Noguchi Saki 野口幸希

Researcher Number	10803661
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 薬学部(芝共立), 助教
Affiliation (based on the past Project Information) *help	2018 – 2024: 慶應義塾大学, 薬学部(芝共立), 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / 0801:Pharmaceutical sciences and related fields / Basic Section 47040:Pharmacology-related Except Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 59040:Nutrition science and health science-related / Basic Section 48030:Pharmacology-related
Keywords	Principal Investigator 有機酸 / メチルマロン酸 / 近位尿細管 / トランスポーター / マイクロRNA / 栄養膜細胞 / 胎盤関門 / 遺伝子発現制御 / ステロイド合成 / 腎排泄 … More / 腎障害 / 有機アニオントランスポーター / 有機アニオン / 合胞体化 / miRNA / 胎盤 … More Except Principal Investigator 胎盤 / 生理学的薬物速度論モデル / 妊婦 / カチオントランスポーター / 胎盤関門 / アミノ酸トランスポーター / 降圧薬 / 有害事象解析 / 妊娠高血圧症 / 降圧剤 / 胎盤透過性 / アンジオテンシン受容体拮抗薬 / トランスポーター / 胎児移行性 / 胎児毒性 / アンジオテンシンII受容体拮抗薬 / 妊娠高血圧症候群 Less

Ex vivo-in silicoハイブリッドによるヒト胎児薬物移行の新解析プラットフォーム構築
- Principal Investigator
  
  登美斉俊
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Keio University
Analysis of the regulation of placental barrier factors for prediction of placental endocrine disruptionPrincipal Investigator
- Principal Investigator
  
  野口幸希
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Keio University
Developing prophylaxis of renal failure by targeting organic acid uptake transportersPrincipal Investigator
- Principal Investigator
  
  Noguchi Saki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  Keio University
Regulation of pharmacokinetics during pregnancy by placental exosomes
- Principal Investigator
  
  Tomi Masatoshi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Keio University
Developing the kinetic approach to treat the metabolic disorder from the bilateral side of proximal tubulesPrincipal Investigator
- Principal Investigator
  
  Noguchi Saki
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Keio University
Development of therapeutic agents for preeclampsia based on comparative analysis of adverse event reports between antihypertensive drugs
- Principal Investigator
  
  NISHIMURA Tomohiro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Keio University
Targetable regulatory mechanism in placental syncytialization and endocrine function for treating the pregnancy complicationPrincipal Investigator
- Principal Investigator
  
  Noguchi Saki
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Keio University
Significance of a balanced tryptophan diet for supporting fetal growth
- Principal Investigator
  
  Tomi Masatoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Keio University

All 2024 2023 2022 2021 2020 2019 2018 Other

All Journal Article Presentation Other

[Journal Article] L-type Amino Acid Transporter 1 (SLC7A5)-Mediated Transport of Pregabalin at the Rat Blood-Spinal Cord Barrier and its Sensitivity to Plasma Branched-Chain Amino Acids2023
- Author(s)
  Akashi Tomoya、Noguchi Saki、Takahashi Yu、Nishimura Tomohiro、Tomi Masatoshi
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 112 Issue: 4 Pages: 1137-1144
- DOI
  10.1016/j.xphs.2022.12.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K20723, KAKENHI-PROJECT-21H02651
[Journal Article] Role of Uptake Transporters OAT4, OATP2A1, and OATP1A2 in Human Placental Bio-disposition of Pravastatin2022
- Author(s)
  Fokina Valentina M.、Patrikeeva Svetlana、Wang Xiao-ming、Noguchi Saki、Tomi Masatoshi、Konig Jorg、Ahmed Mahmoud S.、Nanovskaya Tatiana
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: 111 Issue: 2 Pages: 505-516
- DOI
  10.1016/j.xphs.2021.09.035
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16056, KAKENHI-PROJECT-21H02651
[Journal Article] Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers2022
- Author(s)
  Fujita Arimi、Noguchi Saki、Hamada Rika、Inoue Satoko、Shimada Tsutomu、Katakura Satomi、Maruyama Tetsuo、Sai Yoshimichi、Nishimura Tomohiro、Tomi Masatoshi
- Journal Title
  
