KAWAGUCHI MITSUYASU 川口充康

… Alternative Names

Kawaguchi Mitsuyasu 川口充康

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Researcher Number	10735682
Other IDs
Affiliation (Current)	2025: 名古屋市立大学, 医薬学総合研究院(薬学), 准教授
Affiliation (based on the past Project Information) *help	2025: 名古屋市立大学, 医薬学総合研究院(薬学), 准教授 2023: 名古屋市立大学, 医薬学総合研究院(薬学), 准教授 2019 – 2022: 名古屋市立大学, 医薬学総合研究院(薬学), 講師 2016 – 2018: 名古屋市立大学, 大学院薬学研究科, 助教 2014 – 2015: 名古屋市立大学, 薬学研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Drug development chemistry / Complex systems / Basic Section 37030:Chemical biology-related Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Drug development chemistry
Keywords	Principal Investigator 蛍光プローブ / 阻害剤 / Sirtuin / 光操作 / 中分子 / 光異性化 / SIRT2 / 中分子阻害剤 / 長鎖脂肪酸脱アシル化 / スクリーニング … More / UPS / プロテアソーム / イメージングプローブ / PROTAC / ユビキチン / がん幹細胞 / ENPP1 / プロドラッグ / ワールブルグ効果 / ネクロプトーシス … More Except Principal Investigator ケミカルバイオロジー / 蛍光プローブ / 薬物動態 / 解糖系酵素 / がん代謝 / 腎細胞がん / ミトコンドリア / スーパーオキシド / 尿細管上皮細胞 / 薬剤性腎障害 / イメージング / エピジェネティクス / ニトロン / 一酸化窒素 Less

リン酸基代謝酵素を標的とした新基質・新酵素活性の網羅的創出Principal Investigator
- Principal Investigator
  
  川口充康
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Nagoya City University
がん分子標的薬による腎障害の発現機序解明：BRAF阻害剤に着目した検討
- Principal Investigator
  
  真川明将
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Nagoya City University
SIRT脱ミリストイル化活性選択的阻害剤の開発と細胞機能の光操作Principal Investigator
- Principal Investigator
  
  川口充康
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Nagoya City University
プロテアソーム分解過程可視化蛍光プローブの開発と新規プロテアソーム阻害剤の探索Principal Investigator
- Principal Investigator
  
  川口充康
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Nagoya City University
Fluorescent imaging probes for epigenetic enzymes with specialized amino acids
- Principal Investigator
  
  Nakagawa Hidehiko
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Nagoya City University
Development of molecular-targeting prodrug for ENPP1Principal Investigator
- Principal Investigator
  
  Kawaguchi Mitsuyasu
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Nagoya City University
New fluorescence NO probe adopting radical-specific reactivity
- Principal Investigator
  
  Nakagawa Hidehiko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagoya City University
Development of SIRT6 activators targeting for Warburg effectPrincipal Investigator
- Principal Investigator
  
  Kawaguchi Mitsuyasu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagoya City University
ネクロプトーシス特異的検出蛍光プローブの開発Principal Investigator
- Principal Investigator
  
  川口充康
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Drug development chemistry
- Research Institution
  Nagoya City University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation Book Patent Other

[Book] Precision Medicine2019
- Author(s)
  川口充康、中川秀彦
- Total Pages
  6
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-18K14358
[Journal Article] Photoinduced NO-release from polymer dots doped with an Ir(<scp>iii</scp>) complex and N-methyl-N-nitroso-4-aminophenol2023
- Author(s)
 Saitoh Daisuke、Suzuki Ayumi、Ieda Naoya、Liu Zuoyue、Osakada Yasuko、Fujitsuka Mamoru、Kawaguchi Mitsuyasu、Nakagawa Hidehiko
- Journal Title
 
 Organic & Biomolecular Chemistry
 
 Volume: 21 Issue: 14 Pages: 2983-2989
- DOI
 10.1039/d3ob00047h
- Peer Reviewed
- Data Source
 KAKENHI-PROJECT-22K06505, KAKENHI-PROJECT-20K05752, KAKENHI-PUBLICLY-21H00290, KAKENHI-PROJECT-19H02812, KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05259
[Journal Article] A BODIPY-picolinium-cation conjugate as a blue-light-responsive caged group2023
- Author(s)
  Ieda Naoya、Nakamura Akira、Tomita Natsumi、Ohkubo Kei、Izumi Ryo、Hotta Yuji、Kawaguchi Mitsuyasu、Kimura Kazunori、Nakagawa Hidehiko
- Journal Title
  
