Sakamoto Akihiko 坂本明彦

Researcher Number	10737290
Other IDs
Affiliation (based on the past Project Information) *help	2024: 千葉科学大学, 薬学部, 助教 2023: 星薬科大学, 薬学部, 助教 2019 – 2022: 千葉科学大学, 薬学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Keywords	Principal Investigator 翻訳 / ポリアミン / 遺伝子発現 / ヒストン修飾 / ヒストン脱メチル化酵素 / ヒストンメ脱メチル化酵素 / ヒストンアセチル化酵素

細胞増殖促進因子ポリアミンによるRNA修飾酵素発現制御機構の解析Principal Investigator
- Principal Investigator
  
  坂本明彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Chiba Institute of Science
Regulation of gene expression through translational stimulation of histone modifying enzymes by polyaminesPrincipal Investigator
- Principal Investigator
  
  Sakamoto Akihiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Hoshi University
  Chiba Institute of Science
Identification of translational regulators of histone acetyltransferasesPrincipal Investigator
- Principal Investigator
  
  Sakamoto Akihiko
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Chiba Institute of Science

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Caldomycin, a new guanidopolyamine produced by a novel agmatine homocoupling enzyme involved in homospermidine biosynthesis2024
- Author(s)
  Kobayashi Teruyuki、Sakamoto Akihiko、Hisano Tamao、Kashiwagi Keiko、Igarashi Kazuei、Takao Koichi、Uemura Takeshi、Furuchi Takemitsu、Sugita Yoshiaki、Moriya Toshiyuki、Oshima Tairo、Terui Yusuke
- Journal Title
  
  Scientific Reports
  
  Volume: 14 Issue: 1 Pages: 7566-7566
- DOI
  10.1038/s41598-024-58296-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06714, KAKENHI-PROJECT-21K15258
[Journal Article] Transient Receptor Potential Ankyrin 1 (TRPA1) Channel Mediates Acrolein Cytotoxicity in Human Lung Cancer Cells2023
- Author(s)
  Sakamoto Akihiko、Terui Yusuke、Igarashi Kazuei、Kashiwagi Keiko
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 14 Pages: 11847-11847
- DOI
  10.3390/ijms241411847
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06714, KAKENHI-PROJECT-21K15258
[Journal Article] Urinary Amino Acid-Conjugated Acrolein and Taurine as New Biomarkers for Detection of Dementia2023
- Author(s)
  Yoshida Madoka、Uemura Takeshi、Mizoi Mutsumi、Waragai Masaaki、Sakamoto Akihiko、Terui Yusuke、Kashiwagi Keiko、Igarashi Kazuei
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 92 Issue: 1 Pages: 361-369
- DOI
  10.3233/jad-220912
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06714, KAKENHI-PROJECT-21K15258
[Journal Article] A search for acrolein scavengers among food components2023
- Author(s)
  Uemura Takeshi、Uchida Masashi、Nakamura Mizuho、Shimekake Momo、Sakamoto Akihiko、Terui Yusuke、Higashi Kyohei、Ishii Itsuko、Kashiwagi Keiko、Igarashi Kazuei
- Journal Title
  
  Amino Acids
  
  Volume: - Issue: 4 Pages: 509-518
- DOI
  10.1007/s00726-023-03248-7
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06714, KAKENHI-PROJECT-21K15258
[Journal Article] Putrescine Biosynthesis from Agmatine by Arginase (TtARG) in <i>Thermus thermophilus</i>2023
- Author(s)
  Kobayashi Teruyuki、Sakamoto Akihiko、Kashiwagi Keiko、Igarashi Kazuei、Takao Koichi、Uemura Takeshi、Moriya Toshiyuki、Oshima Tairo、Terui Yusuke
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 174 Issue: 1 Pages: 81-88
- DOI
  10.1093/jb/mvad026
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06714, KAKENHI-PROJECT-21K15258
[Journal Article] Alkaline Stress Causes Changes in Polyamine Biosynthesis in Thermus thermophilus2022
- Author(s)
  Kobayashi Teruyuki、Sakamoto Akihiko、Kashiwagi Keiko、Igarashi Kazuei、Moriya Toshiyuki、Oshima Tairo、Terui Yusuke
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 21 Pages: 13523-13523
- DOI
  10.3390/ijms232113523
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06714, KAKENHI-PROJECT-21K15258
[Journal Article] Polyamines produced by an extreme thermophile are essential for cell growth at high temperature2022
- Author(s)
  Sakamoto Akihiko、Tamakoshi Masatada、Moriya Toshiyuki、Oshima Tairo、Takao Koichi、Sugita Yoshiaki、Furuchi Takemitsu、Niitsu Masaru、Uemura Takeshi、Igarashi Kazuei、Kashiwagi Keiko、Terui Yusuke
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 172 Issue: 2 Pages: 109-115
- DOI
  10.1093/jb/mvac048
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06714, KAKENHI-PROJECT-21K15258
[Journal Article] Translational Regulation of Clock Genes BMAL1 and REV-ERBα by Polyamines2021
- Author(s)
  Sakamoto A, Terui Y, Uemura T, Igarashi K, Kashiwagi K.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 22(3) Issue: 3 Pages: 1307-1307
- DOI
  10.3390/ijms22031307
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16357, KAKENHI-PROJECT-21K06714, KAKENHI-PROJECT-21K15258
[Journal Article] Cytotoxic Mechanism of Excess Polyamines Functions through Translational Repression of Specific Proteins Encoded by Polyamine Modulon.2020
- Author(s)
  Sakamoto A, Sahara J, Kawai G, Yamamoto K, Ishihama A, Uemura T, Igarashi K, Kashiwagi K, Terui Y.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 21 Issue: 7 Pages: 2406-2406
- DOI
  10.3390/ijms21072406
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16357, KAKENHI-PROJECT-20K05795
[Journal Article] 細胞増殖因子ポリアミンによるヒストンアセチル化酵素の翻訳促進2020
- Author(s)
  坂本明彦
- Journal Title
  
