YOSHIO SACHIYO 由雄祥代

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Yoshio Sachiyo 由雄祥代

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Researcher Number	10774060
Other IDs	https://orcid.org/0000-0001-7860-6916
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立国際医療研究所, テニュアトラック部長
Affiliation (based on the past Project Information) *help	2022 – 2023: 国立研究開発法人国立国際医療研究センター, その他部局等, 室長 2017 – 2021: 国立研究開発法人国立国際医療研究センター, その他部局等, 肝疾患先端治療研究室長 2016: 国立研究開発法人国立国際医療研究センター, その他部局等, 上級研究員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 免疫 / ナチュラルキラー細胞 / 肝がん / 肝硬変 / 免疫低下 / NK細胞 / 肝癌 / 肝臓癌 / DAA / マスサイトメトリー … More / 免疫応答 / C型肝炎ウイルス / C型肝炎 / 樹状細胞 / C型慢性肝炎 / 生態学 / ウィルス / 細胞・組織 / 免疫学 / Natural Killer 細胞 / 線維芽細胞 / IDO / 免疫能低下 / 肝線維化 / YKL-40 / IL-34 / 肝線維芽細胞 / NAFLD / キヌレニン … More Except Principal Investigator ウイルス変異 / ＨBs抗原消失 / 免疫応答 / インターフェロン / 腸内細菌 / コア変異 / 機能的治癒 / Functional Cure / HBs抗原消失 / B型肝炎 Less

Immunoregulatory mechanisms in patients with LC-HCCPrincipal Investigator
- Principal Investigator
  
  Sachiyo Yoshio
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  National Center for Global Health and Medicine
Elucidation of hepatitis B virus mutations and immune responses associated with HBs antigen loss affected by the intestinal microbiota
- Principal Investigator
  
  HONDA Takashi
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Nagoya University
Analysis of immune responses in patients with chronic hepatitis C after viral clearancePrincipal Investigator
- Principal Investigator
  
  Sachiyo Yoshio
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  National Center for Global Health and Medicine
The effect of kynurenine on liver fibrosisPrincipal Investigator
- Principal Investigator
  
  Yoshio Sachiyo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  National Center for Global Health and Medicine

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Immunoglobulin-like transcript 2 as an impaired anti-tumor cytotoxicity marker of natural killer cells in patients with hepatocellular carcinoma2024
- Author(s)
  Sakata Toshihiro、Yoshio Sachiyo、Yamazoe Taiji、Mori Taizo、Kakazu Eiji、Aoki Yoshihiko、Aoyanagi Nobuyoshi、Okamoto Toru、Ito Takanori、Toyoda Hidenori、Kawaguchi Takumi、Ono Yoshihiro、Takahashi Yu、Taketomi Akinobu、Kanto Tatsuya
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 15 Pages: 1389411-1389411
- DOI
  10.3389/fimmu.2024.1389411
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08020
[Journal Article] Serum osteopontin predicts the response to atezolizumab plus bevacizumab in patients with hepatocellular carcinoma2023
- Author(s)
  Yamauchi Reika、Ito Takanori、Yoshio Sachiyo、Yamamoto Takafumi、Mizuno Kazuyuki、Ishigami Masatoshi、Kawashima Hiroki、Yasuda Satoshi、Shimose Shigeo、Iwamoto Hideki、Yamazoe Taiji、Mori Taizo、Kakazu Eiji、Kawaguchi Takumi、Toyoda Hidenori、Kanto Tatsuya
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: - Issue: 6 Pages: 565-574
- DOI
  10.1007/s00535-023-01985-w
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08020, KAKENHI-PROJECT-20K17038, KAKENHI-PROJECT-21K07904
[Journal Article] Preoperative serum brain‐derived neurotrophic factor as a predictive biomarker for sepsis after living‐donor liver transplantation2022
- Author(s)
  Tsutsui Yuriko、Yoshio Sachiyo、Tomiyama Takahiro、Shimagaki Tomonari、Itoh Shinji、Harada Noboru、Yoshida Yuichi、Yoshikawa Shiori、Kakazu Eiji、Kanto Tatsuya、Yoshizumi Tomoharu
- Journal Title
  
