Maekawa Masashi 前川大志

Researcher Number	10771917
Other IDs	https://orcid.org/0000-0002-9574-1906
Affiliation (based on the past Project Information) *help	2021 – 2024: 慶應義塾大学, 薬学部(芝共立), 講師 2023: 愛媛大学, プロテオサイエンスセンター, 講師 2020 – 2021: 愛媛大学, プロテオサイエンスセンター, 講師 2017 – 2019: 愛媛大学, プロテオサイエンスセンター, 助教 2017: 愛媛大学, プロテオサイエンスセンター, テニュアトラック助教 2016: 愛媛大学, 医学系研究科, 助教(特定教員)
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Complex systems / General medical chemistry Except Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology / Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator SPOP / 血管内皮細胞 / Integrin β1 / 細胞内膜輸送 / CUL3 / 血管新生 / 脂質酸化 / インタラクトーム / リポキシゲナーゼ / 前立腺癌 … More / ゲノム不安定性 / DNA複製ストレス / 角化細胞 / 前立腺癌細胞 / タンパク質代謝 / 脂質代謝 / DNA複製 / プロテインノックダウン / タンパク質分解システム / アルファスクリーン / DNAアプタマー / タンパク質分解 / CBF1 / アプタマー / エンドソーム / 初期エンドソーム / ユビキチン化基質タンパク質 / タンパク質間結合阻害剤 / ユビキチンE3リガーゼ … More Except Principal Investigator CUL3 / Cullin3 / KCTD10 / 血管新生 / PD-L1 / ANKFY1 / HER / ユビキチンリガーゼ / 阻害剤 / チロシンフォスファターゼ / CUL3 ユビキチンリガーゼ / EGFR/HER2 / HER2 / PTPRH / Phosphatase / EGFR / プロテインアレイ / CUL3 ユビキチンリガーゼ / PTPRH・PTPRJ / プロテインチロシンホスファターゼ / CNKSR1 / RhoB / HER2陽性乳がん / 免疫チェックポイント / 免疫療法 / Rab5 / PD-L1細胞内移行システム / 胞内輸送メカニズム / 細胞内輸送メカニズム / Cullin3 E3ユビキチンリガーゼ / microRNA / CUL3/KCTD10 / 血管新生能 / 翻訳制御 / ユビキチンリガーゼ / 抗腫瘍血管新生 / 大腸がん / BTBP / Cullin-3 / コレステロール / 大腸癌 / シグナル伝達 / 癌 / 細胞内膜輸送 / Cullin 3 / 消化器がん / 細胞内膜輸送メカニズム Less

リポキシゲナーゼシグナルの制御機構を無細胞ヒトプロテインアレイで解き明かすPrincipal Investigator
- Principal Investigator
  
  前川大志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Keio University
Bivalent DNAアプタマーによるプロテインノックダウン法の開発Principal Investigator
- Principal Investigator
  
  前川大志
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Keio University
Regulation of HER1/2 receptor tyrosine kinases by RhoB-CNKSR1 complex
- Principal Investigator
  
  Higashiyama Shigeki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Ehime University
Regulatory mechanisms of attenuating DNA replication stress mediated by a prostate cancer-associated gene SPOPPrincipal Investigator
- Principal Investigator
  
  Maekawa Masashi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Keio University
Development of New immunotherapy targetting immune check protein, PD-L1
- Principal Investigator
  
  Tanida Satoshi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nagoya City University
Elucidation of mechanisms underlying angiogenesis is important for the development of new anti-angiogenic drugs
- Principal Investigator
  
  Hayashi Noriyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nagoya City University
Angiogenesis regulated by an endosomal ubiquitin E3 complexPrincipal Investigator
- Principal Investigator
  
  Masashi Maekawa
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Ehime University
Development of novel inhibitor of tumor angiogenesis focusing on CUL3-dependent cholesterol transport
- Principal Investigator
  
  Shikano Michiko
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University
Membrane trafficking of PD-L1 which is regulated by CUL3-BTBP
- Principal Investigator
  
