Kawashima Akihiro 川嶋章弘

… Alternative Names

KAWASHIMA AKIHIRO 川嶋章弘

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Researcher Number	10783376
Other IDs	https://orcid.org/0000-0002-3501-4854
Affiliation (Current)	2025: 昭和医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2025: 昭和医科大学, 医学部, 講師 2019 – 2024: 昭和大学, 医学部, 講師 2016 – 2018: 昭和大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Embryonic/Neonatal medicine / Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Obstetrics and gynecology / Basic Section 56040:Obstetrics and gynecology-related / Basic Section 57020:Oral pathobiological science-related
Keywords	Principal Investigator 胎児治療 / 妊娠初期 / 脂肪組織由来幹細胞 / ダウン症 / 再生医療 / preeclampsia / Adora2b / フェロトーシス / 胎盤 / 妊娠初期絨毛 … More / メチル化異常 / エピゲノム / 初期絨毛 / DNAメチル化 / cell-free DNA / 胎盤幹細胞 / メチル化 / 妊娠高血圧腎症 / 精神神経発達遅滞 / 間葉系幹細胞 / 脳疾患 / 神経誘導 / 胎児幹細胞治療 / 幹細胞治療 / 脂肪由来間葉系幹細胞 / 脳機能障害 / 先天代謝異常症 / 脳神経疾患 / 先天性代謝疾患 / 幹細胞 … More Except Principal Investigator 妊娠高血圧腎症 / 遺伝子 / DNAメチル化 / 妊娠高血圧症候群 / 遺伝 / アスピリン抵抗性 / アスピリン / シグナル伝達 / エキソソーム / 亜鉛トランスポーター / 骨格成長 / 細胞・組織 / 軟骨 / 骨格形成 / 血液型 / ゲノム / 血液型不適合妊娠 / RHD / 出生前診断 / 血液型不適合姙娠 / RhD / 絨毛検査 / 妊娠初期絨毛 / 妊娠高血圧症侯群 / 絨毛細胞 / 胎盤 / 絨毛 / 卵巣癌 / 子宮頸癌 / 子宮体癌 / 遺伝子産物 / 癌バイオマーカー / 腫瘍マーカー / 染色体不安定性 / CNV / 婦人科悪性腫瘍 / MPS法 / cell free DNA Less

Development of a Preventive Strategy for Preeclampsia through Modulation of Oxidative Stress Response in Placental Stem Cells via ADORA2B InhibitionPrincipal Investigator
- Principal Investigator
  
  川嶋章弘
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Showa Medical University
Elucidation of the pathogenasis and the development of prevention and treatment of preeclampsia through genetic analysis of aspirin resistance
- Principal Investigator
  
  金子真由美 (徳中真由美)
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Showa University
Epigenetic Approaches for the Elucidation of Preeclampsia Development Mechanisms in Primary PlacentaPrincipal Investigator
- Principal Investigator
  
  川嶋章弘
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Showa University
Development a method to predict preeclampsia using maternal plasma DNA/RNA
- Principal Investigator
  
  Koide Keiko
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Showa University
Development of the fetal therapy using maternal adipose-derived stem cellsPrincipal Investigator
- Principal Investigator
  
  Akihiro Kawashima
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  Showa University
The exploration of exosome involvement in skeletal abnormalities induced by dysregulation of zinc homeostasis
- Principal Investigator
  
  Yasuhara Rika
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Showa University
Pathophysiology of hypertensive disorder of pregnancy through DNA methylation analysis of villous trophoblasts in first trimester
- Principal Investigator
  
  Sekizawa Akihiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Showa University
日本人のRhD陰性の遺伝子型の探索：母体血からの胎児RhD血液型診断法の確立
- Principal Investigator
  
  那須美智子
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Showa University
ENGRAFTMENT POTENTIAL OF MATERNAL ADIPOSE-DERIVED STEM CELLS FOR IN UTERO TRANSPLANTATIONPrincipal Investigator
- Principal Investigator
  
