Yabuuchi Kenichi 藪内健一

Researcher Number	10763807
Other IDs
Affiliation (Current)	2025: 大分大学, 医学部, 医員
Affiliation (based on the past Project Information) *help	2025: 大分大学, 医学部, 医員 2016 – 2024: 大分大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology Except Principal Investigator Basic Section 52010:General internal medicine-related / Laboratory medicine
Keywords	Principal Investigator アルツハイマー型認知症 / 行動薬理学 / マイクロダイアリシス / Aβオリゴマー抗体 / BPSD / 抗Aβオリゴマー抗体 / 高分子マイクロダイアリシス / 経鼻投与製剤 / 細胞内Aβオリゴマー / 行動薬理 … More / 血液脳関門 / 最小フラグメント化抗体 / 抗Aβオリゴマー特異的抗体 / Aβオリゴマー特異的抗体 / CDRペプチド / Aβオリゴマー / 神経内科学 / 抗位ディオタイプ抗体 / 神経病態免疫学 / 抗イディオタイプ抗体 / アミロイドベータオリゴマー / ワクチン … More Except Principal Investigator 認知症 / PETイメージング / 画像バイオマーカー / Aβオリゴマー / オリゴマー / アミリン / 糖尿病 / アルツハイマー病 / PET　imaging / PET画像診断 / PET画像 / ジルコニウム / 画像診断 / PET / PETイメジング / 抗体 Less

A challenge to overcome BPSD in dementia using anti-Abeta minimized antibody fragmentsPrincipal Investigator
- Principal Investigator
  
  藪内健一
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Oita University
アミリンを標的とした糖尿病性認知症の発症機序解明と治療法の開発
- Principal Investigator
  
  角華織
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Oita University
Pharmacological and pharmacokinetic studies for the clinical application of anti-Abeta oligomeric ultra-fragmented antibodiesPrincipal Investigator
- Principal Investigator
  
  藪内健一
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Oita University
Development of a novel antibody therapy for Alzheimer's disease using anti-Abeta oligomeric minimal fragment antibodiesPrincipal Investigator
- Principal Investigator
  
  Yabuuchi Kenichi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Oita University
Novel PET imaging of Abeta oligomer using cell- and BBB-penetrating microantibody
- Principal Investigator
  
  Matsubara Etsuro
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Oita University
Development of anti-idiotypic vaccine therapy for Alzheimer's diseasePrincipal Investigator
- Principal Investigator
  
  Yabuuchi Kenichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Oita University
Development of a novel imaging biomarker of Abeta oligomers in the brain
- Principal Investigator
  
  Matsubara Etsuro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory medicine
- Research Institution
  Oita University

All 2023 2021 2020 2019 2017

All Journal Article Presentation

[Journal Article] Predicting positron emission tomography brain amyloid positivity using interpretable machine learning models with wearable sensor data and lifestyle factors2023
- Author(s)
  Kimura Noriyuki、Aota Tomoki、Aso Yasuhiro、Yabuuchi Kenichi、Sasaki Kotaro、Masuda Teruaki、Eguchi Atsuko、Maeda Yoshitaka、Aoshima Ken、Matsubara Etsuro
- Journal Title
  
  Alzheimer's Research & Therapy
  
  Volume: 15 Issue: 1 Pages: 212-212
- DOI
  10.1186/s13195-023-01363-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19510, KAKENHI-PROJECT-22K07474, KAKENHI-PROJECT-22K07518, KAKENHI-PROJECT-23K06911
[Journal Article] Comparison of Brain Amyloid Deposition and Cortical Glucose Metabolism Between Clinic- and Community-Based Cohort2023
- Author(s)
  Yabuuchi Kenichi、Kimura Noriyuki、Masuda Teruaki、Matsubara Etsuro
- Journal Title
  
  Journal of Alzheimer's Disease
  
  Volume: 95 Issue: 1 Pages: 299-306
- DOI
  10.3233/jad-230550
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19510, KAKENHI-PROJECT-22K07474, KAKENHI-PROJECT-22K07518, KAKENHI-PROJECT-23K06911
[Journal Article] Relationship between Cerebrospinal Fluid Matrix Metalloproteinases Levels and Brain Amyloid Deposition in Mild Cognitive Impairment2021
- Author(s)
  Sasaki Yuuki、Kimura Noriyuki、Aso Yasuhiro、Yabuuchi Kenichi、Aikawa Miki、Matsubara Etsuro
- Journal Title
  
  Biomolecules
  
  Volume: 11 Issue: 10 Pages: 1496-1496
- DOI
  10.3390/biom11101496
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07916, KAKENHI-PROJECT-19K07998, KAKENHI-PROJECT-19H03566
[Journal Article] Association between objectively measured walking steps and sleep in community-dwelling older adults: A prospective cohort study.2020
- Author(s)
  Kimura N, Aso Y, Yabuuchi K, Matsubara E.
- Journal Title
  
  PLoS One.
  