  RSC Advances
  
  Volume: 13 Issue: 38 Pages: 26375-26379
- DOI
  10.1039/d3ra03826b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K06505
[Journal Article] Substituent Effects at the N-Nitrosoaminophenol Moiety of a Photoinduced-Electron-Transfer-Driven Nitric Oxide Releaser2023
- Author(s)
 Ieda Naoya、Kawaguchi Mitsuyasu、Nakagawa Hidehiko
- Journal Title
 
 Chemical and Pharmaceutical Bulletin
 
 Volume: 71 Issue: 6 Pages: 447-450
- DOI
 10.1248/cpb.c23-00146
- ISSN
 0009-2363, 1347-5223
- Year and Date
 2023-06-01
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-22K06505, KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05259
[Journal Article] An Optochemical Oxygen Scavenger Enabling Spatiotemporal Control of Hypoxia2023
- Author(s)
  Ieda Naoya、Sawada Masato、Oguchi Runa、Itoh Masato、Hirakata Seina、Saitoh Daisuke、Nakao Akito、Kawaguchi Mitsuyasu、Sawamoto Kazunobu、Yoshihara Toshitada、Mori Yasuo、Nakagawa Hidehiko
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 62 Issue: 20
- DOI
  10.1002/anie.202217585
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06395, KAKENHI-PROJECT-22K06505, KAKENHI-PROJECT-20H05700, KAKENHI-PROJECT-20K05752, KAKENHI-PUBLICLY-21H00290, KAKENHI-PROJECT-21K15208, KAKENHI-ORGANIZER-21H05258, KAKENHI-PLANNED-21H05259, KAKENHI-PROJECT-23K25173
[Journal Article] Development of Sirtuin Fluorescence Probes and Medicinal Chemistry Research Targeting SIRT Family2022
- Author(s)
  Kawaguchi Mitsuyasu、Nakajima Yuya、Nakagawa Hidehiko
- Journal Title
  
  Journal of Synthetic Organic Chemistry, Japan
  
  Volume: 80 Issue: 9 Pages: 831-842
- DOI
  10.5059/yukigoseikyokaishi.80.831
- ISSN
  0037-9980, 1883-6526
- Year and Date
  2022-09-01
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-19KK0197
[Journal Article] Development of Nucleoside Diphosphate-Bearing Fragile Histidine Triad-Imaging Fluorescence Probes with Well-Tuned Hydrophobicity for Intracellular Delivery2022
- Author(s)
  Kawaguchi Mitsuyasu、Furuse Yuri、Ieda Naoya、Nakagawa Hidehiko
- Journal Title
  
  ACS Sensors
  
  Volume: 7 Issue: 9 Pages: 2732-2742
- DOI
  10.1021/acssensors.2c01273
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06505, KAKENHI-PROJECT-19KK0197, KAKENHI-ORGANIZER-21H05258, KAKENHI-PUBLICLY-21H00290
[Journal Article] Stereochemistries of mariannamides C and D, two lipohexapeptides, isolated from Mariannaea elegans NBRC1023012022
- Author(s)
  Kan’ichiro Ishiuchi, Akiho Nagumo, Mitsuyasu Kawaguchi, Honoka Furuyashiki, Hidehiko Nakagawa, Dai Hirose
- Journal Title
  
  Heterocycles
  
  Volume: 104 Issue: 10 Pages: 1822-1835
- DOI
  10.3987/com-22-14728
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07103, KAKENHI-PROJECT-22K06505, KAKENHI-PROJECT-19KK0197, KAKENHI-PUBLICLY-21H00290
[Journal Article] Ascorbate-assisted nitric oxide release from photocontrollable nitrosonium ion releasers for potent ex vivo photovasodilation2022
- Author(s)
 Ieda Naoya、Yoshikawa Yuka、Tomita Natsumi、Ohkubo Kei、Hotta Yuji、Kawaguchi Mitsuyasu、Kimura Kazunori、Nakagawa Hidehiko
- Journal Title
 
