Hirata Yusuke 平田祐介

Researcher Number	10748221
Other IDs
Affiliation (Current)	2025: 東北大学, 薬学研究科, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2023: 東北大学, 薬学研究科, 助教 2016: 東北大学, 薬学研究科, 助教 2015: 東北大学, 薬学研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Biological pharmacy
Keywords	Principal Investigator 細胞死 / トランス脂肪酸 / 炎症 / フェロトーシス / シグナル伝達 / 細胞老化 / 細胞外ATP / DNA損傷 / がん / メカノセンシング … More / 脂質酸化 / 酸化ストレス / 機械刺激受容体 / 毒性 / 循環器系疾患 / 食品衛生 / NASH / MAPK / ミトコンドリア / 活性酸素 / 脂肪肝 / 老化 / 免疫応答 / TLR4 / ユビキチン化 / TRIM48 / Roquin-2 / ASK1 Less

Development of cancer prevention and treatment strategies based on novel cell death regulation mechanisms mediated by trans-fatty acidsPrincipal Investigator
- Principal Investigator
  
  平田祐介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Tohoku University
Toxicological assessment of trans fatty acids (TFAs) based on the novel molecular mechanisms of their toxicity for prevention and treatment of TFA-related diseasesPrincipal Investigator
- Principal Investigator
  
  Hirata Yusuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Tohoku University
Regulatory mechanisms for cell death and inflammatory signaling mediated by the diversity of membrane fatty acid speciesPrincipal Investigator
- Principal Investigator
  
  Hirata Yusuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Tohoku University
Development of prevention and treatment strategies for trans-fatty acid-related diseases based on novel toxicity mechanismsPrincipal Investigator
- Principal Investigator
  
  Hirata Yusuke
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Tohoku University
Elucidation of the regulatory mechanisms of ASK1 ubiquitination for developing a new treatment strategy for ASK1-related diseasesPrincipal Investigator
- Principal Investigator
  
  Hirata Yusuke
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tohoku University

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation Other

[Journal Article] Aggregability of the SQSTM1/p62-based aggresome-like induced structures determines the sensitivity to parthanatos2024
- Author(s)
  Hamano Shuhei、Noguchi Takuya、Asai Yukino、Ito Ryo、Komatsu Ryuto、Sato Tetsu、Inoue Aya、Maruyama Tomoe、Kudo Tada-aki、Hirata Yusuke、Shindo Sawako、Uchida Yasuo、Hwang Gi-Wook、Matsuzawa Atsushi
- Journal Title
  
  Cell Death Discovery
  
  Volume: 10 Issue: 1 Pages: 74-74
- DOI
  10.1038/s41420-024-01838-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23KJ0165, KAKENHI-PROJECT-21K09929, KAKENHI-PROJECT-23K06111, KAKENHI-PROJECT-21H02620, KAKENHI-PROJECT-21H02691
[Journal Article] Membrane Dynamics and Cation Handling in Ferroptosis2024
- Author(s)
  Hirata Yusuke、Mishima Eikan
- Journal Title
  
  Physiology
  
  Volume: 39 Issue: 2 Pages: 73-87
- DOI
  10.1152/physiol.00029.2023
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06111, KAKENHI-PROJECT-20KK0363
[Journal Article] Industrially produced trans-fatty acids are potent promoters of DNA damage-induced apoptosis2024
- Author(s)
 Hirata Yusuke、Kojima Ryota、Ashida Ryo、Nada Yuki、Kimura Shinnosuke、Sato Emiko、Noguchi Takuya、Matsuzawa Atsushi
- Journal Title
 
 The Journal of Toxicological Sciences
 
 Volume: 49 Issue: 1 Pages: 27-36
- DOI
 10.2131/jts.49.27
- ISSN
 0388-1350, 1880-3989
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-23K06111, KAKENHI-PROJECT-21H02620
[Journal Article] Geometrical isomerization of arachidonic acid during lipid peroxidation interferes with ferroptosis2023
- Author(s)
  Hirata Yusuke、Ferreri Carla、Yamada Yuto、Inoue Aya、Sansone Anna、Vetica Fabrizio、Suzuki Wakana、Takano Saya、Noguchi Takuya、Matsuzawa Atsushi、Chatgilialoglu Chryssostomos
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 204 Pages: 374-384
- DOI
  10.1016/j.freeradbiomed.2023.05.026
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06111, KAKENHI-PROJECT-21H02620
[Journal Article] Grinstein, S., Freeman, S. A. Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis2023
- Author(s)
  Hirata Y, Cai R, Volchuk A, Steinberg BE, Saito Y, Matsuzawa A, Grinstein S, Freeman SA
- Journal Title
  
