Fujino Shiki 藤野志季

Researcher Number	10768956
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 招へい教員
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 大学院医学系研究科, 招へい教員 2021: 大阪大学, 医学系研究科, 招へい教員 2018 – 2020: 大阪大学, 医学系研究科, 特任助教(常勤) 2017: 大阪大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 50010:Tumor biology-related / Digestive surgery Except Principal Investigator Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator 大腸癌 / 初代培養 / 癌幹細胞 / 幹細胞 / 治療抵抗性 / 多様性 / リキッドバイオプシー / 微小転移 / 癌関連線維芽細胞 / 免疫抑制 … More / 癌微小環境 / 免疫 / ミニチュアモデル / 癌関連維芽細胞 / 薬剤感受性 / 個別化医療 / 癌 … More Except Principal Investigator 時計遺伝子 / アポトーシス / DEC1 / 大腸がん / がん関連線維芽細胞 / オルガノイド / 癌関連線維芽細胞 / 大腸癌 Less

Early detection of cancer micrometastasis and development of new treatment strategiesPrincipal Investigator
- Principal Investigator
  
  藤野志季
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Osaka University
Investigating personalized chronotherapy through the regulation of clock genes expression related to cancer.
- Principal Investigator
  
  南壮一郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
大腸癌における特異的な新規がん関連線維芽細胞マーカーの同定
- Principal Investigator
  
  加藤伸弥
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
Exploring the Interaction Between Cancer Cells and the Cancer Microenvironment Aimed at Novel TherapiesPrincipal Investigator
- Principal Investigator
  
  Fujino Shiki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
Elucidation and control of cancer diversity maintenance mechanism aiming at total kill therapyPrincipal Investigator
- Principal Investigator
  
  Fujino Shiki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka University
Establishment of primary culture of gastrointestinal tumor for clinical applicationPrincipal Investigator
- Principal Investigator
  
  Fujino Shiki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Efficacy of transanal drainage tube in preventing anastomotic leakage after surgery for rectal cancer: A meta-analysis2023
- Author(s)
  Fujino Shiki、Yasui Masayoshi、Ohue Masayuki、Miyoshi Norikatsu
- Journal Title
  
  World Journal of Gastrointestinal Surgery
  
  Volume: 15 Issue: 6 Pages: 1202-1210
- DOI
  10.4240/wjgs.v15.i6.1202
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08709
[Journal Article] Cancer Stem Cells Persist Despite Cellular Damage, Emergence of the Refractory Cell Population2023
- Author(s)
  Nagae Ayumi、Miyoshi Norikatsu、Fujino Shiki、Horie Masafumi、Yachida Shinichi、Sasaki Masaru、Sekido Yuki、Hata Tsuyoshi、Hamabe Atsushi、Ogino Takayuki、Takahashi Hidekazu、Uemura Mamoru、Yamamoto Hirofumi、Doki Yuichiro、Eguchi Hidetoshi
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 30 Issue: 11 Pages: 6913-6924
- DOI
  10.1245/s10434-023-13849-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08128, KAKENHI-PROJECT-21K08709
[Journal Article] Tumor-infiltrating T cells as a risk factor for lymph node metastasis in patients with submucosal colorectal cancer2023
- Author(s)
  Kitakaze Masatoshi、Fujino Shiki、Miyoshi Norikatsu、Sekido Yuki、Hata Tsuyoshi、Ogino Takayuki、Takahashi Hidekazu、Uemura Mamoru、Mizushima Tsunekazu、Doki Yuichiro、Eguchi Hidetoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 2077-2077
- DOI
  10.1038/s41598-023-29260-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08709, KAKENHI-PROJECT-23K08128
[Journal Article] Metastases and treatment-resistant lineages in patient-derived cancer cells of colorectal cancer2023
- Author(s)
  Fujino Shiki、Miyoshi Norikatsu、Ito Aya、Hayashi Rie、Yasui Masayoshi、Matsuda Chu、Ohue Masayuki、Horie Masafumi、Yachida Shinichi、Koseki Jun、Shimamura Teppei、Hata Tsuyoshi、Ogino Takayuki、Takahashi Hidekazu、Uemura Mamoru、Mizushima Tsunekazu、Doki Yuichiro、Eguchi Hidetoshi
- Journal Title
  