  Tanida Satoshi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Nagoya City University
Molecular basis of angiogenesis regulated by CUL3-dependent membrane traffickingPrincipal Investigator
- Principal Investigator
  
  Maekawa Masashi
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Ehime University

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Patent

[Journal Article] SPOP is essential for DNA replication licensing through maintaining translation of CDT1 and CDC6 in HaCaT cells2023
- Author(s)
  Sanada Sayoko、Maekawa Masashi、Tate Sota、Nakaoka Hiroki、Fujisawa Yasuhiro、Sayama Koji、Higashiyama Shigeki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 651 Pages: 30-38
- DOI
  10.1016/j.bbrc.2023.02.012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07126, KAKENHI-PROJECT-20K18413, KAKENHI-PUBLICLY-21H00286
[Journal Article] CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP2021
- Author(s)
  Nishiyama Kanako、Maekawa Masashi、Nakagita Tomoya、Nakayama Jun、Kiyoi Takeshi、Chosei Mami、Murakami Akari、Kamei Yoshiaki、Takeda Hiroyuki、Takada Yasutsugu、Higashiyama Shigeki
- Journal Title
  
  Life Science Alliance
  
  Volume: 4 Issue: 9 Pages: e202101095-e202101095
- DOI
  10.26508/lsa.202101095
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18029, KAKENHI-PROJECT-19K18030, KAKENHI-PUBLICLY-21H00286, KAKENHI-PROJECT-21H02763, KAKENHI-PROJECT-20K05709
[Journal Article] ANKFY1 is essential for retinal endothelial cell proliferation and migration via VEGFR2/Akt/eNOS pathway2020
- Author(s)
  Tanaka M, Nakamura S, Maekawa M, Higashiyama S, Hara H
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 533(4) Issue: 4 Pages: 1406-1412
- DOI
  10.1016/j.bbrc.2020.10.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15244
[Journal Article] SNX9 determines the surface levels of integrin β1 in vascular endothelial cells: Implication in poor prognosis of human colorectal cancers overexpressing SNX9.2019
- Author(s)
  Tanigawa K, Maekawa M, Kiyoi T, Nakayama J, Kitazawa R, Kitazawa S, Semba K, Taguchi T, Akita S, Yoshida M, Ishimaru K, Watanabe Y, Higashiyama S.
- Journal Title
  
  J Cell Physiol.
  
  Volume: in press Issue: 10 Pages: 17280-17294
- DOI
  10.1002/jcp.28346
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15244, KAKENHI-PROJECT-16H04698, KAKENHI-ORGANIZER-15H05897, KAKENHI-PROJECT-18K16317
[Journal Article] The Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB2018
- Author(s)
  Kovacevic Igor、Sakaue Tomohisa、Majolee Jisca、Pronk Manon C.、Maekawa Masashi、Geerts Dirk、Fernandez-Borja Mar、Higashiyama Shigeki、Hordijk Peter L.
- Journal Title
  
  The Journal of Cell Biology
  
  Volume: 217 Issue: 3 Pages: 1015-1032
- DOI
  10.1083/jcb.201606055
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038, KAKENHI-PROJECT-18K07234
[Journal Article] Cullin 3 regulates ADAMs-mediated ectodomain shedding of amphiregulin2018
- Author(s)
  Nakayama Hironao、Sakaue Tomohisa、Maekawa Masashi、Fujisaki Ayako、Higashiyama Shigeki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 499 Issue: 1 Pages: 17-23
- DOI
  10.1016/j.bbrc.2018.03.097
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15221, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038, KAKENHI-PROJECT-16K20013, KAKENHI-PROJECT-18K07234, KAKENHI-PROJECT-16H04698
[Journal Article] Neddylated Cullin 3 is required for vascular endothelial-cadherin-mediated endothelial barrier function.2017
- Author(s)
  Sakaue T, Fujisaki A, Nakayama H, Maekawa M, Hiyoshi H, Kubota E, Joh T, Izutani H, Higashiyama S.
- Journal Title
  
  Cancer Sci.
  