  Curr Biol
  
  Volume: 33 Issue: 7 Pages: 1282-1294
- DOI
  10.1016/j.cub.2023.02.060
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02620, KAKENHI-PROJECT-20K07011, KAKENHI-PROJECT-21K19325, KAKENHI-PROJECT-20KK0361, KAKENHI-PUBLICLY-21H00268
[Journal Article] Reactive sulfur species disaggregate the SQSTM1/p62-based aggresome-like induced structures via the HSP70 induction and prevent parthanatos2023
- Author(s)
  Yamada Yutaro、Noguchi Takuya、Suzuki Midori、Yamada Mayuka、Hirata Yusuke、Matsuzawa Atsushi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: in press Issue: 6 Pages: 104710-104710
- DOI
  10.1016/j.jbc.2023.104710
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02691, KAKENHI-PROJECT-20J20688, KAKENHI-PROJECT-21J10638, KAKENHI-PROJECT-23K06111, KAKENHI-PROJECT-21H02620
[Journal Article] LLPS of SQSTM1/p62 and NBR1 as outcomes of lysosomal stress response limits cancer cell metastasis2023
- Author(s)
  Noguchi Takuya、Sekiguchi Yuto、Shimada Tatsuya、Suzuki Wakana、Yokosawa Takumi、Itoh Tamaki、Yamada Mayuka、Suzuki Midori、Kurokawa Reon、Hirata Yusuke、Matsuzawa Atsushi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 120 Issue: 43 Pages: 44-44
- DOI
  10.1073/pnas.2311282120
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K06111, KAKENHI-PROJECT-23KJ0096, KAKENHI-WRAPUP-23H05424, KAKENHI-PROJECT-21H02620, KAKENHI-PROJECT-21H02691
[Journal Article] The NLRP3 Inflammasome Works as a Sensor for Detecting Hypoactivity of the Mitochondrial Src Family Kinases2023
- Author(s)
  Sekiguchi Y, Takano S, Noguchi T, Kagi T, Komatsu R, Tan M, Hirata Y, Matsuzawa A
- Journal Title
  
  J Immunol
  
  Volume: 210 Issue: 6 Pages: 795-806
- DOI
  10.4049/jimmunol.2200611
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02620, KAKENHI-PROJECT-21H02691, KAKENHI-PROJECT-21J10592, KAKENHI-PROJECT-22KJ0288, KAKENHI-PROJECT-21K19325, KAKENHI-PROJECT-20KK0361, KAKENHI-PUBLICLY-21H00268
[Journal Article] A comprehensive toxicological analysis of trans-fatty acids (TFAs) reveals a pro-apoptotic action specific to industrial TFAs counteracted by polyunsaturated FAs2023
- Author(s)
  Hirata Yusuke、Kashiwabara Naoki、Nada Yuki、Inoue Aya、Sato Emiko、Noguchi Takuya、Matsuzawa Atsushi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 5883-5883
- DOI
  10.1038/s41598-023-32083-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07011, KAKENHI-PROJECT-20KK0361, KAKENHI-PROJECT-21H02620
[Journal Article] The polypeptide antibiotic polymyxin B acts as a pro-inflammatory irritant by preferentially targeting macrophages2022
- Author(s)
  Kagi T, Naganuma R, Inoue A, Noguchi T, Hamano S, Sekiguchi Y, Hwang GW, Hirata Y, Matsuzawa A
- Journal Title
  
  J Antibiot
  
  Volume: 75 Issue: 1 Pages: 29-39
- DOI
  10.1038/s41429-021-00490-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H00268, KAKENHI-PROJECT-21H02620, KAKENHI-PROJECT-21H02691, KAKENHI-PROJECT-21J10592, KAKENHI-PROJECT-20KK0361, KAKENHI-PROJECT-21K19325, KAKENHI-PROJECT-20K07011
[Journal Article] The Distinct Roles of LKB1 and AMPK in p53-Dependent Apoptosis Induced by Cisplatin2022
- Author(s)
  Shimada Tatsuya、Yabuki Yohsuke、Noguchi Takuya、Tsuchida Mei、Komatsu Ryuto、Hamano Shuhei、Yamada Mayuka、Ezaki Yusuke、Hirata Yusuke、Matsuzawa Atsushi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 17 Pages: 10064-10064
- DOI
  10.3390/ijms231710064
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02691, KAKENHI-PROJECT-21J10638, KAKENHI-PROJECT-20K07011, KAKENHI-PROJECT-20KK0361
[Journal Article] trans-Fatty Acids as an Enhancer of Inflammation and Cell Death: Molecular Basis for Their Pathological Actions2021
- Author(s)
 Yusuke Hirata
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 44 Issue: 10 Pages: 1349-1356
- DOI
 10.1248/bpb.b21-00449
- NAID
 130008095751
- ISSN
 0918-6158, 1347-5215
- Year and Date
 2021-10-01
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-20K07011, KAKENHI-PROJECT-20KK0361
[Journal Article] The E3 Ubiquitin-Protein Ligase RNF4 Promotes TNF-α-Induced Cell Death Triggered by RIPK12021
- Author(s)
  Shimada T, Kudoh Y, Noguchi T, Kagi T, Suzuki M, Tsuchida M, Komatsu H, Takahashi M, Hirata Y, Matsuzawa A
- Journal Title
  
  Int J Mol Sci
  
  Volume: 22 Issue: 11 Pages: 5796-5796
- DOI
  10.3390/ijms22115796
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H00268, KAKENHI-PROJECT-21H02620, KAKENHI-PROJECT-21H02691, KAKENHI-PROJECT-20J20688, KAKENHI-PROJECT-20K07011, KAKENHI-PROJECT-20KK0361, KAKENHI-PROJECT-21K19325
[Journal Article] trans-Fatty acids promote p53-dependent apoptosis triggered by cisplatin-induced DNA interstrand crosslinks via the Nox-RIP1-ASK1-MAPK pathway2021
- Author(s)
  Hirata Y, Takahashi M, Yamada Y, Matsui R, Inoue A, Ashida R, Noguchi T, Matsuzawa A
- Journal Title
  
  Sci Rep
  
  Volume: 11 Issue: 1 Pages: 10350-10350
- DOI
  10.1038/s41598-021-89506-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-21H00268, KAKENHI-PROJECT-21H02620, KAKENHI-PROJECT-21H02691, KAKENHI-PROJECT-20K07011, KAKENHI-PROJECT-20KK0361, KAKENHI-PROJECT-21K19325
[Journal Article] Gefitinib initiates sterile inflammation by pomoting IL-1β and HMGB1 release via two distinct mechanisms2021
- Author(s)
  Takuya Noguchi, Yuto Sekiguchi, Yuki Kudoh, Rio Naganuma, Tomohiro Kagi, Akiko Nishidate, Kazuhiro Maeda, Chizuru Ishii, Takashi Toyama, Yusuke Hirata, Gi-Wook Hwang, Atsushi Matsuzawa
- Journal Title
  
  Cell Death. Dis.
  
