saju, P., Murata-Kamiya, N., Hayashi, T., Senda, Y., Nagase, L., Noda, S., Matusaka, K., Funata, S., Kunita, A., Urabe, M., Seto, Y., Fukayama, M., Kaneda, A., Hatakeyama, M.
- Journal Title
  
  Nature Microbiology
  
  Volume: 1 Issue: 4 Pages: 16026-16026
- DOI
  10.1038/nmicrobiol.2016.26
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860284, KAKENHI-PROJECT-16H06373, KAKENHI-PROJECT-16K15273
[Journal Article] Determination of the catalytic activity of LEOPARD syndrome- associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling2016
- Author(s)
  Saori Noda, Atsushi Takahashi, Takeru Hayashi, Sei-ichi Tanuma and Masanori Hatakeyama
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 469 Issue: 4 Pages: 1133-1139
- DOI
  10.1016/j.bbrc.2015.12.117
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18399, KAKENHI-ORGANIZER-22114001, KAKENHI-PROJECT-25250016, KAKENHI-PROJECT-15H04315, KAKENHI-PROJECT-25460156, KAKENHI-PROJECT-26860284, KAKENHI-PROJECT-16H06373, KAKENHI-PROJECT-16K15273
[Journal Article] Improvement of Helicobacter pylori CagA crystals by the multi-step soaking method2016
- Author(s)
  Senda, M.
- Journal Title
  
  Cryst. Growth Des.
  
  Volume: 16 Issue: 3 Pages: 1565-1571
- DOI
  10.1021/acs.cgd.5b01692
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-22114001, KAKENHI-PROJECT-25250016, KAKENHI-PROJECT-26650026, KAKENHI-PROJECT-26860284, KAKENHI-PROJECT-16H06373, KAKENHI-PROJECT-16K15273
[Journal Article] Impact of structural polymorphism for the Helicobacter pylori CagA oncoprotein on binding to polarity-regulating kinase PAR1b.2016
- Author(s)
  Nishikawa, H., Hayashi, T., Arisaka, F., Senda, T., Hatakeyama, M.
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 30031-30031
- DOI
  10.1038/srep30031
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H06373, KAKENHI-PROJECT-16K15273, KAKENHI-PROJECT-16K19121
[Journal Article] Dramatic increase in SHP2 binding activity of Helicobacter pylori Western CagA by EPIYA-C duplication: its implications in gastric carcinogenesis2015
- Author(s)
  Nagase, L.
- Journal Title
  
  Sci. Rep.
  
  Volume: 5 Issue: 1 Pages: 15749-15749
- DOI
  10.1038/srep15749
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-22114001, KAKENHI-PROJECT-25250016, KAKENHI-PROJECT-26860284
[Presentation] Screening and validation of a novel small chemical compound that inhibits pro-oncogenic signaling triggered by the Helicobacter pylori CagA oncoprotein2022
- Author(s)
  Takeru Hayashi, Miki Senda, Toshiya Senda, Daisuke Takaya, Teruki Homma, Wataru Ikeda, Keiji Tanino, Masanori Hatakeyama
- Organizer
  12th AACR-JCA Joint Conference, Breakthroughs in Cancer Research - Translating Knowledge into Practice
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07019
[Presentation] Structure-function analysis for deregulation of SHP2 by geographically distinct variants of Helicobacter pylori CagA2018
- Author(s)
  Takeru Hayashi, Miki Senda, Nobuhiro Suzuki, Chi Ben, Toshiya Senda, Masanori Hatakeyama
- Organizer
  The 37th Sapporo International Cancer Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07105
[Presentation] ピロリ菌CagAによる細胞内シグナル撹乱の構造生物学的解析2017
- Author(s)
  林　剛瑠
- Organizer
  マックスプランク・東京大学統合延焼学センタージュニアフェローセミナー
- Invited
- Data Source
  KAKENHI-PROJECT-16K19121
[Presentation] Structural insights into the mechanism underlying activation of SHP2 by the Helicobacter pylori CagA oncoprotein.2017
- Author(s)
  Hayashi, T., Senda, M., Suzuki, N., Inoue, K., Nagase, L., Nishikawa, H., Senda, T., Hatakeyama, M.
- Organizer
  Europhosphatase 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19121
[Presentation] Solution structure analysis of SHP2 in complex with the EPIYA region of Helicobacter pylori CagA2016
- Author(s)
  鈴木喜大、林剛瑠、千田美紀、長瀬里沙、畠山昌則、千田俊哉
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K19121
[Presentation] Structural insights into the mechanism underlying activation of SHP2 by the Helicobacter pylori CagA oncoprotein2016
- Author(s)
  林剛瑠、千田美紀、千田俊哉、畠山昌則
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K19121
[Presentation] ピロリ菌CagAによる宿主分子撹乱機構の構造と機能
- Author(s)
  林剛瑠、長瀬里沙、千田美紀、千田俊哉、畠山昌則
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-26860284
[Presentation] ピロリ菌がんタンパク質CagAと標的分子Cskとの相互作用における生物物理化学的解析
- Author(s)
  林剛瑠、畠山昌則
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26860284

1. 高橋昌史

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 畠山昌則

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Hayashi Takeru 林 剛瑠

Research Projects

Research Products

Co-Researchers

チロシンホスファターゼSHP1/2を標的とした新規の作用機序を有する低分子阻害剤の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on drug discovery targeting the molecular mechanism of gastric carcinogenesis caused by H. pylori infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structure-function analysis for the induction of pathogenic signaling by H. pylori CagA oncoproteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring the small molecule inhibitors that specifically block the intracellular signal perturbation induced by Helicobacter pylori CagA oncoproteinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structural and functional analysis of the mechanism underlying perturbation of Csk by Helicobacter pylori virulence factor CagAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Photon Factory Highlights 20172018

Author(s)

Total Pages

Publisher

Data Source

[Book] 実験医学 増刊2014

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Kinase Activity of PAR1b, Which Mediates Nuclear Translocation of the BRCA1 Tumor Suppressor, Is Potentiated by Nucleic Acid-Mediated PAR1b Multimerization2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Alternative splicing reverses the cell-intrinsic and cell-extrinsic pro-oncogenic potentials of YAP12020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ピロリ菌の遺伝子多型と胃がん発症リスクを結びつける分子構造解析2019

Author(s)

Journal Title

Data Source

[Journal Article] Evaluating the origin and virulence of a Helicobacter pylori cagApositive strain isolated from a non-human primate2018

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Differential mechanisms for SHP2 binding and activation are exploited by geographically distinct Helicobacter pylori CagA Oncoproteins.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Host SHP1 phosphatase antagonizes Helicobacter pylori CagA and can be downregulated by EBV.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Determination of the catalytic activity of LEOPARD syndrome- associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Improvement of Helicobacter pylori CagA crystals by the multi-step soaking method2016

Hayashi Takeru 林剛瑠

[Book] 実験医学増刊2014