Sakisaka Yukihiko 向阪幸彦

… Alternative Names

SAKISAKA Yukihiko 向阪幸彦

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Researcher Number	10760457
Other IDs
Affiliation (Current)	2025: 東北大学, 大学病院, 助教
Affiliation (based on the past Project Information) *help	2023 – 2024: 東北大学, 大学病院, 助教 2017 – 2022: 東北大学, 大学病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 57030:Conservative dentistry-related / Periodontology Except Principal Investigator Medium-sized Section 57:Oral science and related fields / Basic Section 57040:Regenerative dentistry and dental engineering-related / Basic Section 57030:Conservative dentistry-related
Keywords	Principal Investigator 歯学 / シグナル伝達 / 再生医療 / RANKL / エクソソーム / メカニカルストレス / 細胞・組織 / Extracellular Vesicles / Wnt / LIPUS / ハイドロキシアパタイト / 歯周再生医学 / 歯科 … More Except Principal Investigator … More miRNA / 細胞外小胞 / M2マクロファージ / エクソソーム / メカニカルストレス / 歯周組織再生 / デザイナー細胞 / 細胞移植治療 / TCR / iPS / iPS化 / 歯周炎 / Dysbiosis / 絹糸結紮歯周炎モデル / TCRレパトア / Dysbiotic細菌叢 / 歯周病 / MAIT細胞 / 顎骨骨粗鬆症 / 歯周組織 / 低カルシウム Less

歯周組織再生におけるRANK発現EVsの機能解析とその治療応用への基盤構築Principal Investigator
- Principal Investigator
  
  向阪幸彦
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Tohoku University
歯周組織特異的CAR-MSC細胞を用いた革新的な歯周組織再生移植治療への挑戦
- Principal Investigator
  
  山田聡
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Tohoku University
力学誘導M2マクロファージエクソソームによる新規歯周組織再生療法の基盤構築
- Principal Investigator
  
  丸山顕太郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57040:Regenerative dentistry and dental engineering-related
- Research Institution
  Tohoku University
低Ca摂取による顎骨骨粗鬆症が歯周病を進行させるメカニズムの解明
- Principal Investigator
  
  荘司佳奈子
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Tohoku University
Development of Dysbiotic Microbiota-specific MAIT Cells and Their Application to the Treatment for Periodontitis
- Principal Investigator
  
  KAJIKAWA TETSUHIRO
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  Tohoku University
Development of a new periodontal regenerative therapy with RANKL reverse signaling and osteoclast-derived exosomePrincipal Investigator
- Principal Investigator
  
  Sakisaka Yukihiko
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Tohoku University
A basic study of a new periodontal regenerative therapy with periodontal ligament cell-derived exosome and Wnt signalingPrincipal Investigator
- Principal Investigator
  
  SAKISAKA Yukihiko
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Tohoku University
A basic study of a new periodontal regenerative therapy with nanoparticles of hydroxyapatite and Low Intensity Pulsed UltrasoundPrincipal Investigator
- Principal Investigator
  
  SAKISAKA Yukihiko
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Periodontology
- Research Institution
  Tohoku University

All 2024 2023 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] Cementocyte-derived extracellular vesicles regulate osteoclastogenesis and osteoblastogenesis2024
- Author(s)
  Li Jiajun、Sakisaka Yukihiko、Nemoto Eiji、Maruyama Kentaro、Suzuki Shigeki、Xiong Kaixin、Tada Hiroyuki、Tenkumo Taichi、Yamada Satoru
- Journal Title
  
  Journal of Dental Sciences
  
  Volume: ‐ Issue: 4 Pages: 2236-2246
- DOI
  10.1016/j.jds.2024.02.025
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K09212, KAKENHI-PROJECT-22K19611, KAKENHI-PROJECT-23K24524
[Journal Article] Serial Cultivation of an MSC-Like Cell Line with Enzyme-Free Passaging Using a Microporous Titanium Scaffold2023
- Author(s)
  Sakisaka Y, Ishihata H, Maruyama K, Nemoto E, Chiba S, Nagamine M, Hasegawa H, Hatsuzawa T, Yamada S.
- Journal Title
  
  Materials
  
  Volume: 16 Issue: 3 Pages: 1165-1165
- DOI
  10.3390/ma16031165
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10144, KAKENHI-PROJECT-21K09868, KAKENHI-PROJECT-20H03613, KAKENHI-PROJECT-20K09933, KAKENHI-PROJECT-21K16983
[Journal Article] Evaluation of Preosteoblast MC3T3-E1 Cells Cultured on a Microporous Titanium Membrane Fabricated Using a Precise Mechanical Punching Process2020
- Author(s)
  Zhang Jingyu、Sakisaka Yukihiko、Ishihata Hiroshi、Maruyama Kentaro、Nemoto Eiji、Chiba Shigeki、Nagamine Masaru、Hasegawa Hiroshi、Yamada Satoru
- Journal Title
  
