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Sasaguri Hiroki  笹栗 弘貴

ORCIDConnect your ORCID iD *help
Researcher Number 10783053
Other IDs
Affiliation (Current) 2025: 国立研究開発法人理化学研究所, 脳神経科学研究センター, ユニットリーダー
Affiliation (based on the past Project Information) *help 2022 – 2024: 国立研究開発法人理化学研究所, 脳神経科学研究センター, ユニットリーダー
2019 – 2021: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 副チームリーダー
2018: 国立研究開発法人理化学研究所, 脳神経科学研究センター, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 51030:Pathophysiologic neuroscience-related
Except Principal Investigator
Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Basic Section 59040:Nutrition science and health science-related
Keywords
Principal Investigator
マウスモデル / アルツハイマー病 / 健康長寿 / タウ病理 / PLCG2 / アミロイド病理 / PLCG2遺伝子 / 保護的変異 / βアミロイド / Base editor … More / 家族性アルツハイマー病 / ノックイン法 / 塩基編集 / ゲノム編集 / モデルマウス / 認知症 / アミロイドβ / プレセニリン / 塩基編集技術 / ゲノム編集技術 / γセクレターゼ / アミロイドβ(Aβ) / プレセニリン1遺伝子 … More
Except Principal Investigator
アルツハイマー病 / 神経変性疾患 / Aβ蓄積 / トランスクリプトーム / 病態モデル / タウ病理 / アミロイドβペプチド / APOE2 / 長寿 / APOE2 Less
  • Research Projects

    (4 results)
  • Research Products

    (13 results)
  • Co-Researchers

    (8 People)
  •  How does Abeta amyloidosis promotes tau pathology in vivo?

    • Principal Investigator
      西道 隆臣
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  アルツハイマー病予防および健康長寿達成を目指したPLCG2遺伝子の機能解明Principal Investigator

    • Principal Investigator
      笹栗 弘貴
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Institute of Physical and Chemical Research
  •  アルツハイマー病保護因子APOE2多型の作用機序の解明と治療薬開発への応用

    • Principal Investigator
      篠原 充
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      National Center for Geriatrics and Gerontology
  •  Systematic analysis of Alzheimer's disease pathomechanisms utilizing genome editing technologyPrincipal Investigator

    • Principal Investigator
      Sasaguri Hiroki
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      Institute of Physical and Chemical Research

All 2023 2021 2020 2019 2018

All Journal Article Presentation

  • [Journal Article] Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer’s disease2023

    • Author(s)
      Daniels Michael JD、Lefevre Lucas、Szymkowiak Stefan、Drake Alice、McCulloch Laura、Tzioras Makis、Barrington Jack、Dando Owen R、He Xin、Mohammad Mehreen、Sasaguri Hiroki、Saito Takashi、Saido Takaomi C、Spires-Jones Tara L、McColl Barry W
    • Journal Title

      eLife

      Volume: 12

    • DOI

      10.7554/elife.85279

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K26790
  • [Journal Article] A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury2023

    • Author(s)
      Zhao Xinyi、Zeng Wen、Xu Hong、Sun Zihan、Hu Yingxin、Peng Beibei、McBride Jennifer D.、Duan Jiangtao、Deng Juan、Zhang Bin、Kim Soo-Jung、Zoll Bryan、Saito Takashi、Sasaguri Hiroki、Saido Takaomi C.、Ballatore Carlo、Yao Haishan、Wang Zhaoyin、Trojanowski John Q.、Brunden Kurt R.、Lee Virginia M.-Y.、He Zhuohao
    • Journal Title

      Science Translational Medicine

      Volume: 15 Issue: 713

    • DOI

      10.1126/scitranslmed.abo6889

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K26790
  • [Journal Article] A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior2023

    • Author(s)
      Ho Hinze、Kejzar Nejc、Sasaguri Hiroki、Saito Takashi、Saido Takaomi C.、De Strooper Bart、Bauza Marius、Krupic Julija
    • Journal Title

      Cell Reports Methods

      Volume: 3 Issue: 7 Pages: 100532-100532

    • DOI

      10.1016/j.crmeth.2023.100532

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K26790
  • [Journal Article] A third-generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide2021

    • Author(s)
      Sato Kaori、Watamura Naoto、Fujioka Ryo、Mihira Naomi、Sekiguchi Misaki、Nagata Kenichi、Ohshima Toshio、Saito Takashi、Saido Takaomi C.、Sasaguri Hiroki
    • Journal Title

      Journal of Biological Chemistry

      Volume: 297 Issue: 3 Pages: 101004-101004

    • DOI

      10.1016/j.jbc.2021.101004

    • Data Source
      KAKENHI-PROJECT-18K07402
  • [Journal Article] Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID2018

    • Author(s)
      Sasaguri Hiroki、Nagata Kenichi、Sekiguchi Misaki、Fujioka Ryo、Matsuba Yukio、Hashimoto Shoko、Sato Kaori、Kurup Deepika、Yokota Takanori、Saido Takaomi C.
    • Journal Title

      Nature Communications

      Volume: 9 Issue: 1 Pages: 2892-2892

    • DOI

      10.1038/s41467-018-05262-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07402
  • [Presentation] ゲノム編集技術と認知症研究最前線2020

    • Author(s)
      笹栗弘貴
    • Organizer
      第20回日本抗加齢医学会総会
    • Data Source
      KAKENHI-PROJECT-18K07402
  • [Presentation] 塩基編集技術を利用した高効率な変異Psen1マウス作製2019

    • Author(s)
      笹栗 弘貴
    • Organizer
      第38回日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K07402
  • [Presentation] Generation of animal models using a novel RNA-guided base editing technology2019

    • Author(s)
      Hiroki Sasaguri
    • Organizer
      第4回日本ゲノム編集学会
    • Data Source
      KAKENHI-PROJECT-18K07402
  • [Presentation] Generation of AD animal models using a novel RNA-guided gene editing technology2019

    • Author(s)
      Hiroki Sasaguri
    • Organizer
      Alzheimer's Association International Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07402
  • [Presentation] Generation of Alzheimer’s disease animal models using an RNA-guided base editing technology2019

    • Author(s)
      Hiroki Sasaguri
    • Organizer
      第60回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-18K07402
  • [Presentation] 新規ゲノム編集技術を利用したアルツハイマー病動物モデル作製2018

    • Author(s)
      笹栗弘貴、関口みさき、藤岡亮、永田健一、松葉由紀夫、西道隆臣
    • Organizer
      第37回 日本認知症学会
    • Data Source
      KAKENHI-PROJECT-18K07402
  • [Presentation] 新規ゲノム編集技術を利用したアルツハイマー病動物モデル作製2018

    • Author(s)
      笹栗弘貴、関口みさき、藤岡亮、永田健一、松葉由紀夫、西道隆臣
    • Organizer
      第3回 日本ゲノム編集学会大会
    • Data Source
      KAKENHI-PROJECT-18K07402
  • [Presentation] Generation of mutant presenilin 1 mice using a novel RNA-guided base editing technology2018

    • Author(s)
      Hiroki Sasaguri, Misaki Sekiguchi, Ryo Fujioka, Kenichi Nagata, Takaomi C Saido
    • Organizer
      第59回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-18K07402
  • 1.  篠原 充 (60800521)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  大塚 礼 (00532243)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  齊藤 祐子 (60344066)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  西田 裕紀子 (60393170)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  佐藤 亜希子 (80800979)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  菊地 正隆 (90722538)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  小木曽 昇 (40638350)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  西道 隆臣 (80205690)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results

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