  Volume: 108 Issue: 2 Pages: 208-215
- DOI
  10.1111/cas.13133
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-15K18858, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038, KAKENHI-PROJECT-17K09357
[Journal Article] Prospect of divergent roles for the CUL3 system in vascular endothelial cell function and angiogenesis2017
- Author(s)
  Sakaue Tomohisa、Maekawa Masashi、Nakayama Hironao、Higashiyama Shigeki
- Journal Title
  
  The Journal of Biochemistry
  
  Volume: 162 Pages: 237-245
- DOI
  10.1093/jb/mvx051
- NAID
  40021380486
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038, KAKENHI-PROJECT-16K20013
[Journal Article] Domain 4 (D4) of Perfringolysin O to Visualize Cholesterol in Cellular Membranes-The Update.2017
- Author(s)
  Maekawa M
- Journal Title
  
  Sensors (Basel)
  
  Volume: 17 Issue: 3 Pages: 504-504
- DOI
  10.3390/s17030504
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19038
[Journal Article] Cullin-3 and its adaptor protein ANKFY1 determine the surface level of integrin beta1 in endothelial cells.2017
- Author(s)
  Maekawa M, Tanigawa K, Sakaue T, Hiyoshi H, Kubota E, Joh T, Watanabe Y, Taguchi T, Higashiyama S
- Journal Title
  
  Biolology Open
  
  Volume: 6 Pages: 1707-1719
- DOI
  10.1242/bio.029579
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09357, KAKENHI-PROJECT-16H04698, KAKENHI-PROJECT-15K18858, KAKENHI-PROJECT-16K18421, KAKENHI-PROJECT-16K19038
[Journal Article] Perfringolysin O Theta Toxin as a Tool to Monitor the Distribution and Inhomogeneity of Cholesterol in Cellular Membranes.2016
- Author(s)
  Maekawa M, Yang Y, Fairn GD
- Journal Title
  
  Toxins (Basel)
  
  Volume: 8 Issue: 3 Pages: 67-67
- DOI
  10.3390/toxins8030067
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19038
[Journal Article] Staurosporines decrease ORMDL proteins and enhance sphingomyelin synthesis resulting in depletion of plasmalemmal phosphatidylserine.2016
- Author(s)
  Maekawa M, Lee M, Wei K, Ridgway ND, Fairn GD
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 35762-35762
- DOI
  10.1038/srep35762
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19038
[Patent] 血管新生制御剤及びその利用法2017
- Inventor(s)
  東山繁樹、前川大志、坂上倫久、城卓志、久保田英嗣
- Industrial Property Rights Holder
  東山繁樹、前川大志、坂上倫久、城卓志、久保田英嗣
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-193118
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K19038
[Patent] 細胞内輸送を介した膜蛋白質の分解又はリサイクリングの制御剤2017
- Inventor(s)
  東山繁樹、前川大志、坂上倫久、城卓志、久保田英嗣
- Industrial Property Rights Holder
  東山繁樹、前川大志、坂上倫久、城卓志、久保田英嗣
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-244776
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16K19038
[Presentation] G1/S arrest細胞の脂質シグナチュアの解析2023
- Author(s)
  大谷航平, 前川大志, 津川裕司, 有田誠
- Organizer
  第17回メタボロームシンポジウム
- Data Source
  KAKENHI-PROJECT-21K07126
[Presentation] ヒト角化細胞におけるSPOPの生理機能の解明2022
- Author(s)
  眞田紗代子、前川大志、田手壮太、戸澤麻美、森秀樹、中岡啓喜、東山繁樹
- Organizer
  第31回日本形成外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-21K07126
[Presentation] ヒト角化細胞におけるSPOPの生理機能の解明2022
- Author(s)
  眞田紗代子、前川大志、東山繁樹
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07126
[Presentation] A novel mechanism of phosphatase activation for EGFR by Cullin-3/KCTD10 ubiquitin E3 complex in HER2-positive breast cancer cells2021
- Author(s)
  Kanako Nishiyama, Masashi Maekawa, Akari Murakami, Kaho Utsunomiya, Kana Takemoto, Erina Kusakabe, Haruna Noda, Reina Aoki, Kana Taguchi, Michiko Yamashita, Tomoya Nakagita, Jun Nakayama, Mami Chosei, Takeshi Kiyoi, Yoshiaki Kamei, Hiroyuki Takeda, Yasutsugu Takada and Shigeki Higashiyama.
- Organizer
  2021 San Antonio Breast Cancer Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02763
[Presentation] A novel mechanism of phosphatase activation for EGFR in HER2-positive breast cancer cells2021
- Author(s)
  Kanako Nishiyama, Masashi Maekawa, Jun Nakayama, Akari Murakami, Yoshiaki Kamei, Yasutugu Takada, Shigeki Higashiyama
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02763
[Presentation] Novel functions of SPOP in the DNA replication process2021
- Author(s)
  Masashi Maekawa, Ryuta Watanabe, Sayoko Sanada, Shigeki Higashiyama
- Organizer
  第94回日本生化学会大会シンポジウム
- Data Source
  KAKENHI-PROJECT-21K07126
[Presentation] 血管新生を制御するCUL3ユビキチンE3複合体依存的な細胞内膜輸送2018
- Author(s)
  前川大志，谷川和史，坂上倫久，渡部祐司、田口友彦，東山繁樹
- Organizer
  第59回日本生化学会中国・四国支部例会
- Data Source
  KAKENHI-PROJECT-18K15244
[Presentation] 低濃度staurosporine処理によるスフィンゴミエリンの生合成亢進を介したホスファチジルセリンの細胞膜局在制御2017
- Author(s)
  前川大志
- Organizer
  第58回日本生化学会中国・四国支部例会
- Data Source
  KAKENHI-PROJECT-16K19038
[Presentation] 血管内皮細胞におけるユビキチンE3リガーゼ複合体依存的な細胞内膜輸送2017
- Author(s)
  前川大志
- Organizer
  ConBio2017
- Data Source
  KAKENHI-PROJECT-16K19038
[Presentation] 生体膜の細胞質側のコレステロールを可視化する新規コレステロールプローブD4Hの開発と応用2016
- Author(s)
  前川大志
- Organizer
  第57回日本生化学会中国・四国支部例会
- Place of Presentation
  高知大学
- Year and Date
  2016-05-28
- Data Source
  KAKENHI-PROJECT-16K19038