  Materials
  
  Volume: 13 Issue: 22 Pages: 5288-5288
- DOI
  10.3390/ma13225288
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10144, KAKENHI-PROJECT-20K09933, KAKENHI-PROJECT-19K18984
[Journal Article] Cyclic stretch force induces periodontal ligament cells to secrete exosomes that suppress IL-1β production through the inhibition of the NF-κB signaling pathway in macrophages.2019
- Author(s)
  Wang Z, Maruyama K, Sakisaka Y, Suzuki S, Tada H, Suto M, Saito M, Yamada S, Nemoto E
- Journal Title
  
  Front Immunol,
  
  Volume: ecollection Pages: 01310-01310
- DOI
  10.3389/fimmu.2019.01310
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10104, KAKENHI-PROJECT-19K18984, KAKENHI-PROJECT-16H05553, KAKENHI-PROJECT-17K17116
[Journal Article] Extracellular calcium increases fibroblast growth factor 2 gene expression via extracellular signal-regulated kinase 1/2 and protein kinase A signaling in mouse dental papilla cells2018
- Author(s)
  Kanaya Sousuke、Xiao Binlu、Sakisaka Yukihiko、Suto Mizuki、Maruyama Kentaro、Saito Masahiro、Nemoto Eiji
- Journal Title
  
  Journal of Applied Oral Science
  
  Volume: 26 Issue: 0 Pages: 231-241
- DOI
  10.1590/1678-7757-2017-0231
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K17116, KAKENHI-PROJECT-16H05553, KAKENHI-PROJECT-17K17345
[Journal Article] The effect of Berberine on cell differentiation and proliferation in human periodontal ligament cells2018
- Author(s)
  Ikeno Shuko、Nemoto Eiji、Kanaya Sousuke、Suto Mizuki、Sakisaka Yukihiko、Shimauchi Hidetoshi、Yamada Satoru
- Journal Title
  
  Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology)
  
  Volume: 60 Issue: 1 Pages: 13-25
- DOI
  10.2329/perio.60.13
- NAID
  130006594281
- ISSN
  0385-0110, 1880-408X
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K17345
[Journal Article] Cyclic Stretch Negatively Regulates IL-1β Secretion Through the Inhibition of NLRP3 Inflammasome Activation by Attenuating the AMP Kinase Pathway2018
- Author(s)
  Maruyama K, Sakisaka Y, Suto M, Tada H, Nakamura T, Yamada S, Nemoto E.
- Journal Title
  
  Front. Physiol.
  
