Fujino Kousuke 藤野孝介

Researcher Number	10837339
Other IDs
Affiliation (Current)	2025: 熊本大学, 病院, 講師
Affiliation (based on the past Project Information) *help	2023 – 2024: 熊本大学, 病院, 講師 2020 – 2022: 熊本大学, 大学院生命科学研究部(医), 助教
Review Section/Research Field	Principal Investigator Basic Section 55040:Respiratory surgery-related Except Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 49020:Human pathology-related / Basic Section 53030:Respiratory medicine-related
Keywords	Principal Investigator INSM1 / 薬剤耐性化 / 小細胞肺癌 / PDX / 化学療法耐性化 / 化学療法耐性化メカニズム / Notchシグナル / 神経内分泌分化 / PDXマウスモデル / PDXモデル / 癌治療 / 肺癌 … More Except Principal Investigator … More 小細胞肺癌 / YAP1 / Notch / mTOR / Small cell lung cancer / YAP1（転写因子） / NOTCHシグナル / mTOR阻害剤 / PI3K/Akt/mTOR / epigenetics / single cell RNAseq解析 / 腫瘍内heterogeneity / 組織型決定機構 / シグナル分子 / フローサイトメーター / WNT11 / SOX2 / Pdxモデル / フローサイトメーター解析 / 次世代シークエンサー解析 / WNT5a / AuRKA/B / PDXモデル / 小細胞肺癌マウスモデル / Ror2 / Ascl1 / 神経内分泌分化転換 / single cell RNAseq / マウスモデル / SOX1 / NOTCH2 / ROR2 / Notchシグナル / ASCL1 / 神経内分泌分化 Less

Intratumor heterogeneity of small cell lung cancer
- Principal Investigator
  
  伊藤隆明
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Kumamoto Health Science University
Development of Personalized Medicine through the Monitoring of Molecular Expression Patterns During Chemotherapy in Small Cell Lung CancerPrincipal Investigator
- Principal Investigator
  
  藤野孝介
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Kumamoto University
小細胞肺がんでのmTOR・NOTCH1・YAP1の相互関係解析と抗がん剤耐性克服の検証
- Principal Investigator
  
  川畑茂
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Osaka Medical and Pharmaceutical University
Patient-derived AVATAR mouse models for developing novel treatment for chemo-resistant SCLC patientsPrincipal Investigator
- Principal Investigator
  
  藤野孝介
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Kumamoto University
Signal molecules of ASCL1, a lineage-specific transcription factor for small cell carcinoma of the lung
- Principal Investigator
  
  Ito Takaaki
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Kumamoto Health Science University
  Kumamoto University

All 2022 2021 2020

All Journal Article Presentation

[Journal Article] Pulmonary Neuroendocrine Cells and Small Cell Lung Carcinoma: Immunohistochemical Study Focusing on Mechanisms of Neuroendocrine Differentiation2022
- Author(s)
  Ito Takaaki、Kudoh Shinji、Fujino Kosuke、Sanada Mune、Tenjin Yuki、Saito Haruki、Nakaishi-Fukuchi Yuko、Kameyama Hiroki、Ichimura Takaya、Udaka Naoko、Kudo Noritaka、Matsuo Akira、Sato Younosuke
- Journal Title
  
  ACTA HISTOCHEMICA ET CYTOCHEMICA
  
  Volume: 55 Issue: 3 Pages: 75-83
- DOI
  10.1267/ahc.22-00031
- ISSN
  0044-5991, 1347-5800
- Year and Date
  2022-06-29
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03691
[Journal Article] Heterogeneous expression and role of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in small cell lung cancer2022
- Author(s)
  Sanada Mune、Yamazaki Masaya、Yamada Tatsuya、Fujino Kosuke、Kudoh Shinji、Tenjin Yuki、Saito Haruki、Kudo Noritaka、Sato Younosuke、Matsuo Akira、Suzuki Makoto、Ito Takaaki
- Journal Title
  
  Human Cell
  
  Volume: 36 Issue: 1 Pages: 409-420
- DOI
  10.1007/s13577-022-00830-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08258, KAKENHI-PROJECT-20H03691
[Journal Article] Distinct transcriptional programs of SOX2 in different types of small cell lung cancers2020
- Author(s)
  Tenjin Yuki、Matsuura Kumi、Kudoh Shinji、Usuki Shingo、Yamada Tatsuya、Matsuo Akira、Sato Younosuke、Saito Haruki、Fujino Kosuke、Wakimoto Joeji、Ichimura Takaya、Kohrogi Hirotsugu、Sakagami Takuro、Niwa Hitoshi、Ito Takaaki
- Journal Title
  
