Kusunose Naoki 楠瀬直喜

Researcher Number	10725964
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2021: 山陽小野田市立山口東京理科大学, 薬学部, 助教 2017 – 2018: 九州大学, 薬学研究院, 特任助教 2014 – 2015: 大分大学, 医学部, 特任助教
Review Section/Research Field	Principal Investigator Ophthalmology Except Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related
Keywords	Principal Investigator 時計遺伝子 / 体内時計 / 概日リズム / 血管新生 / VEGF / 網膜 / 神経障害 / グルココルチコイド / マイトマイシンC Except Principal Investigator 天然医薬資源 / プルダウンアッセイ / 天然化合物 / 脂質メディエーター

Discovery of new anti-inflammatory natural compounds through a highly selective isolation method
- Principal Investigator
  
  TANAKA HIROYUKI
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Tokyo University of Science, Yamaguchi
Influence of clock gene on angiogenesis in retinaPrincipal Investigator
- Principal Investigator
  
  Kusunose Naoki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Tokyo University of Science, Yamaguchi
  Kyushu University
Basis for chronobiological approach in treatment of corneal nerve damagePrincipal Investigator
- Principal Investigator
  
  Kusunose Naoki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Oita University

All 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Dosing Time-Dependent Changes in the Anti-tumor Effect of xCT Inhibitor Erastin in Human Breast Cancer Xenograft Mice2019
- Author(s)
  Shiromizu S, Yamauchi T, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 11 Pages: 1921-1925
- DOI
  10.1248/bpb.b19-00546
- NAID
  130007740594
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-11-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-18H04019
[Journal Article] Estradiol regulation of P-glycoprotein expression in mouse kidney and human tubular epithelial cells, implication for renal clearance of drugs.2019
- Author(s)
  Kanado Y, Tsurudome Y, Omata Y, Yasukochi S, Kusunose N, Akamine T, Matsunaga N, Koyanagi S, Ohdo S.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 519 Issue: 3 Pages: 613-619
- DOI
  10.1016/j.bbrc.2019.09.021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-18H04019
[Journal Article] Microcurrent stimulation activates the circadian machinery in mice.2019
- Author(s)
  Matsunaga N, Yoshida Y, Kitajou N, Shiraishi A, Kusunose N, Koyanagi S, Ohdo S.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 513 Issue: 2 Pages: 292-299
- DOI
  10.1016/j.bbrc.2019.02.022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-18J20628
[Journal Article] Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene2018
- Author(s)
  Katamune Chiharu、Koyanagi Satoru、Hashikawa Ken-ichi、Kusunose Naoki、Akamine Takahiro、Matsunaga Naoya、Ohdo Shigehiro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 2 Pages: 547-558
- DOI
  10.1074/jbc.ra118.004942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17H06976
[Journal Article] Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice.2018
- Author(s)
  Shiromizu S, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 136 Issue: 4 Pages: 228-233
- DOI
  10.1016/j.jphs.2018.01.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17K16972
[Journal Article] Angiotensin-II regulates dosing time-dependent intratumoral accumulation of macromolecular drug formulations via 24-h blood pressure rhythm in tumor-bearing mice2018
- Author(s)
  Matsunaga Takashi、Matsunaga Naoya、Kusunose Naoki、Ikeda Eriko、Okazaki Hiroyuki、Kakimoto Keisuke、Hamamura Kengo、Koyanagi Satoru、Ohdo Shigehiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 498 Issue: 1 Pages: 86-91
- DOI
  10.1016/j.bbrc.2017.11.162
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-17K18298
[Journal Article] Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system2018
- Author(s)
  Kimura Hinako、Matsunaga Naoya、Kakimoto Keisuke、Watanabe Miyako、Tsuruta Akito、Kusunose Naoki、Shiromizu Shoya、Koyanagi Satoru、Ohdo Shigehiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 503 Issue: 2 Pages: 1063-1069
- DOI
  10.1016/j.bbrc.2018.06.117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262
[Journal Article] Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation of HIF1α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (M?ller) cells2018
- Author(s)
  Kusunose Naoki、Akamine Takahiro、Kobayashi Yoshiyuki、Yoshida Shigeo、Kimoto Kenichi、Yasukochi Sai、Matsunaga Naoya、Koyanagi Satoru、Ohdo Shigehiro、Kubota Toshiaki
- Journal Title
  
