Yamashita Yasunobu 山下泰信

Researcher Number	10873408
Other IDs
Affiliation (Current)	2025: 大阪大学, 産業科学研究所, 助教
Affiliation (based on the past Project Information) *help	2021 – 2024: 大阪大学, 産業科学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields
Keywords	Principal Investigator エピジェネティクス / HDAC / 創薬化学 / AI / 深層学習 Except Principal Investigator 創薬 / がん / エピジェネティクス / 複合体 / キメラ分子 … More / in situクリックケミストリー / 阻害薬 / 医薬品 / 標的誘導型合成 Less

Development of chimera molecules targeting epigenetic complexes
- Principal Investigator
  
  鈴木孝禎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Osaka University
Development of innovative drug candidates by target guided synthesis
- Principal Investigator
  
  Suzuki Takayoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Osaka University
深層学習を用いた新規活性予測器の開発とHDAC阻害薬探索への応用Principal Investigator
- Principal Investigator
  
  山下泰信
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Osaka University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Design, synthesis, and biological evaluation of phenylcyclopropylamine-entinostat conjugates that selectively target cancer cells2024
- Author(s)
  Ota Y, Itoh Y, Takada Y, Yamashita Y, Hu C, Horinaka M, Sowa Y, Masuda M, Sakai T, Suzuki T
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 100 Pages: 117632-117632
- DOI
  10.1016/j.bmc.2024.117632
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K18407, KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-21H04795
[Journal Article] Identification of a Histone Deacetylase 8 Inhibitor through Drug Screenings Based on Machine Learning2024
- Author(s)
  Nurani Atika、Yamashita Yasunobu、Taki Yuuki、Takada Yuri、Itoh Yukihiro、Suzuki Takayoshi
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 2 Pages: 173-178
- DOI
  10.1248/cpb.c23-00577
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-21H04795
[Journal Article] A Structure–Activity Relationship Study of SNAIL1 Peptides as Inhibitors of Lysine-Specific Demethylase 12024
- Author(s)
  Takada Yuri、Adachi Kyohei、Fujinaga Yuka、Yamashita Yasunobu、Itoh Yukihiro、Suzuki Takayoshi
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 2 Pages: 155-160
- DOI
  10.1248/cpb.c23-00671
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-02-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-21H04795
[Journal Article] Structural optimization of a lysine demethylase 5 inhibitor for improvement of its cellular activity2024
- Author(s)
  Terao Mitsuhiro、Yamashita Yasunobu、Takada Yuri、Itoh Yukihiro、Suzuki Takayoshi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 98 Pages: 117579-117579
- DOI
  10.1016/j.bmc.2023.117579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K18186, KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-21H04795
[Journal Article] Discovery of selective histone deacetylase 1 and 2 inhibitors: screening of a focused library constructed by click chemistry, kinetic binding analysis, and biological evaluation2023
- Author(s)
  Itoh Y, Zhan P, Tojo T, Jaikhan P, Ota Y, Suzuki M, Li Y, Hui Z, Moriyama Y, Takada Y, Yamashita Y, Oba M, Uchida S, Masuda M, Ito S, Sowa Y, Sakai T, Suzuki T
- Journal Title
  
  J Med Chem
  
  Volume: 66 Issue: 22 Pages: 15171-15188
- DOI
  10.1021/acs.jmedchem.3c01095
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18407, KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-20K15959, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-23K23487
[Journal Article] Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC)2022
- Author(s)
  Jiranan Chotitumnavee, Yasunobu Yamashita, Yukari Takahashi, Yuri Takada, Tetsuya Iida, Makoto Oba, Yukihiro Itoh, Takayoshi Suzuki
- Journal Title
  
  Chem. Commun.
  