  Hepatology Research
  
  Volume: 53 Issue: 1 Pages: 72-83
- DOI
  10.1111/hepr.13834
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K08020
[Journal Article] Increased Frequency of Dysfunctional Siglec-7?CD57+PD-1+ Natural Killer Cells in Patients With Non-alcoholic Fatty Liver Disease2021
- Author(s)
  Sakamoto Yuzuru, Yoshio Sachiyo, et al
- Journal Title
  
  Frontiers in Immunology
  
  Volume: 12 Pages: 603133-603133
- DOI
  10.3389/fimmu.2021.603133
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K17509, KAKENHI-PROJECT-21K08014, KAKENHI-PROJECT-21K08020
[Journal Article] Phenotypic Characterization by Single-Cell Mass Cytometry of Human Intrahepatic and Peripheral NK Cells in Patients with Hepatocellular Carcinoma2021
- Author(s)
  Yoshida Yuichi、Yoshio Sachiyo、Yamazoe Taiji、Mori Taizo、Tsustui Yuriko、Kawai Hironari、Yoshikawa Shiori、Fukuhara Takasuke、Okamoto Toru、Ono Yoshihiro、Takahashi Yu、Hashida Ryuki、Kawaguchi Takumi、Taketomi Akinobu、Kanto Tatsuya
- Journal Title
  
  Cells
  
  Volume: 10 Issue: 6 Pages: 1495-1495
- DOI
  10.3390/cells10061495
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08020, KAKENHI-PROJECT-20K17038
[Journal Article] Hepatitis C virus modulates signal peptide peptidase to alter host protein processing.2021
- Author(s)
  11.Hirano J, Yoshio S, Sakai Y, Songling L, Suzuki T, Itoh Y, Zhang H, Chen DV, Haga S, Oomori H, Kodama T, Maeda Y, Ono Y, Takahashi Y, Standley DM, Yamamoto M, Moriishi K, Moriya K, Kanto T, Takehara T, Koike K, Matsuura Y, Okamoto T.
- Journal Title
  
  Proc Natl Acad Sci U S A.
  
  Volume: 118(22) Issue: 22 Pages: 2026184118-2026184118
- DOI
  10.1073/pnas.2026184118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03479, KAKENHI-PROJECT-20H03495, KAKENHI-PROJECT-20H03661, KAKENHI-PROJECT-21K08020
[Journal Article] Impact of branched-chain amino acids and frailty on the management of lenvatinib-related fatigue in patients with hepatocellular carcinoma2021
- Author(s)
  Shimose Shigeo、Koya Shunji、Kawaguchi Takumi、Hirota Keisuke、Yoshio Sachiyo、Niizeki Takashi、Matsuse Hiroo、Torimura Takuji
- Journal Title
  
  Clinical and Molecular Hepatology
  
  Volume: 27 Issue: 4 Pages: 616-619
- DOI
  10.3350/cmh.2021.0258
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08395, KAKENHI-PROJECT-21K08020
[Journal Article] Effects of a low‐intensity resistance exercise program on serum miR‐630, miR‐5703, and Fractalkine/CX3CL1 expressions in subjects with No exercise habits: A preliminary study2021
- Author(s)
  Hashida Ryuki、Matsuse Hiroo、Kawaguchi Takumi、Yoshio Sachiyo、Bekki Masafumi、Iwanaga Sohei、Sugimoto Takahiro、Hara Koji、Koya Shunji、Hirota Keisuke、Nakano Dan、Tsutsumi Tsubasa、Kanto Tatsuya、Torimura Takuji、Shiba Naoto
- Journal Title
  
  Hepatology Research
  
  Volume: 51 Issue: 7 Pages: 823-833
- DOI
  10.1111/hepr.13670
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08395, KAKENHI-PROJECT-21K08020
[Journal Article] Bone morphogenetic protein 4 provides cancer-supportive phenotypes to liver fibroblasts in patients with hepatocellular carcinoma2019
- Author(s)
  Mano Y, Yoshio S, Shoji H, Tomonari S, Aoki Y, Aoyanagi N, Okamoto T, Matsuura Y, Osawa Y, Kimura K, Yugawa K, Wang H, Oda Y, Yoshizumi T, Maehara Y, Kanto T
- Journal Title
  