  Japanese Journal of Ophthalmology
  
  Volume: 62 Issue: 6 Pages: 677-685
- DOI
  10.1007/s10384-018-0622-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-17H06976
[Journal Article] Accumulation of sorbitol in the sciatic nerve modulates circadian properties of diabetes-induced neuropathic pain hypersensitivity in a diabetic mouse model2018
- Author(s)
  Akamine Takahiro、Kusunose Naoki、Matsunaga Naoya、Koyanagi Satoru、Ohdo Shigehiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 503 Issue: 1 Pages: 181-187
- DOI
  10.1016/j.bbrc.2018.05.209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17H06976
[Journal Article] Dysfunction of the circadian transcriptional factor CLOCK in mice resists chemical carcinogen-induced tumorigenesis2017
- Author(s)
  Hashikawa KI, Katamune C, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S
- Journal Title
  
  Scientific reports
  
  Volume: 7 Issue: 1 Pages: 9995-9995
- DOI
  10.1038/s41598-017-10599-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636
[Journal Article] Dietary supplementation with essence of chicken enhances daily oscillations in plasma glucocorticoid levels and behavioral adaptation to the phase-shifted environmental light?dark cycle in mice2017
- Author(s)
  Dilixiati A, Koyanagi S, Kusunose N, Matsunaga N, Ohdo S
- Journal Title
  
  Journal of pharmacological sciences
  
  Volume: 134 Issue: 4 Pages: 211-217
- DOI
  10.1016/j.jphs.2017.07.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16972
[Journal Article] Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARα.2017
- Author(s)
  Kanemitsu T, Tsurudome Y, Kusunose N, Oda M, Matsunaga N, Koyanagi S, Ohdo S
- Journal Title
  
  The Journal of biological chemistry
  
  Volume: 292 Issue: 52 Pages: 21397-21406
- DOI
  10.1074/jbc.m117.791285
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262
[Journal Article] Mitomycin C modulates the circadian oscillation of clock gene period 2 expression through attenuating the glucocorticoid signaling in mouse fibroblasts.2015
- Author(s)
  Kusunose N, Matsunaga N, Kimoto K, Akamine T, Hamamura K, Koyanagi S, Ohdo S, Kubota T.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 467 Issue: 1 Pages: 157-163
- DOI
  10.1016/j.bbrc.2015.09.086
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H06795, KAKENHI-PROJECT-26861456
[Journal Article] Dosing time-dependent changes in the analgesic effect of pregabalin on diabetic neuropathy in mice.2015
- Author(s)
  Akamine T, Koyanagi S, Kusunose N, Hashimoto H, Taniguchi M, Matsunaga N, Ohdo S.
- Journal Title
  
  Journal of Pharmacology and Experimental Therapeutics
  
  Volume: 354 Issue: 1 Pages: 65-72
- DOI
  10.1124/jpet.115.223891
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26861456
[Journal Article] Modulation of peroxisome proliferator-activated receptor-α activity by bile acids causes circadian changes in the intestinal expression of Octn1/Slc22a4 in mice.2015
- Author(s)
  Wada E, Koyanagi S, Kusunose N, Akamine T, Masui H, Hashimoto H, Matsunaga N, Ohdo S.
- Journal Title
  
  Mol Pharmacol
  
  Volume: 87 Issue: 2 Pages: 314-322
- DOI
  10.1124/mol.114.094979
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390149, KAKENHI-PUBLICLY-25136716, KAKENHI-PROJECT-25253038, KAKENHI-PROJECT-25670079, KAKENHI-PROJECT-26670317, KAKENHI-PROJECT-26861456
[Journal Article] Bile acid-regulated peroxisome proliferator-activated receptor-α (PPARα) activity underlies circadian expression of intestinal peptide absorption transporter PepT1/Slc15a1.2014
- Author(s)
  Okamura A, Koyanagi S, Dilxiat A, Kusunose N, Chen JJ, Matsunaga N, Shibata S, Ohdo S.
- Journal Title
  
  J Biol Chem.
  