 Chemical Communications
 
 Volume: 58 Issue: 60 Pages: 8420-8423
- DOI
 10.1039/d2cc03193k
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-22K06505, KAKENHI-PROJECT-21K19576, KAKENHI-PLANNED-21H05259, KAKENHI-PROJECT-20H02779, KAKENHI-PROJECT-20K05752, KAKENHI-PROJECT-20K09583, KAKENHI-PUBLICLY-21H00290, KAKENHI-PUBLICLY-20H04819
[Journal Article] FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells2021
- Author(s)
  Maeda Keisuke、Habara Makoto、Kawaguchi Mitsuyasu、Matsumoto Hiroaki、Hanaki Shunsuke、Masaki Takahiro、Sato Yuki、Matsuyama Hideyasu、Kunieda Kazuki、Nakagawa Hidehiko、Shimada Midori
- Journal Title
  
  Molecular Oncology
  
  Volume: 16 Issue: 4 Pages: 940-956
- DOI
  10.1002/1878-0261.13030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16333, KAKENHI-PUBLICLY-21H00290, KAKENHI-PROJECT-21H02403, KAKENHI-PROJECT-20K21503
[Journal Article] Live-Cell Imaging of Sirtuin Activity Using a One-Step Fluorescence Probe2021
- Author(s)
  Mitsuyasu Kawaguchi, Hidehiko Nakagawa
- Journal Title
  
  Methods in molecular biology
  
  Volume: 2274 Pages: 155-168
- DOI
  10.1007/978-1-0716-1258-3_14
- ISBN
  9781071612576, 9781071612583
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21H00290, KAKENHI-PROJECT-19KK0197
[Journal Article] Synthesis of Fluorescent Probes Targeting Tumor-Suppressor Protein FHIT and Identification of Apoptosis-Inducing FHIT Inhibitors2021
- Author(s)
  Kawaguchi Mitsuyasu、Sekimoto Eriko、Ohta Yuhei、Ieda Naoya、Murakami Takashi、Nakagawa Hidehiko
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 64 Issue: 13 Pages: 9567-9576
- DOI
  10.1021/acs.jmedchem.1c00874
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08276, KAKENHI-PUBLICLY-21H00290
[Journal Article] A visible light-controllable Rho kinase inhibitor based on a photochromic phenylazothiazole2021
- Author(s)
  Matsuo Kazuya、Thayyil Sampreeth、Kawaguchi Mitsuyasu、Nakagawa Hidehiko、Tamaoki Nobuyuki
- Journal Title
  
  Chemical Communications
  
  Volume: 57 Issue: 93 Pages: 12500-12503
- DOI
  10.1039/d1cc04905d
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H05432, KAKENHI-PUBLICLY-21H00290, KAKENHI-PROJECT-21K19317, KAKENHI-PROJECT-19KK0181
[Journal Article] A Set of Highly Sensitive Sirtuin Fluorescence Probes for Screening Small-Molecular Sirtuin Defatty-Acylase Inhibitors2021
- Author(s)
  Yuya Nakajima, Mitsuyasu Kawaguchi, Naoya Ieda, Hidehiko Nakagawa
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 12 Issue: 4 Pages: 617-624
- DOI
  10.1021/acsmedchemlett.1c00010
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-21H00290, KAKENHI-PROJECT-19KK0197
[Journal Article] Multiplexed single-molecule enzyme activity analysis for counting disease-related proteins in biological samples2020
- Author(s)
  Shingo Sakamoto, Toru Komatsu, Rikiya Watanabe, Yi Zhang, Taiki Inoue, Mitsuyasu Kawaguchi, Hidehiko Nakagawa, Takaaki Ueno, Takuji Okusaka, Kazufumi Honda, Hiroyuki Noji, Yasuteru Urano
- Journal Title
  
  Science Advances
  
  Volume: 6 Issue: 11
- DOI
  10.1126/sciadv.aay0888
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14260, KAKENHI-PUBLICLY-18H04538, KAKENHI-PROJECT-19H02846, KAKENHI-PROJECT-18J23224, KAKENHI-PROJECT-17K19477, KAKENHI-PROJECT-18K14358, KAKENHI-PROJECT-19H05632, KAKENHI-PROJECT-19H03856, KAKENHI-PROJECT-19H05624
[Journal Article] In Cellullo and ex Vivo Availability of a Yellowish-Green-Light-Controllable NO Releaser2019
- Author(s)
 Naoya Ieda, Yuji Hotta, Mitsuyasu Kawaguchi, Kazunori Kimura, and Hidehiko Nakagawa
- Journal Title
 