  Kawashima Akihiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Showa University
Adipose-tissue-derived stem cells could be an ideal cell source for neural regeneration when to treat a fetus in uteroPrincipal Investigator
- Principal Investigator
  
  KAWASHIMA AKIHIRO
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Embryonic/Neonatal medicine
- Research Institution
  Showa University
Development of a novel biomarker using peripheral blood for detection of tumor derived chromosome instability
- Principal Investigator
  
  Shimizu Hanako
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Showa University

All 2024 2023 2022 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Engraftment potential of maternal adipose-derived stem cells for fetal transplantation2020
- Author(s)
  Kawashima Akihiro、Yasuhara Rika、Akino Ryosuke、Mishima Kenji、Nasu Michiko、Sekizawa Akihiko
- Journal Title
  
  Heliyon
  
  Volume: 6 Issue: 3 Pages: 1-9
- DOI
  10.1016/j.heliyon.2020.e03409
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09540, KAKENHI-PROJECT-17K16311, KAKENHI-PROJECT-20K21688, KAKENHI-PROJECT-19H03827, KAKENHI-PROJECT-19K17378
[Journal Article] Cytokine profiles in maternal serum are candidates for predicting an optimal timing for the delivery in early‐onset fetal growth restriction2020
- Author(s)
  Kawashima Akihiro、Oba Tomohiro、Yasuhara Rika、Sekiya Bunbu、Sekizawa Akihiko
- Journal Title
  
  Prenatal Diagnosis
  
  Volume: Epub Issue: 6 Pages: 728-737
- DOI
  10.1002/pd.5679
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09540, KAKENHI-PROJECT-17K16311, KAKENHI-PROJECT-19K17378
[Journal Article] Amplicon Sequencing-Based Noninvasive Fetal Genotyping for RHD-Positive D Antigen-Negative Alleles2019
- Author(s)
  Takahashi Ken、Migita Ohsuke、Sasaki Aiko、Nasu Michiko、Kawashima Akihiro、Sekizawa Akihiko、Sato Taisuke、Ito Yuki、Sago Haruhiko、Okamoto Aikou、Nakabayashi Kazuhiko、Hata Kenichiro
- Journal Title
  
  Clinical Chemistry
  
  Volume: 65 Issue: 10 Pages: 1307-1316
- DOI
  10.1373/clinchem.2019.307074
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01588, KAKENHI-PROJECT-17K16311, KAKENHI-PROJECT-18H03556
[Journal Article] Generation of orthotopically functional salivary gland from embryonic stem cells2018
- Author(s)
  Tanaka Junichi、Ogawa Miho、Hojo Hironori、Kawashima Yusuke、Mabuchi Yo、Hata Kenji、Nakamura Shiro、Yasuhara Rika、Takamatsu Koki、Irie Tarou、Fukada Toshiyuki、Sakai Takayoshi、Inoue Tomio、Nishimura Riko、Ohara Osamu、Saito Ichiro、Ohba Shinsuke、Tsuji Takashi、Mishima Kenji
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 4216-4216
- DOI
  10.1038/s41467-018-06469-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11488, KAKENHI-PROJECT-18K09540, KAKENHI-PROJECT-18K19636, KAKENHI-PROJECT-16H06393, KAKENHI-PROJECT-17H04011, KAKENHI-PROJECT-17H04373, KAKENHI-PROJECT-17H05106, KAKENHI-PROJECT-15K06853, KAKENHI-PROJECT-16K11459, KAKENHI-PROJECT-15K15737, KAKENHI-PROJECT-17K19775, KAKENHI-PROJECT-17K17088, KAKENHI-PROJECT-15H02575
[Journal Article] Massively parallel sequencing of cell-free DNA in plasma for detecting gynaecological tumour-associated copy number alteration.2018
- Author(s)
  Nakabayashi M, Kawashima A, Yasuhara R, Hayakawa Y, Miyamoto S, Iizuka C, Sekizawa A.
- Journal Title
  
  Sci Rep.
  