  Volume: 12 Issue: 1 Pages: 49-49
- DOI
  10.1038/s41419-020-03335-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07011, KAKENHI-PUBLICLY-19H05282, KAKENHI-PUBLICLY-20H05493, KAKENHI-PROJECT-18H02567, KAKENHI-PROJECT-18K06622, KAKENHI-PROJECT-19K22481, KAKENHI-PROJECT-19K16345
[Journal Article] トランス脂肪酸による毒性発現機構2020
- Author(s)
  平田祐介, 松沢厚
- Journal Title
  
  B&I バイオサイエンスとインダストリー
  
  Volume: 78 Pages: 404-405
- Data Source
  KAKENHI-PROJECT-20K07011
[Journal Article] TAK1 Mediates ROS Generation Triggered by the Specific Cephalosporins through Noncanonical Mechanisms.2020
- Author(s)
  Midori Suzuki, Yukino Asai, Tomohiro Kagi, Takuya Noguchi, Mayuka Yamada, Yusuke Hirata, Atsushi Matsuzawa
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 21 Issue: 24 Pages: 9497-9497
- DOI
  10.3390/ijms21249497
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07011, KAKENHI-PUBLICLY-19H05282, KAKENHI-PROJECT-18H02567, KAKENHI-PROJECT-20J20688, KAKENHI-PROJECT-18K06622
[Journal Article] trans-Fatty acids facilitate DNA damage-induced apoptosis through the mitochondrial JNK-Sab-ROS positive feedback loop2020
- Author(s)
  Yusuke Hirata, Aya Inoue, Saki Suzuki, Miki Takahashi, Ryosuke Matsui, Nozomu Kono, Takuya Noguchi, Atsushi Matsuzawa
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1-16
- DOI
  10.1038/s41598-020-59636-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06622, KAKENHI-PROJECT-19K22481, KAKENHI-PUBLICLY-19H05282, KAKENHI-PROJECT-18H02567, KAKENHI-PROJECT-17H05053, KAKENHI-PROJECT-18J10828, KAKENHI-PROJECT-18K14894
[Journal Article] Pro-caspase-3 protects cells from polymyxin B-induced cytotoxicity by preventing ROS accumulation2020
- Author(s)
  T Yokosawa, M Yamada, T Noguchi, S Suzuki, Y Hirata, A Matsuzawa
- Journal Title
  
  The Journal of antibiotics
  
  Volume: 72 Issue: 11 Pages: 848-852
- DOI
  10.1038/s41429-019-0216-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06622, KAKENHI-PUBLICLY-19H05282, KAKENHI-PROJECT-18H02567, KAKENHI-PROJECT-18K14894
[Journal Article] The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis.2020
- Author(s)
  Yosuke Funato, Atsushi Yoshida, Yusuke Hirata, Osamu Hashizume, Daisuke Yamazaki, Hiroaki Miki
- Journal Title
  
  Developmental cell
  
  Volume: 55 Issue: 4 Pages: 387-397
- DOI
  10.1016/j.devcel.2020.08.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07011, KAKENHI-PROJECT-20K07312, KAKENHI-PROJECT-20K07616, KAKENHI-PROJECT-19K16125, KAKENHI-PUBLICLY-20H05508, KAKENHI-ORGANIZER-20H05787, KAKENHI-PLANNED-20H05789, KAKENHI-PROJECT-17K08631, KAKENHI-PROJECT-17K19396, KAKENHI-PROJECT-20H03515
[Journal Article] トランス脂肪酸と動脈硬化症2020
- Author(s)
  平田祐介, 松沢厚
- Journal Title
  
  食と医療
  
  Volume: 14 Pages: 81-89
- Data Source
  KAKENHI-PROJECT-20K07011
[Journal Article] Elaidic Acid Potentiates Extracellular ATP-Induced Apoptosis via the P2X7-ROS-ASK1-p38 Axis in Microglial Cell Lines2020
- Author(s)
 Yusuke Hirata, Yuki Nada, Yuto Yamada, Takashi Toyama, Kohji Fukunaga, Gi-Wook Hwang, Takuya Noguchi, Atsushi Matsuzawa
- Journal Title
 
 Biological and Pharmaceutical Bulletin
 
 Volume: 43 Issue: 10 Pages: 1562-1569
- DOI
 10.1248/bpb.b20-00409
- NAID
 130007920887
- ISSN
 0918-6158, 1347-5215
- Year and Date
 2020-10-01
- Language
 English
- Peer Reviewed / Open Access
- Data Source
 KAKENHI-PROJECT-20K07011, KAKENHI-PUBLICLY-19H05282, KAKENHI-PROJECT-18H02567, KAKENHI-PROJECT-19K22481
[Journal Article] The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells2019
- Author(s)
  Yuto Sekiguchi, Mayuka Yamada, Takuya Noguchi, Chise Noomote, Mei Tsuchida, Yuki Kudoh, Yusuke Hirata, Atsushi Matsuzawa
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 44 Issue: 6 Pages: 435-440
- DOI
  10.2131/jts.44.435
- NAID
  130007659535
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06622, KAKENHI-PUBLICLY-19H05282, KAKENHI-PROJECT-18H02567, KAKENHI-PROJECT-18J11303, KAKENHI-PROJECT-18J20440, KAKENHI-PROJECT-18K14894
[Journal Article] Regulatory mechanisms of stress-responsive signaling pathways mediated by various types of post-translational modifications2018
- Author(s)
  平田祐介, 松沢厚
- Journal Title
  