  Pharmaceutical Research
  
  Volume: - Issue: 7 Pages: 1645-1658
- DOI
  10.1007/s11095-022-03165-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16056, KAKENHI-PROJECT-20K22703, KAKENHI-PROJECT-20H03826, KAKENHI-PROJECT-21H02651
[Journal Article] Transplacental pharmacokinetic model of digoxin based on ex vivo human placental perfusion study.2022
- Author(s)
  Kurosawa K., Noguchi S., Nishimura T., Tomi M., Chiba K..
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 50(3) Issue: 3 Pages: 287-298
- DOI
  10.1124/dmd.121.000648
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08470, KAKENHI-PROJECT-20K16056, KAKENHI-PROJECT-21H02651
[Journal Article] Fluorouracil uptake in triple‐negative breast cancer cells: Negligible contribution of equilibrative nucleoside transporters 1 and 22021
- Author(s)
  Noguchi Saki、Takagi Akinori、Tanaka Takahiro、Takahashi Yu、Pan Xiaole、Kibayashi Yuka、Mizokami Ryo、Nishimura Tomohiro、Tomi Masatoshi
- Journal Title
  
  Biopharmaceutics & Drug Disposition
  
  Volume: 42 Issue: 2-3 Pages: 85-93
- DOI
  10.1002/bdd.2261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16056, KAKENHI-PROJECT-18H03183, KAKENHI-PROJECT-20K21489
[Journal Article] Substrate recognition of renally eliminated angiotensin II receptor blockers by organic anion transporter 42021
- Author(s)
  Noguchi Saki、Okochi Moeko、Atsuta Hayumi、Kimura Rika、Fukumoto Ayaka、Takahashi Kyoko、Nishimura Tomohiro、Tomi Masatoshi
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 36 Pages: 100363-100363
- DOI
  10.1016/j.dmpk.2020.10.002
- NAID
  210000188615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16056
[Journal Article] MicroRNA-126 suppresses the invasion of trophoblast-model JEG-3 cells by targeting LIN28A2021
- Author(s)
  Pan Xiaole、Noguchi Saki、Ando Misuzu、Nishimura Tomohiro、Tomi Masatoshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 545 Pages: 132-137
- DOI
  10.1016/j.bbrc.2021.01.077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21489, KAKENHI-PROJECT-20K16056, KAKENHI-PROJECT-18H03183
[Journal Article] Development of a pharmacokinetic model of transplacental transfer of metformin to predict in vivo fetal exposure.2020
- Author(s)
  Kurosawa K, Chiba K, Noguchi S, Nishimura T, Tomi M.
- Journal Title
  
  Drug Metab Dispos.
  
  Volume: 48 Issue: 12 Pages: 1293-1302
- DOI
  10.1124/dmd.120.000127
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08470, KAKENHI-PROJECT-20K16056
[Journal Article] 妊娠による生理学的変化と薬物動態2020
- Author(s)
  西村　友宏、野口　幸希
- Journal Title
  
  月刊薬事
  
  Volume: 62 Pages: 33-43
- Data Source
  KAKENHI-PROJECT-18K14926
[Journal Article] Contribution of Prostaglandin Transporter OATP2A1/SLCO2A1 to Placenta-to-Maternal Hormone Signaling and Labor Induction2020
- Author(s)
  Inagaki Mai、Nishimura Tomohiro、Nakanishi Takeo、Shimada Hiroaki、Noguchi Saki、Akanuma Shin-ichi、Tachikawa Masanori、Hosoya Ken-ichi、Tamai Ikumi、Nakashima Emi、Tomi Masatoshi
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 5 Pages: 101098-101098
- DOI
  10.1016/j.isci.2020.101098
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18J12895, KAKENHI-PROJECT-20K16056, KAKENHI-PROJECT-18H03183
[Journal Article] Quantification of ENT1 and ENT2 Proteins at the Placental Barrier and Contribution of These Transporters to Ribavirin Uptake.2019
- Author(s)
  Nishimura T, Sano Y, Takahashi Y, Noguchi S, Uchida Y, Takagi A, Tanaka T, Katakura S, Nakashima E, Tachikawa M, Maruyama T, Terasaki T, Tomi M.
- Journal Title
  
  J Pharm Sci.
  
