Kosaka Yoshinori 小坂祥範

Researcher Number	10835242
Affiliation (Current)	2025: 琉球大学, 医学(系)研究科(研究院), 客員研究員
Affiliation (based on the past Project Information) *help	2022 – 2023: 琉球大学, 医学(系)研究科(研究院), 客員研究員 2020 – 2021: 琉球大学, 医学研究科, 客員研究員 2019: 琉球大学, 医学部, 委託非常勤講師
Review Section/Research Field	Principal Investigator Basic Section 59010:Rehabilitation science-related
Keywords	Principal Investigator allodynia / KCC2 / GABA / 神経障害性疼痛 / hydrogen sulfate / withdrawal threshold / spinal cord / microglia / von Frey / CSF-1R inhibitor … More / hydrosulfate / tibial nerve ligation / exercise therapy / tibial nerve / 神経変性と再生 / K+, Cl- 共輸送体（KCC2) / 自走式回転式運動具 / 疼痛行動検査 / 自走式回転ケージ / ミクログリア / 脊髄後角 / 脛骨神経 / 疼痛行動評価 / KCC2（K, Cl, 共輸送体） / GABA（γ―アミノ酪酸） Less

New therapy for the chronic neuropathic pain through microglial regulationPrincipal Investigator
- Principal Investigator
  
  小坂祥範
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  University of the Ryukyus
Analysis of the mechanisms underlying chronic neuropathic pain using tibial nerve injury model mice and the effect of exercise therapyPrincipal Investigator
- Principal Investigator
  
  Kosaka Yoshinori
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 59010:Rehabilitation science-related
- Research Institution
  University of the Ryukyus

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Slow progression of sciatic nerve degeneration and regeneration after loose ligation through microglial activation and decreased KCC2 levels in the mouse spinal cord ventral horn2022
- Author(s)
  Yafuso Tsukasa、Kosaka Yoshinori、Shimizu-Okabe Chigusa、Okura Nobuhiko、Kobayashi Shiori、Kim Jeongtae、Matsuda Koyata、Kinjo Daichi、Okabe Akihito、Takayama Chitoshi
- Journal Title
  
  Neuroscience Research
  
  Volume: 177 Pages: 52-63
- DOI
  10.1016/j.neures.2021.10.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07823, KAKENHI-PROJECT-21K06394, KAKENHI-PROJECT-19K19871
[Journal Article] Developmental Formation of the GABAergic and Glycinergic Networks in the Mouse Spinal Cord2022
- Author(s)
  Shimizu-Okabe Chigusa、Kobayashi Shiori、Kim Jeongtae、Kosaka Yoshinori、Sunagawa Masanobu、Okabe Akihito、Takayama Chitoshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 2 Pages: 834-834
- DOI
  10.3390/ijms23020834
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07823, KAKENHI-PROJECT-20K16111, KAKENHI-PROJECT-21K06394, KAKENHI-PROJECT-19K19871
[Journal Article] Development of the GABAergic network in the mouse spinal cord2021
- Author(s)
  Kobayashi Shiori、Shimizu-Okabe Chigusa、Kim Jeongtae、Kosaka Yoshinori、Sunagawa Masanobu、Okabe Akihito、Takayama Chitoshi
- Journal Title
  
  Factors Affecting Neurodevelopment - Genetics, Neurology, Behavior, and Diet
  
  Volume: - Pages: 273-286
- DOI
  10.1016/b978-0-12-817986-4.00024-9
- ISBN
  9780128179864
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06394, KAKENHI-PROJECT-19K19871
[Journal Article] Development and persistence of neuropathic pain through microglial activation and KCC2 decreasing after mouse tibial nerve injury2020
- Author(s)
  Kosaka Yoshinori、Yafuso Tsukasa、Shimizu-Okabe Chigusa、Kim Jeongtae、Kobayashi Shiori、Okura Nobuhiko、Ando Hironobu、Okabe Akihito、Takayama Chitoshi
- Journal Title
  