  生化学
  
  Volume: 90 Issue: 6 Pages: 815-819
- DOI
  10.14952/SEIKAGAKU.2018.900815
- NAID
  40021783184
- ISSN
  0037-1017
- Year and Date
  2018-12-25
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-18K14894
[Journal Article] Nuclear-accumulated SQSTM1/p62-based ALIS act as microdomains sensing cellular stresses and triggering oxidative stress-induced parthanatos2018
- Author(s)
  Noguchi Takuya、Suzuki Midori、Mutoh Natsumi、Hirata Yusuke、Tsuchida Mei、Miyagawa Sayoko、Hwang Gi-Wook、Aoki Junken、Matsuzawa Atsushi
- Journal Title
  
  Cell Death & Disease
  
  Volume: 9 Issue: 12 Pages: 1193-1193
- DOI
  10.1038/s41419-018-1245-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06622, KAKENHI-PROJECT-18K14894, KAKENHI-PUBLICLY-17H05494, KAKENHI-PUBLICLY-17H05518, KAKENHI-PROJECT-18H02567
[Journal Article] Antibiotic vancomycin promotes the gene expression of NOD-like receptor families in macrophages2018
- Author(s)
  Kudoh Y, Noguchi T, Ishii C, Nishidate A, Hirata Y, and Matsuzawa A
- Journal Title
  