  Volume: 108(12) Issue: 12 Pages: 3917-3922
- DOI
  10.1016/j.xphs.2019.09.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06900, KAKENHI-PUBLICLY-18H04534, KAKENHI-PROJECT-18H03183, KAKENHI-PROJECT-18K14926
[Presentation] OAT4介在輸送がアンジオテンシンII受容体拮抗薬(ARB)の経細胞透過に果たす役割2024
- Author(s)
  野口幸希、榊原早織、平原優有、舟橋和毅、増田豪、大槻純男、西村友宏、登美斉俊
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K20723
[Presentation] Uptake of methylmalonic acid by proximal tubular transporters2023
- Author(s)
  Noguchi Saki, Nakada Yukiko, Nishimura Tomohiro, Tomi Masatoshi
- Organizer
  日本薬物動態学会第38回年会／第23回シトクロムP450国際会議国際合同大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K20723
[Presentation] Transport mechanism of propionic acid in human choriocarcinoma JEG-3 cells2023
- Author(s)
  Akari Kasuya, Saki Noguchi, Tomohiro Nishimura, Masatoshi Tomi
- Organizer
  Asian Federation for Pharmaceutical Sciences 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06240
[Presentation] OAT4を介したアンジオテンシンⅡ受容体拮抗薬の経細胞輸送評価2023
- Author(s)
  野口幸希、榊原早織、平原優有、舟橋和毅、増田豪、大槻純男、西村友宏、登美斉俊
- Organizer
  日本薬剤学会第38年会
- Data Source
  KAKENHI-PROJECT-22K20723
[Presentation] 近位尿細管有機アニオントランスポーターを介したメチルマロン酸の輸送の評価2023
- Author(s)
  小林咲央里, 野口幸希, 中田柚貴子, 西村友宏, 登美斉俊
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-22K20723
[Presentation] アンジオテンシンII受容体拮抗薬 (ARBs) の経細胞輸送におけるOAT4の役割2022
- Author(s)
  榊原早織, 野口幸希, 平原優有, 舟橋和毅, 加島里菜, 西村友宏, 登美斉俊
- Organizer
  日本薬物動態学会第37回年会
- Data Source
  KAKENHI-PROJECT-22K20723
[Presentation] Olmesartanのプロドラッグ化によるOATP2B1認識性獲得2021
- Author(s)
  深澤尚美, 野口幸希, 西村友宏, 登美斉俊
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-20K16056
[Presentation] LIN28A発現抑制を介したmiR-126によるJEG-3細胞の浸潤抑制2021
- Author(s)
  野口幸希, 潘暁楽, 安藤美鈴, 西村友宏, 登美斉俊
- Organizer
  第29回日本胎盤学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16056
[Presentation] 有機アニオントランスポーターOAT1, 3及び4を介したメチルマロン酸輸送の評価2021
- Author(s)
  中田柚貴子, 野口幸希, 西村友宏, 登美斉俊
- Organizer
  日本薬物動態学会第36回年会
- Data Source
  KAKENHI-PROJECT-20K16056
[Presentation] ヒト胎盤透過性の定量予測に向けたアプローチ2021
- Author(s)
  登美斉俊, 野口幸希, 西村友宏
- Organizer
  第61回日本先天異常学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21489
[Presentation] Evaluation of methylmalonic acid transport via transporters expressed in proximal tubules2021
- Author(s)
  Nakada Y, Noguchi S, Nishimura T, Tomi M
- Organizer
  第15回次世代を担う若手医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-20K16056
[Presentation] miR-126によるLIN28A制御を介した、胎盤栄養膜モデルJEG-3細胞の浸潤抑制2021
- Author(s)
  野口幸希、潘暁楽、西村友宏、登美斉俊
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K16056
[Presentation] マウス胎盤におけるPGE2受容体の発現解析2021
- Author(s)
  高橋駿太, 稲垣舞, 野口幸希, 西村友宏, 登美斉俊
- Organizer
  第29回日本胎盤学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21489
[Presentation] LIN28A発現抑制を介したmiR-126によるJEG-3細胞の浸潤抑制2021
- Author(s)
  野口幸希, 潘暁楽, 安藤美鈴, 西村友宏, 登美斉俊
- Organizer
  第29回日本胎盤学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21489
[Presentation] Effect of maternofetal albumin concentration gradient on species differences in fetal drug transfer2021
- Author(s)
  Tomi M, Nomura T, Noguchi S, Nishimura T
- Organizer
  International Federation of Placenta Associations (IFPA) 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21489
[Presentation] マウス胎盤におけるオメガ3脂肪酸輸送体Mfsd2aの発現解析2021
- Author(s)
  関誠悟, 山本元輝, 赤沼伸乙, 定村龍太, 野口幸希, 河野早弥賀, 盛武浩, 細谷健一, 西村友宏, 登美斉俊
