Sassa Akira 佐々彰

… Alternative Names

佐々彰サッサアキラ

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Researcher Number	10738347
Other IDs
Affiliation (Current)	2022: 千葉大学, 大学院理学研究院, 助教
Affiliation (based on the past Project Information) *help	2022: 千葉大学, 大学院理学研究院, 特任助教 2017 – 2020: 千葉大学, 大学院理学研究院, 特任助教 2016: 千葉大学, 大学院理学研究科, 特任助教 2016: 千葉大学, 理学(系)研究科(研究院), 助教 2015: 国立医薬品食品衛生研究所, 変異遺伝部, 研究助手
Review Section/Research Field	Principal Investigator Basic Section 63030:Chemical substance influence on environment-related / Risk sciences of radiation and chemicals Except Principal Investigator Risk sciences of radiation and chemicals
Keywords	Principal Investigator DNA修復 / ゲノム不安定性 / DNA損傷 / リボヌクレオチド / 突然変異 / ゲノム / 損傷乗り越えDNA合成 / 酵素 / 遺伝子 / 核酸 / 自然免疫 / エピジェネティクス … More Except Principal Investigator … More DNA付加体 / DNA損傷 / 二本鎖切断 / 遺伝子変異 / １分子 / 遺伝子破壊 / トキシコロジー / 遺伝子座特異的 / 遺伝学 / 環境 / 遺伝毒性 / 遺伝子ターゲティング / ゲノム Less

DNA損傷が自然免疫を惹起する多階層の分子機構の解明Principal Investigator
- Principal Investigator
  
  佐々彰
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Chiba University
リボヌクレオチドが引き起こす重篤なゲノム不安定化の分子機構Principal Investigator
- Principal Investigator
  
  佐々彰
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Chiba University
Genome instability induced by high-energy phosphate compoundsPrincipal Investigator
- Principal Investigator
  
  Sassa Akira
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Chiba University
Site-specific gene mutagenesis involving a single DNA adduct in vivo
- Principal Investigator
  
  Manabu Yasui
- Project Period (FY)
  2013 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  National Institute of Health Sciences

All 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells2021
- Author(s)
  Suzuki Tetsuya、Sassa Akira、Gruz Petr、Gupta Ramesh C.、Johnson Francis、Adachi Noritaka、Nohmi Takehiko
- Journal Title
  
  DNA Repair (Amst)
  
  Volume: 100 Pages: 103052-103052
- DOI
  10.1016/j.dnarep.2021.103052
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12339, KAKENHI-PROJECT-19H01151
[Journal Article] Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide2021
- Author(s)
  Jamsen Joonas A.、Sassa Akira、Shock David D.、Beard William A.、Wilson Samuel H.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Pages: 2059-2059
- DOI
  10.1038/s41467-021-21354-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12339
[Journal Article] Understanding the sequence and structural context effects in oxidative DNA damage repair2020
- Author(s)
  Sassa Akira、Odagiri Mizuki
- Journal Title
  
  DNA Repair
  
  Volume: 93 Pages: 102906-102906
- DOI
  10.1016/j.dnarep.2020.102906
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K12339
[Journal Article] Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide embedded into DNA in human cells.2020
- Author(s)
  Takeishi Ayuna、Kogashi Hiroyuki、Odagiri Mizuki、Sasanuma Hiroyuki、Takeda Shunichi、Yasui Manabu、Honma Masamitsu、Suzuki Tetsuya、Kamiya Hiroyuki、Sugasawa Kaoru、Ura Kiyoe、Sassa Akira
- Journal Title
  
