Tezuka Kenta 手塚健太

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TEZUKA Kenta 手塚健太

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Researcher Number	10754533
Other IDs
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立感染症研究所次世代生物学的製剤研究センター, 室長
Affiliation (based on the past Project Information) *help	2025: 国立健康危機管理研究機構, 次世代生物学的製剤研究センター, 室長 2023: 国立感染症研究所, 次世代生物学的製剤研究センター, 室長 2022: 国立感染症研究所, 次世代生物学的製剤研究センター, 主任研究官 2019 – 2021: 国立感染症研究所, 血液・安全性研究部, 主任研究官 2016 – 2017: 国立感染症研究所, 血液・安全性研究部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 42040:Laboratory animal science-related / Basic Section 54030:Infectious disease medicine-related / Hematology
Keywords	Principal Investigator HTLV-1感染 / HTLV-1 / Tax特異的CTL / 感染受容体遺伝子 / 感染動物モデル / 感染経路 / モノクローナル抗体 / 水平感染 / 中和抗体 / HTLV-1 Env蛋白質gp46 … More / モノクローナル中和抗体 / 抗原特異的記憶B細胞 / HTLV-1水平感染者 / 感染免疫 / HLA拘束性CTL応答 / 潜伏感染 / HLA-A*02:01遺伝子 / 次世代ヒト化マウス / HTLV-1感染症 / ウイルス / 免疫学 / 移植・再生医療 / 感染症 / iPS細胞 / 発症高リスク群 / HTLV-1 感染症 Less

HTLV-1感染経路の機序解明に資する遺伝的ヒト化マウスモデルPrincipal Investigator
- Principal Investigator
  
  手塚健太
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  Japan Institute for Health Security
HTLV-1水平感染者で誘導されるEnv特異的抗体の性状解析Principal Investigator
- Principal Investigator
  
  手塚健太
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54030:Infectious disease medicine-related
- Research Institution
  National Institute of Infectious Diseases
Development of the next-generation humanized mouse model for HTLV-1 infectionPrincipal Investigator
- Principal Investigator
  
  TEZUKA Kenta
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 42040:Laboratory animal science-related
- Research Institution
  National Institute of Infectious Diseases
Development of iPSC-based CTL therapy for HTLV-1 infectionPrincipal Investigator
- Principal Investigator
  
  TEZUKA Kenta
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  National Institute of Infectious Diseases

All 2024 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Book Patent

[Book] 創薬研究者がこれだけは知っておきたい最新のウイルス学2021
- Author(s)
  大隈和、手塚健太、浜口功
- Total Pages
  601
- Publisher
  技術情報協会
- ISBN
  9784861048555
- Data Source
  KAKENHI-PROJECT-19K16032
[Journal Article] Establishment of a novel human T-cell leukemia virus type 1 infection model using cell-free virus2024
- Author(s)
  Nagata Koh、Tezuka Kenta、Kuramitsu Madoka、Fuchi Naoki、Hasegawa Yuri、Hamaguchi Isao、Miura Kiyonori
- Journal Title
  
  Journal of Virology
  
  Volume: 98 Issue: 2
- DOI
  10.1128/jvi.01862-23
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09497, KAKENHI-PROJECT-22K08594, KAKENHI-PROJECT-22K09622
[Journal Article] Cytolytic Recombinant Vesicular Stomatitis Viruses Expressing STLV-1 Receptor Specifically Eliminate STLV-1 Env-Expressing Cells in an HTLV-1 Surrogate Model In Vitro2022
- Author(s)
  Seki Y, Kitamura T, Tezuka K, Murata M, Akari H, Hamaguchi I, Okuma K.
- Journal Title
  
  Viruses
  
  Volume: 14 Issue: 4 Pages: 740-740
- DOI
  10.3390/v14040740
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06465, KAKENHI-PROJECT-21K06007, KAKENHI-PROJECT-22K08594
[Journal Article] No SARS-CoV-2 RNA detected in the convalescent plasma of COVID-19 patients with different disease severity2021
- Author(s)
  Hidetoshi Nomoto, Satoshi Kutsuna, Kazu Okuma, Madoka Kuramitsu, Kenta Tezuka, Emi Ikebe, Sho Saito, Noriko Kinoshita, Mari Terada, Mio Endo, Tetsuya Suzuki, Yusuke Miyazato, Takato Nakamoto, Makoto Inada, Isao Hamaguchi, Norio Ohmagari.
- Journal Title
  
  J Infect Chemother.
  