- Organizer
  第45回日本女性栄養・代謝学会学術集会・第10回日本DOHaD学会学術集会
- Data Source
  KAKENHI-PROJECT-20K21489
[Presentation] OATP2A1を介した胎盤PGE2代謝制御が分娩誘発に果たす役割2020
- Author(s)
  稲垣舞、登美斉俊、中西猛夫、島田紘明、野口幸希、赤沼伸乙、立川正憲、細谷健一、玉井郁巳、中島恵美、西村友宏
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-20K16056
[Presentation] 薬物の胎盤透過を規定するメカニズムとその影響2020
- Author(s)
  登美斉俊, 野口幸希, 西村友宏
- Organizer
  第60回日本先天異常学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K21489
[Presentation] OlmesartanのMDCK細胞層透過におけるOAT4介在輸送の方向性評価2020
- Author(s)
  野口幸希、舟橋和毅、西村友宏、登美斉俊
- Organizer
  日本薬剤学会第35年会
- Data Source
  KAKENHI-PROJECT-20K16056
[Presentation] エステル修飾型酸性プロドラッグに対するOATP2B1 の輸送能2020
- Author(s)
  深澤尚美、野口幸希、西村友宏、登美斉俊
- Organizer
  第5回トランスポーター研究会関東部会
- Data Source
  KAKENHI-PROJECT-20K16056
[Presentation] 関門としての胎盤：薬物透過制御機構とその種差2020
- Author(s)
  登美斉俊, 野口幸希, 西村友宏
- Organizer
  第47回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-18H03183
[Presentation] OAT1 及びOAT3 を介したアンジオテンシンⅡ受容体拮抗薬輸送の評価2020
- Author(s)
  三輪晴香、野口幸希、加島里菜、西村友宏、登美斉俊
- Organizer
  第5回トランスポーター研究会関東部会
- Data Source
  KAKENHI-PROJECT-20K16056
[Presentation] 関門としての胎盤：薬物透過制御機構とその種差2020
- Author(s)
  登美斉俊, 野口幸希, 西村友宏
- Organizer
  第47回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-20K21489
[Presentation] プレガバリンのラット脳移行における血漿中LAT1基質アミノ酸の影響2020
- Author(s)
  野口幸希、高橋優、西村友宏、登美斉俊
- Organizer
  第15回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-20K16056
[Presentation] プレガバリンのラット脳移行における血漿中LAT1基質アミノ酸の影響2020
- Author(s)
  野口幸希, 高橋優, 西村友宏, 登美斉俊
- Organizer
  第15回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-18H03183
[Presentation] エステル修飾型酸性プロドラッグ対する OATP2B1 の輸送能2020
- Author(s)
  深澤尚美、野口幸希、西村友宏、登美斉俊
- Organizer
  第5回トランスポーター研究会関東部会
- Data Source
  KAKENHI-PROJECT-18K06900
[Presentation] 胎盤におけるOCTN1の発現とメトホルミン輸送への関与の検討2020
- Author(s)
  中口佳美、西村友宏、市田智久、高橋優、野口幸希、丸山哲夫、石本尚大、加藤将夫、登美斉俊
- Organizer
  第35回日本薬物動態学会年会
- Data Source
  KAKENHI-PROJECT-20K16056
[Presentation] 薬物の胎盤透過を規定するメカニズムとその影響2020
- Author(s)
  登美斉俊, 野口幸希, 西村友宏
- Organizer
  第60回日本先天異常学会学術集会
- Data Source
  KAKENHI-PROJECT-18H03183
[Presentation] 胎児/母体血漿中非結合形濃度比を用いたdigoxinのラット胎盤透過性評価2019
- Author(s)
  野村岳広、西村友宏、野口幸希、登美斉俊
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18H03183
[Presentation] 血漿中アミノ酸濃度変動がpregabalinの脳移行に与える影響2019
- Author(s)
  野口幸希、高橋優、西村友宏、登美斉俊
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-18K14926
[Presentation] マウス栄養膜幹細胞3次元培養系における関門機能分子の発現誘導2019
- Author(s)
  木林由佳、野口幸希、田辺美那子、齋藤義正、西村友宏、登美斉俊
- Organizer
  日本薬剤学会第34年会
- Data Source
  KAKENHI-PROJECT-18H03183
[Presentation] 胎盤特異的なヒトSLC22A11 発現における転写制御の解析2019
- Author(s)
  野口幸希、古郡加奈子、深澤尚美、西村友宏、登美斉俊
- Organizer
  第41回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-18K14926
[Presentation] ヒト栄養膜由来JEG-3細胞の分化過程におけるmiR-126の役割2019
- Author(s)
  潘暁楽、野口幸希、安藤美鈴、竹村千尋、西村友宏、登美斉俊
- Organizer
  日本薬学会第１３９年会
- Data Source
  KAKENHI-PROJECT-18K14926
[Presentation] OAT4/OAT3発現MDCK細胞を介したolmesartan経細胞輸送におけるOAT4の役割2019
- Author(s)
  舟橋和毅、野口幸希、西村友宏、登美斉俊
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-18K14926
[Presentation] げっ歯類の妊娠後期胎盤におけるhypotaurine取り込み輸送に関わるトランスポーターの解明2019
- Author(s)
  柳下晴也、西村友宏、斉藤慶、野口幸希、登美斉俊
- Organizer
  第4回トランスポーター研究会関東部会
- Data Source
  KAKENHI-PROJECT-18K06900
[Presentation] Possibilities and limitations of extrapolating fetal drug transfer data from rodents to human pregnancy2019