  Volume: 289(36) Issue: 36 Pages: 25296-25305
- DOI
  10.1074/jbc.m114.577023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25136716, KAKENHI-PROJECT-25253038, KAKENHI-PROJECT-25670079, KAKENHI-PROJECT-26220201, KAKENHI-PROJECT-26670317, KAKENHI-PROJECT-26861456
[Presentation] cAMP response element binding protein (CREB) modulates circadian oscillation of Glycoprotein 2 (Gp2) gene expression in Peyer's patches of mice.2019
- Author(s)
  Naoki Kusunose, Kengo hamamura, Akito Tsuruta, Yuya Tsurudome, Yuya Yoshida, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo
- Organizer
  EBRS2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16972
[Presentation] 神経障害性疼痛の概日リズム制御機構を基盤とした病態解明と創薬への応用2018
- Author(s)
  楠瀬直喜
- Organizer
  日本薬学会第138年回
- Data Source
  KAKENHI-PROJECT-17K16972
[Presentation] Glucocorticoid regulation of ATP release from spinal astrocytes underlies circadian exacerbation of neuropathic pain2018
- Author(s)
  Naoki Kusunose, Satoru Koyanagi, Naoya Matsunaga, Shigehiro Ohdo
- Organizer
  The 18th World Congress of Basic and Clinical Pharmacology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16972
[Presentation] 時間生物学的視点から迫る、糖尿病関連眼疾患の病態2016
- Author(s)
  楠瀬直喜
- Organizer
  第4回大分糖尿病眼合併症セミナー
- Place of Presentation
  レンブラントホテル (大分県, 大分市)
- Year and Date
  2016-02-13
- Invited
- Data Source
  KAKENHI-PROJECT-26861456
[Presentation] 眼科疾患の新規治療法の開発にむけた時間生物学的研究2015
- Author(s)
  楠瀬直喜
- Organizer
  第85回九州眼科学会
- Place of Presentation
  鹿児島県医師会館 (鹿児島県, 鹿児島市)
- Year and Date
  2015-05-29
- Invited
- Data Source
  KAKENHI-PROJECT-26861456
[Presentation] Alteration of the circadian clock system by mitomycin C in fibroblast2015
- Author(s)
  Naoki KUSUNOSE, Naoya MATSUNAGA, Satoru KOYANAGI, Kenichi KIMOTO, Shigehiro OHDO, Toshiaki KUBOTA
- Organizer
  The 8th Joint Meeting of Korea-China-Japan Ophthalmologists
- Place of Presentation
  ヒルトン福岡シーホーク (福岡県, 福岡市)
- Year and Date
  2015-10-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861456
[Presentation] 体内時計に着目したミューラー細胞におけるVEGFの発現制御機構の解明2015
- Author(s)
  楠瀬直喜、中野聡子、木許賢一、久保田敏昭
- Organizer
  第119回日本眼科学会総会
- Place of Presentation
  ロイトン札幌／さっぽろ芸術文化の館／札幌市教育文化会館 (北海道, 札幌市)
- Year and Date
  2015-04-16
- Data Source
  KAKENHI-PROJECT-26861456
[Presentation] マイトマイシンCによる線維芽細胞の時計遺伝子発現変容とそのメカニズムの解明2015
- Author(s)
  楠瀬直喜、松永直哉、小柳悟、木許賢一、大戸茂弘、久保田敏昭
- Organizer
  第22回日本時間生物学会学術大会
- Place of Presentation
  東京大学本郷キャンパス伊藤国際学術研究センター (東京都, 文京区)
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-26861456
[Presentation] マイトマイシンCによる線維芽細胞の時計遺伝子発現変容とそのメカニズムの解明2015
- Author(s)
  楠瀬直喜、松永直哉、小柳悟、木許賢一、大戸茂弘、久保田敏昭
- Organizer
  第26回日本緑内障学会
- Place of Presentation
  ウインクあいち (愛知県, 名古屋市)
- Year and Date
  2015-09-11
- Data Source
  KAKENHI-PROJECT-26861456
[Presentation] Effect of mitomycin C on molecular clock system in fibroblast2015
- Author(s)
  Naoki KUSUNOSE, Naoya MATSUNAGA, Satoru KOYANAGI, Satoko NAKANO, Shigehiro OHDO, Toshiaki KUBOTA
- Organizer
  The 6th World Glaucoma Congress
- Place of Presentation
  中国 (香港)
- Year and Date
  2015-06-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861456
[Presentation] Alteration of clock gene expression by mitomycin C in fibroblast2015
- Author(s)
  Naoki KUSUNOSE, Naoya MATSUNAGA, Satoru KOYANAGI, Kenichi KIMOTO, Shigehiro OHDO, and Toshiaki KUBOTA
- Organizer
  EBRS/WCC Meeting 2015
- Place of Presentation
  イギリス (マンチェスター)
- Year and Date
  2015-08-02
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26861456
[Presentation] グルココルチコイドによる神経障害性疼痛の概日リズム制御
- Author(s)
  楠瀬直喜、小柳悟、松永直哉、大戸茂弘
- Organizer
  第21回日本時間生物学会学術大会
- Place of Presentation
  九州大学医学部百年講堂 (福岡県福岡市)
- Year and Date
  2014-11-07 – 2014-11-09
- Invited
- Data Source
  KAKENHI-PROJECT-26861456
[Presentation] In vitro study concerning the alteration effect of mitomycin C on clock gene expression in fibroblast
- Author(s)
  Naoki KUSUNOSE, Satoko NAKANO, Toshiaki KUBOTA
- Organizer
  The 7th Joint Meeting of Korea-China-Japan Ophthalmologists in conjunction
- Place of Presentation
  KINTEX (韓国ソウル)
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-26861456