 Chemical and Pharmaceutical Bulletin
 
 Volume: 67 Issue: 6 Pages: 576-579
- DOI
 10.1248/cpb.c19-00112
- NAID
 130007657414
- ISSN
 0009-2363, 1347-5223
- Year and Date
 2019-06-01
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-19H03354, KAKENHI-PROJECT-18K14358
[Journal Article] Development of a highly sensitive fluorescence probe for peptidyl arginine deiminase (PAD) activity2019
- Author(s)
  Kunieda Kazuki、Kawaguchi Mitsuyasu、Ieda Naoya、Nakagawa Hidehiko
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 29 Issue: 7 Pages: 923-928
- DOI
  10.1016/j.bmcl.2019.01.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14358
[Journal Article] Ratiometric assay of CARM1 activity using a FRET-based fluorescent probe2019
- Author(s)
  Ohta Yuhei、Wakita Hiroo、Kawaguchi Mitsuyasu、Ieda Naoya、Osada Shigehiro、Nakagawa Hidehiko
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 29 Issue: 22 Pages: 126728-126728
- DOI
  10.1016/j.bmcl.2019.126728
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14358
[Journal Article] Life-oriented Chemistry in Pharmaceutical Sciences2019
- Author(s)
  Kawaguchi M, Taniguchi A.
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 139 Issue: 2 Pages: 261-262
- DOI
  10.1248/yakushi.18-00174-F
- NAID
  130007599887
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2019-02-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14358
[Journal Article] Development of an ENPP1 Fluorescence Probe for Inhibitor Screening, Cellular Imaging, and Prognostic Assessment of Malignant Breast Cancer2019
- Author(s)
  Kawaguchi Mitsuyasu、Han Xiang、Hisada Tomoka、Nishikawa Sayaka、Kano Kuniyuki、Ieda Naoya、Aoki Junken、Toyama Tatsuya、Nakagawa Hidehiko
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 62 Issue: 20 Pages: 9254-9269
- DOI
  10.1021/acs.jmedchem.9b01213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14358
[Journal Article] Development of Peptide-Based Sirtuin Defatty-Acylase Inhibitors Identified by the Fluorescence Probe, SFP3, That Can Efficiently Measure Defatty-Acylase Activity of Sirtuin2019
- Author(s)
  Mitsuyasu Kawaguchi, Naoya Ieda, and Hidehiko Nakagawa
- Journal Title
  
  J. Med. Chem.
  
  Volume: 62 Issue: 11 Pages: 5434-5452
- DOI
  10.1021/acs.jmedchem.9b00315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19KK0197, KAKENHI-PROJECT-18K14358
[Journal Article] Structure-efficiency relationship of photoinduced electron transfer-triggered nitric oxide releasers.2019
- Author(s)
  Ieda N, Oka Y, Yoshihara T, Tobita S, Sasamori T, Kawaguchi M, Nakagawa H
- Journal Title
  
  Sci Rep
  
  Volume: 9 Issue: 1 Pages: 1430-1430
- DOI
  10.1038/s41598-018-38252-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14358, KAKENHI-PROJECT-18K14873, KAKENHI-PLANNED-26111012, KAKENHI-PROJECT-16H05103, KAKENHI-PROJECT-17H02078, KAKENHI-PROJECT-18H03509
[Journal Article] Development of a Novel Intraocular-Pressure-Lowering Therapy Targeting ATX2019
- Author(s)
  Nagano Norimichi、Honjo Megumi、Kawaguchi Mitsuyasu、Nishimasu Hiroshi、Nureki Osamu、Kano Kuniyuki、Aoki Junken、Komatsu Toru、Okabe Takayoshi、Kojima Hirotatsu、Nagano Tetsuo、Aihara Makoto
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 11 Pages: 1926-1935
- DOI
  10.1248/bpb.b19-00567
- NAID
  130007740593
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-11-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09965, KAKENHI-PROJECT-18K14358
[Journal Article] Development of a fluorescent probe for detection of citrulline based on photo-induced electron transfer2018
- Author(s)
  Kunieda Kazuki、Yamauchi Hiromasa、Kawaguchi Mitsuyasu、Ieda Naoya、Nakagawa Hidehiko
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 28 Issue: 5 Pages: 969-973
- DOI
  10.1016/j.bmcl.2018.01.026
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-26111012, KAKENHI-PROJECT-18K14358
[Journal Article] Development and cellular application of visible-light-controllable HNO releasers based on caged Piloty's acid.2018
- Author(s)
  Kawaguchi M, Tani T, Hombu R, Ieda N, Nakagawa H
- Journal Title
  