- Author(s)
  Tomi Masatoshi、Noguchi Saki、Nishimura Tomohiro
- Organizer
  Asian Federation for Pharmaceutical Sciences (AFPS) 2019 Conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03183
[Presentation] OAT4を介したlosartan carboxylic acidおよびcandesartanのCl-依存性輸送2019
- Author(s)
  飛田萌子、野口幸希、木村りか、福本文香、西村友宏、登美斉俊
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18H03183
[Presentation] Effect of plasma amino acids on the brain penetration of pregabalin2019
- Author(s)
  Saki Noguchi, Yu Takahashi, Tomohiro Nishimura, Masatoshi Tomi
- Organizer
  日本薬物動態学会第34年会
- Data Source
  KAKENHI-PROJECT-18K06900
[Presentation] Prediction of fetal metformin exposure using transplacental pharmacokinetic model developed in ex vivo perfused human placenta2019
- Author(s)
  Ken Kurosawa, Koji Chiba, Saki Noguchi, Tomohiro Nishimura, Masatoshi Tomi
- Organizer
  日本薬物動態学会第34年会
- Data Source
  KAKENHI-PROJECT-18K06900
[Presentation] Association of SNAT2 3’UTR with the Upregulation of Placental SNAT2 Expression Induced by Hypertonic Stress2019
- Author(s)
  Yu Takahashi, Tomohiro Nishimura, Chiho Fukushima, Saki Noguchi, Masatoshi Tomi
- Organizer
  The 3rd Workshop for Japan-Korea Young Scientists on Pharmaceutics (JKPW2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06900
[Presentation] ヒトSLC22A11の胎盤特異的プロモーター領域の解析2019
- Author(s)
  野口幸希、古郡加奈子、深澤尚美、西村友宏、中島恵美、登美斉俊
- Organizer
  日本薬学会第１３９年会
- Data Source
  KAKENHI-PROJECT-18K14926
[Presentation] The role of OAT4, a bidirectional organic anion transporter, on drug distribution and excretion in humans2019
- Author(s)
  Saki Noguchi
- Organizer
  3rd Workshop for Japan-Korea Young Scientists on Pharmaceutics
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14926
[Presentation] 血漿タンパク結合率が薬物胎児移行性の種差に及ぼす影響2019
- Author(s)
  野村岳広、野口幸希、西村友宏、登美斉俊
- Organizer
  日本薬剤学会第34年会
- Data Source
  KAKENHI-PROJECT-18H03183
[Presentation] Identification of SLC22A11 promoter for placental OAT4 expression2019
- Author(s)
  Naomi Fukazawa, Saki Noguchi, Kanako Furugori, Tomohiro Nishimura, Masatoshi Tomi
- Organizer
  3rd Workshop for Japan-Korea Young Scientists on Pharmaceutics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14926
[Presentation] 副作用報告頻度に基づく低胎児毒性アンジオテンシンII受容体拮抗薬の探索と低胎盤透過性の要因2019
- Author(s)
  西村友宏、石川優、野口幸希、登美斉俊
- Organizer
  第40回日本妊娠高血圧学会学術集会
- Data Source
  KAKENHI-PROJECT-18K06900
[Presentation] マウス栄養膜幹細胞の分化に伴うOATP2A1発現変動とHIF1αの影響2019
- Author(s)
  井坂真実、西村友宏、稲垣舞、田辺美那子、野口幸希、登美斉俊
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18H03183
[Presentation] 妊娠満期ラットにおけるolmesartanに対するirbesartanの胎児低移行性とヒトOATP2B1 による基質認識性の違い2019
- Author(s)
  石川優、西村友宏、野口幸希、登美斉俊
- Organizer
  第4回トランスポーター研究会関東部会
- Data Source
  KAKENHI-PROJECT-18K06900
[Presentation] 有害事象データを用いたARB同効薬間胎児毒性多寡比較と胎盤透過性の差2019
- Author(s)
  西村友宏、石川優、野口幸希、登美斉俊
- Organizer
  第41回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-18K06900
[Presentation] Mother-to-Fetal Transfer Profiles of Statins in Rats2019
- Author(s)
  Tomohiro Nishimura, Natsuki Yonemura, Saki Noguchi, Masatoshi Tomi
- Organizer
  Asian Federation of Pharmaceutical Sciences 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06900
[Presentation] SUBSTRATE RECOGNITION AND CHLORIDE ION DEPENDENT TRANSPORT OF ANGIOTHENSIN II RECEPTOR BLOCKERS BY OAT42019