  Communications Biology
  
  Volume: 6 Issue: 1 Pages: 1191-1191
- DOI
  10.1038/s42003-023-05562-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08128, KAKENHI-PROJECT-21K08709, KAKENHI-PLANNED-23H04938, KAKENHI-PROJECT-23K24941
[Journal Article] Fibroblast Activation Protein and Tertiary Lymphoid Structure in Colorectal Cancer Recurrence2022
- Author(s)
  HAYASE SHIMON、MIYOSHI NORIKATSU、FUJINO SHIKI、YASUI MASAYOSHI、OHUE MASAYUKI、MINAMI SOICHIRO、KATO SHINYA、NAGAE AYUMI、SEKIDO YUKI、HATA TSUYOSHI、HAMABE ATSUSHI、OGINO TAKAYUKI、TAKAHASHI HIDEKAZU、UEMURA MAMORU、YAMAMOTO HIROFUMI、DOKI YUICHIRO、EGUCHI HIDETOSHI
- Journal Title
  
  Anticancer Research
  
  Volume: 42 Issue: 12 Pages: 5897-5907
- DOI
  10.21873/anticanres.16099
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08709, KAKENHI-PROJECT-20K09056
[Journal Article] HNF1A regulates colorectal cancer progression and drug resistance as a downstream of POU5F12021
- Author(s)
  Fujino Shiki、Miyoshi Norikatsu、Ito Aya、Yasui Masayoshi、Matsuda Chu、Ohue Masayuki、Uemura Mamoru、Mizushima Tsunekazu、Doki Yuichiro、Eguchi Hidetoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 11 Issue: 1 Pages: 10363-10363
- DOI
  10.1038/s41598-021-89126-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09056, KAKENHI-PROJECT-21K08709
[Journal Article] Crenolanib Regulates ERK and AKT/mTOR Signaling Pathways in RAS/BRAF-Mutated Colorectal Cancer Cells and Organoids2021
- Author(s)
  Fujino Shiki、Miyoshi Norikatsu、Ito Aya、Yasui Masayoshi、Ohue Masayuki、Ogino Takayuki、Takahashi Hidekazu、Uemura Mamoru、Matsuda Chu、Mizushima Tsunekazu、Doki Yuichiro、Eguchi Hidetoshi
- Journal Title
  
  Molecular Cancer Research
  
  Volume: Feb12 Issue: 5 Pages: 812-822
- DOI
  10.1158/1541-7786.mcr-20-0600
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18145, KAKENHI-PROJECT-20K09056, KAKENHI-PROJECT-21K08709
[Journal Article] A new fat-dissociation method to detect lymph nodes in colorectal cancer: a prospective randomized study2020
- Author(s)
  Fujino Shiki、Miyoshi Norikatsu、Ohue Masayuki、Ito Aya、Yasui Masayoshi、Ogino Takayuki、Takahashi Hidekazu、Uemura Mamoru、Matsuda Chu、Yamamoto Hirofumi、Mizushima Tsunekazu、Doki Yuichiro、Eguchi Hidetoshi、Matsuura Nariaki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 20205-20205
- DOI
  10.1038/s41598-020-77195-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18145
[Journal Article] Oct4 gene expression in primary colorectal cancer promotes liver metastasis.2019
- Author(s)
  Fujino, S., Miyoshi, N.
- Journal Title
  
  Stem Cells International
  
  Volume: in press
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16542
[Journal Article] Phenotypic heterogeneity of 2D organoid reflects clinical tumor characteristics2019
- Author(s)
  Fujino, S., Ito, A., Ohue, M., Yasui, M., Mizushima, T., Doki, Y., Mori, M., Miyoshi, N
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: in press Issue: 2 Pages: 332-339
- DOI
  10.1016/j.bbrc.2019.03.173
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16542, KAKENHI-PROJECT-19K18145
[Journal Article] Oct4 gene expression in primary colorectal cancer promotes liver metastasis.2019
- Author(s)
  Fujino, S., Miyoshi, N.
- Journal Title
  
