Kamata Shotaro 鎌田祥太郎

Researcher Number	10823932
Affiliation (Current)	2025: 昭和薬科大学, 薬学部, 助教
Affiliation (based on the past Project Information) *help	2025: 昭和薬科大学, 薬学部, 助教 2020 – 2023: 昭和薬科大学, 薬学部, 助教 2019: 昭和薬科大学, 薬学部, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 43030:Functional biochemistry-related / Basic Section 43020:Structural biochemistry-related / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Keywords	Principal Investigator PPAR / X線結晶構造解析 / NASH / NAFLD / FRET / アミノ酸

Research Projects
(3 results)
Research Products
(23 results)

超硫黄分子によるPPARα/δ/γ活性制御Principal Investigator
- Principal Investigator
  
  鎌田祥太郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Showa Pharmaceutical University
Dual/panアゴニストによるPPARα/δ/γの差動的制御メカニズムの解明Principal Investigator
- Principal Investigator
  
  鎌田祥太郎
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Showa Pharmaceutical University
Structural mechanism for PPARalpha regulation by endogenous amino acidsPrincipal Investigator
- Principal Investigator
  
  Kamata Shotaro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Showa Pharmaceutical University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Different Coactivator Recruitment to Human PPARα/δ/γ Ligand-Binding Domains by Eight PPAR Agonists to Treat Nonalcoholic Fatty Liver Disease2024
- Author(s)
  Kamata Shotaro、Honda Akihiro、Kashiwagi Nonoka、Shimamura Ayumi、Yashiro Sayaka、Komori Yuna、Hosoda Aoi、Akahoshi Noriyuki、Ishii Isao
- Journal Title
  
  Biomedicines
  
  Volume: 12 Issue: 3 Pages: 624-624
- DOI
  10.3390/biomedicines12030624
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15049, KAKENHI-PUBLICLY-22H05577
[Journal Article] Current Clinical Trial Status and Future Prospects of PPAR-Targeted Drugs for Treating Nonalcoholic Fatty Liver Disease2023
- Author(s)
  Kamata Shotaro、Honda Akihiro、Ishii Isao
- Journal Title
  
  Biomolecules
  
  Volume: 13 Issue: 8 Pages: 1264-1264
- DOI
  10.3390/biom13081264
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15049, KAKENHI-PUBLICLY-22H05577
[Journal Article] Functional and Structural Insights into the Human PPARα/δ/γ Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor2023
- Author(s)
  Kamata Shotaro、Honda Akihiro、Ishikawa Ryo、Akahane Makoto、Fujita Ayane、Kaneko Chihiro、Miyawaki Saeka、Habu Yuki、Shiiyama Yui、Uchii Kie、Machida Yui、Oyama Takuji、Ishii Isao
- Journal Title
  
  Antioxidants
  
  Volume: 12 Issue: 8 Pages: 1523-1523
- DOI
  10.3390/antiox12081523
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15049, KAKENHI-PUBLICLY-22H05577
[Journal Article] Functional and Structural Insights into Human PPARα/δ/γ Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate2022
- Author(s)
  Honda Akihiro、Kamata Shotaro、Akahane Makoto、Machida Yui、Uchii Kie、Shiiyama Yui、Habu Yuki、Miyawaki Saeka、Kaneko Chihiro、Oyama Takuji、Ishii Isao
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 9 Pages: 4726-4726
- DOI
  10.3390/ijms23094726
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15049, KAKENHI-PUBLICLY-22H05577
[Journal Article] Preparation of co-crystals of human PPARα-LBD and ligand for high-resolution X-ray crystallography2021
- Author(s)
  Kamata Shotaro、Oyama Takuji、Ishii Isao
- Journal Title
  
  STAR Protocols
  
  Volume: 2 Issue: 1 Pages: 100364-100364
- DOI
  10.1016/j.xpro.2021.100364
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16359, KAKENHI-PROJECT-18K06081
[Journal Article] PPARα-Ligand Binding Modes Revealed by X-ray Crystallography2021
- Author(s)
  Kamata Shotaro、Ishii Isao
- Journal Title
  