- Author(s)
  Saki Noguchi, Moeko Tobita, Hayumi Atsuta, Rika Kimura, Ayaka Fukumoto, Tomohiro Nishimura, and Masatoshi Tomi
- Organizer
  12TH INTERNATIONAL ISSX MEETING
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14926
[Presentation] COMPARISON OF TOXICITY AND PERMEABILITY AMONG ANGIOTENSIN RECEPTOR BLOCKERS TO THE FETUS2019
- Author(s)
  Tomohiro Nishimura, Yu Ishikawa, Saki Noguchi, Masatoshi Tomi
- Organizer
  ISSX2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06900
[Presentation] マウス栄養膜幹細胞3次元培養系における関門機能分子の発現誘導2019
- Author(s)
  木林由佳、野口幸希、田辺美那子、齋藤義正、西村友宏、登美斉俊
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-18H03183
[Presentation] miR-126が栄養膜モデルJEG-3細胞における合胞体化促進因子の発現に与える影響2019
- Author(s)
  潘曉楽、野口幸希、安藤美鈴、竹村千尋、西村友宏、登美斉俊
- Organizer
  日本薬剤学会第34年会
- Data Source
  KAKENHI-PROJECT-18K14926
[Presentation] ヒト栄養膜由来JEG-3細胞の分化過程におけるmiR-126の役割2019
- Author(s)
  潘曉楽、野口幸希、安藤美鈴、竹村千尋、西村友宏、登美斉俊
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18H03183
[Presentation] miR-126が栄養膜モデルJEG-3細胞における合胞体化促進因子の発現に与える影響2019
- Author(s)
  潘曉楽、野口幸希、安藤美鈴、竹村千尋、西村友宏、登美斉俊
- Organizer
  日本薬剤学会第34年会
- Data Source
  KAKENHI-PROJECT-18H03183
[Presentation] マウス栄養膜幹細胞3次元培養系における関門機能分子の発現誘導2019
- Author(s)
  木林由佳、野口幸希、田辺美那子、齋藤義正、西村友宏、登美斉俊
- Organizer
  日本薬剤学会第34年会
- Data Source
  KAKENHI-PROJECT-18K14926
[Presentation] Identification of SLC22A11 promoter for placental OAT4 expression2019
- Author(s)
  Naomi Fukazawa, Saki Noguchi, Kanako Furugori, Tomohiro Nishimura, Masatoshi Tomi
- Organizer
  The 3rd Workshop for Japan-Korea Young Scientists on Pharmaceutics (JKPW2019)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06900
[Presentation] Induction of expression of placental barrier function molecules in a three-dimensional culture model of mouse trophoblast stem cells2019
- Author(s)
  Yuka Kibayashi, Saki Noguchi, Minako Tanabe, Yoshimasa Saito, Tomohiro Nishimura, Masatoshi Tomi
- Organizer
  日本薬物動態学会第34年会
- Data Source
  KAKENHI-PROJECT-18K06900
[Presentation] Induction mechanism of MDR1 in mouse trophoblast stem cell differentiation2018
- Author(s)
  Tanabe M, Noguchi S, Nishimura T, Tomi M
- Organizer
  International Federation of Placenta Associations (IFPA) 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03183
[Presentation] 血液脳関門における中性アミノ酸トランスポーターLAT1 を介したpregabalin輸送2018
- Author(s)
  "高橋優、西村友宏、樋口慧、野口幸希、手賀悠真、黒澤俊樹、出口芳春、登美斉俊"
- Organizer
  第40回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-18H03183
[Presentation] ヒト絨毛癌由来JEG-3細胞の分化過程におけるmiR-126発現がLIN28A発現に与える影響2018
- Author(s)
  潘暁楽、野口幸希、安藤美鈴、竹村千尋、西村友宏、登美斉俊
- Organizer
  第3回トランスポーター研究会関東部会
- Data Source
  KAKENHI-PROJECT-18K14926
[Presentation] 有機アニオン系薬物トランスポーターOAT4を介したアンジオテンシンII受容体拮抗薬の輸送2018
- Author(s)
  野口幸希、熱田萩弓、木村りか、飛田萌子、福本文香、西村友宏、登美斉俊
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-18K14926
[Presentation] LAT1 が血液脳関門におけるpregabalin 輸送に果たす役割2018
- Author(s)
  髙橋優、西村友宏、樋口慧、野口幸希、手賀悠真、黒澤俊樹、出口芳春、登美斉俊
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-18H03183
[Presentation] Transcriptional regulatory element for the placental expression of organic anion transporter 42018
- Author(s)
  Noguchi S,Furugori K,Nishimura T,Nakashima E,Tomi M
- Organizer
  International Federation of Placenta Associations (IFPA) 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K14926
[]

