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Kobayashi Norio  小林 記緒

ORCIDConnect your ORCID iD *help
Researcher Number 10803885
Other IDs
Affiliation (based on the past Project Information) *help 2018 – 2023: 東北大学, 医学系研究科, 助教
2017: 東北大学, 医学系研究科, 産学官連携研究員
Review Section/Research Field
Principal Investigator
Basic Section 44020:Developmental biology-related / Obstetrics and gynecology
Except Principal Investigator
Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields / Basic Section 58020:Hygiene and public health-related: including laboratory approach
Keywords
Principal Investigator
エピゲノム / ゲノムインプリンティング / 栄養膜幹細胞 / ヒト胎盤発生 / DNAメチル化 / C19MC / 転写因子 / 胚性幹細胞 / 細胞運命決定 / 分化転換 … More / 胚体外細胞系 / 胚体外細胞系譜 / 栄養膜幹細胞(TS細胞) / 精子 / ヒト精子 … More
Except Principal Investigator
オルガノイド / 胎盤幹細胞 / 胚着床不全 / 生殖補助医療(ART) / 3)低分子RNA(miRNA) / 低分子RNA(miRNA) / 低分子RNA(miRNA) / 胎盤 / 不妊治療 / 凍結胚移植 / 母体ー胎児間相互作用 / 母体-胎児間相互作用 / 妊娠高血圧症候群 / ヒト胎盤 Less
  • Research Projects

    (6 results)
  • Research Products

    (38 results)
  • Co-Researchers

    (9 People)
  •  ヒト胎盤特異的なインプリント遺伝子C19MCの発現制御因子の解明Principal Investigator

    • Principal Investigator
      小林 記緒
    • Project Period (FY)
      2022
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 44020:Developmental biology-related
    • Research Institution
      Tohoku University
  •  ヒト胎盤形成のエピゲノム制御と母体-胎盤間分子シグナルコミュニケーションの理解

    • Principal Investigator
      ARIMA TAKAHIRO
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Tohoku University
  •  An Empirical Study of the Effects of the Frozen Embryo Transfer Method on the Neurobehavioral Development of ART Births

    • Principal Investigator
      miyauchi naoko
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 58020:Hygiene and public health-related: including laboratory approach
    • Research Institution
      Tohoku University
  •  Embryonic implantation organoids using human placental stem cells and challenges to treatment of implantation defects

    • Principal Investigator
      ARIMA TAKAHIRO
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Tohoku University
  •  Investigation of the molecular mechanism involving the transdifferentiation of human embryonic stem cells into extraembryonic lineagePrincipal Investigator

    • Principal Investigator
      KOBAYASHI Norio
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 44020:Developmental biology-related
    • Research Institution
      Tohoku University
  •  Epigenetics of Next-Generation Inheritance in Sperm AgingPrincipal Investigator

    • Principal Investigator
      Kobayashi Norio
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Obstetrics and gynecology
    • Research Institution
      Tohoku University

All 2024 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation Book

  • [Book] 産婦人科の実際2023

    • Author(s)
      柴田 峻, 小林 枝里, 有馬 隆博
    • Total Pages
      870
    • Publisher
      金原出版(株)
    • Data Source
      KAKENHI-PROJECT-21H04834
  • [Book] トロホブラスト幹細胞と展開2021

    • Author(s)
      小林枝里、岡江寛明、有馬隆博
    • Total Pages
      6
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-21H04834
  • [Book] ヒトTS細胞を用いた胎盤疾患モデルの構築2021

    • Author(s)
      大池 輝, 小林 枝里, 小林 記緒, 柴田 峻, 岡江 寛明, 北村 茜, 宮内 尚子, 有馬 隆博
    • Total Pages
      5
    • Publisher
      北隆館/ニューサイエンス社
    • Data Source
      KAKENHI-PROJECT-21H04834
  • [Book] ヒトTS細胞を用いた胎盤疾患モデルの構築2021