  Volume: 58 Issue: 29 Pages: 5051-5056
- DOI
  10.1039/d2cc00272h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-21K20719
[Journal Article] Cancer-cell-selective targeting by arylcyclopropylamine-vorinostat conjugates2022
- Author(s)
  Ota Y, Itoh Y, Kurohara T, Singh R, Elboray EE, Hu C, Zamani F, Mukherjee A, Takada Y, Yamashita Y, Morita M, Horinaka M, Sowa Y, Masuda M, Sakai T, Suzuki T
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 13 Issue: 10 Pages: 1568-1573
- DOI
  10.1021/acsmedchemlett.2c00126
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K18407, KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-19H01079, KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-19H03889, KAKENHI-PROJECT-20F40107, KAKENHI-PROJECT-21K20719
[Journal Article] Medicinal Chemistry Research on Targeting Epigenetic Complexes2022
- Author(s)
  Yuri Takada, Yasunobu Yamashita, Yukihiro Itoh, Takayoshi Suzuki
- Journal Title
  
  Journal of Synthetic Organic Chemistry, Japan
  
  Volume: 80 Issue: 7 Pages: 664-675
- DOI
  10.5059/yukigoseikyokaishi.80.664
- ISSN
  0037-9980, 1883-6526
- Year and Date
  2022-07-01
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-22K15251, KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-21K20719
[Journal Article] Recent progress on small molecules targeting epigenetic complexes2022
- Author(s)
  Itoh Yukihiro、Takada Yuri、Yamashita Yasunobu、Suzuki Takayoshi
- Journal Title
  
  Current Opinion in Chemical Biology
  
  Volume: 67 Pages: 102130-102130
- DOI
  10.1016/j.cbpa.2022.102130
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-21K15226, KAKENHI-PROJECT-21K20719
[Journal Article] Identification of Novel Histone Deacetylase 6‐Selective Inhibitors Bearing 3,3,3‐Trifluorolactic Amide (TFLAM) Motif as a Zinc Binding Group2021
- Author(s)
  Kurohara Takashi、Tanaka Keita、Takahashi Daisuke、Ueda Satoshi、Yamashita Yasunobu、Takada Yuri、Takeshima Hirokazu、Yu Shengwang、Itoh Yukihiro、Hase Koji、Suzuki Takayoshi
- Journal Title
  
