Koide Shuhei 小出周平

Researcher Number	10845126
Other IDs	https://orcid.org/0000-0001-8599-6115
Affiliation (Current)	2024: 東京大学, 医科学研究所, 特任助教
Affiliation (based on the past Project Information) *help	2024: 東京大学, 医科学研究所, 特任助教 2022: 東京大学, 医科学研究所, 特任助教 2020 – 2021: 東京大学, 医科学研究所, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator 加齢 / シングルセル解析 / 造血器腫瘍 / 老化 / 造血幹細胞 / 炎症 / 分子シャペロン

Deciphering Hematopoietic Stem Cell Aging via the New Marker Clusterin and Establishing Control StrategiesPrincipal Investigator
- Principal Investigator
  
  小出周平
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo
Elucidation of the principles of hematopoietic stem cells in aging and overcoming aging-related diseasesPrincipal Investigator
- Principal Investigator
  
  小出周平
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo
Elucidation of the Mechanism of Functional Decline of Aged Hematopoietic Stem Cells and Attempts to Restore Their Function.Principal Investigator
- Principal Investigator
  
  Koide Shuhei
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  The University of Tokyo

All 2022 2021 2020

All Journal Article Presentation

[Journal Article] A culture platform to study quiescent hematopoietic stem cells following genome editing2022
- Author(s)
  Shiroshita Kohei、Kobayashi Hiroshi、Watanuki Shintaro、Karigane Daiki、Sorimachi Yuriko、Fujita Shinya、Tamaki Shinpei、Haraguchi Miho、Itokawa Naoki、Aoyama Kazumasa、Koide Shuhei、Masamoto Yosuke、Kobayashi Kenta、Nakamura-Ishizu Ayako、Kurokawa Mineo、Iwama Atsushi、Okamoto Shinichiro、Kataoka Keisuke、Takubo Keiyo
- Journal Title
  
  Cell Reports Methods
  
  Volume: 2 Issue: 12 Pages: 100354-100354
- DOI
  10.1016/j.crmeth.2022.100354
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08431, KAKENHI-PROJECT-22K19550, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-21H02957, KAKENHI-PROJECT-21J11016, KAKENHI-PROJECT-22KJ2948, KAKENHI-PROJECT-23K24366
[Journal Article] Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of β-catenin degradation2022
- Author(s)
  Jimbo K, Nakajima-Takagi Y, Ito T, Koide S, Nannya Y, Iwama A, Tojo A, Konuma T
- Journal Title
  
  Leukemia
  
  Volume: In press Issue: 6 Pages: 1550-1562
- DOI
  10.1038/s41375-022-01564-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08748, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-22K16317
[Journal Article] CD244 expression represents functional decline of murine hematopoietic stem cells after in vitro culture2022
- Author(s)
  Koide Shuhei、Sigurdsson Valgardur、Radulovic Visnja、Saito Kiyoka、Zheng Zhiqian、Lang Stefan、Soneji Shamit、Iwama Atsushi、Miharada Kenichi
- Journal Title
  
  iScience
  
  Volume: 25 Issue: 1 Pages: 103603-103603
- DOI
  10.1016/j.isci.2021.103603
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17370
[Journal Article] Noncanonical EZH2 drives retinoic acid resistance of variant acute promyelocytic leukemias2022
- Author(s)
  Poplineau Mathilde、Platet Nadine、Mazuel Adrien、Herault Leonard、N’Guyen Lia、Koide Shuhei、Nakajima-Takagi Yaeko、Kuribayashi Wakako、Carbuccia Nadine、Haboub Loreen、Vernerey Julien、Oshima Motohiko、Birnbaum Daniel、Iwama Atsushi、Duprez Estelle
- Journal Title
  
  Blood
  
  Volume: 140 Issue: 22 Pages: 2358-2370
- DOI
  10.1182/blood.2022015668
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16298
[Journal Article] Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells2022
- Author(s)
  Itokawa Naoki、Oshima Motohiko、Koide Shuhei、Takayama Naoya、Kuribayashi Wakako、Nakajima-Takagi Yaeko、Aoyama Kazumasa、Yamazaki Satoshi、Yamaguchi Kiyoshi、Furukawa Yoichi、Eto Koji、Iwama Atsushi
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 2691-2691
- DOI
  10.1038/s41467-022-30440-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-21F21108, KAKENHI-PROJECT-20K07563, KAKENHI-PLANNED-19H05746
[Journal Article] Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia2022
- Author(s)
  Jimbo Koji、Hattori Ayuna、Koide Shuhei、Ito Takahiro、Sasaki Katsuhiro、Iwai Kazuhiro、Nannya Yasuhito、Iwama Atsushi、Tojo Arinobu、Konuma Takaaki
- Journal Title
  
  Leukemia
  
  Volume: 37 Issue: 1 Pages: 122-133
- DOI
  10.1038/s41375-022-01750-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16298, KAKENHI-PROJECT-22K16317, KAKENHI-PROJECT-22H04988, KAKENHI-PROJECT-20K07337, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05499
[Journal Article] Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche2021
- Author(s)
  Kuribayashi W, Oshima M, Itokawa N, Koide S, Nakajima-Takagi Y, Yamashita M, Yamazaki S, Rahmutulla B, Miura F, Ito T, Kaneda A, Iwama A.
- Journal Title
  