    • Author(s)
      大池 輝, 小林 枝里, 小林 記緒, 柴田 峻, 岡江 寛明, 北村 茜, 宮内 尚子, 有馬 隆博
    • Total Pages
      5
    • Publisher
      北隆館/ニューサイエンス社
    • Data Source
      KAKENHI-PROJECT-21K10391
  • [Book] トロホブラスト幹細胞と展開2021

    • Author(s)
      小林枝里、岡江寛明、有馬隆博
    • Total Pages
      6
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-21K19546
  • [Book] ヒトTS細胞を用いた胎盤疾患モデルの構築2021

    • Author(s)
      大池 輝, 小林 枝里, 小林 記緒, 柴田 峻, 岡江 寛明, 北村 茜, 宮内 尚子, 有馬 隆博
    • Total Pages
      5
    • Publisher
      北隆館/ニューサイエンス社
    • Data Source
      KAKENHI-PROJECT-21K19546
  • [Book] ヒトTS細胞を用いた胎盤疾患モデルの構築2021

    • Author(s)
      大池 輝, 小林 枝里, 小林 記緒, 柴田 峻, 岡江 寛明, 北村 茜, 宮内 尚子, 有馬 隆博
    • Total Pages
      5
    • Publisher
      北隆館/ニューサイエンス社
    • Data Source
      KAKENHI-PROJECT-19K16135
  • [Book] 加齢によるエピジェネティクス変異2019

    • Author(s)
      服部裕充、小林記緒、岡江寛明、有馬隆博
    • Total Pages
      6
    • Publisher
      医学書院
    • Data Source
      KAKENHI-PROJECT-19K16135
  • [Book] ART治療における遺伝的安全性とリスク2019

    • Author(s)
      宮内尚子、服部裕充、小林記緒、樋浦仁、有馬隆博
    • Total Pages
      4
    • Publisher
      ニューサイエンス社
    • Data Source
      KAKENHI-PROJECT-19K16135
  • [Book] Epigenetics in Human Disease, Second Edition2018

    • Author(s)
      Hiura H, Hattori H, Kobayashi N, Takahashi S, Okae H, Arima T
    • Publisher
      Elsevier
    • Data Source
      KAKENHI-PROJECT-17H06529
  • [Book] Therapeutic approaches to imprinting diseases. Epigenetics in Human Disease2018

    • Author(s)
      Hattori H, Hiura H, Kobayashi N, Takahashi S, Okae H, Arima T.
    • Total Pages
      6
    • Publisher
      Academic Press.
    • Data Source
      KAKENHI-PROJECT-17H06529
  • [Book] Handbook of Nutrition, Diet, and Epigenetics2017

    • Author(s)
      Miyauchi N, Kitamura A, Hiura H, Okae H, Kobayashi N, Hattori H, Takahashi S, Arima T
    • Publisher
      Springer International Publishing
    • Data Source
      KAKENHI-PROJECT-17H06529
  • [Journal Article] Trophoblast stem cell-based organoid models of the human placental barrier2024

    • Author(s)
      Hori Takeshi、Okae Hiroaki、Shibata Shun、Kobayashi Norio、Kobayashi Eri H.、Oike Akira、Sekiya Asato、Arima Takahiro、Kaji Hirokazu
    • Journal Title

      Nature Communications

      Volume: 15 Issue: 1 Pages: 1-1

    • DOI

      10.1038/s41467-024-45279-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K04852, KAKENHI-PROJECT-22K18936, KAKENHI-PROJECT-21K15098, KAKENHI-PROJECT-21K16782, KAKENHI-PROJECT-21H04834, KAKENHI-PROJECT-21H03072, KAKENHI-PROJECT-23K26514, KAKENHI-PLANNED-19H05757
  • [Journal Article] Modeling embryo-endometrial interface recapitulating human embryo implantation2024

    • Author(s)
      Shibata Shun、Endo Shun、Nagai Luis A. E.、H. Kobayashi Eri、Oike Akira、Kobayashi Norio、Kitamura Akane、Hori Takeshi、Nashimoto Yuji、Nakato Ryuichiro、Hamada Hirotaka、Kaji Hirokazu、Kikutake Chie、Suyama Mikita、Saito Masatoshi、Yaegashi Nobuo、Okae Hiroaki、Arima Takahiro
    • Journal Title

