Hirakawa Yosuke 平川陽亮

… Alternative Names

HIRAKAWA YOSUKE 平川陽亮

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Researcher Number	10780736
Other IDs
Affiliation (Current)	2025: 東京大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2025: 東京大学, 医学部附属病院, 助教 2017 – 2023: 東京大学, 医学部附属病院, 助教
Review Section/Research Field	Principal Investigator Basic Section 53040:Nephrology-related / Kidney internal medicine Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields / Basic Section 90110:Biomedical engineering-related / Basic Section 53040:Nephrology-related / Basic Section 52010:General internal medicine-related
Keywords	Principal Investigator 慢性腎臓病 / 低酸素応答因子 / 酸素勾配 / 酸素 / りん光 / 低酸素 / 腎臓 / 短鎖脂肪酸 / 線維化 / 活性酸素 … More / 酢酸 / ミトコンドリア / 酸化ストレス / 酢酸イオン / 尿細管細胞 … More Except Principal Investigator 慢性腎臓病 / 低酸素 / オルガネラ間相互作用 / オルガネラストレス / 尿細管間質障害 / リゾリン脂質 / 脂肪毒性 / 代謝リプログラミング / オルガネラコンタクトサイト / 尿細管障害 / 尿細管上皮細胞 / イメージング / 光イメージング / りん光 / イリジウム錯体 / 酸素プローブ / CKD / ミトコンドリア / HIF / 尿細管間質線維化 / ATF6 / 脂質毒性 / 脂質代謝 / エネルギー代謝 / 急性腎不全 / cGAS-STING経路 / ミトコンドリアDNA / IFT88 / オルガネラクロストーク / 尿細管細胞代謝 / 尿細管炎症 / 尿細管脂質代謝 / 一次繊毛 / ミトコンドリアストレス / 小胞体ストレス Less

慢性腎臓病関連代謝物であるDHA及びSDMAの病態意義の解明Principal Investigator
- Principal Investigator
  
  平川陽亮
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  The University of Tokyo
Elucidation of mechanism how short chain fatty acids suppress kidney fibrosis.Principal Investigator
- Principal Investigator
  
  平川陽亮
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  The University of Tokyo
Pathophysiological role of organelle contact site in tubular homeostasis
- Principal Investigator
  
  Inagi Reiko
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  The University of Tokyo
Examination of biological meaning of change in oxygen status and oxygen gradation in chronic kidney diseasePrincipal Investigator
- Principal Investigator
  
  Hirakawa Yosuke
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  The University of Tokyo
Molecular mechanism of organelle crosstalk on organ homeostasis in aging and disease
- Principal Investigator
  
  Inagi Reiko
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  The University of Tokyo
Elucidation of metabolic reprogramming in the kidney and development of novel therapeutic approaches utilizing HIF against kidney disease
- Principal Investigator
  
  Nangaku Masaomi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  The University of Tokyo
Oxygen imaging of living tissues using confocal phosphorescence lifetime imaging microscope
- Principal Investigator
  
  Tobita Seiji
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Gunma University
Elucidation of the mechanisms of renal hypoxia by phosphorescence lifetime measurementPrincipal Investigator
- Principal Investigator
  
  HIRAKAWA YOSUKE
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Kidney internal medicine
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book

[Book] RSC Detection Science: Quenched-phosphorescence Detection of Molecular Oxygen: Applications in Life Sciences2018
- Author(s)
  Yoshihara T, Hirakawa Y, Nangaku M, Tobita S
- Total Pages
  368
- Publisher
  Royal Society of Chemistry
- Data Source
  KAKENHI-PROJECT-17K16070
[Journal Article] Acetate attenuates kidney fibrosis in an oxidative stress‐dependent manner2023
- Author(s)
  Kawabata Chiaki、Hirakawa Yosuke、Inagi Reiko、Nangaku Masaomi
- Journal Title
  