  BPB Reports
  
  Volume: 1 Pages: 6-10
- NAID
  130007938418
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K14894
[Journal Article] Post-Translational Modifications of the TAK1-TAB Complex.2017
- Author(s)
  Hirata, Y., Takahashi, M., Morishita, T., Noguchi, T., Matsuzawa, A.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 18 Issue: 1 Pages: 205-205
- DOI
  10.3390/ijms18010205
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01168, KAKENHI-PUBLICLY-15H01391, KAKENHI-PROJECT-26293011, KAKENHI-PROJECT-15K18856, KAKENHI-PROJECT-16K15146
[Journal Article] Trans-fatty acids promote proinflammatory signaling and cell death by stimulating the apoptosis signal-regulating kinase 1 (ASK1)-p38 pathway.2017
- Author(s)
  Hirata, Y., Takahashi, M., Kudoh, Y., Kano, K., Kawana, H., Makide, K., Shinoda, Y., Yabuki, Y., Fukunaga, K., Aoki, J., Noguchi, T., Matsuzawa, A.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 印刷中 Issue: 20 Pages: 8174-8185
- DOI
  10.1074/jbc.m116.771519
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01168, KAKENHI-PUBLICLY-15H01391, KAKENHI-PROJECT-16H05219, KAKENHI-PROJECT-15H06036, KAKENHI-PROJECT-26293011, KAKENHI-PROJECT-15K18856, KAKENHI-PROJECT-16K14574, KAKENHI-PUBLICLY-17H05518, KAKENHI-PROJECT-16K15146
[Journal Article] Brefeldin A-inhibited guanine nucleotide-exchange factor 1 (BIG1) governs the recruitment of tumor necrosis factor receptor-associated factor 2 (TRAF2) to tumor necrosis factor receptor 1 (TNFR1) signaling complexes.2016
- Author(s)
  Noguchi, T., Tsuchida, M., Kogue, Y., Spadini, C., Hirata, Y., Matsuzawa, A.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 17 Issue: 11 Pages: 1869-1869
- DOI
  10.3390/ijms17111869
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01168, KAKENHI-PUBLICLY-15H01391, KAKENHI-PROJECT-26293011, KAKENHI-PROJECT-15K18856, KAKENHI-PROJECT-16K15146
[Presentation] トランス脂肪酸の新規毒性分子基盤に基づく脂肪酸種ごとの毒性リスク評価2024
- Author(s)
  平田祐介, 柏原直樹, 野口拓也, 松沢厚
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06111
[Presentation] Lipid peroxidation drives ferroptosis by modulating membrane dynamics and cation permeability via mechanosensitive channels2024
- Author(s)
  Yusuke Hirata
- Organizer
  The 1st International G-ReXS Conference in Sendai
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06111
[Presentation] 食品中化合物によるフェロトーシスのユニークな抑制作用機構の解析2024
- Author(s)
  小島諒太, 平田祐介, 野口拓也, 斎藤芳郎, 黒川洋一, 松沢厚
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K06111
[Presentation] 機械刺激受容体Piezo1/TRPチャネルのフェロトーシス実行における機能的役割2023
- Author(s)
  平田祐介, 斎藤芳郎, Spencer Freeman, Sergio Grinstein, 松沢厚
- Organizer
  第76回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-23K06111
[Presentation] トランス脂肪酸の新規毒性分子基盤に基づく包括的リスク評価2023
- Author(s)
  柏原直樹，平田祐介, 蘆田諒, 野口拓也，松沢厚
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] DHA・EPAによるトランス脂肪酸毒性の抑制作用機構2023
- Author(s)
  平田祐介
- Organizer
  第24回公開講演会『食品として健康に寄与するDHA・EPA』
- Invited
- Data Source
  KAKENHI-PROJECT-23K06111
[Presentation] 食品中化合物によるフェロトーシスの新規抑制作用機序の解析2023
- Author(s)
  小島諒太, 平田祐介, 野口拓也, 斎藤芳郎, 黒川洋一, 松沢厚
- Organizer
  第62回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-23K06111
[Presentation] キナーゼ分子TAK1による新規フェロトーシス制御機構2023
- Author(s)
  田口蒼真, 平田祐介, 野口拓也, 松沢厚
- Organizer
  第62回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-23K06111
[Presentation] Geometrical isomerization of arachidonic acid upon lipid peroxidation serves as a negative feedback mechanism in ferroptosis2023
- Author(s)
  Carla Ferreri, Yusuke Hirata, Wakana Suzuki, Saya Takano, Takuya Noguchi, Chryssostomos Chatgilialoglu, Atsushi Matsuzawa
- Organizer
  フォーラム2023：衛生薬学・環境トキシコロジー
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06111
[Presentation] 共役トランス脂肪酸によるフェロトーシス誘導機構の解明2023
- Author(s)
  平田祐介, 山田侑杜, 野口拓也，松沢厚
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] 共役脂肪酸によるフェロトーシス誘導作用の分子機構の解析2023
- Author(s)
  平田祐介, 山田侑杜, 野口拓也, 松沢厚
- Organizer
  フォーラム2023：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-23K06111
[Presentation] 食品中化合物による新規フェロトーシス抑制作用機構の解析2023
- Author(s)
  小島諒太, 平田祐介, 野口拓也, 黒川洋一, 松沢厚
- Organizer
  フォーラム2023：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-23K06111
[Presentation] トランス脂肪酸の新規毒性分子基盤に基づく包括的リスク評価2023
- Author(s)
  柏原直樹，平田祐介, 蘆田諒, 野口拓也，松沢厚
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20KK0361
[Presentation] Elucidation of the protective mechanism of a food-derived compound against ferroptosis2023
- Author(s)
  Ryota Kojima, Yusuke Hirata, Takuya Noguchi, Yoichi Kurokawa, Atsushi Matsuzawa
- Organizer
  フォーラム2023：衛生薬学・環境トキシコロジー
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06111
[Presentation] 共役トランス脂肪酸によるフェロトーシス誘導機構の解明2023
- Author(s)
  平田祐介, 山田侑杜, 野口拓也，松沢厚
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-20KK0361
[Presentation] 細胞膜上の脂質酸化を感知するメカノセンサーPiezo1/TRPチャネルを介したフェロトーシス誘導機構2023
- Author(s)
  平田祐介
- Organizer
  第44回生体膜と薬物の相互作用シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-23K06111
[Presentation] Piezo1/TRPチャネルを介したメカノセンシングによる新規フェロトーシス実行機構2023
- Author(s)
  平田祐介, 斎藤芳郎, Spencer A. Freeman, Sergio Grinstein, 松沢厚
- Organizer
  第96回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-23K06111
[Presentation] 生体膜脂肪酸鎖の多様性とストレス応答2023
- Author(s)
  平田祐介
- Organizer
  2023年度第2回慶應薬学先端実学（サイヤンス）セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-23K06111
[Presentation] 共役脂肪酸による新規プログラム細胞死フェロトーシス誘導機構の解析2022
- Author(s)
  山田侑杜, 平田祐介, 野口拓也，松沢厚
- Organizer
  第61回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] Peroxidation accompanied by increased cation permeability of the plasma membrane via Piezo1 engenders ferroptosis2022
- Author(s)
  Yusuke Hirata, Atsushi Matsuzawa, Spencer A. Freeman, Sergio Grinstein
- Organizer
  Iron, Reactive Oxygen Species & Ferroptosis in Life, Death & Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] Increased ion permeability of the plasma membrane through lipid peroxidation is essential for triggering of ferroptosis2022
- Author(s)
  Yusuke Hirata
- Organizer
  Redox Week in Sendai 2022, STINT-JSPS Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0361