      Science Advances

      Volume: 10 Issue: 8

    • DOI

      10.1126/sciadv.adi4819

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K18936, KAKENHI-PROJECT-21K15098, KAKENHI-PROJECT-21K16782, KAKENHI-PROJECT-21H04834, KAKENHI-PROJECT-21H03072, KAKENHI-PROJECT-21H03803, KAKENHI-PROJECT-23K26514, KAKENHI-PLANNED-19H05757
  • [Journal Article] CRISPR screening in human trophoblast stem cells reveals both shared and distinct aspects of human and mouse placental development2023

    • Author(s)
      Takanori Shimizu*, Akira Oike*, Eri H. Kobayashi*, Asato Sekiya, Norio Kobayashi, Shun Shibata, Hirotaka Hamada, Masatoshi Saito, Nobuo Yaegashi, Mikita Suyama, Takahiro Arima, and Hiroaki Okae. *T.S., A.O., and E.H.K. contributed equally to this work.
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 120 Issue: 51

    • DOI

      10.1073/pnas.2311372120

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K08838, KAKENHI-PROJECT-21K15098, KAKENHI-PROJECT-21K16782, KAKENHI-PROJECT-21H04834, KAKENHI-PROJECT-21H03072, KAKENHI-PLANNED-19H05757
  • [Journal Article] The microRNA cluster C19MC confers differentiation potential into trophoblast lineages upon human pluripotent stem cells2022

    • Author(s)
      Kobayashi Norio、Okae Hiroaki、Hiura Hitoshi、Kubota Naoto、Kobayashi Eri H.、Shibata Shun、Oike Akira、Hori Takeshi、Kikutake Chie、Hamada Hirotaka、Kaji Hirokazu、Suyama Mikita、Bortolin-Cavaill? Marie-Line、Cavaill? J?r?me、Arima Takahiro
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 3071-3071

    • DOI

      10.1038/s41467-022-30775-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K04852, KAKENHI-PROJECT-22K18936, KAKENHI-PROJECT-21K15098, KAKENHI-PROJECT-21K16782, KAKENHI-PROJECT-21H04834, KAKENHI-PROJECT-21H03072, KAKENHI-PROJECT-21K19546, KAKENHI-PROJECT-22K15117, KAKENHI-ORGANIZER-19H05749, KAKENHI-PLANNED-19H05757
  • [Journal Article] Unique features and emerging in vitro models of human placental development.2020

    • Author(s)
      Shun Shibata, Eri H Kobayashi, Norio Kobayashi, Akira Oike, Hiroaki Okae, Takahiro Arima.
    • Journal Title

      Reprod Med Biol .

      Volume: 12 Issue: 4 Pages: 301-313

    • DOI

      10.1002/rmb2.12347

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K16135, KAKENHI-PROJECT-20K22615, KAKENHI-PROJECT-20K22943, KAKENHI-PLANNED-19H05757, KAKENHI-PROJECT-18K09216
  • [Journal Article] Loss of p57KIP2expression confers resistance to contact inhibition in human androgenetic trophoblast stem cells2019

    • Author(s)
      Takahashi Sota、Okae Hiroaki、Kobayashi Norio、Kitamura Akane、Kumada Kanako、Yaegashi Nobuo、Arima Takahiro
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 116 Issue: 52 Pages: 26606-26613

    • DOI

      10.1073/pnas.1916019116

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09216, KAKENHI-PROJECT-19K16135, KAKENHI-PROJECT-19K18660, KAKENHI-PLANNED-19H05757, KAKENHI-PROJECT-17H04335
  • [Journal Article] Association of four imprinting disorders and ART.2019

    • Author(s)
      Hattori H, Hiura H, Kitamura A, Miyauchi N, Kobayashi N, Takahashi S, Okae H, Kyono K, Kagami M, Ogata T, Arima T.
    • Journal Title

      Clinical Epigenetics

      Volume: 11 Pages: 21-21

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06529
  • [Journal Article] The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children’s Study2019

