CHIBA KYOKO 千葉杏子

Researcher Number	10795701
Other IDs
Affiliation (Current)	2025: 東北大学, 学際科学フロンティア研究所, 助教
Affiliation (based on the past Project Information) *help	2021 – 2023: 東北大学, 学際科学フロンティア研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 43030:Functional biochemistry-related / 0701:Biology at molecular to cellular levels, and related fields
Keywords	Principal Investigator 細胞内輸送 / 筋萎縮性側索硬化症 / ALS / KIF5 / キネシン / 微小管 / モータータンパク質 / Kinesin-1 / 神経変性疾患 / 一分子観察 … More / リコンビナント抗体 / KIF5A / 細胞骨格 / 抗体配列決定 / H2抗体 / scFv Less

Research Projects
(2 results)
Research Products
(13 results)

Altered autoinhibition of KIF5A in neurodegenerationPrincipal Investigator
- Principal Investigator
  
  Chiba Kyoko
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Tohoku University
Analysis of H2 antibody and the inhibitory effect on kinesinPrincipal Investigator
- Principal Investigator
  
  CHIBA KYOKO
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0701:Biology at molecular to cellular levels, and related fields
- Research Institution
  Tohoku University

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] Autoinhibition and activation of kinesin-1 and their involvement in amyotrophic lateral sclerosis2024
- Author(s)
  Chiba Kyoko、Niwa Shinsuke
- Journal Title
  
  Current Opinion in Cell Biology
  
  Volume: 86 Pages: 102301-102301
- DOI
  10.1016/j.ceb.2023.102301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15053, KAKENHI-PUBLICLY-22H05523
[Journal Article] Comparative analysis of two Caenorhabditis elegans kinesins KLP-6 and UNC-104 reveals a common and distinct activation mechanism in kinesin-32024
- Author(s)
  Kita Tomoki、Chiba Kyoko、Wang Jiye、Nakagawa Atsushi、Niwa Shinsuke
- Journal Title
  
  eLife
  
  Volume: 12
- DOI
  10.7554/elife.89040
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15053
[Journal Article] Generation of recombinant and chickenized scFv versions of an anti‐kinesin monoclonal antibody H22023
- Author(s)
  Niwa Shinsuke、Chiba Kyoko
- Journal Title
  
  Cytoskeleton
  
  Volume: - Issue: 9-10 Pages: 356-366
- DOI
  10.1002/cm.21756
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K20621, KAKENHI-PROJECT-22K15053
[Journal Article] Insight into the regulation of axonal transport from the study of KIF1A-associated neurological disorder2023
- Author(s)
  Chiba Kyoko、Kita Tomoki、Anazawa Yuzu、Niwa Shinsuke
- Journal Title
  
  Journal of Cell Science
  
  Volume: 136 Issue: 5
- DOI
  10.1242/jcs.260742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15053, KAKENHI-PUBLICLY-22H05523, KAKENHI-PROJECT-20H03247, KAKENHI-PROJECT-21K20621
[Journal Article] Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity2022
- Author(s)
  Chiba Kyoko、Ori-McKenney Kassandra M.、Niwa Shinsuke、McKenney Richard J.
- Journal Title
  
  Cell Reports
  
  Volume: 39 Issue: 9 Pages: 110900-110900
- DOI
  10.1016/j.celrep.2022.110900
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15053, KAKENHI-PUBLICLY-22H05523, KAKENHI-PROJECT-20H03247, KAKENHI-PROJECT-21K20621
[Journal Article] An ALS‐associated KIF5A mutant forms oligomers and aggregates and induces neuronal toxicity2022
- Author(s)
  Nakano Juri、Chiba Kyoko、Niwa Shinsuke
- Journal Title
  
  Genes to Cells
  
  Volume: 27 Issue: 6 Pages: 421-435
- DOI
  10.1111/gtc.12936
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15053, KAKENHI-PUBLICLY-22H05523, KAKENHI-PROJECT-20H03247, KAKENHI-PROJECT-21K20621
[Presentation] KIF1A and KIF1Bβ form a heterodimer2023
- Author(s)
  Kyoko CHIBA, Shinsuke NIWA
- Organizer
  The 49th Naito Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15053
[Presentation] The FHA domain is essential for the autoinhibition of KIF1A2023
- Author(s)
  Kyoko CHIBA, Shinsuke NIWA
- Organizer
  Cell Bio 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15053
[Presentation] Kinesin-3の分子内相互作用と自己阻害2023
- Author(s)
  千葉杏子
- Organizer
  第12回分子モーター討論会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15053
[Presentation] KIF5A のALS 関連遺伝子変異はKIF5A のオリゴマー化と凝集を促進し神経毒性を引き起こす2022
- Author(s)
  千葉杏子
- Organizer
  第60回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K20621
[Presentation] An ALS-associated KIF5A mutant forms oligomers and aggregates and induces neuronal toxicity2022
- Author(s)
  Kyoko Chiba
- Organizer
  The American Society for Cell Biology (ASCB), Annual Meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20621
[Presentation] KIF5A のALS 関連遺伝子変異はKIF5A のオリゴマー化と凝集を促進し神経毒性を引き起こす2022
- Author(s)
  千葉杏子
- Organizer
  第60回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-22K15053
[Presentation] An ALS-associated KIF5A mutant forms oligomers and aggregates and induces neuronal toxicity2022
- Author(s)
  千葉杏子
- Organizer
  The American Society for Cell Biology (ASCB), Annual Meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15053

CHIBA KYOKO 千葉 杏子

Research Projects

Research Products

Altered autoinhibition of KIF5A in neurodegenerationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of H2 antibody and the inhibitory effect on kinesinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Autoinhibition and activation of kinesin-1 and their involvement in amyotrophic lateral sclerosis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Comparative analysis of two Caenorhabditis elegans kinesins KLP-6 and UNC-104 reveals a common and distinct activation mechanism in kinesin-32024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Generation of recombinant and chickenized scFv versions of an anti‐kinesin monoclonal antibody H22023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Insight into the regulation of axonal transport from the study of KIF1A-associated neurological disorder2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An ALS‐associated KIF5A mutant forms oligomers and aggregates and induces neuronal toxicity2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] KIF1A and KIF1Bβ form a heterodimer2023

Author(s)

Organizer

Data Source

[Presentation] The FHA domain is essential for the autoinhibition of KIF1A2023

Author(s)

Organizer

Data Source

[Presentation] Kinesin-3の分子内相互作用と自己阻害2023

Author(s)

Organizer

Data Source

[Presentation] KIF5A のALS 関連遺伝子変異はKIF5A のオリゴマー化と凝集を促進し神経毒性を引き起こす2022

Author(s)

Organizer

Data Source

[Presentation] An ALS-associated KIF5A mutant forms oligomers and aggregates and induces neuronal toxicity2022

Author(s)

Organizer

Data Source

[Presentation] KIF5A のALS 関連遺伝子変異はKIF5A のオリゴマー化と凝集を促進し神経毒性を引き起こす2022

Author(s)

Organizer

Data Source

[Presentation] An ALS-associated KIF5A mutant forms oligomers and aggregates and induces neuronal toxicity2022

Author(s)

Organizer

Data Source

CHIBA KYOKO 千葉杏子