  Volume: 14;15(12) Issue: 12 Pages: e0243910-e0243910
- DOI
  10.1371/journal.pone.0243910
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07916, KAKENHI-PROJECT-19K07998, KAKENHI-PROJECT-19H03566
[Journal Article] Association of Modifiable Lifestyle Factors With Cortical Amyloid Burden and Cerebral Glucose Metabolism in Older Adults With Mild Cognitive Impairment.2020
- Author(s)
  Kimura N, Aso Y, Yabuuchi K, Ishibashi M, Hori D, Sasaki Y, Nakamichi A, Uesugi S, Jikumaru M, Sumi K, Eguchi A, Obara H, Kakuma T, Matsubara E.
- Journal Title
  
  JAMA Netw Open.
  
  Volume: 3(6):e205719. Issue: 6 Pages: e205719-e205719
- DOI
  10.1001/jamanetworkopen.2020.5719
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07916, KAKENHI-PROJECT-19K07998, KAKENHI-PROJECT-19H03566
[Journal Article] Modifiable Lifestyle Factors and Cognitive Function in Older People: A Cross-Sectional Observational Study.2019
- Author(s)
  Kimura N, Aso Y, Yabuuchi K, Ishibashi M, Hori D, Sasaki Y, Nakamichi A, Uesugi S, Fujioka H, Iwao S, Jikumaru M, Katayama T, Sumi K, Eguchi A, Nonaka S, Kakumu M, Matsubara E.
- Journal Title
  
  Front Neurol.
  
  Volume: - Pages: 401-401
- DOI
  10.3389/fneur.2019.00401
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07998, KAKENHI-PROJECT-19H03566
[Journal Article] Relationship Between the Japanese Version of the Montreal Cognitive Assessment and PET Imaging in Subjects with Mild Cognitive Impairment.2019
- Author(s)
  Eguchi A, Kimura N, Aso Y, Yabuuchi K, Ishibashi M, Hori D, Sasaki Y, Nakamichi A, Uesugi S, Jikumaru M, Sumi K, Shimomura T, Matsubara E.
- Journal Title
  
  Curr Alzheimer Res.
  
  Volume: 16(9) Issue: 9 Pages: 852-860
- DOI
  10.2174/1567205016666190805155230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07998, KAKENHI-PROJECT-19H03566
[Presentation] Characteristics of a patient population of Dementia with Lewy bodies (DLB) and Parkinson’s disease with dementia (PDD) exhibiting frontal hypoperfusion in brain perfusion SPECT2017
- Author(s)
  Yabuuchi K, Kimura N, Miura Y, Matsubara E
- Organizer
  World Congress of Neurology - Kyoto, 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09696

1. Matsubara Etsuro (70219468)

# of Collaborated Projects: 7 results

# of Collaborated Products: 5 results
2. 松浦栄次 (20181688)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 佐々木崇了 (10461253)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 三浦由真子 (40761101)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. 角華織 (10938525)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KIMURA Noriyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
7. 麻生泰弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Yabuuchi Kenichi 藪内 健一

Research Projects

Research Products

Co-Researchers

A challenge to overcome BPSD in dementia using anti-Abeta minimized antibody fragmentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

アミリンを標的とした糖尿病性認知症の発症機序解明と治療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pharmacological and pharmacokinetic studies for the clinical application of anti-Abeta oligomeric ultra-fragmented antibodiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel antibody therapy for Alzheimer's disease using anti-Abeta oligomeric minimal fragment antibodiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel PET imaging of Abeta oligomer using cell- and BBB-penetrating microantibody

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of anti-idiotypic vaccine therapy for Alzheimer's diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel imaging biomarker of Abeta oligomers in the brain

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Predicting positron emission tomography brain amyloid positivity using interpretable machine learning models with wearable sensor data and lifestyle factors2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparison of Brain Amyloid Deposition and Cortical Glucose Metabolism Between Clinic- and Community-Based Cohort2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Relationship between Cerebrospinal Fluid Matrix Metalloproteinases Levels and Brain Amyloid Deposition in Mild Cognitive Impairment2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association between objectively measured walking steps and sleep in community-dwelling older adults: A prospective cohort study.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of Modifiable Lifestyle Factors With Cortical Amyloid Burden and Cerebral Glucose Metabolism in Older Adults With Mild Cognitive Impairment.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Modifiable Lifestyle Factors and Cognitive Function in Older People: A Cross-Sectional Observational Study.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Relationship Between the Japanese Version of the Montreal Cognitive Assessment and PET Imaging in Subjects with Mild Cognitive Impairment.2019

Author(s)

Journal Title

DOI

Yabuuchi Kenichi 藪内健一