  PLoS One
  
  Volume: 15 Pages: 0244790-0244790
- DOI
  10.1371/journal.pone.0244790
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12339, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-19K22561
[Journal Article] Processing of a single ribonucleotide embedded into DNA by human nucleotide excision repair and DNA polymerase eta2019
- Author(s)
  Sassa Akira、Tada Haruto、Takeishi Ayuna、Harada Kaho、Suzuki Megumi、Tsuda Masataka、Sasanuma Hiroyuki、Takeda Shunichi、Sugasawa Kaoru、Yasui Manabu、Honma Masamitsu、Ura Kiyoe
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Pages: 13910-13910
- DOI
  10.1038/s41598-019-50421-8
- NAID
  120006898174
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12339, KAKENHI-PROJECT-16H06307, KAKENHI-PROJECT-19H04267, KAKENHI-PROJECT-19J10397, KAKENHI-PROJECT-16K16195
[Journal Article] Comparative study of cytotoxic effects induced by environmental genotoxins using XPC- and CSB-deficient human lymphoblastoid TK6 cells.2019
- Author(s)
  Sassa Akira、Fukuda Takayuki、Ukai Akiko、Nakamura Maki、Takabe Michihito、Takamura-Enya Takeji、Honma Masamitsu、Yasui Manabu
- Journal Title
  
  Genes Environ.
  
  Volume: 41 Pages: 15-15
- DOI
  10.1186/s41021-019-0130-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K12339, KAKENHI-PROJECT-19K12344, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-16K16195
[Journal Article] Current perspectives on mechanisms of ribonucleotide incorporation and processing in mammalian DNA.2019
- Author(s)
  Sassa Akira、Yasui Manabu、Honma Masamitsu
- Journal Title
  
  Genes Environ.
  
  Volume: 41 Pages: 3-3
- DOI
  10.1186/s41021-019-0118-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16195, KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-25281022
[Journal Article] Challenges of young scientists at the cutting-edge of genotoxicity research: the open symposium of the Japanese Environmental Mutagen Society (JEMS), 20182018
- Author(s)
  Yasui Manabu、Muto Shigeharu、Sassa Akira
- Journal Title
  
  Genes and Environment
  
  Volume: 40 Pages: 22-22
- DOI
  10.1186/s41021-018-0111-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16195
[Journal Article] DNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis.2017
- Author(s)
  Y. Kanemaru, T. Suzuki, A. Sassa, K. Matsumoto, N. Adachi, M. Honma, S. Numazawa and T. Nohmi
- Journal Title
  
  Genes Environ
  
  Volume: 39 Pages: 6-6
- DOI
  10.1186/s41021-016-0067-3
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26281029, KAKENHI-PROJECT-15K07973, KAKENHI-PROJECT-16K16195
[Journal Article] Impact of Ribonucleotide Backbone on Translesion Synthesis and Repair of 7,8-Dihydro-8-oxoguanine2016
- Author(s)
  Sassa A, Caglayan M, Rodriguez Y, Beard WA, Wilson SH, Nohmi T, Honma M, Yasui M
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 291 Pages: 24314-24323
- DOI
  10.1074/jbc.m116.738732
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06306, KAKENHI-PROJECT-25281022, KAKENHI-PROJECT-16K16195
[Journal Article] Mutagenic consequences of cytosine alterations site-specifically embedded in the human genome2016
- Author(s)
  Sassa A, Kanemaru Y, Kamoshita N, Honma M, Yasui M.
- Journal Title
  
  Gens and Environment
  
  Volume: 38 Pages: 17-17
- DOI
  10.1186/s41021-016-0045-9
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25281022, KAKENHI-PROJECT-25340044, KAKENHI-PROJECT-16K16195
[Journal Article] Xeroderma Pigmentosum Group A Suppresses Mutagenesis Caused by Clustered Oxidative DNA Adducts in the Human Genome.2015
- Author(s)
  Sassa A, Kamoshita N, Kanemaru Y, Honma M, Yasui M
- Journal Title
  