  月刊　細胞
  
  Volume: 52(9) Pages: 24-26
- NAID
  40022799111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16357
[Journal Article] Development of an ELISA for Measurement of Urinary 3-Hydroxypropyl Mercapturic Acid (3-HPMA), the Marker of Stroke2020
- Author(s)
  Sakamoto A, Uemura T, Terui Y, Yoshida M, Fukuda K, Nakamura T, Kashiwagi K, Igarashi K.
- Journal Title
  
  Med Sci (Basel).
  
  Volume: 8(3) Issue: 3 Pages: 33-33
- DOI
  10.3390/medsci8030033
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16357
[Journal Article] Polyamines regulate gene expression by stimulating translation of histone acetyltransferase mRNAs2020
- Author(s)
  Sakamoto A, Terui Y, Uemura T, Igarashi K, Kashiwagi K.
- Journal Title
  
  J Biol Chem.
  
  Volume: 295(26) Issue: 26 Pages: 8736-8745
- DOI
  10.1074/jbc.ra120.013833
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16357
[Journal Article] Structural change and degradation of cytoskeleton due to the acrolein conjugation with vimentin and actin during brain infarction2020
- Author(s)
  Uemura T, Suzuki T, Ko K, Nakamura M, Dohmae N, Sakamoto A, Terui Y, Toida T, Kashiwagi K, Igarashi K.
- Journal Title
  
  Cytoskeleton (Hoboken)
  
  Volume: 77(10) Issue: 10 Pages: 414-421
- DOI
  10.1002/cm.21638
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16357
[Journal Article] Inhibition of dendritic spine extension through acrolein conjugation with α-, β-tubulin proteins.2019
- Author(s)
  Uemura T, Suzuki T, Ko K, Watanabe K, Dohmae N, Sakamoto A, Terui Y, Toida T, Kashiwagi K, Igarashi K.
- Journal Title
  
  Int J Biochem Cell Biol.
  