  Volume: 27(4) Issue: 4 Pages: 653-655
- DOI
  10.1016/j.jiac.2021.01.004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16032, KAKENHI-PROJECT-20K07670
[Journal Article] Activation of PERK-ATF4-CHOP pathway as a novel therapeutic approach for efficient elimination of HTLV-1-infected cells2020
- Author(s)
  Ikebe E, Matsuoka S, Tezuka K, Kuramitsu M, Okuma K, Nakashima M,, Seiichiro Kobayashi S, Makiyama J, Yamagishi M, Oyadomari S, Uchimaru K, Hamaguchi I
- Journal Title
  
  Blood adv
  
  Volume: 4 Issue: 9 Pages: 1845-1858
- DOI
  10.1182/bloodadvances.2019001139
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08378, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-20K07670, KAKENHI-PROJECT-19K16032, KAKENHI-PROJECT-20K17390, KAKENHI-PROJECT-19H02853, KAKENHI-PROJECT-19H03575, KAKENHI-PROJECT-19K16580
[Journal Article] HTLV-1 targets human placental trophoblasts in seropositive pregnant women2020
- Author(s)
  Tezuka Kenta、Fuchi Naoki、Okuma Kazu、Tsukiyama Takashi、Miura Shoko、Hasegawa Yuri、Nagata Ai、Komatsu Nahoko、Hasegawa Hiroo、Sasaki Daisuke、Sasaki Eita、Mizukami Takuo、Kuramitsu Madoka、Matsuoka Sahoko、Yanagihara Katsunori、Miura Kiyonori、Hamaguchi Isao
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 130 Issue: 11 Pages: 6171-6186
- DOI
  10.1172/jci135525
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09265, KAKENHI-PROJECT-20K07670, KAKENHI-PROJECT-18K16805, KAKENHI-PROJECT-19K16032, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-17K11241, KAKENHI-PROJECT-18K08378
[Journal Article] Development and Evaluation of Human T-cell Leukemia virus-1 and -2 Multiplex Quantitative PCR2019
- Author(s)
  Madoka Kuramitsu, Kazu Okuma, Kenta Tezuka, Hitomi Nakamura, Yasuko Sagara, Ichiro Kurane, Isao Hamaguchi.
- Journal Title
  
  Microbiology and immunology.
  
  Volume: 63(11) Issue: 11 Pages: 458-464
- DOI
  10.1111/1348-0421.12740
- NAID
  40022072167
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16032, KAKENHI-PROJECT-16H06277
[Journal Article] Control of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Infection by Eliminating Envelope Protein-Positive Cells with Recombinant Vesicular Stomatitis Viruses Encoding HTLV-1 Primary Receptor.2018
- Author(s)
  Tezuka K, Okuma K, Kuramitsu M, Matsuoka S, Tanaka R, Tanaka Y, Hamaguchi I.
- Journal Title
  
  Journal of Virology
  
  Volume: 92(4) Issue: 4
- DOI
  10.1128/jvi.01885-17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08439, KAKENHI-PROJECT-15K09462, KAKENHI-PROJECT-16K19590
[Journal Article] Establishment of a reference material for standardization of the anti-complementary activity test in intravenous immunoglobulin products used in Japan: A collaborative study.2017
- Author(s)
  Kiyoko Nojima, Kazu Okuma, Masaki Ochiai, Madoka Kuramitsu, Kenta Tezuka, Mieko Ishii, Sadao Ueda, Takashi Miyamoto, Koichiro Kamimura, Enki Kou, Sanae Uchida, Yoshiharu Watanabe, Yoshiaki Okada, Isao Hamaguchi
- Journal Title
  