  PLoS ONE
  
  Volume: 10
- DOI
  10.1371/journal.pone.0142218
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25340044, KAKENHI-PROJECT-25281022
[Journal Article] In vivo evidence that phenylalanine l7l acts as a molecular brake for translesion DNA synthesis across benzo[a]pyrene DNA adducts by human DNA polymerase kappa2014
- Author(s)
  A. Sassa, T. Suzuki, Y. Kanemaru, N. Niimi, H. Fujimoto, A. Katafuchi, P. Gruz, M. Yasui, R.C. Gupta, F. Johnson, T. Ohta, M. Honma, N. Adachi and T. Nohmi
- Journal Title
  
  DNA Repair (Amst)
  
  Volume: 15 Pages: 21-28
- DOI
  10.1016/j.dnarep.2013.12.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22241016, KAKENHI-PROJECT-24659035, KAKENHI-PROJECT-25281022, KAKENHI-PROJECT-25340044
[Presentation] 化学物質が引き起こすエピゲノム変化を定量的に評価可能な "epi-TK試験" の構築2020
- Author(s)
  小田切瑞基, 安井学, 本田大士, 浦聖恵, 佐々彰
- Organizer
  日本環境変異原学会第49回大会
- Data Source
  KAKENHI-PROJECT-19K12339
[Presentation] Tyrosyl-DNA phosphodiesterasesはDNA中のリボヌクレオチドを起因とする突然変異形成に関与する2020
- Author(s)
  竹石歩奈, 古樫浩之, 安井学, 笹沼博之, 武田俊一, 菅澤薫, 本間正充, 浦聖恵, 佐々彰
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K12339
[Presentation] 転写活性領域におけるDNA二本鎖切断修復経路の選択に果たすヒストンメチル化酵素NSD2の役割2020
- Author(s)
  小林春花, 東條あかり, 佐々彰, 安井学, 本間正充, 浦聖恵
- Organizer
  第43回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K12339
[Presentation] DNA修復障害疾患で引き起こされる多次元のゲノム不安定化2020
- Author(s)
  佐々彰, 竹石歩奈, 高藤賢, 黛結衣子, 中谷一真, 小田切瑞基, 浦聖恵
- Organizer
  第5回千葉大学グローバルプロミネント研究基幹シンポジウム
- Data Source
  KAKENHI-PROJECT-19K12339
[Presentation] 多次元に及ぶゲノム不安定性の分子機構解明に向けて2020
- Author(s)
  佐々彰
- Organizer
  日本環境変異原学会第49回大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K12339
[Presentation] FTO's roles in DNA damage response and underlying mechanism2019
- Author(s)
  Weiying LIU, Manabu YASUI, Akira SASSA, Yiyi CAO, Jing XI, Xinyue YOU, Masamitsu HONMA, Yang LUAN
- Organizer
  The Joint Meeting of The 6th Asian Congress on Environmental Mutagens and the 48th Annual Meeting of the Japanese Environmental Mutagen Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12339
[Presentation] Comparison analysis of backbones between 8-oxoG added DNA and intact DNA enclosed with water molecules by using an accelerated quantum chemical calculation2019
- Author(s)
  Ai SUZUKI, Akira SASSA, Manabu YASUI, Masamitsu HONMA
- Organizer
  The Joint Meeting of The 6th Asian Congress on Environmental Mutagens and the 48th Annual Meeting of the Japanese Environmental Mutagen Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12339
[Presentation] ゲノム恒常性維持におけるヒストンメチル化酵素NSD2の役割2019
- Author(s)
  浦聖恵、佐々彰、東條あかり、原田佳歩、安井学、本間正充
- Organizer
  第13回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-19K12339
[Presentation] Mechanistic insight of unique mutations caused by a ribonucleotide embedded into DNA2019
- Author(s)
  Ayuna Takeishi, Manabu Yasui, Hiroyuki Sasanuma, Shunichi Takeda,Kaoru Sugasawa, Masamitsu Honma, Kiyoe Ura, Akira Sassa
- Organizer
  The Joint Meeting of The 6th Asian Congress on Environmental Mutagens and the 48th Annual Meeting of the Japanese Environmental Mutagen Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12339
