Takashima Ken 高島謙

… Alternative Names

高島謙タカシマケン

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Researcher Number	10802647
Other IDs
Affiliation (Current)	2025: 熊本大学, 大学院生命科学研究部(医), 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 熊本大学, 大学院生命科学研究部(医), 助教 2017 – 2018: 北海道大学, 医学研究院, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 49070:Immunology-related / Transformative Research Areas, Section (III) / 0901:Oncology and related fields / Immunology
Keywords	Principal Investigator ヒストン修飾 / 核小体 / B細胞クラススイッチ / エピジェネティクス / 炎症応答 / ヘテロクロマチン / ヒストン模倣 / 天然変性領域 / SARS-CoV2 / クラススイッチ … More / B細胞 / マクロファージ / 免疫応答 / 自然免疫応答 / 乳癌 / 免疫学 / MDA5 / インターフェロン / ウイルス / 自己免疫疾患 / 自然免疫 Less

「内在性ヒストン模倣分子」による免疫応答の制御機構の解明Principal Investigator
- Principal Investigator
  
  高島謙
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kumamoto University
Role of a novel histone modification regulator in immune responsePrincipal Investigator
- Principal Investigator
  
  Takashima Ken
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Kumamoto University
天然変性タンパク質による「ヒストン模倣」現象の作動原理の解明Principal Investigator
- Principal Investigator
  
  高島謙
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Kumamoto University
Role of a novel histone modification regulator in breast cancer tumorigenesisPrincipal Investigator
- Principal Investigator
  
  Takashima Ken
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0901:Oncology and related fields
- Research Institution
  Kumamoto University
過剰な自然免疫応答が引き起こす自己免疫疾患の発症メカニズムの解明Principal Investigator
- Principal Investigator
  
  高島謙
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Immunology
- Research Institution
  Hokkaido University

All 2023 2022 2018 2017

All Journal Article Presentation

[Journal Article] NOP16 is a histone mimetic that regulates Histone H3K27 methylation and gene repression2023
- Author(s)
  Takashima Ken、Lee Dian-Jang、Trovero Mar?a Fernanda、Rothi M. Hafiz、Mistry Meeta、Zhang Ying、Li Zhouyihan、Davis Christopher P.、Li Zilan、Natale Julia、Schmid Ernst、Al Haddad Joseph、Hoffmann Gabriela Brunsting、Dietmann Sabine、Sui Shannan Ho、Oshiumi Hiroyuki、Lieberman Judy、Greer Eric Lieberman
- Journal Title
  
  BioRxiv
  
  Volume: ?
- DOI
  10.1101/2023.06.13.544862
- Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15498, KAKENHI-PUBLICLY-22H05603
[Journal Article] HPV vaccines induce trained immunity and modulate pro‐inflammatory cytokine expression in response to secondary Toll‐like receptor stimulations2023
- Author(s)
  Yamaguchi Mako、Mtali Yohana S.、Sonokawa Hitomi、Takashima Ken、Fukushima Yoshimi、Kouwaki Takahisa、Oshiumi Hiroyuki
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 68 Issue: 2 Pages: 65-74
- DOI
  10.1111/1348-0421.13108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15498, KAKENHI-PUBLICLY-22H05603, KAKENHI-PROJECT-23K27640
[Journal Article] Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccination.2022
- Author(s)
  Miyashita Y, Yoshida T, Takagi Y, Tsukamoto H, Takashima K, Kouwaki T, Makino K, Fukushima S, Nakamura K, Oshiumi H.
- Journal Title
  
  NPJ Vaccines
  
  Volume: 7 Issue: 1 Pages: 16-16
- DOI
  10.1038/s41541-022-00439-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03480, KAKENHI-PROJECT-21H02788, KAKENHI-PROJECT-21K08351, KAKENHI-PUBLICLY-22H05603, KAKENHI-PROJECT-20K08259, KAKENHI-PROJECT-21K20841
[Journal Article] TICAM-1 is dispensable in STING-mediated innate immune responses in myeloid immune cells2018
- Author(s)
  Takashima Ken、Oshiumi Hiroyuki、Matsumoto Misako、Seya Tsukasa
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H06486
[Journal Article] DNAJB1/HSP40 Suppresses Melanoma Differentiation-Associated Gene 5-Mitochondrial Antiviral Signaling Protein Function in Conjunction with HSP702017
- Author(s)
  Takashima Ken、Oshiumi Hiroyuki、Matsumoto Misako、Seya Tsukasa
- Journal Title
  