  Volume: 8(1):15883 Issue: 1 Pages: 1-12
- DOI
  10.1038/s41598-018-34168-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09540
[Presentation] Early onset preeclampsia is associated with altered DNA methylation in the first trimester villi2024
- Author(s)
  Akihiro Kawashima
- Organizer
  2024 Annual Congress of Taiwan Association of Obstetrics and Gynecology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K09551
[Presentation] Knockdown of Adora2b accelerates ferroptosis in placental stem cells2023
- Author(s)
  Akihiro Kawashima
- Organizer
  第75回日本産科婦人科学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K09551
[Presentation] 妊娠高血圧腎症の発症につながる妊娠初期絨毛の　　機能変化についての検討2022
- Author(s)
  Akihiro Kawashima
- Organizer
  第74回日本産科婦人科学術集会　シンポジウム
- Data Source
  KAKENHI-PROJECT-21K09551
[Presentation] In utero transplantation with organoid of mesenchymal stem cell-derived neural progenitor2020
- Author(s)
  Akihiro Kawashima
- Organizer
  第72回日本産婦人科学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17378
[Presentation] Each negative alteration in early-onset fetal growth restriction changes the profile of maternal serum cytokines into a peculiar feature. We want to explore this further as an early warning system.2019
- Author(s)
  Akihiro Kawashima
- Organizer
  the 24th International Conference on Prenatal Diagnosis and Therapy.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16311
[Presentation] Loss of ZIP10 impairs skeletal development via osteochondrocyte functions.2019
- Author(s)
  Rika Yasuhara, Akihiro Kawashima, Akane Yukimori, Junichi Tanaka, Satoko Kujiraoka, Toshiyuki Fukada, Motomi Enomoto-Iwamoto, Kenji Mishima
- Organizer
  ASBMR 2019 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K09540
[Presentation] THE ENGRAFTMENT POTENTIAL OF MATERNAL ADIPOSE-DERIVED STEM CELLS, FOR FETAL TRANSPLANTATION2019
- Author(s)
  Akihiro Kawashima
- Organizer
  日本産科婦人科学会
- Data Source
  KAKENHI-PROJECT-17K16311
[Presentation] The Engraftment potential of maternal adipose-derived stem cells for fetal transplantation2019
- Author(s)
  Akihiro Kawashima
- Organizer
  International Society for Stem Cell Research 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16311
[Presentation] Each negative alteration in early-onset fetal growth restriction changes the profile of maternal serum cytokines into a peculiar feature. We want to explore this further as an early warning system.2019
- Author(s)
  Akihiro Kawashima
- Organizer
  the 24th International Conference on Prenatal Diagnosis and Therapy.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17378
[Presentation] The Engraftment potential of maternal adipose-derived stem cells for fetal transplantation2019
- Author(s)
  Akihiro Kawashima
- Organizer
  International Society for Stem Cell Research 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17378
[Presentation] Engraftment potential of maternal adipose-derived stem cells for fetal transplantation2019
- Author(s)
  Akihiro Kawashima
- Organizer
  The 72nd Annual Congress of JSOG
- Data Source
  KAKENHI-PROJECT-19K17378
[Presentation] Engraftment potential of maternal adipose-derived stem cells for fetal transplantation2019
- Author(s)
  Akihiro Kawashima
- Organizer
  The 72nd Annual Congress of JSOG
- Data Source
  KAKENHI-PROJECT-17K16311
[Presentation] Exploration of the use of adipose tissue-derived stem cells for in utero transplantation2018
- Author(s)
  Akihiro Kawashima
- Organizer
  International society for stem cell research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16311
[Presentation] Development of a novel biomarker for neoplasms through analysis of copy number variations in cell-free DNA of the blood of patients.2017
- Author(s)
  Makoto Nakabayashi, Akihito Kawashima, Akihiko Sekizawa
- Organizer
  日本産科婦人科学会第69回学術講演会
- Place of Presentation
  広島
- Year and Date
  2017-04-14
- Data Source
  KAKENHI-PROJECT-15K15612
[Presentation] Adipose-derived-mesenchymal stem cells could be a promising cell source of tissue regeneration in congenital neural degeneration2017
- Author(s)
  川嶋章弘
- Organizer
  第69回日本産科婦人科学会学術講演会
- Place of Presentation
  広島県立総合体育館
- Year and Date
  2017-04-13
- Data Source
  KAKENHI-PROJECT-16H07193
[Presentation] 子宮内胎仔脳室内投与における脂肪組織由来幹細胞の中枢神経系への有効性2017
- Author(s)
  川嶋章弘
- Organizer
  第39回分子生物学会
- Data Source
  KAKENHI-PROJECT-17K16311
[Presentation] MOUSE ADIPOSE TISSUE-DERIVED STEM CELLS COULD BE AN IDEAL SOURCE FOR IN UTERO THERAPEUTIC REPAIR OF FETAL BRAIN DYSFUNCTION2017
- Author(s)
  川嶋章弘
- Organizer
  ISSCR 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16311
[Presentation] 子宮内胎仔脳室内投与における脂肪組織由来幹細胞の中枢神経系への有効性2016
- Author(s)
  川嶋章弘
- Organizer
  第39回分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H07193