  YAKUGAKU ZASSHI
  
  Volume: 141 Issue: 11 Pages: 1267-1274
- DOI
  10.1248/yakushi.21-00138
- NAID
  130008109792
- ISSN
  0031-6903, 1347-5231
- Year and Date
  2021-11-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16359
[Journal Article] Crystal Structures of the Human Peroxisome Proliferator-Activated Receptor (PPAR)α Ligand-Binding Domain in Complexes with a Series of Phenylpropanoic Acid Derivatives Generated by a Ligand-Exchange Soaking Method2021
- Author(s)
  Oyama Takuji、Kamata Shotaro、Ishii Isao、Miyachi Hiroyuki
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 9 Pages: 1202-1209
- DOI
  10.1248/bpb.b21-00220
- NAID
  130008082324
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-09-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16359
[Journal Article] Structural Basis for Anti-non-alcoholic Fatty Liver Disease and Diabetic Dyslipidemia Drug Saroglitazar as a PPAR α/γ Dual Agonist2021
- Author(s)
  Honda Akihiro、Kamata Shotaro、Satta Chihiro、Machida Yui、Uchii Kie、Terasawa Kazuki、Nemoto Ayane、Oyama Takuji、Ishii Isao
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 44 Issue: 9 Pages: 1210-1219
- DOI
  10.1248/bpb.b21-00232
- NAID
  130008082321
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2021-09-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16359
[Journal Article] PPARα Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates2020
- Author(s)
  Kamata Shotaro、Oyama Takuji、Saito Kenta、Honda Akihiro、Yamamoto Yume、Suda Keisuke、Ishikawa Ryo、Itoh Toshimasa、Watanabe Yasuo、Shibata Takahiro、Uchida Koji、Suematsu Makoto、Ishii Isao
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 11 Pages: 101727-101727
- DOI
  10.1016/j.isci.2020.101727
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16359, KAKENHI-PROJECT-18K06081, KAKENHI-PROJECT-17H06170
[Journal Article] Abnormal Amino Acid Profiles of Blood and Cerebrospinal Fluid from Cystathionine β-Synthase-Deficient Mice, an Animal Model of Homocystinuria2019
- Author(s)
  Akahoshi N, Yokoyama A, Nagata T, Miura A, Kamata S, Ishii I.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 6 Pages: 1054-1057
- DOI
  10.1248/bpb.b19-00127
- NAID
  130007657698
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-06-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16359, KAKENHI-PROJECT-17K08287
[Journal Article] Preeclampsia-Like Features and Partial Lactation Failure in Mice Lacking Cystathionine γ-Lyase-An Animal Model of Cystathioninuria.2019
- Author(s)
  Akahoshi N, Handa H, Takemoto R, Kamata S, Yoshida M, Onaka T, Ishii I.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 20 Issue: 14 Pages: 3507-3507
- DOI
  10.3390/ijms20143507
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16359, KAKENHI-PROJECT-17K08287
[Presentation] NASH病態モデルマウスの短期作成2024
- Author(s)
  本多彰宏、鎌田祥太郎、宮脇瑳恵佳、藤田絢音、金子知央、田中伶奈、蓑毛雪兒、星井瑛介、細田葵衣、今野翼、石井功
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K15049
[Presentation] X線結晶構造解析による4種NASH治験薬の核内受容体PPARα/δ/γへの結合様式の比較2024
- Author(s)
  鎌田祥太郎、本多彰宏、金子知央、藤田絢音、宮脇瑳恵佳、渡瀬健太郎、小森優奈、島村歩実、八代清香、石井功
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K15049
[Presentation] 各種PPARアゴニストによるPPARα/δ/γへのCoactivator結合及び Corepressor解離の同時測定2024
- Author(s)
  八代清香、金子知央、藤田絢音、宮脇瑳恵佳、渡瀬健太郎、小森優奈、島村歩実、本多彰宏、鎌田祥太郎、石井功
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-22K15049
[Presentation] NASH治験薬3種とPPARα/δ/γ受容体との複合体結晶の構造解析2023
- Author(s)
  鎌田祥太郎，本多彰宏，石川諒, 赤羽真，藤田絢音, 金子知央，宮脇　瑳恵佳，垣生有希，椎山結，内井希恵，町田優衣，石井功
- Organizer
  第67回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-22K15049
[Presentation] C57BL/6Jマウスを用いたNASH病態モデルの短期作成2023
- Author(s)
  本多彰宏，宮脇　瑳恵佳，藤田絢音, 金子知央，鎌田祥太郎，石井功
- Organizer
  第67回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-22K15049
[Presentation] NASH治験薬であるElafibranor、Lanifibranor及びSeladelparのPPARα/δ/γサブタイプへの結合・活性化様式の解析2022
- Author(s)
  鎌田祥太郎，内井希恵，垣生有希，金子知央，小森優奈，本多彰宏，石井功
- Organizer
  2022 年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-22K15049
[Presentation] X線結晶構造解析による3種フィブラート系薬のPPARα/δ/γリガンド結合部位それぞれへの結合様式の比較2022
- Author(s)
  鎌田祥太郎, 本多彰宏, 町田優衣, 内井希恵, 椎山結増田莉紗, 垣生有希, 柏木野花, 大山拓次, 石井功
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-19K16359
[Presentation] Fibrate系脂質異常症薬Bezafibrate、Fenofibric acidおよびPemafibrateのPPARα／δ／γサブタイプ選択性に関する機能的および構造的な洞察2022
- Author(s)
  本多彰宏，鎌田祥太郎，赤羽　真，町田優衣，内井希恵，椎山結，垣生有希，宮脇瑳恵佳，金子知央，大山拓次，石井功
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-22K15049
[Presentation] NASH治験薬Lanifibranor－ヒトPPARγ複合体結晶のX線構造解析2021
- Author(s)
  町田優衣, 内井希恵, 増田莉紗, 椎山結, 本多彰宏, 鎌田祥太郎, 石井功
- Organizer
  2021年度生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-19K16359
[Presentation] NAFLD治験薬かつ糖尿病性脂質異常症治療薬SaroglitazarのPPARα/γ dualアゴニストとしての構造基盤2021
- Author(s)
  本多彰宏, 颯田千尋, 町田優衣, 内井希恵, 寺沢和樹, 根本彩音, 鎌田祥太郎, 大山拓次, 石井功
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16359
[Presentation] X線結晶構造解析により得られたPPARαリガンド結合部位と内在性脂肪酸及びフィブラート系薬の複合体構造2021
- Author(s)
  鎌田祥太郎, 大山拓次, 齊藤健太, 本多彰宏, 山本ゆめ, 須田圭介, 石川諒, 石井功
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K16359
[Presentation] 核内受容体PPAR alphaのCD測定法による熱安定性評価2019
- Author(s)
  石川諒, 本多彰宏, 鎌田祥太郎, 石井功
- Organizer
  第5回　次世代を担う若手のためのレギュラトリーサイエンスフォーラム
- Data Source
  KAKENHI-PROJECT-19K16359

