takahashi hiroyuki 高橋広行

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Takahashi Hiroyuki 高橋広行

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Researcher Number	10770745
Other IDs
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立国際医療センター, 診療登録医
Affiliation (based on the past Project Information) *help	2022: 国立研究開発法人国立国際医療研究センター, その他部局等, 膠原病科医師 2021: 筑波大学, 附属病院, 病院登録医 2017 – 2020: 筑波大学, 附属病院, 病院講師 2016: 筑波大学, 医学医療系, 助教
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Pathobiological dentistry/Dental radiology
Keywords	Principal Investigator T細胞 / シェーグレン症候群 / ヒドロキシクロロキン / NR4A2 / RORγt / 歯学 / 遺伝子 / 免疫学 / 内科 / Th17細胞

Therapeutic strategies for Sjogren's syndrome by NR4A2-mediated regulation of autoreactive T cellsPrincipal Investigator
- Principal Investigator
  
  Takahashi Hiroyuki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  National Center for Global Health and Medicine
  University of Tsukuba
Development of novel therapeutic strategies targeting NR4A2 in Sjogren's syndrome.Principal Investigator
- Principal Investigator
  
  Takahashi Hiroyuki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  University of Tsukuba
Novel therapeutic target molecules in Sjogren's syndrome: NR4A2 and DPP4Principal Investigator
- Principal Investigator
  
  Takahashi Hiroyuki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  University of Tsukuba

All 2023 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Book

[Book] 分子リウマチ2017
- Author(s)
  高橋広行、坪井洋人、住田孝之
- Total Pages
  58
- Publisher
  先端医学社
- ISBN
  9784865502787
- Data Source
  KAKENHI-PROJECT-16K20934
[Journal Article] Humanized NOD/SCID/IL2rγnull mice exhibit functionally augmented human regulatory T cells associated with enzymatic up‐regulation of H3K27me3 in comparison with humans2021
- Author(s)
  Takahashi H.、Tsuboi H.、Abe S.、Honda F.、Kondo Y.、Matsumoto I.、Sumida T.
- Journal Title
  
  Clinical & Experimental Immunology
  
  Volume: - Issue: 2 Pages: 239-250
- DOI
  10.1111/cei.13583
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08767, KAKENHI-PROJECT-20K08795
[Journal Article] RORγt antagonist improves Sj?gren's syndrome‐like sialadenitis through downregulation of CD252020
- Author(s)
  Ono Yuko、Tsuboi Hiroto、Moriyama Masafumi、Asashima Hiromitsu、Kudo Hanae、Takahashi Hiroyuki、Honda Fumika、Abe Saori、Kondo Yuya、Takahashi Satoru、Matsumoto Isao、Nakamura Seiji、Sumida Takayuki
- Journal Title
  
  Oral Diseases
  
  Volume: - Issue: 4 Pages: 766-777
- DOI
  10.1111/odi.13255
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22723, KAKENHI-PROJECT-17H01603, KAKENHI-PROJECT-18H03003, KAKENHI-PROJECT-17K09966, KAKENHI-PROJECT-18K16137, KAKENHI-PROJECT-17H04671
[Journal Article] Transgenic rice seeds expressing altered peptide ligands against the M3 muscarinic acetylcholine receptor suppress experimental sialadenitis-like Sjogren’s syndrome2019
- Author(s)
  Kudo Hanae、Tsuboi Hiroto、Asashima Hiromitsu、Takahashi Hiroyuki、Ono Yuko、Abe Saori、Honda Fumika、Kondo Yuya、Wakasa Yuhya、Takaiwa Fumio、Takano Makoto、Matsui Minoru、Matsumoto Isao、Sumida Takayuki
- Journal Title
  
  Modern Rheumatology
  
  Volume: - Issue: 5 Pages: 1-10
- DOI
  10.1080/14397595.2019.1664368
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09966, KAKENHI-PROJECT-18K16137
[Journal Article] cDNA microarray analysis identifies NR4A2 as a novel molecule involved in the pathogenesis of Sjogren's syndrome2017
- Author(s)
  Takahashi H, Tsuboi H, Asashima H, Hirota T, Kondo Y, Moriyama M, Matsumoto, Nakamura S, Sumida T.
- Journal Title
  