1. Sekizawa Akihiko (10245839)

# of Collaborated Projects: 6 results

# of Collaborated Products: 1 results
2. Shimizu Hanako (20551203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Yasuhara Rika (20453649)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. Koide Keiko (90384437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 四元淳子 (30553648)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 那須美智子 (00750457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 青木弘子 (60465127)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 田中準一 (40710166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 美島健二 (50275343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. 金子真由美 (10643710)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 細沼雅弘 (20836457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. NAKABAYASHI Makoto

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 井上富雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 中村史朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 中林一彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kawashima Akihiro 川嶋 章弘

KAWASHIMA AKIHIRO 川嶋 章弘

Research Projects

Research Products

Co-Researchers

Development of a Preventive Strategy for Preeclampsia through Modulation of Oxidative Stress Response in Placental Stem Cells via ADORA2B InhibitionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the pathogenasis and the development of prevention and treatment of preeclampsia through genetic analysis of aspirin resistance

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Epigenetic Approaches for the Elucidation of Preeclampsia Development Mechanisms in Primary PlacentaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development a method to predict preeclampsia using maternal plasma DNA/RNA

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of the fetal therapy using maternal adipose-derived stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The exploration of exosome involvement in skeletal abnormalities induced by dysregulation of zinc homeostasis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathophysiology of hypertensive disorder of pregnancy through DNA methylation analysis of villous trophoblasts in first trimester

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

日本人のRhD陰性の遺伝子型の探索：母体血からの胎児RhD血液型診断法の確立

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ENGRAFTMENT POTENTIAL OF MATERNAL ADIPOSE-DERIVED STEM CELLS FOR IN UTERO TRANSPLANTATIONPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Adipose-tissue-derived stem cells could be an ideal cell source for neural regeneration when to treat a fetus in uteroPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of a novel biomarker using peripheral blood for detection of tumor derived chromosome instability

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Engraftment potential of maternal adipose-derived stem cells for fetal transplantation2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cytokine profiles in maternal serum are candidates for predicting an optimal timing for the delivery in early‐onset fetal growth restriction2020

Author(s)

Journal Title

DOI

Kawashima Akihiro 川嶋章弘

KAWASHIMA AKIHIRO 川嶋章弘

[Presentation] 妊娠高血圧腎症の発症につながる妊娠初期絨毛の　　機能変化についての検討2022