[Presentation] ゲノム恒常性維持におけるヒストンメチル化酵素NSD2の役割2019
- Author(s)
  浦聖恵、佐々彰、東條あかり、原田佳歩、安井学、本間正充
- Organizer
  第13回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] Mechanistic insight of unique mutations caused by a ribonucleotide embedded into DNA2019
- Author(s)
  Ayuna Takeishi, Manabu Yasui, Hiroyuki Sasanuma, Shunichi Takeda,Kaoru Sugasawa, Masamitsu Honma, Kiyoe Ura, Akira Sassa
- Organizer
  The Joint Meeting of The 6th Asian Congress on Environmental Mutagens and the 48th Annual Meeting of the Japanese Environmental Mutagen Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] Alternate processing pathways of a single ribonucleotide incorporated into DNA and its consequences in human cells2019
- Author(s)
  Akira Sassa, Haruto Tada, Ayuna Takeishi, Kaho Harada, Kazuma Nakatani, Masataka Tsuda, Hiroyuki Sasanuma, Shunichi Takeda, Kaoru Sugasawa, Manabu Yasui, Masamitsu Honma, Kiyoe Ura
- Organizer
  The Joint Meeting of The 6th Asian Congress on Environmental Mutagens and the 48th Annual Meeting of the Japanese Environmental Mutagen Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] ヒストンメチル化酵素NSD2の酵素学的機能解析2019
- Author(s)
  小池望実、佐々彰、安田武嗣、浦聖恵
- Organizer
  第37 回染色体ワークショップ第18 回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-19K12339
[Presentation] FTO's roles in DNA damage response and underlying mechanism2019
- Author(s)
  Weiying LIU, Manabu YASUI, Akira SASSA, Yiyi CAO, Jing XI, Xinyue YOU, Masamitsu HONMA, Yang LUAN
- Organizer
  The Joint Meeting of The 6th Asian Congress on Environmental Mutagens and the 48th Annual Meeting of the Japanese Environmental Mutagen Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] ヒストンメチル化酵素NSD2 の酵素学的機能解析2019
- Author(s)
  小池望実、佐々彰、安田武嗣、浦聖恵
- Organizer
  第37 回染色体ワークショップ第18 回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] Alternate processing pathways of a single ribonucleotide incorporated into DNA and its consequences in human cells2019
- Author(s)
  Akira Sassa, Haruto Tada, Ayuna Takeishi, Kaho Harada, Kazuma Nakatani, Masataka Tsuda, Hiroyuki Sasanuma, Shunichi Takeda, Kaoru Sugasawa, Manabu Yasui, Masamitsu Honma, Kiyoe Ura
- Organizer
  The Joint Meeting of The 6th Asian Congress on Environmental Mutagens and the 48th Annual Meeting of the Japanese Environmental Mutagen Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12339
[Presentation] Mechanistic basis for genome instability induced by non-canonical nucleotide accumulation in human cells2019
- Author(s)
  Akira Sassa
- Organizer
  2019 International Conference for Leading and Young Medical Scientists
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] Mechanistic basis for genome instability induced by non-canonical nucleotide accumulation in human cells2019
- Author(s)
  Akira Sassa
- Organizer
  2019 International Conference for Leading and Young Medical Scientists
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K12339