[Presentation] Characterization of Lipid ROS-Mediated Biological Events Coupled with NADPH Oxidases during Ferroptosis in Macrophages2022
- Author(s)
  Yusuke Hirata, Spencer A. Freeman, Sergio Grinstein
- Organizer
  Gordon Research Seminar
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0361
[Presentation] Increased ion permeability of the plasma membrane through lipid peroxidation is essential for triggering of ferroptosis2022
- Author(s)
  Yusuke Hirata
- Organizer
  Redox Week in Sendai 2022, STINT-JSPS Joint Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] Characterization of Lipid ROS-Mediated Biological Events Coupled with NADPH Oxidases during Ferroptosis in Macrophages2022
- Author(s)
  Yusuke Hirata, Spencer A. Freeman, Sergio Grinstein
- Organizer
  Gordon Research Seminar
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] 共役脂肪酸による新規プログラム細胞死フェロトーシス誘導機構の解析2022
- Author(s)
  山田侑杜, 平田祐介, 野口拓也，松沢厚
- Organizer
  第61回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-20KK0361
[Presentation] フェロトーシス実行における機械刺激受容体Piezo1/TRPチャネルの機能的役割の解析2022
- Author(s)
  平田祐介, 松沢厚
- Organizer
  レドックス R&D 戦略委員会第２回若手シンポジウム
- Data Source
  KAKENHI-PROJECT-20KK0361
[Presentation] Characterization of Lipid ROS-Mediated Biological Events Coupled with NADPH Oxidases during Ferroptosis in Macrophages2022
- Author(s)
  Yusuke Hirata, Spencer A. Freeman, Sergio Grinstein
- Organizer
  Gordon Research Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0361
[Presentation] Peroxidation accompanied by increased cation permeability of the plasma membrane via Piezo1 engenders ferroptosis2022
- Author(s)
  Yusuke Hirata, Atsushi Matsuzawa, Spencer A. Freeman, Sergio Grinstein
- Organizer
  Iron, Reactive Oxygen Species & Ferroptosis in Life, Death & Disease
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0361
[Presentation] トランス脂肪酸の新規毒性メカニズムに基づく包括的リスク評価2022
- Author(s)
  平田祐介, 蘆田諒, 野口拓也, 松沢厚
- Organizer
  フォーラム2022 環境薬学・衛生トキシコロジー
- Data Source
  KAKENHI-PROJECT-20KK0361
[Presentation] トランス脂肪酸の新規毒性メカニズムに基づく包括的リスク評価2022
- Author(s)
  平田祐介, 蘆田諒, 野口拓也, 松沢厚
- Organizer
  フォーラム2022 環境薬学・衛生トキシコロジー
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] Characterization of Lipid ROS-Mediated Biological Events Coupled with NADPH Oxidases during Ferroptosis in Macrophages2022
- Author(s)
  Yusuke Hirata, Spencer A. Freeman, Sergio Grinstein
- Organizer
  Gordon Research Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] フェロトーシス実行における機械刺激受容体Piezo1/TRPチャネルの機能的役割の解析2022
- Author(s)
  平田祐介, 松沢厚
- Organizer
  レドックス R&D 戦略委員会第２回若手シンポジウム
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] トランス脂肪酸によるDNA損傷時の細胞死シグナル増強機構2021
- Author(s)
  平田祐介，山田侑杜，井上綾, 蘆田諒, 野口拓也，松沢厚
- Organizer
  フォーラム2021：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-20KK0361
[Presentation] ユビキチンリガーゼRoquin-2によるTAK1活性調節を介した酸化ストレス応答制御機構2021
- Author(s)
  小松寛武, 平田祐介, 野口拓也, 松沢厚
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] DNA損傷様式によって異なるトランス脂肪酸の細胞死シグナル促進機構2021
- Author(s)
  山田侑杜, 井上綾, 蘆田諒, 平田祐介, 野口拓也, 松沢厚
- Organizer
  第48回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] トランス脂肪酸のDNA損傷様式によって異なる細胞死促進作用の分子機構2021
- Author(s)
  山田侑杜, 井上綾, 平田祐介, 野口拓也, 松沢厚
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] DNA損傷様式によって異なるトランス脂肪酸の細胞死シグナル促進機構2021
- Author(s)
  山田侑杜, 井上綾, 蘆田諒, 平田祐介, 野口拓也, 松沢厚
- Organizer
  第48回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20KK0361
[Presentation] トランス脂肪酸関連疾患の分子病態基盤の解明2021
- Author(s)
  平田祐介
- Organizer
  日本薬学会第141年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] トランス脂肪酸によるDNA損傷時の細胞死シグナル増強機構2021
- Author(s)
  平田祐介，山田侑杜，井上綾, 蘆田諒, 野口拓也，松沢厚
- Organizer
  フォーラム2021：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] トランス脂肪酸によるDNA損傷時の細胞死促進作用とその分子機構の解明2020
- Author(s)
  井上綾, 平田祐介, 野口拓也, 松沢厚
- Organizer
  第59回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] トランス脂肪酸による細胞老化の促進作用機構および関連疾患発症機序の解明2020
- Author(s)
  平田祐介，井上綾，蘆田諒, 野口拓也，松沢厚
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] トランス脂肪酸によるDNA損傷誘導性細胞死の促進作用機構の解明2020
- Author(s)
  井上綾, 平田祐介, 野口拓也, 松沢厚
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] Fine-tuning activation of the oxidative stress-responsive kinase ASK1 mediated by the novel ubiquitin ligase TRIM482020
- Author(s)
  Yusuke Hirata and Atsushi Matsuzawa
- Organizer
  Gordon Research Conference: Oxygen Radicals
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] トランス脂肪酸の細胞老化促進作用による関連疾患発症機序の解明2020
- Author(s)
  平田祐介, 蘆田諒, 井上綾, 野口拓也, 松沢厚
- Organizer
  第59回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] トランス脂肪酸の新たな生体作用機序に基づく毒性リスク評価2020
- Author(s)
  蘆田諒, 灘雄貴, 平田祐介, 野口拓也, 松沢厚
- Organizer
  フォーラム2020：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] ユビキチンリガーゼRoquin-2を介したTAK1分解による酸化ストレス応答制御機構2020
- Author(s)
  小松寛武, 平田祐介, 野口拓也, 松沢厚
- Organizer
  第59回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] 酸化ストレス応答の制御機構とその破綻に伴う疾患発症の分子基盤の解明2020
- Author(s)
  平田祐介
- Organizer
  第2回医薬品開発研究センターシンポジウム酸化ストレスと創薬
- Invited
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] トランス脂肪酸のDNA損傷様式によって異なる細胞死促進機構2020
- Author(s)
  山田侑杜，井上綾, 平田祐介，野口拓也，松沢厚
- Organizer
  フォーラム2020：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] トランス脂肪酸による細胞老化促進作用とその分子機構の解明2020
- Author(s)
  平田祐介，蘆田諒, 井上綾，野口拓也，松沢厚
- Organizer
  日本生化学会東北支部第86回例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] トランス脂肪酸によるDNA損傷時の新規細胞死促進機構2020
- Author(s)
  山田侑杜，平田祐介，野口拓也，松沢厚
- Organizer
  第59回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] トランス脂肪酸によるDNA損傷誘導性細胞死の促進作用とその分子機構の解明2020
- Author(s)
  井上綾, 平田祐介, 野口拓也, 松沢厚
- Organizer
  日本生化学会東北支部第86回例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] トランス脂肪酸によるミトコンドリアROS産生を介したDNA損傷誘導性細胞死の促進機構2020
- Author(s)
  平田祐介, 井上綾, 野口拓也, 松沢厚
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] トランス脂肪酸によるDNA損傷時の細胞死促進機構の解明2020
- Author(s)
  井上綾, 平田祐介, 野口拓也, 松沢厚
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] トランス脂肪酸によるシスプラチン誘導性細胞死の促進作用機構2020
- Author(s)
  山田侑杜，平田祐介，野口拓也，松沢厚
- Organizer
  第93回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] トランス脂肪酸による細胞老化促進作用を介した関連疾患発症機構の解析2020
- Author(s)
  平田祐介，井上綾，蘆田諒, 野口拓也，松沢厚
- Organizer
  フォーラム2020：衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-20K07011
