Hishinuma Eiji 菱沼英史

Researcher Number	10824609
Other IDs
Affiliation (Current)	2025: 東北大学, 未来型医療創成センター, 助教
Affiliation (based on the past Project Information) *help	2022 – 2025: 東北大学, 未来型医療創成センター, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 55060:Emergency medicine-related / Basic Section 56040:Obstetrics and gynecology-related
Keywords	Principal Investigator 薬物代謝酵素 / ファーマコゲノミクス / ジヒドロピリミジナーゼ / ジヒドロピリミジンデヒドロゲナーゼ / フッ化ピリミジン系抗がん剤 Except Principal Investigator メタボローム解析 / プロテオーム / メタボローム / マルチオミックス / 全ゲノム解析 … More / 全エクソーム解析 / 卵巣明細胞癌 / 治療反応生 / 治療反応性 / メタボローム関連解析 / ゲノム関連解析 / サブクラス分類 / 敗血症 / 腫瘍循環DNA / 子宮頸癌 / 子宮内膜癌 / 卵巣癌 / マルチオミックス解析 / プロテオーム解析 / 子宮頸がん / 子宮体がん / 卵巣がん Less

5-フルオロウラシル系抗がん剤代謝酵素の代謝機構メカニズムの解明Principal Investigator
- Principal Investigator
  
  菱沼英史
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tohoku University
Identifying Novel Sepsis Endotypes
- Principal Investigator
  
  工藤大介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55060:Emergency medicine-related
- Research Institution
  Tohoku University
A multi-omics investigation of novel therapeutic strategies for clear cell carcinoma of the ovary focusing on cancer metabolism
- Principal Investigator
  
  重田昌吾
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Tohoku University
Exploration of drug-reactive genomic biomarkers for fluoropyrimidine anticancer drug treatmentPrincipal Investigator
- Principal Investigator
  
  菱沼英史
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Tohoku University
難治性婦人科癌のマルチオミックス解析による病態解明
- Principal Investigator
  
  八重樫伸生
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Tohoku University

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] Functional characterization of 12 dihydropyrimidinase allelic variants in Japanese individuals for the prediction of 5-fluorouracil treatment-related toxicity.2023
- Author(s)
  Hishinuma E, Narita Y, Rico E. G, Ueda A, Obuchi K, Tanaka Y, Saito S, Tadaka S, Kinoshita K, Maekawa M, Mano N, Nakayoshi T, Oda A, Hirasawa N, and Hiratsuka M.
- Journal Title
  
  Drug Metabolism and Disposition
  
  Volume: 51 Issue: 2 Pages: 165-173
- DOI
  10.1124/dmd.122.001045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K18321, KAKENHI-PROJECT-22K15334, KAKENHI-PROJECT-19H00918
[Journal Article] Identification of predictive biomarkers for endometrial cancer diagnosis and treatment response monitoring using plasma metabolome profiling2023
- Author(s)
  Hishinuma Eiji、Shimada Muneaki、Matsukawa Naomi、Shima Yoshiko、Li Bin、Motoike Ikuko N.、Shibuya Yusuke、Hagihara Tatsuya、Shigeta Shogo、Tokunaga Hideki、Saigusa Daisuke、Kinoshita Kengo、Koshiba Seizo、Yaegashi Nobuo
- Journal Title
  
  Cancer & Metabolism
  
  Volume: 11 Issue: 1
- DOI
  10.1186/s40170-023-00317-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09486, KAKENHI-PROJECT-21K09531, KAKENHI-PROJECT-23K24478, KAKENHI-PROJECT-23K27316
[Journal Article] Identification of predictive biomarkers for diagnosis and radiation sensitivity of uterine cervical cancer using wide‐targeted metabolomics2023
- Author(s)
  Hishinuma Eiji、Shimada Muneaki、Matsukawa Naomi、Li Bin、Motoike Ikuko N.、Hagihara Tatsuya、Shigeta Shogo、Tokunaga Hideki、Saigusa Daisuke、Kinoshita Kengo、Koshiba Seizo、Yaegashi Nobuo
- Journal Title
  