  Laboratory Investigation
  
  Volume: 100 Issue: 12 Pages: 1575-1588
- DOI
  10.1038/s41374-020-00479-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03691, KAKENHI-PROJECT-18K19480
[Journal Article] Integrated Immunohistochemical Study on Small-Cell Carcinoma of the Lung Focusing on Transcription and Co-Transcription Factors2020
- Author(s)
  Sato Younosuke、Okamoto Isamu、Kameyama Hiroki、Kudoh Shinji、Saito Haruki、Sanada Mune、Kudo Noritaka、Wakimoto Joeji、Fujino Kosuke、Ikematsu Yuki、Tanaka Kentaro、Nishikawa Ayako、Sakaguchi Ryo、Ito Takaaki
- Journal Title
  
  Diagnostics
  
  Volume: 10 Issue: 11 Pages: 949-949
- DOI
  10.3390/diagnostics10110949
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03691, KAKENHI-PROJECT-18K19480
[Presentation] Establishment of a Preclinical Tools for Precision Oncology: Kumamoto University Lung Cancer Patient Derived Xenograft (KLC-PDX Project)2022
- Author(s)
  Kosuke Fujino
- Organizer
  The 122th Annual Congress of Japan Surgical Society
- Data Source
  KAKENHI-PROJECT-20K17753
[Presentation] 小細胞肺癌のpatient-derived xenotransplantation (PDX) model2021
- Author(s)
  福地裕子、伊藤隆明、山崎昌哉、眞田崇、本岡大和、山田達也、佐藤陽之輔、藤野孝介、鈴木実
- Organizer
  第39回日本ヒト細胞学会学術集会
- Data Source
  KAKENHI-PROJECT-20H03691
[Presentation] PDX（Patient-Derived Xenograft）技術を使用した希少肺癌の生体内バイオバンク構築及び前臨床モデルとしての活用の試み2021
- Author(s)
  藤野孝介
- Organizer
  第38回日本呼吸器外科学会学術集会
- Data Source
  KAKENHI-PROJECT-20K17753

1. Ito Takaaki (70168392)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. 佐藤陽之輔 (00823311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
3. 永原則之 (10208043)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 長谷川功紀 (50525798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 山口知也 (70452191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 亀山広喜 (00389545)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 山崎昌哉 (00962804)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 川畑茂 (90393454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 松尾顕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fujino Kousuke 藤野 孝介

Research Projects

Research Products

Co-Researchers

Intratumor heterogeneity of small cell lung cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of Personalized Medicine through the Monitoring of Molecular Expression Patterns During Chemotherapy in Small Cell Lung CancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

小細胞肺がんでのmTOR・NOTCH1・YAP1の相互関係解析と抗がん剤耐性克服の検証

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Patient-derived AVATAR mouse models for developing novel treatment for chemo-resistant SCLC patientsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Signal molecules of ASCL1, a lineage-specific transcription factor for small cell carcinoma of the lung

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Pulmonary Neuroendocrine Cells and Small Cell Lung Carcinoma: Immunohistochemical Study Focusing on Mechanisms of Neuroendocrine Differentiation2022

Author(s)

Journal Title

DOI

ISSN

Year and Date

Language

Data Source

[Journal Article] Heterogeneous expression and role of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in small cell lung cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distinct transcriptional programs of SOX2 in different types of small cell lung cancers2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Integrated Immunohistochemical Study on Small-Cell Carcinoma of the Lung Focusing on Transcription and Co-Transcription Factors2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Establishment of a Preclinical Tools for Precision Oncology: Kumamoto University Lung Cancer Patient Derived Xenograft (KLC-PDX Project)2022

Author(s)

Organizer

Data Source

[Presentation] 小細胞肺癌のpatient-derived xenotransplantation (PDX) model2021

Author(s)

Organizer

Data Source

[Presentation] PDX（Patient-Derived Xenograft）技術を使用した希少肺癌の生体内バイオバンク構築及び前臨床モデルとしての活用の試み2021

Author(s)

Organizer

Data Source

Fujino Kousuke 藤野孝介