  Biologicals
  
  Volume: 46 Pages: 68-73
- DOI
  10.1016/j.biologicals.2016.12.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19590
[Journal Article] Development of a novel dengue virus serotype-specific multiplex real-time reverse transcription-polymerase chain reaction assay for blood screening.2016
- Author(s)
  Kenta Tezuka, Madoka Kuramitsu, Kazu Okuma, Kiyoko Nojima, Kumiko Araki, Naoya Shinohara, Chieko Matsumoto, Masahiro Satake, Tomohiko Takasaki, Masayuki Saijo, Ichiro Kurane, and Isao Hamaguchi
- Journal Title
  
  Transfusion
  
  Volume: 56 Issue: 12 Pages: 3094-100
- DOI
  10.1111/trf.13875
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19590
[Patent] 発明の名称：血清型２のデングウイルス検出用キット、血清型３のデングウイルス検出用キット及びデングウイルス検出用キット2019
- Inventor(s)
  手塚健太、倉光球、大隈和、浜口功、高崎智彦
- Industrial Property Rights Holder
  手塚健太、倉光球、大隈和、浜口功、高崎智彦
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Acquisition Date
  2019
- Data Source
  KAKENHI-PROJECT-19K16032
[Patent] 検出及び／又は定量用プライマー対、検出及び／又は定量用プローブ、及び、検出及び／又は定量用キット2019
- Inventor(s)
  大隈和、手塚健太、浜口功
- Industrial Property Rights Holder
  大隈和、手塚健太、浜口功
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Acquisition Date
  2021
- Data Source
  KAKENHI-PROJECT-19K16032
[Patent] 組換え水疱性口内炎ウイルスを用いたワクチン・治療薬開発に向けたモニタリングのためのウイルスベクター定量法2017
- Inventor(s)
  大隈和、手塚健太、浜口功
- Industrial Property Rights Holder
  大隈和、手塚健太、浜口功
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-131361
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K19590
[Presentation] Digital PCRを用いたHTLV-1プロウイルス欠失の簡易検出法の開発2023
- Author(s)
  1.平賀　孔、手塚健太、永田　幸、高　起良、中村仁美、相良康子、蕎麦田理英子、佐竹正博、谷生道一、三浦清徳、水上拓郎、浜口　功、倉光　球
- Organizer
  日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-22K08594
[Presentation] ヒトT細胞白血病ウイルス1型 (HTLV-1) の新たな感染経路の機序解明の試み2023
- Author(s)
  手塚健太
- Organizer
  第39回日本産婦人科感染症学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08594
[Presentation] 関西地区における HTLV-1 水平感染の解析2022
- Author(s)
  高起良、南野智、手塚健太、倉光球、浜口功
- Organizer
  日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-22K08594
[Presentation] 夫婦間 HTLV-1 感染における特異抗体発現解析2022
- Author(s)
  徳永雅仁、宇都宮與、倉光球、相良康子、中村仁美、中野伸亮、宮園卓宜、手塚健太、伊藤能清、浜口功
- Organizer
  日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-22K08594
[Presentation] Cell-free 感染系を用いた HTLV-1 新規感染モデルの構築2022
- Author(s)
  永田幸、手塚健太、倉光球、淵直樹、長谷川ゆり、松岡雅雄、三浦清徳、浜口功
- Organizer
  日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-22K08594
[Presentation] ヒト化 NOG-A2 マウスを用いた HTLV-1 持続感染モデルの開発2022
- Author(s)
  大隈和、手塚健太、中嶋伸介、後藤元人、高橋利一、李成一、大高時文、伊藤守、浜口功
- Organizer
  日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-22K08594
[Presentation] STLV-1 自然感染ニホンザルモデルを用いた水平感染に寄与する HTLV-1 の新たな標的細胞の同定2022
- Author(s)
  関洋平、水上拓郎、平舘裕希、永田幸、手塚健太、野島清子、村田めぐみ、兼子明久、森本真弓、長谷川ゆり、淵直樹、三浦清徳、明里宏文、浜口功
- Organizer
  日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-22K08594
[Presentation] HTLV-1 水平感染者で誘導される Env 特異的抗体の性状解析2022
- Author(s)
  手塚健太、小野寺大志、多田稔、高起良、相良康子、中村仁美、倉光球、大隈和、高橋宜聖、浜口功
- Organizer
  日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-22K08594
[Presentation] 長崎県における HTLV-1 母子感染対策の現状と最近の話題2022
- Author(s)
  三浦清徳、手塚健太、浜口功
- Organizer
  日本HTLV-1学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K08594
[Presentation] STLV-1自然感染ニホンザルを用いた水平感染様式解明に向けた検討2021