  Brain Research
  
  Volume: 1733 Pages: 146718-146718
- DOI
  10.1016/j.brainres.2020.146718
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07078, KAKENHI-PROJECT-18K07823, KAKENHI-PROJECT-19K19871
[Presentation] K+-Cl-共輸送体2(KCC2)の発現低下によるGABA/グリシンの興奮性と、脛骨神経損傷後の再生との関係2024
- Author(s)
  安藤博之、清水千草、屋富祖司、小坂祥範、高山千利
- Organizer
  第129回日本総会解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-23K16615
[Presentation] K+-Cl-共輸送体2(KCC2)の発現低下は、損傷脛骨神経の再生を促進し、運動障害を軽減する2023
- Author(s)
  安藤博之、清水千草、屋富祖司、小坂祥範、高山千利
- Organizer
  日本解剖学会第79回九州支部学術集会
- Data Source
  KAKENHI-PROJECT-23K16615
[Presentation] K+-Cl-共輸送体2(KCC2)の発現減少は、脛骨神経損傷による運動障害を軽減する2022
- Author(s)
  安藤博之、屋冨祖司、小坂祥範、小林しおり、大倉信彦、清水千草、高山千利
- Organizer
  第70回日本理学療法学会
- Data Source
  KAKENHI-PROJECT-19K19871
[Presentation] De- and Regeneration of sciatic nerves through microglial activation and KCC2 decreasing in the spinal cord after loose ligation.2020
- Author(s)
  Tsukasa Yafuso, Yoshinori Kosaka, Chigusa Shimizu-Okabe, Shiori Kobayashi, Jeongtae Kim, Hironobu Ando, Akihito Okabe, Chitoshi Takayama
- Organizer
  第43回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-19K19871
[Presentation] KCC2の発現低下は、脛骨神経損傷による運動障害を軽減する2020
- Author(s)
  安藤博之、屋冨祖司、小坂祥範、小林しおり、大倉信彦、清水千草、高山千利
- Organizer
  第125回日本解剖学会総会・全国学術集会
- Data Source
  KAKENHI-PROJECT-19K19871
[Presentation] K+-Cl-共輸送体(KCC2)の発現低下は、脛骨神経損傷による運動障害を軽減する2019
- Author(s)
  安藤博之、屋冨祖司、小坂祥範、小林しおり、大倉信彦、清水千草、高山千利
- Organizer
  日本解剖学会第75回九州支部学術集会
- Data Source
  KAKENHI-PROJECT-19K19871

1. SHIMIZU Chigusa

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
2. 高山千利

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results

Kosaka Yoshinori 小坂 祥範

Research Projects

Research Products

Co-Researchers

New therapy for the chronic neuropathic pain through microglial regulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the mechanisms underlying chronic neuropathic pain using tibial nerve injury model mice and the effect of exercise therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Slow progression of sciatic nerve degeneration and regeneration after loose ligation through microglial activation and decreased KCC2 levels in the mouse spinal cord ventral horn2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Developmental Formation of the GABAergic and Glycinergic Networks in the Mouse Spinal Cord2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of the GABAergic network in the mouse spinal cord2021

Author(s)

Journal Title

DOI

ISBN

Data Source

[Journal Article] Development and persistence of neuropathic pain through microglial activation and KCC2 decreasing after mouse tibial nerve injury2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] K+-Cl-共輸送体2(KCC2)の発現低下によるGABA/グリシンの興奮性と、脛骨神経損傷後の再生との関係2024

Author(s)

Organizer

Data Source

[Presentation] K+-Cl-共輸送体2(KCC2)の発現低下は、損傷脛骨神経の再生を促進し、運動障害を軽減する2023

Author(s)

Organizer

Data Source

[Presentation] K+-Cl-共輸送体2(KCC2)の発現減少は、脛骨神経損傷による運動障害を軽減する2022

Author(s)

Organizer

Data Source

[Presentation] De- and Regeneration of sciatic nerves through microglial activation and KCC2 decreasing in the spinal cord after loose ligation.2020

Author(s)

Organizer

Data Source

[Presentation] KCC2の発現低下は、脛骨神経損傷による運動障害を軽減する2020

Author(s)

Organizer

Data Source

[Presentation] K+-Cl-共輸送体(KCC2)の発現低下は、脛骨神経損傷による運動障害を軽減する2019

Author(s)

Organizer

Data Source

Kosaka Yoshinori 小坂祥範