Kamata Shotaro 鎌田 祥太郎

Research Projects

Research Products

超硫黄分子によるPPARα/δ/γ活性制御Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Dual/panアゴニストによるPPARα/δ/γの差動的制御メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Structural mechanism for PPARalpha regulation by endogenous amino acidsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Different Coactivator Recruitment to Human PPARα/δ/γ Ligand-Binding Domains by Eight PPAR Agonists to Treat Nonalcoholic Fatty Liver Disease2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Current Clinical Trial Status and Future Prospects of PPAR-Targeted Drugs for Treating Nonalcoholic Fatty Liver Disease2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional and Structural Insights into the Human PPARα/δ/γ Targeting Preferences of Anti-NASH Investigational Drugs, Lanifibranor, Seladelpar, and Elafibranor2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional and Structural Insights into Human PPARα/δ/γ Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Preparation of co-crystals of human PPARα-LBD and ligand for high-resolution X-ray crystallography2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PPARα-Ligand Binding Modes Revealed by X-ray Crystallography2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Crystal Structures of the Human Peroxisome Proliferator-Activated Receptor (PPAR)α Ligand-Binding Domain in Complexes with a Series of Phenylpropanoic Acid Derivatives Generated by a Ligand-Exchange Soaking Method2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Structural Basis for Anti-non-alcoholic Fatty Liver Disease and Diabetic Dyslipidemia Drug Saroglitazar as a PPAR α/γ Dual Agonist2021

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] PPARα Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Abnormal Amino Acid Profiles of Blood and Cerebrospinal Fluid from Cystathionine β-Synthase-Deficient Mice, an Animal Model of Homocystinuria2019

Author(s)

Kamata Shotaro 鎌田祥太郎

[Presentation] X線結晶構造解析による4種NASH治験薬の核内受容体PPARα/δ/γへの結合様式の比較2024