- Author(s)
  関洋平、手塚健太、平舘裕希、水上拓郎、大隈和、村田めぐみ、明里宏文、浜口功
- Organizer
  日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16032
[Presentation] STLV-1感染ニホンザルによるHTLV-1標的ウイルス療法の開発に向けた検討2020
- Author(s)
  大隈和、倉光球、手塚健太、水上拓郎、村田めぐみ、明里宏文、浜口功
- Organizer
  日本実験動物学会
- Data Source
  KAKENHI-PROJECT-19K16032
[Presentation] 小胞体ストレス応答を標的とした新規抗HTLV-1薬の開発2020
- Author(s)
  池辺詠美、松岡佐保子、手塚健太、倉光球、大隈和、中島誠、小林誠一郎、牧山純也、山岸誠、親泊政一、内丸薫、浜口功
- Organizer
  日本生化学会
- Data Source
  KAKENHI-PROJECT-19K16032
[Presentation] ニホンザル (Macaca fuscata) のSTLV-1ゲノム解析2019
- Author(s)
  北村知也、倉光球、手塚健太、水上拓郎、明里宏文、村田めぐみ、大隈和、浜口功
- Organizer
  日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-19K16032
[Presentation] VIRAL SAFETY ASSESSMENT IN THE DEVELOPMENT OF HTLV-1 HYPERIMMUNE GLOBULIN2019
- Author(s)
  K Nojima, T Mizukami, R Sobata, K Tezuka, M Kuramitsu, S Matsuoka, K Okuma, M Satake, I Hamaguchi
- Organizer
  ISBT Bangkok 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16032
[Presentation] HTLV-1プロウイルス陽性のWB判定保留例に対するLIAの検討2019
- Author(s)
  倉光球、大隈和、相良康子、中村仁美、手塚健太、浜口功
- Organizer
  日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-19K16032
[Presentation] HTLV-1感染制御に向けたサル薬剤評価系構築による新規ウイルス療法の開発2019
- Author(s)
  大隈和、倉光球、手塚健太、北村知也、水上拓郎、村田めぐみ、明里宏文、浜口功
- Organizer
  日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-19K16032
[Presentation] サル感染モデルを用いたHTLV-1治療薬評価に向けた検討2019
- Author(s)
  大隈和、倉光球、手塚健太、水上拓郎、村田めぐみ、明里宏文、浜口功
- Organizer
  日本実験動物学会
- Data Source
  KAKENHI-PROJECT-19K16032
[Presentation] キャリア妊婦におけるHTLV-1経胎盤感染の実態解明の試み2019
- Author(s)
  手塚健太、淵直樹、大隈和、築山尚史、長谷川ゆり、長谷川寛雄、佐々木大介、三浦生子、東島愛、佐々木永太、水上拓郎、倉光球、松岡佐保子、増﨑英明、三浦清徳、浜口功
- Organizer
  日本HTLV-1学会
- Data Source
  KAKENHI-PROJECT-19K16032
[Presentation] ヒト化マウスモデルを用いた高感度HTLV-1ウイルスRNA検出法の開発2019
- Author(s)
  手塚健太、水上拓郎、佐々木永太、倉光球、松岡佐保子、大隈和、浜口功
- Organizer
  日本実験動物学会
- Data Source
  KAKENHI-PROJECT-19K16032
[Presentation] Application of STLV-1-infected Japanese macaques to a non-human primate model for HTLV-1 infection to develop VSV-based anti-HTLV-1 virotherapy2019
- Author(s)
  大隈和、倉光球、手塚健太、水上拓郎、村田めぐみ、明里宏文、浜口功
- Organizer
  日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-19K16032
[Presentation] Development of a novel high-sensitive nucleic acid testing method for quantifying VSV vector in vivo2017
- Author(s)
  Kenta Tezuka, Kazu Okuma, Isao Hamaguchi
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19590
[Presentation] HTLV-1受容体をコードする組換え水疱性口内炎ウイルスを用いたHTLV-1感染の制御2017
- Author(s)
  手塚健太, 大隈和, 倉光球, 田中勇悦, 田中礼子, 浜口功
- Organizer
  第4回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19590
[Presentation] Targeting and Eliminating HTLV-1-infected Cells with Cytolytic Recombinant Vesicular Stomatitis Viruses Encoding HTLV-1 Primary Receptor2017
- Author(s)
  Kenta Tezuka, Kazu Okuma, Madoka Kuramitsu, Yuetsu Tanaka, Reiko Tanaka, Isao Hamaguchi
- Organizer
  18th International Conference on Human Retrovirology HTLV and Related Viruses
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19590
[Presentation] Multiplex RT-qPCRによるデングウイルス4血清型の高感度同時検出法の開発2016
- Author(s)
  手塚健太、倉光球、大隈和、野島清子、荒木久美子、篠原直也、松本千惠子、佐竹正博、浜口功
- Organizer
  第64回日本輸血・細胞治療学会総会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2016-04-28
- Data Source
  KAKENHI-PROJECT-16K19590