  ChemBioChem
  
  Volume: 22 Issue: 22 Pages: 3158-3163
- DOI
  10.1002/cbic.202100255
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-20K07552
[Journal Article] Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein Using a Fragment-Merging Approach2021
- Author(s)
  Prakash Muthuraj、Itoh Yukihiro、Fujiwara Yoshie、Takahashi Yukari、Takada Yuri、Mellini Paolo、Elboray Elghareeb E.、Terao Mitsuhiro、Yamashita Yasunobu、Yamamoto Chika、Yamaguchi Takao、Kotoku Masayuki、Kitao Yuki、Singh Ritesh、Roy Rohini、Obika Satoshi、Oba Makoto、Wang Dan Ohtan、Suzuki Takayoshi
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 64 Issue: 21 Pages: 15810-15824
- DOI
  10.1021/acs.jmedchem.1c01107
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04795, KAKENHI-PROJECT-20K21488, KAKENHI-PROJECT-21H02580
[Presentation] 相対論的電子ビームをトリガーとするプロドラッグ活性化研究2024
- Author(s)
  山下泰信、室屋裕佐、水田好雄、中野和美、皆巳和賢、Zhidkov Alexei、譽田義英、伊藤幸裕、高田悠里、小泉雅彦、細貝知直、鈴木孝禎
- Organizer
  日本薬学会第１４４年会 (横浜)
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] ヘテロクロマチンタンパク質HP1を阻害する低分子化合物の同定2024
- Author(s)
  徳山あかり、山下泰信、前田亮、高田悠里、伊藤幸裕、立花誠、鈴木孝禎
- Organizer
  日本薬学会第１４４年会 (横浜)
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] E3リガンド構造によるステープル化を基盤としたペプチド性PROTACの創製研究2024
- Author(s)
  川浪紘明、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会第１４４年会 (横浜)
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] Discovery of SNAIL1 Peptide-Based Inhibitors of Lysine-Specific Demethylase 12024
- Author(s)
  Yuka Fujinaga, Yuri Takada, Kyohei Adachi, Yasunobu Yamashita, Yukihiro Itoh, Takayoshi Suzuki
- Organizer
  The 27th SANKEN International Symposium（Awajishima）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] BRD4を標的としたスクアレート型コバレントドラッグの創製研究2024
- Author(s)
  竹島大和、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会第１４４年会 (横浜)
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] ペプチドライブラリーの構築とスクリーニングを基盤としたCBX7阻害薬の創製研究2024
- Author(s)
  山﨑伊吹、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会第１４４年会 (横浜)
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] クリックケミストリーを利用したGLS1 PROTACライブラリーの構築2024
- Author(s)
  林海伶、伊藤幸裕、山下泰信、高田悠里、鈴木孝禎
- Organizer
  日本薬学会第１４４年会 (横浜)
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] Discovery of hydrophobic tag-based degraders targeting lysine-specific demethylase 12024
- Author(s)
  SHENGWANG YU, Yasunobu Yamashita, Yuri Takada, Yukihiro Itoh, Takayoshi Suzuki
- Organizer
  日本薬学会第１４４年会 (横浜)
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] CBX7 阻害薬創製に向けたペプチドライブラリーの構築とスクリーニング2023
- Author(s)
  山崎伊吹、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  第49回反応と合成の進歩シンポジウム（岐阜）
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] Identification of Potent and Selective Inhibitors of Fat Mass Obesity-Associated Protein2023
- Author(s)
  Yuri Takada，Muthuraj Prakash，Yukihiro Itoh，Yoshie Fujiwara，Yukari Takahashi，Paolo Mellini，Elghareeb E. Elboray，Mitsuhiro Terao，Yasunobu Yamashita，Chika Yamamoto，Takao Yamaguchi，Ritesh Singh，Satoshi Obika，Makoto Oba，Dan Ohtan Wang，Takayoshi Suzuki
- Organizer
  14th AFMC International Medicinal Chemistry Symposium (AIMECS 2023)（Seoul）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] Chemotherapy triggered by electron beams2023
- Author(s)
  Yasunobu Yamashita
- Organizer
  Quantum Beam Application for Sciences and Industries 2023 (Osaka)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] 電子線照射によるドキソルビシンプロドラッグの活性化2023
- Author(s)
  山下泰信、室屋裕佐、水田好雄、平井雄大、皆巳和賢、Alexei Zhidkov、譽田義英、伊藤幸裕、高田悠里、古澤孝弘、小泉雅彦、細貝知直、鈴木孝禎
- Organizer
  第49回反応と合成の進歩シンポジウム（岐阜）
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] 細胞評価系での活性向上を目指したKDM5B阻害薬の創製研究2023
- Author(s)
  寺尾允太、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会第１４３年会
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] 逆電子要請型 Diels-Alder 反応に基づく標的タンパク質分解誘導薬PROTAC の創製研究2023
- Author(s)
  Yu Shengwang、伊藤幸裕、山下泰信、高田悠里、鈴木孝禎
- Organizer
  第49回反応と合成の進歩シンポジウム（岐阜）
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] リシン脱メチル化酵素KDM5Cを標的とした分解誘導薬（PROTAC）の創製2023
- Author(s)
  伊藤幸裕、飯田哲也、高橋ゆかり、山下泰信、黒原崇、三宅由花、大庭誠、鈴木孝禎
- Organizer
  日本ケミカルバイオロジー学会　第17回年会（大阪）
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] 新規セレブロン(CRBN)リガンドの同定2023
- Author(s)
  安藤貴章、伊藤幸裕、高田悠里、山下泰信、鈴木孝禎
- Organizer
  第73回日本薬学会関西支部総会・大会（神戸）
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] Identification of a proteolysis targeting chimera (PROTAC) targeting histone deacetylase 82023
