Shiohama Tadashi 塩浜直

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SHIOHAMA Tadashi 塩浜直

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Researcher Number	10737034
Other IDs
Affiliation (Current)	2025: 千葉大学, 大学院医学研究院, 特任教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 千葉大学, 大学院医学研究院, 講師 2021 – 2022: 千葉大学, 医学部附属病院, 助教 2015 – 2018: 千葉大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 52040:Radiological sciences-related / Pediatrics / Embryonic/Neonatal medicine Except Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related / Basic Section 59040:Nutrition science and health science-related
Keywords	Principal Investigator Hedgehog経路 / 巨脳症 / 脳MRI定量解析 / microRNA / 遺伝子多型 / PI3K/AKT/ｍTOR経路 / 定量解析 / 脳MRI / バイオマーカー / PI3K/AKT/mTOR経路 … More / 髄芽腫 / PTCH1 / Gorlin症候群 / map3k1 / hedgehog signal / マイクロアレイ / 線維芽細胞 / ヘッジホッグ経路 / 脳形態 / Hedghog経路 / PI3KCA関連過成長スペクトラム / PI3K/AKT経路 / 巨脳症-毛細血管奇形症候群 … More Except Principal Investigator Gorlin症候群 / 基底細胞母斑症候群 / ヘッジホッグ / 骨密度 / 骨代謝 / ビタミンD / iPS / 天然化合物ライブラリー / 疾患iPS細胞 / 皮膚線維芽細胞 / 阻害薬 / 創薬スクリーニング / GLI1 / 髄芽腫 / 基底細胞癌 / PTCH1 / Gorlin 症候群 / ヘッジホッグシグナリング Less

Brain Morphology Regulation by Macrocephalic Disease-Related SignalingPrincipal Investigator
- Principal Investigator
  
  塩浜直
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Chiba University
母体ビタミンDエピ体による胎児発育抑制機序およびエピ体産生制御因子の解明
- Principal Investigator
  
  高谷具純
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Chiba University
Molecular mechanism of bone metabolism in Gorlin syndrome
- Principal Investigator
  
  藤井克則
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Chiba University
Exploring imaging biomarkers for prognostic prediction of macroencephalitic diseases using comprehensive brain MRI analysisPrincipal Investigator
- Principal Investigator
  
  SHIOHAMA Tadashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Chiba University
Identification of hedgehog signal inhibitors in tumors
- Principal Investigator
  
  FUJII KATSUNORI
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Chiba University
Explorative study inhibitor therapies and biomarkers targeting microRNAs for Gorlin syndromePrincipal Investigator
- Principal Investigator
  
  SHIOHAMA TADASHI
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pediatrics
- Research Institution
  Chiba University
Transcriptomics profiling in megalencephaly capillary malformation with impaired PI3K/AKT signalingPrincipal Investigator
- Principal Investigator
  
  SHIOHAMA Tadashi
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Chiba University

All 2023 2022 2021 2017 2016

All Journal Article Presentation

[Journal Article] Brain structure alterations in girls with central precocious puberty2023
- Author(s)
  Yoshii Shoko、Takatani Tomozumi、Shiohama Tadashi、Takatani Rieko、Konda Yutaka、Hattori Shinya、Yokota Hajime、Hamada Hiromichi
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 17 Pages: 1215492-1215492
- DOI
  10.3389/fnins.2023.1215492
- Data Source
  KAKENHI-PROJECT-21K07694
[Journal Article] A Brain Morphometry Study with Across-Site Harmonization Using a ComBat-Generalized Additive Model in Children and Adolescents2023
- Author(s)
  Shiohama T, Maikusa N, Kawaguchi M, Natsume J, Hirano Y, Saito K, Takanashi J, Levman J, Takahashi E, Matsumoto K, Yokota H, Hattori S, Tsujimura K, Sawada D, Uchida T, Takatani T, Fujii K, Naganawa S, Sato N, Hamada H.
- Journal Title
  
  Diagnostics
  
  Volume: 13 Issue: 17 Pages: 2774-2774
- DOI
  10.3390/diagnostics13172774
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K03309, KAKENHI-PROJECT-21K07694, KAKENHI-PROJECT-20K16691
[Journal Article] microRNA Biology on Brain Development and Neuroimaging Approach2022
- Author(s)
  Tsujimura Keita、Shiohama Tadashi、Takahashi Emi
- Journal Title
  
  Brain Sciences
  
  Volume: 12 Issue: 10 Pages: 1366-1366
- DOI
  10.3390/brainsci12101366
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07694
[Journal Article] Subtle infantile spasms presenting as hyperirritability in <scp>CK</scp> syndrome2022
- Author(s)
  Hagiwara Sho、Shiohama Tadashi、Ogi Tomoo、Ichikawa Tomohiko、Hamada Hiromichi
- Journal Title
  