1. Tomi Masatoshi (30334717)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
2. NISHIMURA Tomohiro (40453518)

# of Collaborated Projects: 2 results

# of Collaborated Products: 21 results
3. 伊藤直樹 (20529177)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 牟田真理子 (40445193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 石川源 (20287767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 千葉康司 (30458864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 佐村修 (90314757)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Noguchi Saki 野口 幸希

Research Projects

Research Products

Co-Researchers

Ex vivo-in silicoハイブリッドによるヒト胎児薬物移行の新解析プラットフォーム構築

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Analysis of the regulation of placental barrier factors for prediction of placental endocrine disruptionPrincipal Investigator

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Developing prophylaxis of renal failure by targeting organic acid uptake transportersPrincipal Investigator

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Regulation of pharmacokinetics during pregnancy by placental exosomes

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Developing the kinetic approach to treat the metabolic disorder from the bilateral side of proximal tubulesPrincipal Investigator

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Development of therapeutic agents for preeclampsia based on comparative analysis of adverse event reports between antihypertensive drugs

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Targetable regulatory mechanism in placental syncytialization and endocrine function for treating the pregnancy complicationPrincipal Investigator

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Significance of a balanced tryptophan diet for supporting fetal growth

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[Journal Article] L-type Amino Acid Transporter 1 (SLC7A5)-Mediated Transport of Pregabalin at the Rat Blood-Spinal Cord Barrier and its Sensitivity to Plasma Branched-Chain Amino Acids2023

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[Journal Article] Role of Uptake Transporters OAT4, OATP2A1, and OATP1A2 in Human Placental Bio-disposition of Pravastatin2022

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[Journal Article] Limited Impact of Murine Placental MDR1 on Fetal Exposure of Certain Drugs Explained by Bypass Transfer Between Adjacent Syncytiotrophoblast Layers2022

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[Journal Article] Transplacental pharmacokinetic model of digoxin based on ex vivo human placental perfusion study.2022

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[Journal Article] Fluorouracil uptake in triple‐negative breast cancer cells: Negligible contribution of equilibrative nucleoside transporters 1 and 22021

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[Journal Article] Substrate recognition of renally eliminated angiotensin II receptor blockers by organic anion transporter 42021

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Noguchi Saki 野口幸希

[Presentation] OAT4介在輸送がアンジオテンシンII受容体拮抗薬(ARB)の経細胞透過に果たす役割2024