  Clinical & Experimental Immunology
  
  Volume: 190 Issue: 1 Pages: 96-109
- DOI
  10.1111/cei.13000
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K11075, KAKENHI-PROJECT-26293430, KAKENHI-PROJECT-16K20934, KAKENHI-PROJECT-17H01603
[Presentation] 維持治療中の全身性エリテマトーデス患者におけるヒドロキシクロロキン有効性予測因子の解析2023
- Author(s)
  高橋広行、秋山優弥、大山節子、山地実紗、原田拓弥、本村杏子、小林俊昭、山下裕之、金子礼志
- Organizer
  第67回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K08795
[Presentation] シェーグレン症候群におけるM3R反応性Th1細胞由来T-iPS細胞を応用した治療戦略2021
- Author(s)
  高橋広行、坪井洋人、安部沙織、本田文香、近藤裕也、松本功、大津真、住田孝之
- Organizer
  第65回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K08795
[Presentation] シェーグレン症候群におけるM3R反応性Th1細胞由来T-iPS細胞を応用した治療戦略2020
- Author(s)
  高橋広行、坪井洋人、安部沙織、本田文香、近藤裕也、松本功、大津真、住田孝之
- Organizer
  第64回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K08795
[Presentation] 唾液腺炎を自然発症するRORγtトランスジェニックマウスに対するRORγtアンタゴニストの効果と作用メカニズム2019
- Author(s)
  小野由湖、高橋広行、坪井洋人、森山雅文、工藤華枝、本田文香、安部沙織、近藤裕也、松本功、中村誠司、住田孝之
- Organizer
  第63回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K16137
[Presentation] 唾液腺炎を自然発症するRORγtトランスジェニックマウスに対するRORγtアンタゴニストの効果と作用メカニズム2019
- Author(s)
  小野由湖、高橋広行、坪井洋人、森山雅文、工藤華枝、本田文香、安部沙織、近藤裕也、松本功、中村誠司、住田孝之
- Organizer
  第28回日本シェーグレン症候群学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16137
[Presentation] シェーグレン症候群におけるM3R反応性Th1細胞由来T-iPS細胞を応用した治療戦略2019
- Author(s)
  高橋広行、坪井洋人、瀬川誠司、浅島弘充、安部沙織、工藤華枝、小野由湖、本田文香、近藤裕也、松本功、大津真、住田孝之
- Organizer
  第28回日本シェーグレン症候群学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16137
[Presentation] シェーグレン症候群におけるM3R反応性Th1細胞由来T-iPS細胞を応用した治療戦略2019
- Author(s)
  高橋広行、坪井洋人、瀬川誠司、浅島弘充、安部沙織、工藤華枝、小野由湖、本田文香、近藤裕也、松本功、大津真、住田孝之
- Organizer
  第63回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K16137
[Presentation] シェーグレン症候群患者のCD4陽性T細胞におけるNR4A2発現亢進とTh17分化2018
- Author(s)
  高橋広行、坪井洋人、浅島弘充、近藤裕也、松本功、住田孝之
- Organizer
  第62回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K16137
[Presentation] シェーグレン症候群患者のCD4陽性T細胞におけるNR4A2発現亢進とTh17分化2018
- Author(s)
  高橋広行、坪井洋人、浅島弘充、近藤裕也、松本功、住田孝之
- Organizer
  第62回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16K20934
[Presentation] 唾液腺炎を自然発症するRORγtトランスジェニックマウスに対するRORγtアンタゴニストの効果と作用メカニズム2018
- Author(s)
  小野由湖、高橋広行、坪井洋人、森山雅文、浅島弘充、工藤華枝、安部沙織、近藤裕也、松本功、中村誠司、住田孝之
- Organizer
  第62回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K16137
[Presentation] RORγt antagonist suppressed spontaneous sialadenitis in RORγt transgenic mice via inhibition of IL-17 production with increase of regulatory T cells.2018
- Author(s)
  Ono Y, Tsuboi H, Moriyama M, Asashima H, Kudo H, Takahashi H, Kondo Y, Matsumoto I, Nakamura S, Sumida T.
- Organizer
  The 14th International Symposium on Sjogren’s syndrome (Washington DC, USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16137
[Presentation] A potential role of NR4A2 overexpression in CD4+ T cells in the pathogenesis of Sjogren’s syndrome.2018
- Author(s)
  Takahashi H, Tsuboi H, Asashima H, Kudo H, Ono Y, Abe S, Kondo Y, Matsumoto I, Sumida T
- Organizer
  The 14th International Symposium on Sjogren’s syndrome (Washington DC, USA), 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20934
[Presentation] A potential role of NR4A2 overexpression in CD4+ T cells in the pathogenesis of Sjogren’s syndrome.2018
- Author(s)
  Takahashi H, Tsuboi H, Asashima H, Kudo H, Ono Y, Abe S, Kondo Y, Matsumoto I, Sumida T.
- Organizer
  The 14th International Symposium on Sjogren’s syndrome (Washington DC, USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16137
[Presentation] DNAマイクロアレイによるシェーグレン症候群の唾液腺における遺伝子発現解析2017
- Author(s)
  高橋広行、坪井洋人、浅島弘充、近藤裕也、松本功、住田孝之
- Organizer
  第45回日本臨床免疫学会総会
- Data Source
  KAKENHI-PROJECT-16K20934
[Presentation] DNA microarray analysis of labial salivary glands in patients with Sjogren's syndrome: comparison with IgG4-related disease2017
- Author(s)
  Hiroyuki Takahashi, Hiroto Tsuboi, Hiromitsu Asashima, Tomoya Hirota, Yuya Kondo, Isao Matsumoto and Takayuki Sumida
- Organizer
  第61回日本リウマチ学会総会・学術集会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2017-04-20
- Data Source
  KAKENHI-PROJECT-16K20934
[Presentation] DNA microarray analysis identifies NR4A2 as a novel molecule involved in the pathogenesis of Sjogren’s syndrome.2017
- Author(s)
  Takahashi H, Tsuboi H, Asashima H, Kudo H, Ono Y, Abe S, Kondo Y, Matsumoto I, Sumida T
- Organizer
  2017 American College of Rheumatology, Annual Meeting (San Diego, USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20934
[Presentation] シェーグレン症候群患者のCD4陽性T細胞におけるNR4A2発現亢進とTh17分化2017
- Author(s)
  高橋広行、坪井洋人、浅島弘充、近藤裕也、森山雅文、松本功、中村誠司、住田孝之
- Organizer
  第26回日本シェーグレン症候群学会学術集会
- Data Source
  KAKENHI-PROJECT-16K20934
[Presentation] DNA microarray analysis identifies NR4A2 as a novel molecule involved in the pathogenesis of Sjogren’s syndrome.2017
- Author(s)
  Takahashi H, Tsuboi H, Asashima H, Hirota T, Kondo Y, Matsumoto I, Sumida T
- Organizer
  The 7th East Asian Group of Rheumatology (Tokyo), 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20934
[Presentation] DNAマイクロアレイによるシェーグレン症候群の唾液腺における遺伝子発現解析2016
- Author(s)
  高橋広行、坪井洋人、中井雄治、浅島弘充、廣田智哉、近藤裕也、古川祥子、森山雅文、松本功、吉原俊雄、中村誠司、阿部啓子、住田孝之
- Organizer
  第25回日本シェーグレン症候群学会学術集会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2016-09-09
- Data Source
  KAKENHI-PROJECT-16K20934
[Presentation] DNA microarray analysis of labial salivary glands in patients with Sjogren’s syndrome: comparison with IgG4-related disease2016
- Author(s)
  Hiroyuki Takahashi, Hiroto Tsuboi, Hiromitsu Asashima, Tomoya Hirota, Yuya Kondo, Isao Matsumoto and Takayuki Sumida
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県宜野湾市）
- Year and Date
  2016-12-06
- Data Source
  KAKENHI-PROJECT-16K20934