- Author(s)
  Yukihiro Itoh, Jiranan Chotitumnavee, Yasunobu Yamashita, Yukari Takahashi, Yuri Takada, Tetsuya Iida, Makoto Oba, Takayoshi Suzuki
- Organizer
  14th AFMC International Medicinal Chemistry Symposium (AIMECS 2023)（Seoul）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] Design, synthesis, and biological evaluation of proteolysis targeting chimeras (PROTACs) targeting G9a methyltransferase2023
- Author(s)
  Anirban Mukherjee, Yasunobu Yamashita, Yuri Takada, Yukihiro Itoh, Takayoshi Suzuki 14th AFMC International Medicinal Chemistry Symposium (AIMECS 2023); 2023年6月27日（Seoul）
- Organizer
  Anirban Mukherjee, Yasunobu Yamashita, Yuri Takada, Yukihiro Itoh, Takayoshi Suzuki 14th AFMC International Medicinal Chemistry Symposium (AIMECS 2023)（Seoul）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] Improved cellular activity of KDM5B inhibitor prodrugs through structure-based drug design2023
- Author(s)
  Mitsuhiro Terao, Yasunobu Yamashita, Yuri Takada, Yukihiro Itoh, Takayoshi Suzuki
- Organizer
  4th AFMC International Medicinal Chemistry Symposium (AIMECS 2023)（Seoul）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] Prodrug activation by electron beam irradiation2023
- Author(s)
  Yasunobu Yamashita, Yusa Muroya, Yoshio Mizuta, Yudai Hirai, Kazumasa Minami, Alexei Zhidkov, Yoshihide Honda, Yukihiro Itoh, Yuri Takada, Takahiro Kozawa, Masahiko Koizumi, Tomonao Hosokai, Takayoshi Suzuki
- Organizer
  14th AFMC International Medicinal Chemistry Symposium (AIMECS 2023)（Seoul）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] 電子線照射によるプロドラッグの活性化2023
- Author(s)
  山下泰信、室屋裕佐、水田好雄、平井雄大、皆巳和賢、Alexei Zhidkov、譽田義英、伊藤幸裕、高田悠里、古澤孝弘、小泉雅彦、細貝知直、鈴木孝禎
- Organizer
  日本ケミカルバイオロジー学会　第17回年会（大阪）
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] 創薬への応用を指向したスクアラミドの反応性検証2023
- Author(s)
  竹島大和、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会第１４３年会
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] タンパク質分解誘導活性を持つペプチド化合物の創製を指向したステープル化2023
- Author(s)
  川浪紘明、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  第73回日本薬学会関西支部総会・大会（神戸）
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] 架橋部位にE3リガンド構造を持つペプチド性PROTACの創製研究2023
- Author(s)
  川浪紘明、高田悠里、山下泰信、伊藤幸裕、鈴木孝禎
- Organizer
  第40回　メディシナルケミストリーシンポジウム（名古屋）
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] 体幹深部に届く相対論的エネルギーの電子ビームをトリガーとするプロドラッグ研究；光線力学療法への適用の可能性2023
- Author(s)
  山下泰信、細貝知直、室屋裕佐、皆巳和賢、水田好雄、中野和美、誉田義英、金展、小泉雅彦、鈴木孝禎
- Organizer
  第33回日本光線力学学会学術講演会 (東京)
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] RNA 創薬への応用を志向したビスマス(III)錯体型 RNA 分解分子の開発2022
- Author(s)
  花谷優太朗，黒原崇，山下泰信，高田悠里，伊藤幸裕，鈴木孝禎
- Organizer
  20 回次世代を担う有機化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] ビスマス（Ⅲ）錯体型RNA分解分子の開発2022
- Author(s)
  花谷優太朗，黒原崇，山下泰信，高田悠里，伊藤幸裕，鈴木孝禎
- Organizer
  日本ケミカルバイオロジー学会第１６回年会
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] 創薬、ケミカルバイオロジー研究を指向したスクアラミドの反応性検証2022
- Author(s)
  竹島大和，高田悠里，山下泰信，伊藤幸裕，鈴木孝禎
- Organizer
  第４８回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] RNA 脱メチル化酵素 FTO 阻害薬の創製2022
- Author(s)
  高田悠里、Muthuraj Prakash、伊藤幸裕、藤原芳江、高橋ゆかり、Paolo Mellini、Elghareeb E.Elboray、寺尾允太、山下泰信、山本知佳、山口卓男、Ritesh Singh、小比賀聡、大庭誠、王丹、鈴木孝禎
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] HDAC8選択的分解誘導薬の創製とその生物学的評価2022
- Author(s)
  山下泰信、Jiranan Chotitumnavee、高橋ゆかり、高田悠里、飯田哲也、大庭誠、伊藤幸裕、鈴木孝禎
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] SBDD による KDM5B 選択的阻害薬の創製研究2022
- Author(s)
  寺尾允太、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] 二核ビスマス錯体（Ⅲ）錯体型RNA分解分子の開発2022
- Author(s)
  花谷優太朗，黒原崇，山下泰信，高田悠里，伊藤幸裕，鈴木孝禎
- Organizer
  第４８回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] Synthesis and evaluation of optically pure phenylcyclopropylamine-drug conjugates targeting LSD12022
- Author(s)
  Chenliang Hu， Yosuke Ota，Yukihiro Itoh，Farzad Zamani，Anirban Mukherjee，Yuri Takada，Yasunobu Yamashita，Takayoshi Suzuki
- Organizer
  第39回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-21K15226
[Presentation] RNA創薬を志向した金属錯体型RNA分解分子の開発2022
- Author(s)
  花谷優太朗、黒原崇、山下泰信、高田悠里、伊藤幸裕、鈴木孝禎
- Organizer
  日本薬学会第１４２年会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04795
[Presentation] エピジェネティクス関連酵素に対する分解誘導薬の創製2021
- Author(s)
  伊藤幸裕、飯田哲也、Chotitumnavee Jiranan、高橋ゆかり、山下泰信、黒原崇、三宅由花、大庭誠、鈴木孝禎
- Organizer
  第15回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PROJECT-21H04795