  Stem Cells Int
  
  Volume: 7896524 Pages: 7896524-7896524
- DOI
  10.1155/2019/7896524
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18145
[Journal Article] The POU5F1 gene expression in colorectal cancer: a novel prognostic marker.2018
- Author(s)
  Miyoshi N, Fujino S, Ohue M, Yasui M, Takahashi Y, Sugimura K, Tomokuni A, Akita H, Kobayashi S, Takahashi H, Omori T, Miyata H, Yano M
- Journal Title
  
  Surg Today
  
  Volume: in press Issue: 7 Pages: 709-715
- DOI
  10.1007/s00595-018-1644-9
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10203, KAKENHI-PROJECT-17K16542, KAKENHI-PROJECT-17K10572
[Presentation] 患者由来オルガノイドの異種移植モデルによる癌微小環境の解析2024
- Author(s)
  加藤伸弥、三吉範克、藤野志季、竹田充伸、関戸悠紀、波多豪、浜部敦史、荻野崇之、植村守、山本浩文、土岐祐一郎、江口英利
- Organizer
  第124回日本外科学会総会
- Data Source
  KAKENHI-PROJECT-22K08824
[Presentation] 患者由来オルガノイドを用いた大腸癌がん関連線維芽細胞の解析2023
- Author(s)
  加藤伸弥、三吉範克、藤野志季、浜部敦史、荻野崇之、高橋秀和、植村守、山本浩文、土岐祐一郎、江口英利
- Organizer
  第78回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-22K08824
[Presentation] Single-cell RNA sequencing of patient-derived organoid reveals treatment-induced tumor resistance through cancer stem cells2022
- Author(s)
  Shiki Fujino; Aya Ito; Masayoshi Yasui; Chu Matsuda; Masayuki Ohue; Masafumi Horie; Shinichi Yachida; Yuichiro Doki; Hidetoshi Eguchi; Norikatsu Miyoshi
- Organizer
  AACR Annual Meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08709
[Presentation] Precision medicine using patient-derived organoid and genomic profiling in gastroenterological surgery2022
- Author(s)
  三吉範克,藤野志季,関戸悠紀,波多豪,浜部敦史,荻野祟之,高橋秀和,植村守,山本浩文,土岐祐一郎,江口英利
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08709
[Presentation] Cancer stem cell reproduce treatment-resistant cells2022
- Author(s)
  藤野志季,武田和,團野克樹,山本慧,東口公哉,野口幸藏,豊田泰弘,平尾隆文,岡義雄,堀江真史,谷内田真一,大植雅之,土岐祐一郎,江口英利,三吉範克
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08709
[Presentation] Heterogeneity inducible tumor stem cells relate distant metastasis and the treatment resistance2022
- Author(s)
  Norikatsu Miyoshi; Shiki Fujino; Yuki Sekido; Tsuyoshi Hata; Takayuki Ogino; Hidekazu Takahashi; Mamoru Uemura; HIrofumi Yamamoto; Yuichiro Doki; Hidetoshi Eguchi
- Organizer
  AACR Annual Meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08709
[Presentation] 2次元培養オルガノイドを利用したシングルセル解析による癌多様性の解明2021
- Author(s)
  藤野志季、武田和、團野克樹、山本慧、野口幸臧、豊田泰弘、徳永俊照、平尾隆文、杉本圭司、岡義雄、堀江真史、谷内田真一、大植雅之、土岐祐一郎、江口英利、三吉範克
- Organizer
  第80回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08709
[Presentation] 癌幹細胞の生み出す腫瘍不均一性と臨床的治療抵抗性の獲得2021
- Author(s)
  三吉範克、藤野志季、荻野崇之、高橋秀和、植村守、山本浩文、水島恒和、土岐祐一郎、江口英利
- Organizer
  第80回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08709
[Presentation] 2D organoid (2DO) as human tumor model for predicting theraputic effect of anti-cancer drugs2019
- Author(s)
  Fujino S., Miyoshi N., Fujino S., Takahashi H., Haraguchi N., Hata T., Matsuda C., Yamamoto H., Mizushima T., Mori M., Doki Y.
- Organizer
  AACR Annual Meeting 2019
- Data Source
  KAKENHI-PROJECT-19K18145
[Presentation] 2D organoid (2DO) as human tumor model for predicting therapeutic effect of anti-cancer drugs2019
- Author(s)
  Fujino, S., Miyoshi, N., Saso, K., Sasaki, M., Yasui, M., Ohue, M., Takahashi, H., Haraguchi, N., Hata, T., Mastuda, C., Mizushima, T., Mori, M., Doki, Y.
- Organizer
  AACR Annual meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16542
[Presentation] Colorectal cancer stem cell expressing POU5F1 promotes liver metastasis2019
- Author(s)
  Miyoshi N., Fujino S., Sasaki M., Saso K., Takahashi H., Haraguchi N., Hata T., Matsuda C., Mizushima T., Mori M., Doki Y.
- Organizer
  AACR Annual Meeting 2019
- Data Source
  KAKENHI-PROJECT-19K18145
[Presentation] Crenolanib suppresses colorectal cancer progression and the tumor microenvironment2019
- Author(s)
  藤野志季, 三吉範克，荻野崇之, 高橋秀和，植村守，松田宙, 水島恒和, 森正樹，土岐祐一郎
- Organizer
  第57回日本癌治療学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18145
[Presentation] Anti-cancer drug sensitivity assay using in vitro primary culture cells2018
- Author(s)
  Shiki Fujino
- Organizer
  AACR Annual meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16542
[Presentation] Anti-cancer drug sensitivity assay using in vitro primary cultured cells2018
- Author(s)
  Fujino, S., Miyoshi, N., Ohue, M., Takahashi, Y., Yasui, M., Mishimura, J., Saso, K., Takahashi, H., Haraguchi, N., Hata, T., Mastuda, C., Mizushima, T., Doki, Y., Mori, M.
- Organizer
  AACR Annual meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16542