1. MIURA Kiyonori

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. OKUMA Kazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
3. MIURA Shoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 浜口功

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tezuka Kenta 手塚 健太

TEZUKA Kenta 手塚 健太

Research Projects

Research Products

Co-Researchers

HTLV-1感染経路の機序解明に資する遺伝的ヒト化マウスモデルPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

HTLV-1水平感染者で誘導されるEnv特異的抗体の性状解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of the next-generation humanized mouse model for HTLV-1 infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of iPSC-based CTL therapy for HTLV-1 infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 創薬研究者がこれだけは知っておきたい最新のウイルス学2021

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Establishment of a novel human T-cell leukemia virus type 1 infection model using cell-free virus2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cytolytic Recombinant Vesicular Stomatitis Viruses Expressing STLV-1 Receptor Specifically Eliminate STLV-1 Env-Expressing Cells in an HTLV-1 Surrogate Model In Vitro2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] No SARS-CoV-2 RNA detected in the convalescent plasma of COVID-19 patients with different disease severity2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Activation of PERK-ATF4-CHOP pathway as a novel therapeutic approach for efficient elimination of HTLV-1-infected cells2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HTLV-1 targets human placental trophoblasts in seropositive pregnant women2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development and Evaluation of Human T-cell Leukemia virus-1 and -2 Multiplex Quantitative PCR2019

Author(s)

Journal Title

DOI

NAID

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[Journal Article] Control of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Infection by Eliminating Envelope Protein-Positive Cells with Recombinant Vesicular Stomatitis Viruses Encoding HTLV-1 Primary Receptor.2018

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[Journal Article] Establishment of a reference material for standardization of the anti-complementary activity test in intravenous immunoglobulin products used in Japan: A collaborative study.2017

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DOI

Data Source

[Journal Article] Development of a novel dengue virus serotype-specific multiplex real-time reverse transcription-polymerase chain reaction assay for blood screening.2016

Author(s)

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DOI

Tezuka Kenta 手塚健太

TEZUKA Kenta 手塚健太