1. TANAKA HIROYUKI (30253470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. MATSUNAGA Naoya

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. 小柳悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
4. 大戸茂弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
5. 濱村賢吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kusunose Naoki 楠瀬 直喜

Research Projects

Research Products

Co-Researchers

Discovery of new anti-inflammatory natural compounds through a highly selective isolation method

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Influence of clock gene on angiogenesis in retinaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Basis for chronobiological approach in treatment of corneal nerve damagePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Dosing Time-Dependent Changes in the Anti-tumor Effect of xCT Inhibitor Erastin in Human Breast Cancer Xenograft Mice2019

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Estradiol regulation of P-glycoprotein expression in mouse kidney and human tubular epithelial cells, implication for renal clearance of drugs.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Microcurrent stimulation activates the circadian machinery in mice.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Angiotensin-II regulates dosing time-dependent intratumoral accumulation of macromolecular drug formulations via 24-h blood pressure rhythm in tumor-bearing mice2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Contribution of the clock gene DEC2 to VEGF mRNA upregulation by modulation of HIF1α protein levels in hypoxic MIO-M1 cells, a human cell line of retinal glial (M?ller) cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Accumulation of sorbitol in the sciatic nerve modulates circadian properties of diabetes-induced neuropathic pain hypersensitivity in a diabetic mouse model2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dysfunction of the circadian transcriptional factor CLOCK in mice resists chemical carcinogen-induced tumorigenesis2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dietary supplementation with essence of chicken enhances daily oscillations in plasma glucocorticoid levels and behavioral adaptation to the phase-shifted environmental light?dark cycle in mice2017

Author(s)

Journal Title

DOI

Kusunose Naoki 楠瀬直喜

[Presentation] マイトマイシンCによる線維芽細胞の時計遺伝子発現変容とそのメカニズムの解明2015

[Presentation] マイトマイシンCによる線維芽細胞の時計遺伝子発現変容とそのメカニズムの解明2015