  Physiological Reports
  
  Volume: 11 Issue: 14
- DOI
  10.14814/phy2.15774
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08348, KAKENHI-PROJECT-21H02824
[Journal Article] Potential progression biomarkers of diabetic kidney disease determined using comprehensive machine learning analysis of non-targeted metabolomics2022
- Author(s)
  Hirakawa Yosuke、Yoshioka Kentaro、Kojima Kensuke、Yamashita Yasuho、Shibahara Takuma、Wada Takehiko、Nangaku Masaomi、Inagi Reiko
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 16287-16287
- DOI
  10.1038/s41598-022-20638-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08321, KAKENHI-PROJECT-21H02824, KAKENHI-PROJECT-21K19439
[Journal Article] Lysophosphatidylcholine mediates fast decline in kidney function in diabetic kidney disease2022
- Author(s)
  Yoshioka Kentaro、Hirakawa Yosuke、Kurano Makoto、Ube Yuko、Ono Yoko、Kojima Kensuke、Iwama Taiga、Kano Kuniyuki、Hasegawa Sho、Inoue Tsuyoshi、Shimada Takashi、Aoki Junken、Yatomi Yutaka、Nangaku Masaomi、Inagi Reiko
- Journal Title
  
  Kidney International
  
  Volume: 101 Issue: 3 Pages: 510-526
- DOI
  10.1016/j.kint.2021.10.039
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17242, KAKENHI-PROJECT-21H02824, KAKENHI-PROJECT-20K07047, KAKENHI-PROJECT-21K19439, KAKENHI-PROJECT-21K16159
[Journal Article] A distinctive distribution of hypoxia-inducible factor-1α in cultured renal tubular cells with hypoperfusion simulated by coverslip placement2021
- Author(s)
  Honda T, Hirakawa Y, Mizukami K, Yoshihara T, Tanaka T, Tobita S, Nangaku M
- Journal Title
  
  Physiol Rep
  
  Volume: 9 Issue: 1
- DOI
  10.14814/phy2.14689
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08626, KAKENHI-PROJECT-18H03509, KAKENHI-PROJECT-19K22947, KAKENHI-PROJECT-19K17697
[Journal Article] The role of oxidative stress and hypoxia in renal disease2019
- Author(s)
  Honda Tomoko、Hirakawa Yosuke、Nangaku Masaomi
- Journal Title
  
  Kidney Research and Clinical Practice
  
  Volume: 38 Issue: 4 Pages: 414-426
- DOI
  10.23876/j.krcp.19.063
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02824
[Journal Article] Quenched-phosphorescence Detection of Molecular Oxygen2018
- Author(s)
  Toshitada Yoshihara, Yosuke Hirakawa, Masaomi Nangaku, Seiji Tobita
- Journal Title
  
  Detection Science
  
  Volume: 11 Pages: 71-90
- DOI
  10.1039/9781788013451-00001
- ISBN
  9781788011754
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03509
[Journal Article] Intravital phosphorescence lifetime imaging of the renal cortex accurately measures renal hypoxia.2018
- Author(s)
  Hirakawa Y, Mizukami K, Yoshihara T, Takahashi I, Khulan P, Honda T, Mimura I, Tanaka T, Tobita S, Nangaku M.
- Journal Title
  
  Kidney Int.
  
  Volume: 印刷中 Issue: 6 Pages: 1483-1489
- DOI
  10.1016/j.kint.2018.01.015
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09688, KAKENHI-PROJECT-17K16070, KAKENHI-PROJECT-16K19477, KAKENHI-PLANNED-26111003, KAKENHI-PLANNED-26111012, KAKENHI-PROJECT-17H02078, KAKENHI-PROJECT-18H02824, KAKENHI-PROJECT-18H03509
[Journal Article] Genome-wide analysis revealed that DZNep reduces tubulointerstitial fibrosis via down-regulation of pro-fibrotic genes.2018
- Author(s)
  Mimura I, Hirakawa Y, Kanki Y, Nakaki R, Suzuki Y, Tanaka T, Aburatani H, Nangaku M.
- Journal Title
  
  Sci Rep.
  