  J Gastroenterol
  
  Volume: Epub ahead of print Issue: 11 Pages: 1007-1018
- DOI
  10.1007/s00535-019-01579-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19382, KAKENHI-PROJECT-17K16559, KAKENHI-INTERNATIONAL-16K21723, KAKENHI-ORGANIZER-16H06429
[Presentation] 肝がん患者におけるNK細胞機能性分子ILT2の同定ーマスサイトメトリーと機能解析の統合2023
- Author(s)
  阪田敏聖、由雄祥代
- Organizer
  第59回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21K08020
[Presentation] 肝がんにおけるNK細胞機能抑制分子であるILT2の新規チェックポイント分子としての可能性2023
- Author(s)
  阪田敏聖、由雄祥代
- Organizer
  第123回日本外科学会総会
- Data Source
  KAKENHI-PROJECT-21K08020
[Presentation] ILT2は肝がん浸潤NK細胞に誘導される抗腫瘍活性抑制分子である2023
- Author(s)
  阪田敏聖、由雄祥代
- Organizer
  第109回日本消化器病学会
- Data Source
  KAKENHI-PROJECT-21K08020
[Presentation] Anti-ILT2 antibody and antioxidant drugs restored antitumor effects antibody-dependent cellular cytotoxicity of natural killer cells in patients with hepatocellular carcinoma2023
- Author(s)
  Sakata T, Yoshio S
- Organizer
  EASL2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08020
[Presentation] ヒト免疫学に基づいた肝疾患病態の解明と新規診断・治療法の開発への応用2023
- Author(s)
  由雄祥代
- Organizer
  第２回日本医学会連合Rising Starリトリート
- Invited
- Data Source
  KAKENHI-PROJECT-21K08020
[Presentation] ILT2は肝がん浸潤NK細胞に誘導される抗腫瘍活性抑制分子である2023
- Author(s)
  阪田敏聖、由雄祥代
- Organizer
  第31回日本医学会学会
- Data Source
  KAKENHI-PROJECT-21K08020
[Presentation] Immunoglobulin-like Transcript 2 as an Impaired Anti-tumor Cytotoxicity Marker of Natural Killer cells in Patients with Hepatocellular Carcinoma2023
- Author(s)
  Yoshio S, Sakata T
- Organizer
  APASL Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08020
[Presentation] 肝疾患患者におけるNK細胞機能低下寄与分子ILT2の同定2022
- Author(s)
  阪田敏聖、由雄祥代、筒井由梨子、吉川詩織、山添太士、森泰三、嘉数英二、青木孝彦、武冨紹信、考藤達哉
- Organizer
  第26回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-21K08020
[Presentation] 肝疾患患者におけるNK機能低下関連分子ILT22022
- Author(s)
  由雄祥代、阪田敏聖、考藤達哉
- Organizer
  第59回日本消化器免疫学会総会
- Data Source
  KAKENHI-PROJECT-21K08020
[Presentation] テクニカルセミナーWet 免疫研究ことはじめ2022
- Author(s)
  由雄祥代
- Organizer
  第58回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21K08020
[Presentation] マスサイトメトリーを用いた C型肝炎患者SVR前後のNK細胞解析2022
- Author(s)
  阪田敏聖、由雄祥代、青木孝彦、考藤達哉、武冨紹信
- Organizer
  第122回日本外科学会総会
- Data Source
  KAKENHI-PROJECT-21K08020
[Presentation] 肝がんにおけるNK細胞機能抑制分子 ILT2ー新規チェックポイント分子の可能性2022
- Author(s)
  阪田敏聖、由雄祥代、考藤達哉
- Organizer
  第44回日本肝臓学会東部会
- Data Source
  KAKENHI-PROJECT-21K08020
[Presentation] High-dimensional single cell mass cytometry characterizes a unique CD56dimNK cell subset in healthy aging2021
- Author(s)
  阪田敏聖、由雄祥代、考藤達哉
- Organizer
  JSH International Liver Conference 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08020
[Presentation] 肝硬変患者におけるナチュラルキラー細胞機能低下に係る新規因子の同定2021
- Author(s)
  由雄祥代, 考藤達哉
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-21K08020
[Presentation] Phenotypic characterization by single-cell mass cytometry of human intrahepatic and peripheral NK cells in patients with hepatocellular carcinoma2021
- Author(s)
  Sachiyo Yoshio, Takumi Kawaguchi, Tatsuya Kanto
- Organizer
  JSH International Liver Conference 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08020
[Presentation] C型肝炎患者におけるDAA治療SVR後の免疫病態―マスサイトメトリーによる単一細胞解析の応用2020
- Author(s)
  吉田祐一、由雄祥代、考藤達哉
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17509
[Presentation] NAFLDにおける肝線維化とNK細胞機能の関連　Siglec-7陰性疲弊型NK細胞の同定2020
- Author(s)
  坂本譲、由雄祥代、考藤達哉
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17509
[Presentation] 肝がん合併肝硬変患者における運動療法が免疫系に及ぼす影響2020
- Author(s)
  吉田祐一、川口巧、由雄祥代
- Organizer
  第24回日本肝臓学会大会
- Data Source
  KAKENHI-PROJECT-19K17509
[Presentation] 肝疾患病態研究を可能にするヒトサンプル免疫解析2020
- Author(s)
  由雄祥代、考藤達哉
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-19K17509
[Presentation] Eradication of HCV by DAAs provides patients with immunological benefits by the restoration of antigen-presenting dendritic cells2019
- Author(s)
  Yoshio S, Sakamoto Y, Kawai H, Matsuda M, Mori T, Aoki Y, Osawa Y, and Kanto T.
- Organizer
  The International Liver Congress: EASL
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17509
[Presentation] Soluble Siglec-7 as a diagnostic biomarker for hepatocellular carcinoma in patients with non-alcoholic fatty liver disease2018
- Author(s)
  Sakamoto Y, Yoshio S, Kawai H, Shimagaki T, Doi H, Aoki Y, Osawa Y, Taketomi A, Kanto T
- Organizer
  The 69th Annual Meeting of AASLD
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19382