[Presentation] Comparison analysis of backbones between 8-oxoG added DNA and intact DNA enclosed with water molecules by using an accelerated quantum chemical calculation2019
- Author(s)
  Ai SUZUKI, Akira SASSA, Manabu YASUI, Masamitsu HONMA
- Organizer
  The Joint Meeting of The 6th Asian Congress on Environmental Mutagens and the 48th Annual Meeting of the Japanese Environmental Mutagen Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] DNA二本鎖切断修復におけるヒストンメチル化酵素NSD2の機能解析2018
- Author(s)
  東條あかり、佐々彰、安井学、本間正充、浦聖恵
- Organizer
  日本環境変異原学会第47回大会
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] DNA 中のリボヌクレオチドが引き起こす特異な突然変異とその誘発機構の解析2018
- Author(s)
  竹石歩奈、安井学、笹沼博之、武田俊一、菅澤薫、本間正充、浦聖恵、佐々彰
- Organizer
  日本環境変異原学会第47回大会
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] DNA二本鎖切断修復におけるヒストンメチル化酵素NSD2の機能解析2018
- Author(s)
  東條あかり, 佐々彰, 安井学, 本間正充, 浦聖恵
- Organizer
  日本環境変異原学会
- Data Source
  KAKENHI-PROJECT-25281022
[Presentation] DNA 中のリボヌクレオチドが引き起こす特異な突然変異とその誘発機構の解析2018
- Author(s)
  竹石歩奈, 安井学, 笹沼博之, 武田俊一, 菅澤薫, 本間正充, 浦聖恵, 佐々彰
- Organizer
  日本環境変異原学会
- Data Source
  KAKENHI-PROJECT-25281022
[Presentation] ゲノム編集に適したハエ培養細胞株の探索およびクローン化方法の確立2018
- Author(s)
  田沼寛章、佐々彰、齋藤都暁、浦聖恵
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] DNAとRNA -僅かな構造の違いが引き起こすゲノム不安定性-2018
- Author(s)
  佐々彰
- Organizer
  日本環境変異原学会平成30年度公開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] ヒストンメチル化酵素NSD2とDNA 損傷修復2018
- Author(s)
  原田佳歩、佐々彰、竹内心、足立典隆、浦聖恵
- Organizer
  日本環境変異原学会第47回大会
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] リボヌクレオチドが誘発する奇異突然変異とその防御機構2018
- Author(s)
  佐々彰、安井学、竹石歩奈、原田佳歩、鈴木慈、津田雅貴、笹沼博之、武田俊一、菅澤薫、本間正充、浦聖恵
- Organizer
  日本遺伝学会第90回大会
- Invited
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] 酸化ストレス応答におけるNSD2の機能解析2018
- Author(s)
  竹内心、原田佳歩、佐々彰、浦聖恵
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] Quantum Chemical Inspection on the DNA Backbone Bias caused by 8oxoG2018
- Author(s)
  Ai Suzuki, Masayuki Miyano, Ryuji Miura, Akira Sassa, Manabu Yasui, Masamitsu Honma
- Organizer
  The 15th International Conference on Flow Dynamics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] DNA二本鎖切断修復におけるヒストンメチル化酵素NSD2の機能解析2018
- Author(s)
  東條あかり、佐々彰、安井学、本間正充、浦聖恵
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] Quantum Chemical Inspection on the DNA Backbone Bias caused by 8oxoG2018
- Author(s)
  Suzuki A, Miyano M, Miura R, Sassa A, Yasui M, Honma M
- Organizer
  The International Conference on Flow Dynamics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25281022
[Presentation] ヒストンメチル化酵素NSD2のDNA損傷修復への関与の解明2018
- Author(s)
  原田佳歩、佐々彰、鈴木慈、前田亮、足立典隆、浦聖恵
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] リボヌクレオチドが誘発する奇異突然変異とその防御機構2018
- Author(s)
  佐々彰, 安井学, 竹石歩奈, 原田佳歩, 鈴木慈, 津田雅貴, 笹沼博之, 武田俊一, 菅澤薫, 本間正充, 浦聖恵
- Organizer
  日本遺伝学会
- Data Source
  KAKENHI-PROJECT-25281022
[Presentation] TK6及びそのDNA修復遺伝子破壊変異体を用いた高感度遺伝毒性試験法の開発2017
- Author(s)
  福田隆之，中村真生，佐藤亮佑，藤原聖，佐々彰，鵜飼明子，武田俊一，安井学，本間正充
- Organizer
  日本環境変異原学会第46回大会
- Data Source
  KAKENHI-PROJECT-25281022
[Presentation] TK6及び変異株を用いたヌクレオチド除去修復機構におけるゲノム全体修復と転写共役修復を区別する方法の開発2017
- Author(s)