[Presentation] トランス脂肪酸による細胞老化促進作用とその分子機構の解析2019
- Author(s)
  井上綾，高橋未来，平田祐介，野口拓也，松沢厚
- Organizer
  フォーラム2019 衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] Toxicological evaluation of trans-fatty acids using novel molecular bases2019
- Author(s)
  Yuki Nada, Yusuke Hirata, Miki Takahashi, Saki Suzuki, Ryosuke Matsui, Takuya Noguchi, and Atsushi Matsuzawa
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] 新規分子基盤に基づくトランス脂肪酸の毒性リスク評価2019
- Author(s)
  灘雄貴，平田祐介，高橋未来，野口拓也，松沢厚
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] NASH治療薬開発を目指した低分子シード化合物スクリーニング2019
- Author(s)
  小島秀介, 平田祐介, 野口拓也, 松沢厚
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] Roquin-2の TAK1ユビキチン化分解による酸化ストレス応答制御機構2019
- Author(s)
  中田悠靖, 平田祐介, 工藤勇気, 野口拓也, 松沢厚
- Organizer
  第58回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] トランス脂肪酸の新規分子基盤に基づく毒性リスク評価2019
- Author(s)
  灘雄貴, 平田祐介, 高橋未来, 野口拓也, 松沢厚
- Organizer
  第58回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] 新規ASK1活性化促進因子TRIM48の発現制御機構の解明2019
- Author(s)
  中島謙心, 平田祐介, 野口拓也, 松沢厚
- Organizer
  第58回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] trans-Fatty acids promote pro-inflammatory signaling and cell death by potentiating the ASK1-p38 MAP kinase signaling pathway2019
- Author(s)
  Yusuke Hirata, Miki Takahashi, Yuki Kudoh, Takuya Noguchi, and Atsushi Matsuzawa
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] トランス脂肪酸による毒性発現の分子基盤の確立2019
- Author(s)
  平田祐介
- Organizer
  フォーラム2019 衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] RING型ユビキチンリガーゼRoquin-2による酸化ストレス応答制御機構の解析2019
- Author(s)
  中田悠靖, 平田祐介, 工藤勇気, 野口拓也, 松沢厚
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] トランス脂肪酸によるDNA損傷誘導性細胞死の促進作用機構2019
- Author(s)
  平田祐介, 高橋未来, 井上綾, 野口拓也, 松沢厚
- Organizer
  第58回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] トランス脂肪酸特異的なDNA損傷応答の促進作用機構の解明2019
- Author(s)
  平田祐介, 高橋未来, 鈴木沙季, 松井稜祐, 野口拓也, 松沢厚
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] Elucidation of the molecular mechanisms underlying pro-apoptotic effect of trans-fatty acid in response to DNA damage2019
- Author(s)
  Miki Takahashi, Yusuke Hirata, Saki Suzuki, Ryosuke Matsui, Takuya Noguchi, Atsushi Matsuzawa
- Organizer
  第15回国際毒性学会（TCT XV）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] トランス脂肪酸によるDNA損傷応答促進作用とその分子機構の解明2019
- Author(s)
  平田祐介, 高橋未来, 井上綾, 野口拓也, 松沢厚
- Organizer
  日本生化学会東北支部第85回例会
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] 新規ASK1活性調節因子TRIM48の発現制御機構とその病態生理学的意義の解明2019
- Author(s)
  平田祐介, 中島謙心, 野口拓也, 松沢厚
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] trans-Fatty acids facilitate DNA damage-induced apoptosis by augmenting mitochondrial JNK signaling2019
- Author(s)
  Aya Inoue, Yusuke Hirata, Saki Suzuki, Miki Takahashi, Ryosuke Matsui, Takuya Noguchi, and Atsushi Matsuzawa
- Organizer
  60th International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] 酸化ストレス応答キナーゼASK1のユビキチン化修飾を介した新規活性調節機構2019
- Author(s)
  平田祐介, 松沢厚
- Organizer
  第72回日本酸化ストレス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] DNA損傷時におけるトランス脂肪酸特異的な細胞死亢進機構の解明2018
- Author(s)
  鈴木沙季, 平田祐介, 松井稜祐, 高橋未来, 野口拓也, 松沢厚
- Organizer
  第40回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] トランス脂肪酸による細胞老化促進作用とその分子機序の解明2018
- Author(s)
  松井稜祐, 高橋未来, 平田祐介, 野口拓也, 松沢厚
- Organizer
  第40回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] DNA損傷時のトランス脂肪酸特異的な細胞死促進機構の解明2018
- Author(s)
  高橋未来，平田祐介，鈴木沙季，松井稜祐，野口拓也，松沢厚
- Organizer
  第57回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] トランス脂肪酸によるDNA損傷応答の促進作用機構の解明2018
- Author(s)
  平田祐介, 高橋未来, 鈴木沙季, 松井稜祐, 野口拓也, 松沢厚
- Organizer
  フォーラム2018 衛生薬学・環境トキシコロジー
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] ストレス応答キナーゼASK1を介した免疫応答におけるトランス脂肪酸特異的作用機構2018
- Author(s)
  高橋未来, 平田祐介, 工藤勇気, 野口拓也, 松沢厚
- Organizer
  第40回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] DNA損傷時におけるトランス脂肪酸特異的な細胞死促進作用とその分子機構の解明2018
- Author(s)
  高橋未来, 平田祐介, 鈴木沙季, 松井稜祐, 野口拓也, 松沢厚
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K14894
[Presentation] Roquin-2によるASK1活性制御を介した免疫応答調節機構の解明2016
- Author(s)
  平田祐介、工藤勇気、野口拓也、松沢厚
- Organizer
  第69回酸化ストレス学会学術集会
- Place of Presentation
  仙台国際センター
- Year and Date
  2016-08-30
- Data Source
  KAKENHI-PROJECT-15K18856
[Presentation] Roquin-2によるASK1の活性制御を介した免疫応答の調節2016
- Author(s)
  工藤勇気、平田祐介、野口拓也、松沢厚
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15K18856
[Presentation] Mechanisms of ROS-induced ASK1 activation regulated by ubiquitin-related enzymes2016
- Author(s)
  Yusuke Hirata, Takuya Noguchi, and Atsushi Matsuzawa
- Organizer
  第16回日本NO学会学術集会 (第9回国際NO学会)
- Place of Presentation
  仙台国際センター
- Year and Date
  2016-05-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18856
[Presentation] ユビキチン化修飾を介したストレス応答キナーゼASK1の活性制御機構2016
- Author(s)
  平田祐介、工藤勇気、森下徹、野口拓也、松沢厚
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K18856
[Presentation] RING型ユビキチンリガーゼTRIM48によるストレス応答キナーゼASK1の活性化制御機構の解明2016
- Author(s)
  森下徹、平田祐介、野口拓也、松沢厚
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15K18856
[Presentation] Regulation of inflammatory responses through Roquin-2-mediated suppression of ASK1 activation2015
- Author(s)
  Yuki Kudoh，Yusuke Hirata，Takuya Noguchi, and Atsushi Matsuzawa
- Organizer
  Pharmaceutical Science Symposium 2015
- Place of Presentation
  東北大学片平さくらホール
- Year and Date
  2015-11-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18856
[Presentation] Roquin-2によるASK1の活性制御を介した免疫応答の調節2015
- Author(s)
  工藤勇気、平田祐介、野口拓也、一條秀憲、松沢厚
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K18856
[Presentation] RING型ユビキチンリガーゼTRIM48によるストレス応答キナーゼASK1の活性制御機構の解明2015
- Author(s)
  森下徹、平田祐介、野口拓也、一條秀憲、松沢厚
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K18856
[Presentation] ユビキチンリガーゼRoquin-2のASK1活性制御を介した免疫応答調節2015
- Author(s)
  工藤勇気，平田祐介，野口拓也，一條秀憲，松沢厚
- Organizer
  第14回次世代を担う若手ファーマ・バイオフォーラム2015
- Place of Presentation
  千葉大学亥鼻キャンパス医薬系総合研究棟 (薬学研究院)
- Year and Date
  2015-09-12
- Data Source
  KAKENHI-PROJECT-15K18856
[Presentation] E3リガーゼTRIM48によるASK1活性化制御機構の解明2015
- Author(s)
  平田祐介, 森下徹, 野口拓也, 松沢厚
- Organizer
  第54回日本薬学会東北支部大会
- Place of Presentation
  岩手医科大学矢巾キャンパス
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-15K18856
[]