  Pediatrics International
  
  Volume: 64 Issue: 1
- DOI
  10.1111/ped.15335
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07694
[Journal Article] Identification of association fibers using ex vivo diffusion tractography in Alexander disease brains2022
- Author(s)
  Shiohama Tadashi、Stewart Natalie、Nangaku Masahito、van der Kouwe Andre J. W.、Takahashi Emi
- Journal Title
  
  Journal of Neuroimaging
  
  Volume: 32 Issue: 5 Pages: 866-874
- DOI
  10.1111/jon.13040
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07694
[Journal Article] Quantitative Structural Brain Magnetic Resonance Imaging Analyses: Methodological Overview and Application to Rett Syndrome2022
- Author(s)
  Tadashi Shiohama, Keita Tsujimura
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 16 Pages: 835964-835964
- DOI
  10.3389/fnins.2022.835964
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07694
[Journal Article] 日本小児神経学会推薦総説　脳MRI定量解析の臨床応用への展望2021
- Author(s)
  塩浜　直
- Journal Title
  
  日本小児科学会雑誌
  
  Volume: 125 Pages: 1644-1654
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K07694
[Journal Article] Brain morphology in children with nevoid basal cell carcinoma syndrome.2017
- Author(s)
  Shiohama, T., Fuji, K., Miyashita, T., Mizuochi, H., Uchikawa, H., Shimojo, N.
- Journal Title
  
  American Journal of Medical Genetics A
  
  Volume: 173 Issue: 4 Pages: 946-952
- DOI
  10.1002/ajmg.a.38115
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26461530, KAKENHI-PROJECT-15K20911, KAKENHI-PROJECT-16K09960, KAKENHI-PROJECT-17K10061
[Presentation] 小児脳における脳局所容量と左右差の検討2023
- Author(s)
  塩浜直, 舞草伯秀, 川口将宏, 夏目淳, 平野好幸, 齋藤慶斗, 髙梨潤一, Jacob Levman, 高橋恵美,松本浩史, 服部真也, 横田元, 辻村啓太, 澤田大輔, 内田智子, 高谷具純, 藤井克則, 長縄伸二, 佐藤典子, 濱田洋通.
- Organizer
  第17回小児神経放射線研究会
- Data Source
  KAKENHI-PROJECT-21K07694
[Presentation] Across-site harmonization of brain morphometry in children and adolescents2023
- Author(s)
  Shiohama T, Maikusa N, Kawaguchi M,et al.
- Organizer
  The 18th congress of Asian Society for Pediatric Research
- Data Source
  KAKENHI-PROJECT-21K07694
[Presentation] MRI 機種間補正が可能な小児脳容量の基準値の創出2023
- Author(s)
  塩浜直, 舞草伯秀, 川口将宏, 夏目淳, 平野好幸, 齋藤慶斗, 髙梨潤一, Levman Jacob, 高橋恵美, 松本浩史, 服部真也, 横田元, 辻村啓太, 澤田大輔, 内田智子, 高谷具純, 佐藤典子, 濱田洋通.
- Organizer
  第126回小児科学会
- Data Source
  KAKENHI-PROJECT-21K07694
[Presentation] シンポジウム16神経放射線医学の最先端と小児. 小児科領域における脳MRI定量解析の臨床応用2023
- Author(s)
  塩浜　直
- Organizer
  第65 回日本小児神経学会
- Data Source
  KAKENHI-PROJECT-21K07694
[Presentation] 小児脳MRI の基準値創出を目指した取り組み2022
- Author(s)
  塩浜　直、内田智子、澤田大輔、吉井祥子、萩原翔、齋藤千尋、岩瀬由紀子、濱田洋通
- Organizer
  第33回千葉県小児神経懇話会
- Data Source
  KAKENHI-PROJECT-21K07694
[Presentation] 脳MRI定量解析を用いた自閉スペクトラム症児の発症予測2022
- Author(s)
  塩浜直, Ortug A, Alatorre WJ L, Valli B, Levman J, Faja SK., 辻村啓太, Maunakae AK, 高橋恵美
- Organizer
  第125回日本小児科学会学術集会
- Data Source
  KAKENHI-PROJECT-21K07694
[Presentation] Alexander病患者の剖検脳のおける連合線維の同定2022
- Author(s)
  塩浜直, Natalie Stewart, 南学正仁, Andre J.W. van der Kouwe, 高橋恵美.
- Organizer
  第16回小児神経放射線研究会
- Data Source
  KAKENHI-PROJECT-21K07694
[Presentation] 脳MRI画像を用いた自閉スペクトラム症の早期診断の試み2022
- Author(s)
  塩浜　直
- Organizer
  第32回千葉県小児神経懇話会
- Data Source
  KAKENHI-PROJECT-21K07694
[Presentation] 多彩な合併症を有する児の在宅移行：巨脳症・毛細血管奇形症候群の乳児例での実践例（2021年9月12日）2021
- Author(s)
  塩浜　直
- Organizer
  第220回日本小児科学会千葉地方会
- Data Source
  KAKENHI-PROJECT-21K07694
[Presentation] 脳MRI定量解析から診る小児神経疾患－Next Generation Brain Phenotypingをめざしてー（2021年6月13日）2021
- Author(s)
  塩浜　直
- Organizer
  第219回日本小児科学会千葉地方会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07694
[Presentation] miR-196a-5p down-regulation in fibroblasts derived from Gorlin syndrome patients2017
- Author(s)
  Tadashi Shiohama, Katsunori Fujii, Tomoko Uchida, Tomozumi Takatani, Toshiyuki Miyashita, Hajime Ikehara, Naoki Shimojo
- Organizer
  第62回人類遺伝学会総会
- Data Source
  KAKENHI-PROJECT-17K16241
[Presentation] MicroRNA analysis in dermal fibroblasts derived from Gorlin syndrome patients2017
- Author(s)
  Tadashi Shiohama, Katsunori Fujii, Tomozumi Takatani, Toshiyuki Miyashita, Hajime Ikehara, Mayuko Fujita, Tomoyuki Fukuhara, Naoki Shimojo
- Organizer
  第59回日本小児神経学会総会
- Data Source
  KAKENHI-PROJECT-17K16241
[Presentation] Gorlin症候群における脳形態解析－ヘッジホッグシグナルのヒト脳への影響－2016
- Author(s)
  塩浜　直
- Organizer
  第58回日本小児神経学会学術集会
- Place of Presentation
  京王プラザ新宿（新宿区，東京都）
- Year and Date
  2016-06-03
- Data Source
  KAKENHI-PROJECT-15K20911
[Presentation] Brain morphology in children with Gorlin syndrome2016
- Author(s)
  Tadashi Shiohama
- Organizer
  45th Annual Child Neurology Society Meeting
- Place of Presentation
  Vancouver, BC, Canada
- Year and Date
  2016-10-26
- Data Source
  KAKENHI-PROJECT-15K20911
[Presentation] Brain morphologyin children withnevoid basal cellcarcinoma syndrome2016
- Author(s)
  Tadashi Shiohama
- Organizer
  13th International Congress of Human Genetics
- Place of Presentation
  国立京都国際会館（京都市，京都府）
- Year and Date
  2016-04-03
- Data Source
  KAKENHI-PROJECT-15K20911