  中村真生, 鵜飼明子, 佐々彰, 髙部道仁, 福田隆之, 高村岳樹, 本間正充, 安井学
- Organizer
  日本環境変異原学会第46回大会
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] TK6及び変異株を用いたヌクレオチド除去修復機構におけるゲノム全体修復と転写共役修復を区別する方法の開発2017
- Author(s)
  中村真生，鵜飼明子，佐々彰，髙部道仁，福田隆之，髙村岳樹，本間正充，安井学
- Organizer
  日本環境変異原学会第46回大会
- Data Source
  KAKENHI-PROJECT-25281022
[Presentation] Trial for establishment of a locus-specific mutation assay system2017
- Author(s)
  Yasui M, Sassa A, Ukai A, Honma M
- Organizer
  12th International Conference of Environmental Mutagens
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25281022
[Presentation] Highly sensitive genotoxicity test system for detection of ames-positive compounds in TK6 and its DNA repair mutants2017
- Author(s)
  Fukuda T, Nakamura M, Sato R, Fujiwara S, Sassa A, Ukai A, Takeda S, Yasui M, Honma M
- Organizer
  12th International Conference of Environmental Mutagens
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25281022
[Presentation] TK6及びそのDNA修復遺伝子破壊変異体を用いた高感度遺伝毒性試験法の開発2017
- Author(s)
  福田隆之, 中村真生, 佐藤亮佑, 藤原聖, 佐々彰, 鵜飼明子, 武田俊一, 安井学, 本間正充
- Organizer
  日本環境変異原学会第46回大会
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] Effect of ribonucleotide backbone on mutagenic potential and repair mechanism of 7,8-dihydro-8-oxoguanine2017
- Author(s)
  Sassa A, Yasui M, Sasanuma H, Takeda S, Sugasawa K, Honma M, Ura K
- Organizer
  The 44th International Symposium on Nucleic Acids Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] ヒト細胞DNA中のリボヌクレオチドが引き起こすゲノム不安定性の解析2017
- Author(s)
  佐々彰, 安井学, 本間正充, 浦聖恵
- Organizer
  第11回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] リボヌクレオチドが誘発する突然変異の抑制におけるDNA修復機構の役割2017
- Author(s)
  佐々彰, 安井学, 笹沼博之, 武田俊一, 菅澤薫, 本間正充, 浦聖恵
- Organizer
  日本環境変異原学会第46回大会
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] リボヌクレオチドが引き起こすゲノム不安定性とその抑制機構2017
- Author(s)
  佐々彰, 安井学, 笹沼博之, 武田俊一, 菅澤薫, 本間正充, 浦聖恵
- Organizer
  第35回染色体ワークショップ・第16回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] DNA中のリボヌクレオチドが引き起こす突然変異とその抑制機構2017
- Author(s)
  佐々彰, 安井学, 笹沼博之, 武田俊一, 菅澤薫, 本間正充, 浦聖恵
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] Effect of Sugar Backbone on Translesion Synthesis, Repair, and Mutagenic Potential of 7,8-Dihydro-8-oxoguanine2017
- Author(s)
  Sassa A, Caglayan M, Rodriguez Y, Beard WA, Wilson SH, Nohmi T, Honma M, Yasui M, Ura K
- Organizer
  Environmental Mutagenesis & Genomics Society 48th Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] DNA 損傷薬剤を用いたヒストンメチル化酵素 NSD2 の機能解析2017
- Author(s)
  原田佳歩, 鈴木慈, 佐々彰, 浦聖恵
- Organizer
  日本環境変異原学会第46回大会
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] DNA中の酸化リボヌクレオチドにおける損傷乗り越えDNA合成と修復2016
- Author(s)
  佐々彰，Melike Caglayan, William A. Beard, Samuel H. Wilson, 能美健彦, 本間正充, 安井学
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] Theoretical Comparison of the Conformational Affinity between hOGG1 DNA Repair Protein and DNA holding different Numbers of 8-oxoG2016
- Author(s)
  Ai Suzuki, Patrick Bonnaud, Akira Sassa, Manabu Yasui, Akira Miyamoto, Masamitsu Honma
- Organizer
  Chem-Bio Informatics Annual Meeting 2016