1. MORIYAMA Masafumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
2. 中村誠司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 住田孝之

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

takahashi hiroyuki 高橋 広行

Takahashi Hiroyuki 高橋 広行

Research Projects

Research Products

Co-Researchers

Therapeutic strategies for Sjogren's syndrome by NR4A2-mediated regulation of autoreactive T cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel therapeutic strategies targeting NR4A2 in Sjogren's syndrome.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Novel therapeutic target molecules in Sjogren's syndrome: NR4A2 and DPP4Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 分子リウマチ2017

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Humanized NOD/SCID/IL2rγnull mice exhibit functionally augmented human regulatory T cells associated with enzymatic up‐regulation of H3K27me3 in comparison with humans2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] RORγt antagonist improves Sj?gren's syndrome‐like sialadenitis through downregulation of CD252020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Transgenic rice seeds expressing altered peptide ligands against the M3 muscarinic acetylcholine receptor suppress experimental sialadenitis-like Sjogren’s syndrome2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] cDNA microarray analysis identifies NR4A2 as a novel molecule involved in the pathogenesis of Sjogren's syndrome2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] 維持治療中の全身性エリテマトーデス患者におけるヒドロキシクロロキン有効性予測因子の解析2023

Author(s)

Organizer

Data Source

[Presentation] シェーグレン症候群におけるM3R反応性Th1細胞由来T-iPS細胞を応用した治療戦略2021

Author(s)

Organizer

Data Source

[Presentation] シェーグレン症候群におけるM3R反応性Th1細胞由来T-iPS細胞を応用した治療戦略2020

Author(s)

Organizer

Data Source

[Presentation] 唾液腺炎を自然発症するRORγtトランスジェニックマウスに対するRORγtアンタゴニストの効果と作用メカニズム2019

Author(s)

Organizer

Data Source

[Presentation] 唾液腺炎を自然発症するRORγtトランスジェニックマウスに対するRORγtアンタゴニストの効果と作用メカニズム2019

Author(s)

Organizer

Data Source

[Presentation] シェーグレン症候群におけるM3R反応性Th1細胞由来T-iPS細胞を応用した治療戦略2019

Author(s)

Organizer

Data Source

[Presentation] シェーグレン症候群におけるM3R反応性Th1細胞由来T-iPS細胞を応用した治療戦略2019

Author(s)

Organizer

Data Source

[Presentation] シェーグレン症候群患者のCD4陽性T細胞におけるNR4A2発現亢進とTh17分化2018

Author(s)

Organizer

takahashi hiroyuki 高橋広行

Takahashi Hiroyuki 高橋広行