  Volume: 113 Pages: 58-66
- DOI
  10.1016/j.biocel.2019.05.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16357
[Presentation] 認知症疾患における尿中アミノ酸抱合アクロレインとタウリン量の低下2023
- Author(s)
  吉田円，植村武史，溝井睦美，藁谷正明，坂本明彦，照井祐介，柏木敬子，五十嵐一衛
- Organizer
  日本ポリアミン学会第13年会
- Data Source
  KAKENHI-PROJECT-21K15258
[Presentation] Thermus thermophilus のホモスペルミジン生合成に関与する新規アグマチンホモカップリング酵素の同定2023
- Author(s)
  小林照幸、坂本明彦、久野玉雄、柏木敬子、五十嵐一衛、高尾浩一、植村武史、古地壯光、杉田義昭、森屋利幸、大島泰郎、照井祐介
- Organizer
  日本ポリアミン学会第14回年会
- Data Source
  KAKENHI-PROJECT-21K15258
[Presentation] Thermus thermophilusのプトレッシン生合成経路2023
- Author(s)
  小林照幸，坂本明彦, 柏木敬子,五十嵐一衛, 高尾浩一, 植村武史, 森屋利幸, 大島泰郎, 照井祐介
- Organizer
  日本ポリアミン学会第13年会
- Data Source
  KAKENHI-PROJECT-21K15258
[Presentation] ポリアミンによるヒストン脱メチル化酵素の合成促進2023
- Author(s)
  坂本明彦, 照井祐介, 五十嵐一衛, 柏木敬子
- Organizer
  日本ポリアミン学会第13年会
- Data Source
  KAKENHI-PROJECT-21K15258
[Presentation] Regulation of gene expression through translational stimulation of histone modifying enzymes by polyamines.2022
- Author(s)
  Kashiwagi, K., Sakamoto, A., Terui, Y., Igarashi, K.
- Organizer
  6th International Conference on Polyamines: Biochemical, Physiological and Clinical Perspectives
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15258
[Presentation] Molecular mechanisms of cell and tissue toxicity caused by acrolein2022
- Author(s)
  Igarashi, K., Uemura, T., Sakamoto, A., Terui, Y., Kashiwagi, K.
- Organizer
  6th International Conference on Polyamines: Biochemical, Physiological and Clinical Perspectives
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15258
[Presentation] アクロレイン毒性を指標とした脳梗塞予防効果を持つ食品成分の同定2021
- Author(s)
  植村武史, 中村瑞穂, 坂本明彦, 照井祐介, 柏木敬子, 五十嵐一衛
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-19K16357
[Presentation] ポリアミンによる翻訳促進に基づく遺伝子発現調節2021
- Author(s)
  柏木敬子, 坂本明彦, 照井祐介, 植村武史, 五十嵐一衛
- Organizer
  第94回年会日本生化学会大会
- Data Source
  KAKENHI-PROJECT-21K15258
[Presentation] ポリアミンは時計遺伝子を翻訳レベルで発現制御する2021
- Author(s)
  坂本明彦, 照井祐介, 植村武史, 五十嵐一衛, 柏木敬子
- Organizer
  日本薬学会　第141年会
- Data Source
  KAKENHI-PROJECT-19K16357
[Presentation] ポリアミンによる時計遺伝子Bmal1の合成促進機構解明2020
- Author(s)
  岩崎倖千、坂本明彦、照井祐介、五十嵐一衛、柏木敬子
- Organizer
  日本ポリアミン学会　第11回年会
- Data Source
  KAKENHI-PROJECT-19K16357
[Presentation] ポリアミンはヒストンアセチル化を促進して遺伝子発現を制御する2020
- Author(s)
  坂本明彦, 照井祐介, 植村武史, 五十嵐一衛, 柏木敬子
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K16357
[Presentation] 尿中アクロレイン代謝物3-HPMA測定法の開発2020
- Author(s)
  坂本明彦、植村武史、照井祐介、柏木敬子、五十嵐一衛
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K16357
[Presentation] Polyamines enhance synthesis of the circadian regulator Bmal1 at translational level2019
- Author(s)
  Akihiko Sakamoto, Sachi Iwasaki, Yusuke Terui, Takeshi Uemura, Kazuei Igarashi, Keiko Kashiwagi
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16357
[Presentation] Inhibition of cell growth and viability by excess polyamines through translational repression of specific proteins encoded by members of polyamine modulon in Escherichia coli2019
- Author(s)
  Yusuke Terui, Akihiko Sakamoto, Junpei Sahara, Gota Kawai, Takeshi Uemura, Kazuei Igarashi, Keiko Kashiwagi
- Organizer
  Gordon Research Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16357
[Presentation] 細胞増殖因子スペルミジンの過剰蓄積が起こす細胞毒性の機序解析2019
- Author(s)
  岩崎倖千、坂本明彦、佐原潤平、河合剛太、山本兼由、石浜明、植村武史、五十嵐一衛、柏木敬子、照井祐介
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16357

1. 柏木敬子

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
2. 五十嵐一衛

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results

Sakamoto Akihiko 坂本 明彦

Research Projects

Research Products

Co-Researchers

細胞増殖促進因子ポリアミンによるRNA修飾酵素発現制御機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of gene expression through translational stimulation of histone modifying enzymes by polyaminesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of translational regulators of histone acetyltransferasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Caldomycin, a new guanidopolyamine produced by a novel agmatine homocoupling enzyme involved in homospermidine biosynthesis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transient Receptor Potential Ankyrin 1 (TRPA1) Channel Mediates Acrolein Cytotoxicity in Human Lung Cancer Cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Urinary Amino Acid-Conjugated Acrolein and Taurine as New Biomarkers for Detection of Dementia2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A search for acrolein scavengers among food components2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Putrescine Biosynthesis from Agmatine by Arginase (TtARG) in <i>Thermus thermophilus</i>2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Alkaline Stress Causes Changes in Polyamine Biosynthesis in Thermus thermophilus2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Polyamines produced by an extreme thermophile are essential for cell growth at high temperature2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Translational Regulation of Clock Genes BMAL1 and REV-ERBα by Polyamines2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cytotoxic Mechanism of Excess Polyamines Functions through Translational Repression of Specific Proteins Encoded by Polyamine Modulon.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 細胞増殖因子ポリアミンによるヒストンアセチル化酵素の翻訳促進2020

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Development of an ELISA for Measurement of Urinary 3-Hydroxypropyl Mercapturic Acid (3-HPMA), the Marker of Stroke2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Polyamines regulate gene expression by stimulating translation of histone acetyltransferase mRNAs2020

Author(s)

Journal Title

Sakamoto Akihiko 坂本明彦

[Presentation] Thermus thermophilus のホモスペルミジン生合成に関与する新規アグマチンホモカップリング酵素の同定2023