1. FUJII KATSUNORI (70344992)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 横田元 (20649280)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. 松本浩史 (60745230)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 高梨潤一 (00302555)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 舞草伯秀 (80631069)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. 宮下俊之 (60174182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 鎌谷洋一郎 (00720880)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 山本緑 (90597121)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 高谷具純 (10608821)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 櫻井健一 (80323434)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 長尾和右 (60392487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 平野好幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shiohama Tadashi 塩浜 直

SHIOHAMA Tadashi 塩浜 直

Research Projects

Research Products

Co-Researchers

Brain Morphology Regulation by Macrocephalic Disease-Related SignalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

母体ビタミンDエピ体による胎児発育抑制機序およびエピ体産生制御因子の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of bone metabolism in Gorlin syndrome

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring imaging biomarkers for prognostic prediction of macroencephalitic diseases using comprehensive brain MRI analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of hedgehog signal inhibitors in tumors

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Explorative study inhibitor therapies and biomarkers targeting microRNAs for Gorlin syndromePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Transcriptomics profiling in megalencephaly capillary malformation with impaired PI3K/AKT signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Brain structure alterations in girls with central precocious puberty2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Brain Morphometry Study with Across-Site Harmonization Using a ComBat-Generalized Additive Model in Children and Adolescents2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] microRNA Biology on Brain Development and Neuroimaging Approach2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Subtle infantile spasms presenting as hyperirritability in <scp>CK</scp> syndrome2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of association fibers using ex vivo diffusion tractography in Alexander disease brains2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Quantitative Structural Brain Magnetic Resonance Imaging Analyses: Methodological Overview and Application to Rett Syndrome2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 日本小児神経学会推薦総説 脳MRI定量解析の臨床応用への展望2021

Author(s)

Journal Title

Shiohama Tadashi 塩浜直

SHIOHAMA Tadashi 塩浜直

[Journal Article] 日本小児神経学会推薦総説　脳MRI定量解析の臨床応用への展望2021