TAKASHIMA HIROKI 高島大輝

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Takashima Hiroki 高島大輝

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Researcher Number	10785588
Other IDs
Affiliation (Current)	2025: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員
Affiliation (based on the past Project Information) *help	2023 – 2024: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員 2022: 国立研究開発法人国立がん研究センター, 先端医療開発センター, ユニット長 2018 – 2020: 国立研究開発法人国立がん研究センター, 先端医療開発センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Keywords	Principal Investigator Drug delivery system / 能動的標的化 / 抗体工学 / 放射線分解 / 毒性学 / 薬理学 / 抗体改変技術 / リンカー技術 / 放射免疫療法 / アスタチン-211 … More / ナノパーティクル / 武装抗体 / Drug Delivery Sｙｓtem / HER2 / 組織因子 / 腫瘍内分布 / エピルビシン / 抗体付加抗がん剤内包ミセル / 抗体-薬物複合体 / 抗体 / Drug Delivery System … More Except Principal Investigator 構造生物学 / 抗体依存性細胞傷害活性 / 糖鎖 / 抗体 Less

系統的抗体糖鎖改変と有機合成糖鎖を用いた抗体機能強化
- Principal Investigator
  
  眞鍋史乃
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Hoshi University
Altered biodistribution of astatine-211 via linker technology and antibody engineering in radioimmunotherapyPrincipal Investigator
- Principal Investigator
  
  Takashima Hiroki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan
Development of drug delivery systems using antibodyPrincipal Investigator
- Principal Investigator
  
  Takashima Hiroki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  National Cancer Center Japan

All 2023 2022 2020 2019

All Journal Article Presentation

[Journal Article] Tumor Targeting of 211At-Labeled Antibody under Sodium Ascorbate Protection against Radiolysis2023
- Author(s)
  Takashima Hiroki、Ohnuki Kazunobu、Manabe Shino、Koga Yoshikatsu、Tsumura Ryo、Anzai Takahiro、Wang Yang、Yin Xiaojie、Sato Nozomi、Shigekawa Yudai、Nambu Akihiro、Usuda Sachiko、Haba Hiromitsu、Fujii Hirofumi、Yasunaga Masahiro
- Journal Title
  
  Molecular Pharmaceutics
  
  Volume: 20 Issue: 2 Pages: 1156-1167
- DOI
  10.1021/acs.molpharmaceut.2c00869
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15594, KAKENHI-PLANNED-22H05024, KAKENHI-PROJECT-20K14500, KAKENHI-PROJECT-19H03357
[Journal Article] Reinforcement of antitumor effect of micelles containing anticancer drugs by binding of an anti-tissue factor antibody without direct cytocidal effects2020
- Author(s)
  Takashima Hiroki、Koga Yoshikatsu、Tsumura Ryo、Yasunaga Masahiro、Tsuchiya Masami、Inoue Tadashi、Negishi Eriko、Harada Mitsunori、Yoshida Sei、Matsumura Yasuhiro
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 323 Pages: 138-150
- DOI
  10.1016/j.jconrel.2020.03.048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15297
[Journal Article] Evaluation of the antitumor mechanism of antibody‐drug conjugates against tissue factor in stroma‐rich allograft models2019
- Author(s)
  Tsumura Ryo、Manabe Shino、Takashima Hiroki、Koga Yoshikatsu、Yasunaga Masahiro、Matsumura Yasuhiro
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 10 Pages: 3296-3305
- DOI
  10.1111/cas.14146
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15297, KAKENHI-PROJECT-18K14931
[Journal Article] Preclinical studies of immunomicelles incorporating anticancer drugs2019
- Author(s)
  Takashima Hiroki、Tsumura Ryo、Koga Yoshikatsu、Yasunaga Masahiro、Harada Mitsunori、Matsumura Yasuhiro
- Journal Title
  