  J Exp Med
  
  Volume: 218 Issue: 3
- DOI
  10.1084/jem.20192283
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21612, KAKENHI-PROJECT-19KK0216, KAKENHI-PLANNED-19H05746, KAKENHI-PUBLICLY-20H05025, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-20H03707, KAKENHI-PROJECT-18K08348, KAKENHI-PROJECT-20K17370, KAKENHI-PROJECT-21K08366
[Journal Article] CD271 + CD51 + PALLADIN - Human Mesenchymal Stromal Cells Possess Enhanced Ossicle-Forming Potential2021
- Author(s)
  Sezaki Maiko、Biswas Subinoy、Nakata Sayuri、Oshima Motohiko、Koide Shuhei、Ho Nicole Pui Yu、Okamoto Nobukazu、Miyamoto Takeshi、Iwama Atsushi、Takizawa Hitoshi
- Journal Title
  
  Stem Cells and Development
  
  Volume: 30 Issue: 14 Pages: 725-735
- DOI
  10.1089/scd.2021.0021
- Data Source
  KAKENHI-PROJECT-20K17370
[Journal Article] Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis2021
- Author(s)
  Shinoda Daisuke、Nakajima-Takagi Yaeko、Oshima Motohiko、Koide Shuhei、Aoyama Kazumasa、Saraya Atsunori、Harada Hironori、Rahmutulla Bahityar、Kaneda Atsushi、Yamaguchi Kiyoshi、Furukawa Yoichi、Koseki Haruhiko、Shimoda Kazuya、Tanaka Tomoaki、Sashida Goro、Iwama Atsushi
- Journal Title
  
  Leukemia
  
  Volume: 36 Issue: 2 Pages: 452-463
- DOI
  10.1038/s41375-021-01402-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08824, KAKENHI-PROJECT-20K21625, KAKENHI-PROJECT-20K17370, KAKENHI-PLANNED-19H05745, KAKENHI-PLANNED-19H05746, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-19H03708, KAKENHI-PROJECT-20H03713, KAKENHI-PROJECT-21K08366, KAKENHI-PROJECT-21K19398, KAKENHI-PROJECT-19H04355
[Journal Article] PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome2020
- Author(s)
  Aoyama K, Shinoda D, Suzuki E, Nakajima-Takagi Y, Oshima M, Koide S, Rizq O, Si S, Tara S, Sashida G, Iwama A.
- Journal Title
  
  Leukemia
  
  Volume: 4 Issue: 4 Pages: 1156-1165
- DOI
  10.1038/s41375-020-01023-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17370, KAKENHI-PROJECT-19H05653, KAKENHI-PROJECT-21K08366
[Presentation] Clu-positive hematopoietic stem cells show decreased stemness and expand the number with aging2022
- Author(s)
  Shuhei Koide
- Organizer
  Hemato-Retreat 2022
- Invited
- Data Source
  KAKENHI-PROJECT-22K16298
[Presentation] Clu-positive hematopoietic stem cells show decreased stemness and expand with aging2022
- Author(s)
  小出周平、大島基彦、西山晃、村上紘一、テイシセン、中島やえ子、遊佐希、横山和明、東條有伸、田村智彦、岩間厚志
- Organizer
  第84回日本血液学会
- Data Source
  KAKENHI-PROJECT-22K16298
[Presentation] Single-cell analysis reveals that Clusterin-positive hematopoietic stem cells with impaired stemness expand with aging2022
- Author(s)
  Shuhei Koide, Motohiko Oshima, Akira Nishiyama, Koichi Murakami, Zhiqian Zheng, Naoki Itokawa, Nakajima Yaeko, Nozomi Yusa, Kazuaki Yokoyama, Arinobu Tojo, Tomohiko Tamura, Atsushi Iwama
- Organizer
  ISEH 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16298
[Presentation] Dysfunctional Clusterin-Positive Hematopoietic Stem Cells Expand with Aging2022
- Author(s)
  Shuhei Koide, Motohiko Oshima, Akira Nishiyama, Koichi Murakami, Naoki Itokawa, Yaeko Nakajima-Takagi, Zhiqian Zheng, Nozomi Yusa, Kazuaki Yokoyama, Arinobu Tojo, Tomohiko Tamura, Atsushi Iwama
- Organizer
  64th ASH Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K16298
[Presentation] Unraveling heterogeneity of aged hematopoietic stem cells by single-cell RNA sequence analysis2021
- Author(s)
  Shuhei Koide
- Organizer
  第83回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-20K17370

1. HARADA Yuka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. OHSHIMA Motohiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 小林央

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 山崎聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 小沼貴晶

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 原田浩徳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Koide Shuhei 小出 周平

Research Projects

Research Products

Co-Researchers

Deciphering Hematopoietic Stem Cell Aging via the New Marker Clusterin and Establishing Control StrategiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the principles of hematopoietic stem cells in aging and overcoming aging-related diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the Mechanism of Functional Decline of Aged Hematopoietic Stem Cells and Attempts to Restore Their Function.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] A culture platform to study quiescent hematopoietic stem cells following genome editing2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of β-catenin degradation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD244 expression represents functional decline of murine hematopoietic stem cells after in vitro culture2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Noncanonical EZH2 drives retinoic acid resistance of variant acute promyelocytic leukemias2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CD271 + CD51 + PALLADIN - Human Mesenchymal Stromal Cells Possess Enhanced Ossicle-Forming Potential2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Insufficiency of non-canonical PRC1 synergizes with JAK2V617F in the development of myelofibrosis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] PRC2 insufficiency causes p53-dependent dyserythropoiesis in myelodysplastic syndrome2020

Author(s)

Journal Title

DOI

Data Source

[Presentation] Clu-positive hematopoietic stem cells show decreased stemness and expand the number with aging2022

Author(s)

Organizer

Data Source

[Presentation] Clu-positive hematopoietic stem cells show decreased stemness and expand with aging2022

Author(s)

Organizer

Data Source

Koide Shuhei 小出周平