  Chem Commun
  
  Volume: 54 Issue: 73 Pages: 10371-10374
- DOI
  10.1039/c8cc04954h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K14358
[Journal Article] PlexinD1 signaling controls morphological changes and migration termination in newborn neurons2018
- Author(s)
  Sawada Masato、Ohno Nobuhiko、Kawaguchi Mitsuyasu、Huang Shih‐hui、Hikita Takao、Sakurai Youmei、Bang Nguyen Huy、Quynh Thai Truc、Ishido Yuri、Yoshida Yutaka、Nakagawa Hidehiko、Uemura Akiyoshi、Sawamoto Kazunobu
- Journal Title
  
  The EMBO Journal
  
  Volume: 37 Issue: 4
- DOI
  10.15252/embj.201797404
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05512, KAKENHI-PUBLICLY-17H05750, KAKENHI-PROJECT-17H01392, KAKENHI-PROJECT-15K10898, KAKENHI-PROJECT-18K14358, KAKENHI-PROJECT-18K14823, KAKENHI-PLANNED-26111012, KAKENHI-PROJECT-16H06280
[Journal Article] A yellowish-green-light-controllable nitric oxide donor based on N-nitrosoaminophenol applicable for photocontrolled vasolidation2017
- Author(s)
  Okuno H, Ieda N, Hotta Y, Kawaguchi M, Kimura K, Nakagawa H.
- Journal Title
  
  Org. Biomol. Chem.
  
  Volume: 15 Issue: 13 Pages: 2791-2796
- DOI
  10.1039/c7ob00245a
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-26111001, KAKENHI-PROJECT-15K18899, KAKENHI-PROJECT-16K15693, KAKENHI-PLANNED-26111012, KAKENHI-PROJECT-16H05103
[Journal Article] Visible Light-Controlled Nitric Oxide Release from Hindered Nitrobenzene Derivatives for Specific Modulation of Mitochondrial Dynamics2016
- Author(s)
  Kai Kitamura, Mitsuyasu Kawaguchi, Naoya Ieda, Naoki Miyata, and Hidehiko Nakagawa
- Journal Title
  
  ACS Chem. Biol.
  
  Volume: 11 Issue: 5 Pages: 1271-1278
- DOI
  10.1021/acschembio.5b00962
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26111012, KAKENHI-PROJECT-16H05103, KAKENHI-PROJECT-15K18899
[Journal Article] (7-Diethylaminocomarin-4-yl)methyl Ester of Suberoylanilide Hydroxamic Acid as a Caged Inhibitor for Photocontrol of Histone Deacetylase Activity2016
- Author(s)
  Naoya Ieda, Sota Yamada, Mitsuyasu Kawaguchi, Naoki Miyata, and Hidehiko Nakagawa
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 24 Issue: 12 Pages: 2789-2793
- DOI
  10.1016/j.bmc.2016.04.042
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-26111012, KAKENHI-PROJECT-16H05103, KAKENHI-PROJECT-15K18899
[Journal Article] Fluorescence Probe for Imaging Sirtuin Activity in Living Cells, Based on One-Step Cleavage of Dabcyl Quencher2016
- Author(s)
  Kawaguchi M, Ikegawa S, Ieda N, Nakagawa H.
- Journal Title
  