1. 野口拓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
2. 松沢厚

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results

Hirata Yusuke 平田 祐介

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Co-Researchers

Development of cancer prevention and treatment strategies based on novel cell death regulation mechanisms mediated by trans-fatty acidsPrincipal Investigator

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Toxicological assessment of trans fatty acids (TFAs) based on the novel molecular mechanisms of their toxicity for prevention and treatment of TFA-related diseasesPrincipal Investigator

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Regulatory mechanisms for cell death and inflammatory signaling mediated by the diversity of membrane fatty acid speciesPrincipal Investigator

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Development of prevention and treatment strategies for trans-fatty acid-related diseases based on novel toxicity mechanismsPrincipal Investigator

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Elucidation of the regulatory mechanisms of ASK1 ubiquitination for developing a new treatment strategy for ASK1-related diseasesPrincipal Investigator

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[Journal Article] Aggregability of the SQSTM1/p62-based aggresome-like induced structures determines the sensitivity to parthanatos2024

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[Journal Article] Membrane Dynamics and Cation Handling in Ferroptosis2024

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[Journal Article] Industrially produced <i>trans</i>-fatty acids are potent promoters of DNA damage-induced apoptosis2024

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[Journal Article] Geometrical isomerization of arachidonic acid during lipid peroxidation interferes with ferroptosis2023

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[Journal Article] Grinstein, S., Freeman, S. A. Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis2023

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[Journal Article] Reactive sulfur species disaggregate the SQSTM1/p62-based aggresome-like induced structures via the HSP70 induction and prevent parthanatos2023

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[Journal Article] LLPS of SQSTM1/p62 and NBR1 as outcomes of lysosomal stress response limits cancer cell metastasis2023

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[Journal Article] The NLRP3 Inflammasome Works as a Sensor for Detecting Hypoactivity of the Mitochondrial Src Family Kinases2023

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[Journal Article] A comprehensive toxicological analysis of trans-fatty acids (TFAs) reveals a pro-apoptotic action specific to industrial TFAs counteracted by polyunsaturated FAs2023

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Hirata Yusuke 平田祐介