1. Suzuki Takayoshi (90372838)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. 高田悠里 (20902357)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. 伊藤幸裕 (30636402)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
4. HORINAKA Mano

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 酒井敏行

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results

Yamashita Yasunobu 山下 泰信

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Development of chimera molecules targeting epigenetic complexes

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Development of innovative drug candidates by target guided synthesis

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深層学習を用いた新規活性予測器の開発とHDAC阻害薬探索への応用Principal Investigator

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[Journal Article] Design, synthesis, and biological evaluation of phenylcyclopropylamine-entinostat conjugates that selectively target cancer cells2024

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[Journal Article] Identification of a Histone Deacetylase 8 Inhibitor through Drug Screenings Based on Machine Learning2024

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[Journal Article] A Structure–Activity Relationship Study of SNAIL1 Peptides as Inhibitors of Lysine-Specific Demethylase 12024

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[Journal Article] Structural optimization of a lysine demethylase 5 inhibitor for improvement of its cellular activity2024

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[Journal Article] Discovery of selective histone deacetylase 1 and 2 inhibitors: screening of a focused library constructed by click chemistry, kinetic binding analysis, and biological evaluation2023

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[Journal Article] Selective degradation of histone deacetylase 8 mediated by a proteolysis targeting chimera (PROTAC)2022

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[Journal Article] Cancer-cell-selective targeting by arylcyclopropylamine-vorinostat conjugates2022

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[Journal Article] Medicinal Chemistry Research on Targeting Epigenetic Complexes2022

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[Journal Article] Recent progress on small molecules targeting epigenetic complexes2022

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[Journal Article] Identification of Novel Histone Deacetylase 6‐Selective Inhibitors Bearing 3,3,3‐Trifluorolactic Amide (TFLAM) Motif as a Zinc Binding Group2021

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Yamashita Yasunobu 山下泰信