  ChemBioChem
  
  Volume: 17 Issue: 20 Pages: 1961-1967
- DOI
  10.1002/cbic.201600374
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-26111001, KAKENHI-PLANNED-26111012, KAKENHI-PROJECT-15K18899
[Journal Article] A double bond-conjugated dimethylnitrobenzene-type photolabile nitric oxide donor with improved two-photon cross section2015
- Author(s)
  1.N. Ieda, K. Hishikawa, K. Eto, K. Kitamura, M. Kawaguchi, T. Suzuki, K. Fukuhara, N. Miyata, T. Furuta, J. Nabekura, H. Nakagawa
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 25 Issue: 16 Pages: 3172-3175
- DOI
  10.1016/j.bmcl.2015.05.095
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460153, KAKENHI-PROJECT-15K18899, KAKENHI-PROJECT-15K21603, KAKENHI-PLANNED-26111012, KAKENHI-PUBLICLY-26115524, KAKENHI-PROJECT-25293028, KAKENHI-PROJECT-26282219
[Journal Article] Development of Photo-controllable Hydrogen Sulfide Donor Applicable in Live Cells2015
- Author(s)
  Naoki Fukushima, Naoya Ieda, Mitsuyasu Kawaguchi, Kiyoshi Sasakura, Tetsuo Nagano, Kenjiro Hanaoka, Naoki Miyata, Hidehiko Nakagawa
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 25 Issue: 2 Pages: 175-178
- DOI
  10.1016/j.bmcl.2014.11.084
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-26104509, KAKENHI-PLANNED-26111012, KAKENHI-PROJECT-26893223, KAKENHI-PROJECT-25293028
[Journal Article] Peptidyl prolyl isomerase Pin1-inhibitory activity of D-glutamic and D-aspartic acid derivatives bearing a cyclic aliphatic amine moiety2015
- Author(s)
  Nakagawa H, Seike S, Sugimoto M, Ieda N, Kawaguchi M, Suzuki T, Miyata N.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 25 Issue: 23 Pages: 5619-5624
- DOI
  10.1016/j.bmcl.2015.10.033
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K18899, KAKENHI-PLANNED-26111012
[Journal Article] Identification of tissue-restricted bio-reaction suitable for in vivo targeting by fluorescent substrate library-based enzyme discovery2015
- Author(s)
  Kentaro Yoshioka, Toru Komatsu, Akihiro Nakada, Jun Onagi, Yugo Kuriki, Mitsuyasu Kawaguchi, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Tetsuo Nagano, and Yasuteru Urano
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: 137 Issue: 38 Pages: 12187-12190
- DOI
  10.1021/jacs.5b05884
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K14937, KAKENHI-PROJECT-15K18899, KAKENHI-PUBLICLY-26104509, KAKENHI-PLANNED-26111012, KAKENHI-PROJECT-15H05371, KAKENHI-PROJECT-24689003
[Patent] 化合物、光応答性酸素消費剤2019
- Inventor(s)
  家田直弥、中川秀彦、川口充康
- Industrial Property Rights Holder
  家田直弥、中川秀彦、川口充康
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18K14358
[Patent] マイクロデバイスを用いたENPP活性検出法の開発2019
- Inventor(s)
  浦野泰照、小松徹、坂本眞伍、野地博行、中川秀彦、川口充康、他
- Industrial Property Rights Holder
  浦野泰照、小松徹、坂本眞伍、野地博行、中川秀彦、川口充康、他
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-18K14358
[Patent] ナノ粒子、水性分散液、一酸化窒素放出制御剤2019
- Inventor(s)
  家田直弥、中川秀彦、川口充康
- Industrial Property Rights Holder
  家田直弥、中川秀彦、川口充康
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18K14358
[Patent] 化合物、光応答性放出制御剤2019
- Inventor(s)
  家田直弥、中川秀彦、川口充康
- Industrial Property Rights Holder
  家田直弥、中川秀彦、川口充康
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Data Source
  KAKENHI-PROJECT-18K14358
[Presentation] 細胞膜透過型ペプチド性 SIRT2 阻害剤の開発と細胞障害性評価2022
- Author(s)
  古屋敷帆乃花、川口充康、家田直弥、中川秀彦
- Organizer
  第68回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-19KK0197
[Presentation] Sirtuin脱ミリストイル化阻害剤のスクリーニングに適用可能なケミカルプローブ群の開発2021
- Author(s)
  中嶋雄哉, 川口充康, 家田直弥, 中川秀彦
- Organizer
  第67回日本薬学会東海支部大会
- Data Source
  KAKENHI-PROJECT-19KK0197
[Presentation] Sirtuin脱脂肪酸アシル化阻害剤開発を指向した蛍光プローブ群の開発2021
- Author(s)
  中嶋雄哉、川口充康、家田直弥、中川秀彦
- Organizer
  日本ケミカルバイオロジー学会第15回年会
- Data Source
  KAKENHI-PROJECT-19KK0197
[Presentation] Sirtuin脱アシル化阻害剤のスクリーニングに適用可能なケミカルプローブ群の開発2021
- Author(s)
  中嶋雄哉、川口充康、家田直弥、中川秀彦
- Organizer
  第74回日本酸化ストレス学会第21回日本NO学会合同学術集会
- Data Source
  KAKENHI-PROJECT-19KK0197
[Presentation] SIRT2脱アシル化活性阻害剤の開発2018
- Author(s)