  Volume: 28 Issue: 1 Pages: 3779-3779
- DOI
  10.1038/s41598-018-22180-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09688, KAKENHI-PROJECT-16K15438, KAKENHI-PROJECT-16K19477, KAKENHI-PROJECT-15H04835, KAKENHI-PROJECT-17H03614, KAKENHI-PROJECT-15KK0251, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-18H02824, KAKENHI-PROJECT-16H06279
[Journal Article] Renal Hypoxia in CKD; Pathophysiology and Detecting Methods.2017
- Author(s)
  Hirakawa Y, Tanaka T, Nangaku M.
- Journal Title
  
  Front Physiol
  
  Volume: 8 Pages: 99-99
- DOI
  10.3389/fphys.2017.00099
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04835, KAKENHI-PROJECT-26461215, KAKENHI-PROJECT-17K16070, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-15K09247
[Presentation] Non-targeted metabolomic analysis with machine learning identified biomarkers to predict rapid decliner in diabetic kidney disease2022
- Author(s)
  Hirakawa Y., etl. al.
- Organizer
  日本腎臓学会
- Data Source
  KAKENHI-PROJECT-21K19439
[Presentation] A distinctive distribution of hypoxia-inducible factor in cultured renal tubular cells with hypoperfusion induced by the placement of a coverslip.2020
- Author(s)
  Tomoko Honda, Yosuke Hirakawa, Tetsuhiro Tanaka, Kiichi Mizukami, Toshitada Yoshihara, Seiji Tobita, Masaomi Nangaku
- Organizer
  18th Asian pacific congress of nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17697
[Presentation] A unique distribution of hypoxia-inducible factor in cultured tubular cells with hypoperfusion2020
- Author(s)
  Yosuke Hirakawa, Tomoko Honda, Tetsuhiro Tanaka, Kiichi Mizukami, Toshitada Yoshihara, Seiji Tobita, Masaomi Nangaku
- Organizer
  World Congress of Nephrology 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17697
[Presentation] 酸素勾配を有する尿細管細胞培養系の確立と特徴的なHIF1αの分布2019
- Author(s)
  本田智子、平川陽亮、水上輝市、吉原利忠、田中哲洋、飛田成史、南学正臣
- Organizer
  検索結果ウェブ検索結果第62回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-19K17697
[Presentation] 水溶性イリジウム錯体(III)を用いた腎臓の血中酸素イメージング2019
- Author(s)
  吉原利忠，水上輝市，平川陽亮，南学正臣，飛田成史
- Organizer
  日本化学会第99回春季年会
- Data Source
  KAKENHI-PROJECT-18H03509
[Presentation] APPLICATION OF PHOSPHORESCENCE LIFETIME IMAGING MICROSCOPE TO ASSESS TUBULAR OXYGENATION2018
- Author(s)
  Yosuke Hirakawa, Kiichi Mizukami, Tomoko Honda, Toshitada Yoshihara, Imari Mimura, Tetsuhiro Tanaka, Seiji Tobita, Masaomi Nangaku
- Organizer
  16th Asian Pacific Congress of Nephrology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16070
[Presentation] APPLICATION OF PHOSPHORESCENCE LIFETIME IMAGING MICROSCOPE TO ASSESS TUBULAR OXYGENATION.2018
- Author(s)
  Yosuke Hirakawa, Kiichi Mizukami, Tomoko Honda, Toshitada Yoshihara, Imari Mimura, Tetsuhiro Tanaka, Seiji Tobita, Masaomi Nangaku.
- Organizer
  16th Asian Pacific Congress of Nephrology.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16070
[Presentation] 共焦点りん光寿命イメージング顕微鏡を用いた組織内酸素分圧計測，吉原利忠，塩崎秀一2018
- Author(s)
  平川陽亮，南学正臣，飛田成史
- Organizer
  第13回日本分子イメージング学会学術集会
- Data Source
  KAKENHI-PROJECT-18H03509
[Presentation] Renal tubular oxygen imaging using phosphorescence lifetime imaging microscope.2018
- Author(s)
  Yosuke Hirakawa, Toshitada Yoshihara, Tomoko Honda, Imari Mimura, Tetsuhiro Tanaka, Seiji Tobita, Masaomi Nangaku.
- Organizer
  ISN Frontiers meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16070
[Presentation] DETERMINATION OF OXYGEN TENSION IN TUBULAR EPITHELIAL CELLS USING PHOSPHORESCENCE LIFETIME IMAGING MICROSCOPY2018
- Author(s)
  Yosuke Hirakawa, Kiichi Mizukami, Toshitada Yoshihara, Tomoko Honda, Imari Mimura, Tetsuhiro Tanaka, Seiji Tobita, Masaomi Nangaku
- Organizer
  55th ERA-EDTA Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16070
[Presentation] りん光寿命イメージング顕微鏡を用いた生体腎皮質の酸素勾配の描出2017
- Author(s)
  平川陽亮, 吉原利忠, 本田智子, 三村維真理, 田中哲洋, 飛田成史, 南学正臣.
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-17K16070
[Presentation] 生体内での近位尿細管における酸素勾配の描出2017
- Author(s)
  平川陽亮, 吉原利忠, 神谷真子, 三村維真理, 田中哲洋, 浦野泰照, 飛田成史, 南学正臣.
- Organizer
  第60回日本腎臓学会学術総会
- Data Source
  KAKENHI-PROJECT-17K16070
[Presentation] りん光寿命イメージング顕微鏡を用いた腎表面酸素分圧勾配の描出.2017
- Author(s)
  平川陽亮, 吉原利忠, 三村維真理, 南学正臣, 飛田成史.
- Organizer
  第12回日本分子イメージング学会学術集会
- Data Source
  KAKENHI-PROJECT-17K16070