1. HIGASHIYAMA Shigeki (60202272)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. Tanida Satoshi (30528782)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 城卓志 (30231369)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. SAKAUE Tomohisa (20709266)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. TAGUCHI Tomohiko (10300881)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. Shikano Michiko (70405190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. Hayashi Noriyuki (60745404)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 日吉裕美 (10406530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 田中守 (80617861)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 片岡洋望 (40381785)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 村上朱里

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 中山寛尚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 久保田英嗣

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Maekawa Masashi 前川 大志

Research Projects

Research Products

Co-Researchers

リポキシゲナーゼシグナルの制御機構を無細胞ヒトプロテインアレイで解き明かすPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Bivalent DNAアプタマーによるプロテインノックダウン法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of HER1/2 receptor tyrosine kinases by RhoB-CNKSR1 complex

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory mechanisms of attenuating DNA replication stress mediated by a prostate cancer-associated gene SPOPPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of New immunotherapy targetting immune check protein, PD-L1

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of mechanisms underlying angiogenesis is important for the development of new anti-angiogenic drugs

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Angiogenesis regulated by an endosomal ubiquitin E3 complexPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel inhibitor of tumor angiogenesis focusing on CUL3-dependent cholesterol transport

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Membrane trafficking of PD-L1 which is regulated by CUL3-BTBP

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular basis of angiogenesis regulated by CUL3-dependent membrane traffickingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] SPOP is essential for DNA replication licensing through maintaining translation of CDT1 and CDC6 in HaCaT cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CNKSR1 serves as a scaffold to activate an EGFR phosphatase via exclusive interaction with RhoB-GTP2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ANKFY1 is essential for retinal endothelial cell proliferation and migration via VEGFR2/Akt/eNOS pathway2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SNX9 determines the surface levels of integrin β1 in vascular endothelial cells: Implication in poor prognosis of human colorectal cancers overexpressing SNX9.2019

Maekawa Masashi 前川大志