- Place of Presentation
  タワーホール船堀（東京都・江戸川区）
- Year and Date
  2016-10-25
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] DNA中の酸化リボヌクレオチドがDNA複製および修復機構に及ぼす影響2016
- Author(s)
  佐々彰，Caglayan M, Beard WA, Wilson SH, 能美健彦，本間正充，安井学
- Organizer
  日本環境変異原学会
- Place of Presentation
  つくば
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-25281022
[Presentation] DNA中の酸化リボヌクレオチドがDNA複製及び修復機構に及ぼす影響2016
- Author(s)
  佐々彰，Melike Caglayan, William A. Beard, Samuel H. Wilson, 能美健彦, 本間正充, 安井学
- Organizer
  日本環境変異原学会第45回大会
- Place of Presentation
  つくば国際会議場（茨城県・つくば市）
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] DNA中の酸化リボヌクレオチドに対する損傷乗り越えDNA合成機構2016
- Author(s)
  佐々彰
- Organizer
  変異機構研究会第29回夏の学校
- Place of Presentation
  あうる京北（京都府・京都市）
- Year and Date
  2016-09-10
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] 8oxoG付加数の異なるDNAに対する修復タンパクhOGG1の高速化量子分子動力学法による親和性評価2016
- Author(s)
  鈴木愛, Patrick Bonnaud, 佐々彰, 安井学, 宮本明, 本間正充
- Organizer
  日本環境変異原学会第45回大会
- Place of Presentation
  つくば国際会議場（茨城県・つくば市）
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-16K16195
[Presentation] 8-oxoG付加数の異なるDNAに対する修復タンパクhOGG1の高速化量子分子動力学法による親和性評価2016
- Author(s)
  鈴木愛，Bonnaud P，佐々彰，安井学，宮本明，本間正充
- Organizer
  日本環境変異原学会
- Place of Presentation
  つくば
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-25281022
[Presentation] DNA損傷１分子の部位特異的なゲノム導入とその遺伝的影響の解析2015
- Author(s)
  安井学，佐々彰，鴨下渚，本間正充
- Organizer
  宇宙生物科学会
- Place of Presentation
  東京
- Year and Date
  2015-09-26
- Invited
- Data Source
  KAKENHI-PROJECT-25281022
[Presentation] ヒトリンパ球細胞のゲノムに導入したシトシン修飾体の潜在的な突然変異誘発能2015
- Author(s)
  佐々彰，鴨下渚，兼丸祐紀，本間正充，安井学
- Organizer
  日本環境変異原学会
- Place of Presentation
  福岡
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-25281022
[Presentation] ヌクレオチド除去修復は酸化的クラスターDNA損傷によって誘発される突然変異を抑制する2015
- Author(s)
  佐々彰，鴨下渚，兼丸祐紀，本間正充，安井学
- Organizer
  日本環境変異原学会
- Place of Presentation
  福岡
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-25281022
[Presentation] Effect of nucleotide excision repair deficiency on mutagenesis induced by clustered 7,8-dihydro-8-oxoguanine in human cells.2015
- Author(s)
  Sassa A, Kamoshita N, Kanemaru Y, Honma M, Yasui M.
- Organizer
  Zing conference: Genomic Integrity 2015
- Place of Presentation
  ケアンズ
- Year and Date
  2015-07-31
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25281022
[Presentation] ゲノムの特定部位に配置させたクラスターDNA損傷の数的遺伝毒性影響
- Author(s)
  佐々彰，鴨下渚，兼丸祐紀，本間正充，安井学
- Organizer
  日本放射線影響学会第57回大会
- Place of Presentation
  鹿児島
- Year and Date
  2014-10-01 – 2014-10-03
- Data Source
  KAKENHI-PROJECT-25281022
[Presentation] ゲノムの特定部位に配置させたクラスターDNA損傷の数的遺伝毒性影響
- Author(s)
  佐々彰，鴨下渚，兼丸祐紀，本間正充，安井学
- Organizer
  第43回日本環境変異原学会
- Place of Presentation
  東京
- Year and Date
  2014-11-04 – 2014-11-05
- Data Source
  KAKENHI-PROJECT-25281022
[Presentation] DNA塩基損傷１分子を部位特異的にもつプラスミドの作製とヒト細胞におけるTLS解析
- Author(s)
  長野聖也，東垣由夏，佐々彰，川西優喜，安井学，高村岳樹，八木孝司
- Organizer
  第43回日本環境変異原学会
- Place of Presentation
  東京
- Year and Date
  2014-11-04 – 2014-11-05
- Data Source
  KAKENHI-PROJECT-25281022