1. Inagi Reiko (50232509)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. Nangaku Masaomi (90311620)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. 西裕志 (90784174)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. Tobita Seiji (30164007)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
5. 田中哲洋 (90508079)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
6. 井上剛 (30821665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 三村維真理 (00727084)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 長谷川頌 (30892658)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Yoshihara Toshitada

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
10. WADA Takehiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirakawa Yosuke 平川 陽亮

HIRAKAWA YOSUKE 平川 陽亮

Research Projects

Research Products

Co-Researchers

慢性腎臓病関連代謝物であるDHA及びSDMAの病態意義の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of mechanism how short chain fatty acids suppress kidney fibrosis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathophysiological role of organelle contact site in tubular homeostasis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Examination of biological meaning of change in oxygen status and oxygen gradation in chronic kidney diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of organelle crosstalk on organ homeostasis in aging and disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of metabolic reprogramming in the kidney and development of novel therapeutic approaches utilizing HIF against kidney disease

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Oxygen imaging of living tissues using confocal phosphorescence lifetime imaging microscope

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanisms of renal hypoxia by phosphorescence lifetime measurementPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] RSC Detection Science: Quenched-phosphorescence Detection of Molecular Oxygen: Applications in Life Sciences2018

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Acetate attenuates kidney fibrosis in an oxidative stress‐dependent manner2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Potential progression biomarkers of diabetic kidney disease determined using comprehensive machine learning analysis of non-targeted metabolomics2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lysophosphatidylcholine mediates fast decline in kidney function in diabetic kidney disease2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A distinctive distribution of hypoxia-inducible factor-1α in cultured renal tubular cells with hypoperfusion simulated by coverslip placement2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The role of oxidative stress and hypoxia in renal disease2019

Author(s)

Hirakawa Yosuke 平川陽亮

HIRAKAWA YOSUKE 平川陽亮