    • Author(s)
      Hattori Hiromitsu、Kitamura Akane、Takahashi Fumiaki、Kobayashi Norio、Sato Akiko、Miyauchi Naoko、Nishigori Hidekazu、Mizuno Satoshi、Sakurai Kasumi、Ishikuro Mami、Obara Taku、Tatsuta Nozomi、Nishijima Ichiko、Fujiwara Ikuma、Kuriyama Shinichi、Metoki Hirohito、Yaegashi Nobuo、Nakai Kunihiko、Arima Takahiro
    • Journal Title

      Reproductive Biology and Endocrinology

      Volume: 17 Issue: 1 Pages: 27-27

    • DOI

      10.1186/s12958-019-0471-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08564, KAKENHI-PROJECT-17K09188, KAKENHI-PROJECT-19K16135, KAKENHI-PROJECT-19K18660
  • [Journal Article] The risk of secondary sex ratio imbalance and increased monozygotic twinning 1 after blastocyst transfer: data from The Japan Environment and Children’s Study.2019

    • Author(s)
      Hattori H, Kitamura A, Takahashi F, Kobayashi N, Sato A, Miyauchi N, Nishigori H, Mizuno S, Sakurai K, Ishikuro M, Obara T, Tatsuta N, Nishijima I, Fujiwara I, Kuriyama S, Metoki H, Yaegashi N, Nakai K, Arima T, Japan Environment Children;s Study Group.
    • Journal Title

      Reproductive Biology and Endocrinology

      Volume: 17 Pages: 27-27

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H06529
  • [Journal Article] Association of four imprinting disorders and ART2019

    • Author(s)
      Hattori H, Hiura H, Kitamura A, Miyauchi N, Kobayashi N, Takahashi S, Okae H, Kyono K, Kagami M, Ogata T, Arima T.
    • Journal Title

      Clin Epigenetics

      Volume: 11 Issue: 1 Pages: 21-21

    • DOI

      10.1186/s13148-019-0623-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02355, KAKENHI-PROJECT-17K09188, KAKENHI-PROJECT-18K09216, KAKENHI-PROJECT-19K16135, KAKENHI-PROJECT-19K18660, KAKENHI-PROJECT-17H04204
  • [Journal Article] Genome-wide microRNA expression profiling in placentae from frozen-thawed blastocyst transfer2017

    • Author(s)
      Hiura Hitoshi、Hattori Hiromitsu、Kobayashi Norio、Okae Hiroaki、Chiba Hatsune、Miyauchi Naoko、Kitamura Akane、Kikuchi Hiroyuki、Yoshida Hiroaki、Arima Takahiro
    • Journal Title

      Clinical Epigenetics

      Volume: 9 Issue: 1

    • DOI

      10.1186/s13148-017-0379-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K19709, KAKENHI-PROJECT-15K20121, KAKENHI-PROJECT-17H04335, KAKENHI-PROJECT-17H06529, KAKENHI-PROJECT-15K10657
  • [Journal Article] Transcriptomic signature of the follicular somatic compartment surrounding an oocyte with high developmental competence2017

    • Author(s)
      Sugimura Satoshi、Kobayashi Norio、Okae Hiroaki、Yamanouchi Tadayuki、Matsuda Hideo、Kojima Takumi、Yajima Akira、Hashiyada Yutaka、Kaneda Masahiro、Sato Kan、Imai Kei、Tanemura Kentaro、Arima Takahiro、Gilchrist Robert B.
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 6815-6815

    • DOI

      10.1038/s41598-017-07039-5

    • NAID

      120006711707

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19709, KAKENHI-PROJECT-17H04335, KAKENHI-PROJECT-17H06529, KAKENHI-PROJECT-15K18768
  • [Presentation] 胎児-母体アセンブロイドを用いたin vitroにおけるヒト胚着床現象の再現2023

    • Author(s)
      柴田 峻, 遠藤俊, 大池輝, 小林枝里, Luis Augusto Eijy Nagai, 中戸隆一郎, 岡江寛明, 有馬隆博
    • Organizer
      第41回日本受精着床学会総会・学術講演会
    • Data Source
      KAKENHI-PROJECT-21H04834
  • [Presentation] Modeling Embryo Endometrial Interface Recapitulating Human Embryo Implantation2023