1. HONDA Takashi (10378052)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 藤城光弘 (70396745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 加藤あす香 (00801333)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 石川哲也 (10288508)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 岡本徹 (80628595)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. KAWAGUCHI Takumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
7. 松浦善治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 橋田竜騎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 中野暖

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YOSHIO SACHIYO 由雄 祥代

Yoshio Sachiyo 由雄 祥代

Research Projects

Research Products

Co-Researchers

Immunoregulatory mechanisms in patients with LC-HCCPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of hepatitis B virus mutations and immune responses associated with HBs antigen loss affected by the intestinal microbiota

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of immune responses in patients with chronic hepatitis C after viral clearancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The effect of kynurenine on liver fibrosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Immunoglobulin-like transcript 2 as an impaired anti-tumor cytotoxicity marker of natural killer cells in patients with hepatocellular carcinoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serum osteopontin predicts the response to atezolizumab plus bevacizumab in patients with hepatocellular carcinoma2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preoperative serum brain‐derived neurotrophic factor as a predictive biomarker for sepsis after living‐donor liver transplantation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Increased Frequency of Dysfunctional Siglec-7?CD57+PD-1+ Natural Killer Cells in Patients With Non-alcoholic Fatty Liver Disease2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phenotypic Characterization by Single-Cell Mass Cytometry of Human Intrahepatic and Peripheral NK Cells in Patients with Hepatocellular Carcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hepatitis C virus modulates signal peptide peptidase to alter host protein processing.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Impact of branched-chain amino acids and frailty on the management of lenvatinib-related fatigue in patients with hepatocellular carcinoma2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of a low‐intensity resistance exercise program on serum miR‐630, miR‐5703, and Fractalkine/CX3CL1 expressions in subjects with No exercise habits: A preliminary study2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bone morphogenetic protein 4 provides cancer-supportive phenotypes to liver fibroblasts in patients with hepatocellular carcinoma2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] 肝がん患者におけるNK細胞機能性分子ILT2の同定ーマスサイトメトリーと機能解析の統合2023

Author(s)

Organizer

Data Source

[Presentation] 肝がんにおけるNK細胞機能抑制分子であるILT2の新規チェックポイント分子としての可能性2023

Author(s)

YOSHIO SACHIYO 由雄祥代

Yoshio Sachiyo 由雄祥代

[Presentation] NAFLDにおける肝線維化とNK細胞機能の関連　Siglec-7陰性疲弊型NK細胞の同定2020