1. Manabu Yasui (50435707)

# of Collaborated Projects: 1 results

# of Collaborated Products: 27 results
2. Honma Masamitsu

# of Collaborated Projects: 1 results

# of Collaborated Products: 24 results
3. TAKAMURA Takeji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. SAJI Tetsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. GRUZ Petr

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. Suzuki Tetsuya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 足立典隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
8. 菅澤薫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 笹沼博之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 武田俊一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 能美健彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
12. 沼澤聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sassa Akira 佐々 彰

佐々 彰 サッサ アキラ

Research Projects

Research Products

Co-Researchers

DNA損傷が自然免疫を惹起する多階層の分子機構の解明Principal Investigator

Principal Investigator

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リボヌクレオチドが引き起こす重篤なゲノム不安定化の分子機構Principal Investigator

Principal Investigator

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Review Section

Research Institution

Genome instability induced by high-energy phosphate compoundsPrincipal Investigator

Principal Investigator

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Research Institution

Site-specific gene mutagenesis involving a single DNA adduct in vivo

Principal Investigator

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Research Institution

[Journal Article] Error-prone bypass patch by a low-fidelity variant of DNA polymerase zeta in human cells2021

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Journal Title

DOI

Data Source

[Journal Article] Watching a double strand break repair polymerase insert a pro-mutagenic oxidized nucleotide2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Understanding the sequence and structural context effects in oxidative DNA damage repair2020

Author(s)

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DOI

Data Source

[Journal Article] Tyrosyl-DNA phosphodiesterases are involved in mutagenic events at a ribonucleotide embedded into DNA in human cells.2020

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[Journal Article] Processing of a single ribonucleotide embedded into DNA by human nucleotide excision repair and DNA polymerase eta2019

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NAID

Data Source

[Journal Article] Comparative study of cytotoxic effects induced by environmental genotoxins using XPC- and CSB-deficient human lymphoblastoid TK6 cells.2019

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Journal Title

DOI

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[Journal Article] Current perspectives on mechanisms of ribonucleotide incorporation and processing in mammalian DNA.2019

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Data Source

[Journal Article] Challenges of young scientists at the cutting-edge of genotoxicity research: the open symposium of the Japanese Environmental Mutagen Society (JEMS), 20182018

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[Journal Article] DNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of Ribonucleotide Backbone on Translesion Synthesis and Repair of 7,8-Dihydro-8-oxoguanine2016

Author(s)

Journal Title

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Data Source

Sassa Akira 佐々彰

佐々彰サッサアキラ