  Drug Delivery System
  
  Volume: 34 Issue: 1 Pages: 29-37
- DOI
  10.2745/dds.34.29
- NAID
  130007636842
- ISSN
  0913-5006, 1881-2732
- Year and Date
  2019-01-25
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-18K15297
[Journal Article] Anti-tissue factor antibody?mediated immuno?SPECT imaging of tissue factor expression in mouse models of pancreatic cancer2019
- Author(s)
  Sugyo Aya、Aung Winn、Tsuji Atsushi、Sudo Hitomi、Takashima Hiroki、Yasunaga Masahiro、Matsumura Yasuhiro、Saga Tsuneo、Higashi Tatsuya
- Journal Title
  
  Oncology Reports
  
  Volume: 41 (4) Pages: 2371-2378
- DOI
  10.3892/or.2019.7017
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K10460, KAKENHI-PROJECT-18K15297, KAKENHI-PROJECT-18H02774, KAKENHI-PROJECT-17K10497
[Presentation] Sodium ascorbate protection against radiolysis is indispensable to maintain active targeting of <sup>211</sup>At-labeled antibody2022
- Author(s)
  Hiroki Takashima, Kazunobu Ohnuki, Shino Manabe, Yoshikatsu Koga, Ryo Tsumura, Takahiro Anzai, Yang Wang, Xiaojie Yin, Nozomi Sato, Yudai Shigekawa, Akihiro Nambu, Sachiko Usuda, Hiromitsu Haba, Hirofumi Fuji, Masahiro Yasunaga
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K15594
[Presentation] Development of micelles containing anticancer drugs conjugated with an anti-tissue factor antibody without direct cytocidal effects2020
- Author(s)
  Hiroki Takashima, Yoshikatsu Koga, Ryo Tsumura, Masahiro Yasunaga, Masami Tsuchiya, Tadashi Inoue, Eriko Negish, Chihiro Tanabe, Mitsunori Harada, Sei Yoshida, Yasuhiro Matsumura
- Organizer
  2020 Controlled Release Society Virtual Annual Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K15297
[Presentation] Antitumor effect of nanomicelles conjugated to an anti-tissue factor antibody without a direct cytocidal effect2020
- Author(s)
  Hiroki Takashima, Yoshikatsu Koga, Ryo Tsumura, Masami Tsuchiya, Tadashi Inoue, Eriko Negishi, Mitsunori Harada, Sei Yoshida, Yasuhiro Matsumura, Masahiro Yasunaga
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K15297

1. 眞鍋史乃 (60300901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 加藤晃一 (20211849)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. Hiranyakorn Methanee (60966133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. U・WINN Aung

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKASHIMA HIROKI 高島 大輝

Takashima Hiroki 高島 大輝

Research Projects

Research Products

Co-Researchers

系統的抗体糖鎖改変と有機合成糖鎖を用いた抗体機能強化

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Altered biodistribution of astatine-211 via linker technology and antibody engineering in radioimmunotherapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of drug delivery systems using antibodyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Tumor Targeting of 211At-Labeled Antibody under Sodium Ascorbate Protection against Radiolysis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Reinforcement of antitumor effect of micelles containing anticancer drugs by binding of an anti-tissue factor antibody without direct cytocidal effects2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of the antitumor mechanism of antibody‐drug conjugates against tissue factor in stroma‐rich allograft models2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preclinical studies of immunomicelles incorporating anticancer drugs2019

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Anti-tissue factor antibody?mediated immuno?SPECT imaging of tissue factor expression in mouse models of pancreatic cancer2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] Sodium ascorbate protection against radiolysis is indispensable to maintain active targeting of <sup>211</sup>At-labeled antibody2022

Author(s)

Organizer

Data Source

[Presentation] Development of micelles containing anticancer drugs conjugated with an anti-tissue factor antibody without direct cytocidal effects2020

Author(s)

Organizer

Data Source

[Presentation] Antitumor effect of nanomicelles conjugated to an anti-tissue factor antibody without a direct cytocidal effect2020

Author(s)

Organizer

Data Source

TAKASHIMA HIROKI 高島大輝

Takashima Hiroki 高島大輝