  川口充康、家田直弥、中川秀彦
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K14358
[Presentation] Dinitrobenzene骨格を有するCys-SSH検出蛍光プローブの開発と細胞での機能評価2018
- Author(s)
  川口充康、若森久幸、家田直弥、中川秀彦
- Organizer
  第71回日本酸化ストレス学会学術集会・第18回日本NO学会合同学術集会
- Data Source
  KAKENHI-PROJECT-18K14358
[Presentation] caspase-1活性を指標とした単一細胞パイロトーシス可視化プローブの開発2018
- Author(s)
  川口充康、山田輝、家田直弥、中川秀彦
- Organizer
  平成30年度生理学研究所研究会
- Data Source
  KAKENHI-PROJECT-18K14358
[Presentation] Dinitrobenzene骨格を基盤としたCys-SSH蛍光プローブ類の開発と生細胞での機能評価2018
- Author(s)
  川口充康、若森久幸、家田直弥、中川秀彦
- Organizer
  日本ケミカルバイオロジー学会第１３回年会
- Data Source
  KAKENHI-PROJECT-18K14358
[Presentation] Sirtuin蛍光プローブの開発と生細胞イメージング2017
- Author(s)
  川口充康、池川祥平、家田直弥、中川秀彦
- Organizer
  日本酸化ストレス学会東海支部　第５回学術集会,
- Place of Presentation
  名古屋
- Year and Date
  2017-02-18
- Data Source
  KAKENHI-PROJECT-15K18899
[Presentation] SIRT6活性検出蛍光プローブの開発とケミカルスクリーニング2017
- Author(s)
  川口充康、池川祥平、家田直弥、中川秀彦
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-15K18899
[Presentation] ニトロニルニトロキシドの化学的性質を利用したNO蛍光検出薬の開発2017
- Author(s)
  犬飼雄哉、川口充康、家田直弥、中川秀彦
- Organizer
  第70回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-16K15144
[Presentation] Development of one-step sirtuin activity fluorescence probe and living cell imaging2016
- Author(s)
  Mitsuyasu Kawaguchi, Shohei Ikegawa, Naoya Ieda, Hidehiko Nakagawa
- Organizer
  ACS National Meeting
- Place of Presentation
  Philadelphia
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18899
[Presentation] Sirtuin活性検出蛍光プローブの開発と細胞イメージング2016
- Author(s)
  川口充康、池川祥平、家田直弥、中川秀彦
- Organizer
  第１４回次世代シンポジウム
- Place of Presentation
  東京
- Year and Date
  2016-05-27
- Data Source
  KAKENHI-PROJECT-15K18899
[Presentation] Sirtuin活性検出蛍光プローブの開発と生細胞応用2016
- Author(s)
  川口充康, 池川祥平, 家田直弥, 中川秀彦
- Organizer
  日本ケミカルバイオロジー学会第11回年会
- Place of Presentation
  京都
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-15K18899
[Presentation] Sirtuin活性検出蛍光プローブの開発と生細胞応用2016
- Author(s)
  川口充康、池川祥平、家田直弥、中川秀彦
- Organizer
  ケミカルバイオロジー学会第１１回年会
- Place of Presentation
  京都
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-15K18899
[Presentation] Development of new fluorescent NO probe utilizing the reaction of nitronyl nitroxide2016
- Author(s)
  Yuya Inukai, Naoya Ieda, Mitsuyasu Kawaguchi, Hidehiko Nakagawa
- Organizer
  ACS National Meeting
- Place of Presentation
  Philadelphia
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15144
[Presentation] Development of a new photocontrollable HNO donor and cellular application2016
- Author(s)
  Takuma Tani, Mitsuyasu Kawaguchi, Naoya Ieda, Hidehiko Nakagawa
- Organizer
  ACS National Meeting
- Place of Presentation
  Philadelphia
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15144
[Presentation] Sirtuin蛍光プローブの開発と生細胞イメージングへの応用2016
- Author(s)
  川口充康, 池川祥平、家田直弥, 中川秀彦
- Organizer
  第14回がんとハイポキシア研究会
- Place of Presentation
  岐阜
- Year and Date
  2016-11-04
- Data Source
  KAKENHI-PROJECT-15K18899
[Presentation] 簡便かつ高感度なSirtuin活性蛍光検出系の構築2016
- Author(s)
  川口充康、池川祥平、家田直弥、中川秀彦
- Organizer
  日本薬学会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K18899
[Presentation] MITOCHONDRIA-TARGETING NITRIC OXIDE RELEASERS CONTROLLABLE WITH VISIBLE LIGHT AND MODULATION OF MITOCHONDRIAL DYNAMICS2016
- Author(s)
  Kai Kitamura, Mitsuyasu Kawaguchi, Naoya Ieda, Kazuhiro Hishikawa, Takayoshi Suzuki, Naoki Miyata, Hidehiko Nakagawa
- Organizer
  26th IUPAC International symposium on photochemistry
- Place of Presentation
  Osaka
- Year and Date
  2016-04-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18899
[Presentation] Sirtuin活性検出蛍光プローブの開発と細胞イメージング2016
- Author(s)
  川口充康, 池川祥平, 家田直弥, 中川秀彦
- Organizer
  第14回次世代を担う有機化学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2016-05-27
- Data Source
  KAKENHI-PROJECT-15K18899
[Presentation] SIRT6活性検出プローブの開発とmodulatorの探索2016
- Author(s)
  池川祥平, 川口充康, 家田直弥, 中川秀彦
- Organizer
  日本薬学会東海支部合同学術大会2016
- Place of Presentation
  岐阜
- Year and Date
  2016-10-30
- Data Source
  KAKENHI-PROJECT-15K18899
[]