1. 三吉範克 (20528624)

# of Collaborated Projects: 5 results

# of Collaborated Products: 15 results
2. 伊藤彩 (30864962)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. 植村守 (10528483)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. 木戸屋浩康 (00543886)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 長江歩 (90850272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. 加藤伸弥 (50912010)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 林理絵 (30966536)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 南壮一郎 (60882222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 村松史隆 (90803627)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. Saso Kazuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. Sasaki Masaru

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. Matsuura Nariaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Ohue Masayuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
14. Yasui Masayoshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
15. Mori Masaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
16. Doki Yuichiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
17. KOBAYASHI Syogo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. UEMURA Takeshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
19. 秋田裕史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. 高橋秀典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fujino Shiki 藤野 志季

Research Projects

Research Products

Co-Researchers

Early detection of cancer micrometastasis and development of new treatment strategiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigating personalized chronotherapy through the regulation of clock genes expression related to cancer.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

大腸癌における特異的な新規がん関連線維芽細胞マーカーの同定

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring the Interaction Between Cancer Cells and the Cancer Microenvironment Aimed at Novel TherapiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation and control of cancer diversity maintenance mechanism aiming at total kill therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of primary culture of gastrointestinal tumor for clinical applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Efficacy of transanal drainage tube in preventing anastomotic leakage after surgery for rectal cancer: A meta-analysis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cancer Stem Cells Persist Despite Cellular Damage, Emergence of the Refractory Cell Population2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Tumor-infiltrating T cells as a risk factor for lymph node metastasis in patients with submucosal colorectal cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Metastases and treatment-resistant lineages in patient-derived cancer cells of colorectal cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fibroblast Activation Protein and Tertiary Lymphoid Structure in Colorectal Cancer Recurrence2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HNF1A regulates colorectal cancer progression and drug resistance as a downstream of POU5F12021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Crenolanib Regulates ERK and AKT/mTOR Signaling Pathways in RAS/BRAF-Mutated Colorectal Cancer Cells and Organoids2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A new fat-dissociation method to detect lymph nodes in colorectal cancer: a prospective randomized study2020

Author(s)

Journal Title

DOI

Data Source

Fujino Shiki 藤野志季