  Journal of Innate Immunity
  
  Volume: 10 Issue: 1 Pages: 44-55
- DOI
  10.1159/000480740
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H06486, KAKENHI-PROJECT-15K08517
[Presentation] Nucleolus dysfunction-induced DNA leaking alters innate immune response under nutrition starvation2023
- Author(s)
  Ken Takashima
- Organizer
  JSICR/MMCB 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H05603
[Presentation] Nucleolus dysfunction-induced DNA leaking alters innate immune response under nutrition starvation2023
- Author(s)
  Ken Takashima
- Organizer
  JSICR/MMCB 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20841
[Presentation] Nucleolus dysfunction-induced DNA leaking alters innate immune response under nutrition starvation2023
- Author(s)
  Ken Takashima
- Organizer
  JSICR/MMCB 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15498
[Presentation] Nucleolus dysfunction-mediated DNA leaking forms innate immune priming under nutrition starvation and ribosomal diseases2023
- Author(s)
  Ken Takashima, Hiroyuki Oshiumi
- Organizer
  第52回日本免疫学会
- Data Source
  KAKENHI-PROJECT-22K15498
[Presentation] 核小体タンパク質NOP16はヒストンを模倣することでH3K27me3修飾を制御し、細胞周期を促進することで乳癌の形成・進展に必須の役割を果たす。2023
- Author(s)
  高島謙, 押海裕之, Greer Eric
- Organizer
  第46回日本分子生物学会
- Data Source
  KAKENHI-PUBLICLY-22H05603
[Presentation] Nucleolus dysfunction-induced DNA leaking alters innate immune response under nutrition starvation2023
- Author(s)
  Ken Takashima
- Organizer
  JSICR/MMCB 2023 Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15498
[Presentation] The protein kinase RIOK3 suppressed MDA5-dependent innate immune response.2017
- Author(s)
  Takashima K, Oshiumi H, Takaki H, Matsumoto M & Seya T
- Organizer
  The 5th Annual Meeting of the International Cytokine and Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06486
[Presentation] Novel Negative Regulators for MDA5-Mediated Innate Immune Response2017
- Author(s)
  Takashima K, Oshiumi H, Matsumoto M & Seya T
- Organizer
  第46回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-17H06486

1. 押海裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takashima Ken 高島 謙

高島 謙 タカシマ ケン

Research Projects

Research Products

Co-Researchers

「内在性ヒストン模倣分子」による免疫応答の制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of a novel histone modification regulator in immune responsePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

天然変性タンパク質による「ヒストン模倣」現象の作動原理の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of a novel histone modification regulator in breast cancer tumorigenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

過剰な自然免疫応答が引き起こす自己免疫疾患の発症メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] NOP16 is a histone mimetic that regulates Histone H3K27 methylation and gene repression2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HPV vaccines induce trained immunity and modulate pro‐inflammatory cytokine expression in response to secondary Toll‐like receptor stimulations2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccination.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TICAM-1 is dispensable in STING-mediated innate immune responses in myeloid immune cells2018

Author(s)

Journal Title

Data Source

[Journal Article] DNAJB1/HSP40 Suppresses Melanoma Differentiation-Associated Gene 5-Mitochondrial Antiviral Signaling Protein Function in Conjunction with HSP702017

Author(s)

Journal Title

DOI

Data Source

[Presentation] Nucleolus dysfunction-induced DNA leaking alters innate immune response under nutrition starvation2023

Author(s)

Organizer

Data Source

[Presentation] Nucleolus dysfunction-induced DNA leaking alters innate immune response under nutrition starvation2023

Author(s)

Organizer

Data Source

[Presentation] Nucleolus dysfunction-induced DNA leaking alters innate immune response under nutrition starvation2023

Author(s)

Organizer

Data Source

[Presentation] Nucleolus dysfunction-mediated DNA leaking forms innate immune priming under nutrition starvation and ribosomal diseases2023

Author(s)

Organizer

Data Source

[Presentation] 核小体タンパク質NOP16はヒストンを模倣することでH3K27me3修飾を制御し、細胞周期を促進することで乳癌の形成・進展に必須の役割を果たす。2023

Author(s)

Organizer

Data Source

[Presentation] Nucleolus dysfunction-induced DNA leaking alters innate immune response under nutrition starvation2023

Takashima Ken 高島謙

高島謙タカシマケン