1. IEDA Naoya (00642026)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
2. Nakagawa Hidehiko (80281674)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
3. 真川明将 (20827670)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 前田康博 (60275146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 日比陽子 (70295616)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 堀田祐志 (90637563)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. INUKAI Yuya

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
8. 羽原誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 村上孝

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 福原潔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 石内勘一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 花岡健二郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 張翼

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 澤本和延

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 澤田雅人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 松尾和哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 小松徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAWAGUCHI MITSUYASU 川口 充康

Kawaguchi Mitsuyasu 川口 充康

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リン酸基代謝酵素を標的とした新基質・新酵素活性の網羅的創出Principal Investigator

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がん分子標的薬による腎障害の発現機序解明：BRAF阻害剤に着目した検討

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SIRT脱ミリストイル化活性選択的阻害剤の開発と細胞機能の光操作Principal Investigator

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プロテアソーム分解過程可視化蛍光プローブの開発と新規プロテアソーム阻害剤の探索Principal Investigator

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Fluorescent imaging probes for epigenetic enzymes with specialized amino acids

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Development of molecular-targeting prodrug for ENPP1Principal Investigator

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New fluorescence NO probe adopting radical-specific reactivity

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Development of SIRT6 activators targeting for Warburg effectPrincipal Investigator

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ネクロプトーシス特異的検出蛍光プローブの開発Principal Investigator

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[Book] Precision Medicine2019

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[Journal Article] Photoinduced NO-release from polymer dots doped with an Ir(<scp>iii</scp>) complex and <i>N</i>-methyl-<i>N</i>-nitroso-4-aminophenol2023

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[Journal Article] A BODIPY-picolinium-cation conjugate as a blue-light-responsive caged group2023

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[Journal Article] Substituent Effects at the <i>N</i>-Nitrosoaminophenol Moiety of a Photoinduced-Electron-Transfer-Driven Nitric Oxide Releaser2023

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KAWAGUCHI MITSUYASU 川口充康

Kawaguchi Mitsuyasu 川口充康