  Volume: 9 Pages: 802-802
- DOI
  10.3389/fphys.2018.00802
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K11824, KAKENHI-PROJECT-17K17116, KAKENHI-PROJECT-16H05553, KAKENHI-PROJECT-17K17345
[Presentation] in vivoでの新規GBR用純チタン製メンブレンの有効性ついて2018
- Author(s)
  向阪幸彦、石幡浩志、須藤瑞樹、小松秀裕、丸山顕太郎、山田聡、長谷川博
- Organizer
  第61回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-17K17345
[Presentation] Serial cultivation of osteogenic cells by automatic transfer between culture substrate of microperforated titanium membrane2018
- Author(s)
  向阪幸彦、丸山顕太郎、張井玉、石幡浩志、根本英二、佐々木啓一、初澤毅、山田聡
- Organizer
  第3回生体医歯工学共同研究拠点国際シンポジウム
- Data Source
  KAKENHI-PROJECT-17K17345
[Presentation] Application of microperforated titanium mesh for tissue engineered regeneration2018
- Author(s)
  Yukihiko Sakisaka, Kentaro Maruyama, Jingyu Zhang, Hiroshi Ishihata, Eiji Nemoto, Keiichi Sasaki, Takeshi Hatsuzawa, Satoru Yamada
- Organizer
  The 104th Annual Meeting of the American Academy of Periodontology in collaboration with the Canadian Academy of Periodontology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17345
[Presentation] Cyclic stretch inhibits IL-1β secretion by attenuating NLRP3 inflammasome activation2018
- Author(s)
  Eiji Nemoto, Kentaro Maruyama, Yukihiko Sakisaka, Mizuki Suto, Hiroyuki Tada, Takashi Nakamura, Satoru Yamada
- Organizer
  The 104th Annual Meeting of the American Academy of Periodontology in collaboration with the Canadian Academy of Periodontology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17345
[Presentation] LIPUS inhibits IL-β secretion through NF-κB signaling pathway in macrophages2018
- Author(s)
  Mizuki Suto, Eiji Nemoto, Kentaro Maruyama, Yukihiko Sakisaka, Satoru Yamada
- Organizer
  The 104th Annual Meeting of the American Academy of Periodontology in collaboration with the Canadian Academy of Periodontology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K17345
[Presentation] 新規GBR用純チタン製メンブレンの有用性ついて：βTCPを用いたin vivoでの評価2018
- Author(s)
  須藤瑞樹、石幡浩志、向阪幸彦、山田聡、長谷川博
- Organizer
  第61回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-17K17345
[Presentation] 骨補填材を用いたGBRにおける純チタン製メンブレンの有効性ついて2018
- Author(s)
  石幡浩志、須藤瑞樹、向阪幸彦、小松秀裕、丸山顕太郎、山田聡、長谷川博
- Organizer
  第61回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-17K17345
[Presentation] チタン製メンブレンを用いた新規細胞培養法の開発2018
- Author(s)
  向阪幸彦、丸山顕太郎、張井玉、石幡浩志、根本英二、佐々木啓一、初澤毅、山田聡
- Organizer
  平成29年度生体医歯工学共同研究拠点成果報告会（横浜）
- Data Source
  KAKENHI-PROJECT-17K17345
[Presentation] 周期的伸展刺激はマクロファージNLRP3インフラマソーム活性を抑制する2017
- Author(s)
  丸山顕太郎、須藤瑞樹、向阪幸彦、金谷総介、根本英二
- Organizer
  日本炎症・再生医学会（大阪）
- Data Source
  KAKENHI-PROJECT-17K17345
[Presentation] Application of microperforated titanium mesh for the tissue engineered regeneration therapy2017
- Author(s)
  向阪幸彦、丸山顕太郎、張井玉、石幡浩志、根本英二、佐々木啓一、初澤毅、山田聡
- Organizer
  第2回生体医歯工学共同研究拠点国際シンポジウム（東京）
- Data Source
  KAKENHI-PROJECT-17K17345

1. 山田聡 (40359849)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
2. 鈴木茂樹 (30549762)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
3. 根本英二 (40292221)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
4. KAJIKAWA TETSUHIRO (90611252)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. 丸山顕太郎 (80833805)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 荘司佳奈子 (90302158)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 齋藤正寛 (40215562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TADA Hiroyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 石幡浩志

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
10. 佐藤秀明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 須藤瑞樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakisaka Yukihiko 向阪 幸彦

SAKISAKA Yukihiko 向阪 幸彦

Research Projects

Research Products

Co-Researchers

歯周組織再生におけるRANK発現EVsの機能解析とその治療応用への基盤構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

歯周組織特異的CAR-MSC細胞を用いた革新的な歯周組織再生移植治療への挑戦

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

力学誘導M2マクロファージエクソソームによる新規歯周組織再生療法の基盤構築

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

低Ca摂取による顎骨骨粗鬆症が歯周病を進行させるメカニズムの解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Dysbiotic Microbiota-specific MAIT Cells and Their Application to the Treatment for Periodontitis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a new periodontal regenerative therapy with RANKL reverse signaling and osteoclast-derived exosomePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A basic study of a new periodontal regenerative therapy with periodontal ligament cell-derived exosome and Wnt signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A basic study of a new periodontal regenerative therapy with nanoparticles of hydroxyapatite and Low Intensity Pulsed UltrasoundPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Cementocyte-derived extracellular vesicles regulate osteoclastogenesis and osteoblastogenesis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serial Cultivation of an MSC-Like Cell Line with Enzyme-Free Passaging Using a Microporous Titanium Scaffold2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of Preosteoblast MC3T3-E1 Cells Cultured on a Microporous Titanium Membrane Fabricated Using a Precise Mechanical Punching Process2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cyclic stretch force induces periodontal ligament cells to secrete exosomes that suppress IL-1β production through the inhibition of the NF-κB signaling pathway in macrophages.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Extracellular calcium increases fibroblast growth factor 2 gene expression via extracellular signal-regulated kinase 1/2 and protein kinase A signaling in mouse dental papilla cells2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The effect of Berberine on cell differentiation and proliferation in human periodontal ligament cells2018

Author(s)

Sakisaka Yukihiko 向阪幸彦

SAKISAKA Yukihiko 向阪幸彦