  Journal of Obstetrics and Gynaecology Research
  
  Volume: 49 Issue: 8 Pages: 2109-2117
- DOI
  10.1111/jog.15709
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09486, KAKENHI-PROJECT-21K09531, KAKENHI-PROJECT-23K24478, KAKENHI-PROJECT-23K27316
[Journal Article] Importance of Rare DPYD Genetic Polymorphisms for 5-Fluorouracil Therapy in the Japanese Population2022
- Author(s)
  Hishinuma Eiji、Narita Yoko、Obuchi Kai、Ueda Akiko、Saito Sakae、Tadaka Shu、Kinoshita Kengo、Maekawa Masamitsu、Mano Nariyasu、Hirasawa Noriyasu、Hiratsuka Masahiro
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 13 Pages: 930470-930470
- DOI
  10.3389/fphar.2022.930470
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15334
[Presentation] 日本人8,380人の全ゲノム解析から同定された29種のDPDバリアントの酵素機能変化解析2024
- Author(s)
  寺内健人、菱沼英史、上田昭子、小渕開、前川正充、佐藤裕、齋藤さかえ、田高周、木下賢吾、平澤典保、平塚真弘
- Organizer
  日本薬学会第144回年会
- Data Source
  KAKENHI-PROJECT-22K15334
[Presentation] 子宮体癌における血漿メタボローム解析による新規バイオマーカーの探索（高得点演題）2023
- Author(s)
  萩原達也、島田宗昭, 菱沼英史, 李　賓, 橋本栄文, 栃木実佳子, 遠藤　俊, 清水孝規, 湊　純子, 渋谷祐介, 橋本千明, 石橋ますみ, 重田昌吾, 徳永英樹, 八重樫伸生
- Organizer
  第65回日本婦人科腫瘍学会学術講演会
- Data Source
  KAKENHI-PROJECT-23K24478
[Presentation] 大規模ゲノム解析データを活用した日本人 DPD 活性予測パネルの構築2023
- Author(s)
  菱沼英史、小渕開、寺内健人、上田昭子、田高周、齋藤さかえ、前川正充、木下賢吾、平澤典保、平塚真弘
- Organizer
  第62回日本薬学会東北支部大会
- Data Source
  KAKENHI-PROJECT-22K15334
[Presentation] Functional Characterization of Seven Dihydropyrimidinase Allelic Variants in Japanese Individuals for the Prediction of 5-Fluorouracil Treatment-Related Toxicity2023
- Author(s)
  Kai Obuchi, Eiji Hishinuma, Akiko Ueda, Masamitsu Maekawa, Sakae Saito, Kengo Kinoshita, Masahiro Hiratsuka
- Organizer
  2023 International Joint Meeting of the 23rd International Conference on Cytochrome P450 and the 38th Annual Meeting of the Japanese Society for the Study of Xenobiotics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K15334

1. 田宮元 (10317745)

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2. 八重樫伸生 (00241597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. 安田純 (00281684)

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4. 工藤大介 (30455844)

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5. 早川峰司 (10374282)

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6. 久志本成樹 (50195434)

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7. 成田暁 (50459468)

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8. 山川一馬 (50597507)

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9. 佐藤哲哉 (50830197)

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10. 小柴生造 (70332301)

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11. 湯本哲也 (80535790)

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12. 後藤匡啓 (80622894)

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13. 近藤豊 (90642091)

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14. 石原唯史 (70648295)

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15. 佐藤幸男 (00445272)

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16. 錦見満曉 (00816118)

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17. 堤悠介 (50627320)

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18. 高山渉 (50825502)

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19. 鈴木浩大 (80724583)

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20. 春日井大介 (60844909)

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21. 重田昌吾 (90842633)

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# of Collaborated Products: 2 results
22. 徳永英樹 (30595559)

# of Collaborated Projects: 1 results

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23. 島田宗昭 (40362892)

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24. 田中良和

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Hishinuma Eiji 菱沼 英史

Research Projects

Research Products

Co-Researchers

5-フルオロウラシル系抗がん剤代謝酵素の代謝機構メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identifying Novel Sepsis Endotypes

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A multi-omics investigation of novel therapeutic strategies for clear cell carcinoma of the ovary focusing on cancer metabolism

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration of drug-reactive genomic biomarkers for fluoropyrimidine anticancer drug treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

難治性婦人科癌のマルチオミックス解析による病態解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Functional characterization of 12 dihydropyrimidinase allelic variants in Japanese individuals for the prediction of 5-fluorouracil treatment-related toxicity.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of predictive biomarkers for endometrial cancer diagnosis and treatment response monitoring using plasma metabolome profiling2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of predictive biomarkers for diagnosis and radiation sensitivity of uterine cervical cancer using wide‐targeted metabolomics2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Importance of Rare DPYD Genetic Polymorphisms for 5-Fluorouracil Therapy in the Japanese Population2022

Author(s)

Journal Title

DOI

Data Source

[Presentation] 日本人8,380人の全ゲノム解析から同定された29種のDPDバリアントの酵素機能変化解析2024

Author(s)

Organizer

Data Source

[Presentation] 子宮体癌における血漿メタボローム解析による新規バイオマーカーの探索（高得点演題）2023

Author(s)

Organizer

Data Source

[Presentation] 大規模ゲノム解析データを活用した日本人 DPD 活性予測パネルの構築2023

Author(s)

Organizer

Data Source

[Presentation] Functional Characterization of Seven Dihydropyrimidinase Allelic Variants in Japanese Individuals for the Prediction of 5-Fluorouracil Treatment-Related Toxicity2023

Author(s)

Organizer

Data Source

Hishinuma Eiji 菱沼英史