    • Author(s)
      Shun Shibata, Luis A. E. Nagai, Akira Oike, Eri H. Kobayashi, Norio Kobayashi, Ryuichiro Nakato, Mikita Suyama, Hiroaki Okae, Takahiro Arima
    • Organizer
      IHEC Annual Meeting 2023
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H04834
  • [Presentation] マルチオミックス解析による妊娠高血圧症候群の胎盤特性2022

    • Author(s)
      遠藤俊, 柴田峻, 大池輝, 小林枝里, 岡江寛明, 有馬隆博
    • Organizer
      第30回日本胎盤学会学術集会
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H04834
  • [Presentation] Activation of the miRNA cluster C19MC confers differentiation potential into trophoblast lineages upon human pluripotent stem cells2022

    • Author(s)
      Kobayashi N, Okae H, Kaji H, Suyama M, Arima T
    • Organizer
      IHEC2022
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H04834
  • [Presentation] Activation of the miRNA cluster C19MC confers differentiation potential into trophoblast lineages upon human pluripotent stem cells.2022

    • Author(s)
      Kobayashi N, Okae H, Hiura H, Kubota N, Kobayashi EH, Shibata S, Oike A, Hori T, Kikutake C, Hamada H, Kaji H, Suyama M, Bortolin-Cavaille ML, Cavaille J, Arima T.
    • Organizer
      The CEEHRC and IHEC annual meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K15117
  • [Presentation] マルチオミックス解析による妊娠高血圧症候群の胎盤特性2022

    • Author(s)
      遠藤俊, 柴田峻, 大池輝, 小林枝里, 岡江寛明, 有馬隆博.
    • Organizer
      第30回日本胎盤学会学術集会
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K19546
  • [Presentation] Activation of the miRNA cluster C19MC confers differentiation potential into trophoblast lineages upon human pluripotent stem cells2022

    • Author(s)
      Kobayashi N, Okae H, Kaji H, Suyama M, Arima T
    • Organizer
      IHEC2022
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K19546
  • [Presentation] ヒト胎盤幹細胞のエピジェネティクス2020

    • Author(s)
      有馬隆博、岡江寛明、小林記緒
    • Organizer
      第93回日本内分泌学会学術総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K16135
  • [Presentation] Epigenetic restriction of human pluripotency by silencing of the chromosome 19 miRNA cluster2020

    • Author(s)
      岡江寛明、小林記緒、有馬隆博
    • Organizer
      第43回日本分子生物学会年会
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K16135
  • [Presentation] 分化全能性の消失に関わるインプリント遺伝子の同定2020

    • Author(s)
      岡江寛明、小林記緒、有馬隆博
    • Organizer
      日本繁殖生物学会第113回大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K16135
  • [Presentation] ヒト胎盤幹(TS)細胞の樹立とその細胞特性2019

    • Author(s)
      小林記緒、樋浦仁、岡江寛明、有馬隆博
    • Organizer
      第14回日本生殖発生医学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H06529
  • [Presentation] ヒト胚性幹細胞の栄養膜幹細胞への分化転換2019

    • Author(s)
      小林記緒
    • Organizer
      第42回日本分子生物学会年会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K16135
  • [Presentation] ARTによるエピジェネティクスの変調2018

    • Author(s)
      小林記緒、樋浦仁、岡江寛明、有馬隆博
    • Organizer
      第63回日本生殖医学会学術講演会・総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H06529
  • [Presentation] ヒト胎盤のトロフォブラスト幹細胞の樹立と臨床への応用2018

    • Author(s)
      小林記緒、樋浦仁、岡江寛明、有馬隆博
    • Organizer
      第70回日本産科婦人科学会学術講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H06529
  • 1.  小林 枝里 (70634971)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 13 results
  • 2.  ARIMA TAKAHIRO (80253532)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 14 results
  • 3.  miyauchi naoko (60596162)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  柴田 峻 (40885670)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 5.  岡江 寛明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  堀 武志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 7.  梶 弘和
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 8.  大歳 維知子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  樋浦 仁
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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