Ushimaru Richiro 牛丸理一郎

Researcher Number	10873648
Other IDs
Affiliation (Current)	2025: 九州大学, 高等研究院(理学系), 准教授
Affiliation (based on the past Project Information) *help	2020 – 2025: 東京大学, 大学院薬学系研究科(薬学部), 助教
Review Section/Research Field	Principal Investigator Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Transformative Research Areas, Section (II) / Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Basic Section 47050:Environmental and natural pharmaceutical resources-related / Transformative Research Areas, Section (III) / 0801:Pharmaceutical sciences and related fields Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields / Transformative Research Areas, Section (II)
Keywords	Principal Investigator 天然物生合成 / 生合成 / 酵素反応機構 / 天然物化学 / 生合成遺伝子クラスター / メチル基転移酵素 / 生合成酵素 / 鉄硫黄クラスター / 含硫黄天然物 / 鉄酵素 … More / 非典型アミノ酸 / 立体化学解析 / シクロプロパン / シクロプロパン化 / ヘムオキシゲナーゲ / 非ヘム鉄酵素 / 酵素 / 天然物 / ヌクレオシド天然物 … More Except Principal Investigator 生合成工学 / 合成生物学 / 酵素工学 / 酵素 / 生合成 / 薬用天然物 / 遷移状態 / 酵素の精密構造機能解析 / 構造生物学 / 酵素化学 / 予知生合成化学 / 予知生合成科学 / 天然物化学 / 中国南西部 / 生物多様性 / 生合成マシナリー / 天然物生合成 / 創薬資源採集調査 Less

新規リン酸アミド含有天然物の生合成経路の探索と解明Principal Investigator
- Principal Investigator
  
  牛丸理一郎
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
  Sections That Are Subject to Joint Review: Basic Section47010:Pharmaceutical chemistry and drug development sciences-related , Basic Section47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  The University of Tokyo
酵素的硫黄挿入反応による糖分子リプログラミングPrincipal Investigator
- Principal Investigator
  
  牛丸理一郎
- Project Period (FY)
  2025 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  The University of Tokyo
炭素-硫黄結合形成酵素における鉄硫黄クラスターの硫黄供与機能と再構築機構の解明Principal Investigator
- Principal Investigator
  
  牛丸理一郎
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  The University of Tokyo
薬用天然物の複雑骨格構築を担う新奇生合成酵素を用いた革新的次世代型天然物創薬
- Principal Investigator
  
  阿部郁朗
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
微生物由来メチル基転移酵素阻害剤の生合成機構解明と物質生産への応用Principal Investigator
- Principal Investigator
  
  牛丸理一郎
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  The University of Tokyo
酵素機能発掘と合成生物学による次世代型物質生産系の構築
- Principal Investigator
  
  淡川孝義
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (II)
- Research Institution
  Institute of Physical and Chemical Research
Mechanistic studies on nonheme iron enzymes catalyzing cyclopropanationPrincipal Investigator
- Principal Investigator
  
  Ushimaru Richiro
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  The University of Tokyo
Investigation into the heteroatom incorporation into nucleoside natural productsPrincipal Investigator
- Principal Investigator
  
  Ushimaru Richiro
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0801:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
Survey for new drug discovery resources and exploration & elucidation of novel natural product biosynthetic machineries
- Principal Investigator
  
  Abe Ikuro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo
Structure-function studies of enzymes involved in natural product biosynthesis for drug discovery
- Principal Investigator
  
  ABE Ikuro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020

All Journal Article Presentation

[Journal Article] Characterization of Aziridine-Forming α-Ketoglutarate-Dependent Oxygenase in L-Isovaline Biosynthesis2024
- Author(s)
  Zhou Lu、Awakawa Takayoshi、Ushimaru Richiro、Kanaida Masahiro、Abe Ikuro
- Journal Title
  
  Organic Letters
  
  Volume: 26 Issue: 3 Pages: 724-727
- DOI
  10.1021/acs.orglett.3c04185
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-23K21363
[Journal Article] Unusual Enzymatic C–C Bond Formation and Cleavage Reactions during Natural Product Biosynthesis2024
- Author(s)
  Ushimaru Richiro
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 72 Issue: 3 Pages: 241-247
- DOI
  10.1248/cpb.c23-00889
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2024-03-01
- Language
  English
- Data Source
  KAKENHI-PROJECT-23K13847
[Journal Article] Back-to-back cycloadditions in nature2023
- Author(s)
  Ushimaru Richiro、Abe Ikuro
- Journal Title
  
  Nature Chemistry
  
  Volume: 15 Issue: 8 Pages: 1056-1057
- DOI
  10.1038/s41557-023-01282-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K13847, KAKENHI-PROJECT-20KK0173
[Journal Article] Mechanistic Analysis of Stereodivergent Nitroalkane Cyclopropanation Catalyzed by Nonheme Iron Enzymes2023
- Author(s)
  Ushimaru Richiro、Cha Lide、Shimo Shotaro、Li Xiaojun、Paris Jared C.、Mori Takahiro、Miyamoto Kazunori、Coffer Lindsay、Uchiyama Masanobu、Guo Yisong、Chang Wei-chen、Abe Ikuro
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 145 Issue: 44 Pages: 24210-24217
- DOI
  10.1021/jacs.3c08413
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K13847, KAKENHI-PROJECT-23KJ0656, KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-20KK0173, KAKENHI-PLANNED-22H05125, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-22H00320
[Journal Article] Assembling neuroactive alkaloids2023
- Author(s)
  Ushimaru Richiro、Abe Ikuro
- Journal Title
  
  Nature Plants
  
  Volume: 9 Issue: 12 Pages: 1946-1947
- DOI
  10.1038/s41477-023-01586-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K13847, KAKENHI-PROJECT-20KK0173
[Journal Article] Structural and Mechanistic Insights into the C?C Bond-Forming Rearrangement Reaction Catalyzed by Heterodimeric Hinokiresinol Synthase2023
- Author(s)
  Ushimaru Richiro、Ding Yiling、Mori Takahiro、Miyamoto Kazunori、Uchiyama Masanobu、Abe Ikuro
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 145 Issue: 40 Pages: 21966-21973
- DOI
  10.1021/jacs.3c06762
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K13847, KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-20KK0173, KAKENHI-PLANNED-22H05125, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-22H00320
[Journal Article] Diverse enzymatic chemistry for propionate side chain cleavages in tetrapyrrole biosynthesis2023
- Author(s)
  Ushimaru Richiro、Lyu Jiaqi、Abe Ikuro
- Journal Title
  
  Journal of Industrial Microbiology and Biotechnology
  
  Volume: 50 Issue: 1
- DOI
  10.1093/jimb/kuad016
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K13847, KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-22H04922
[Journal Article] Structure-based engineering of α-ketoglutarate dependent oxygenases in fungal meroterpenoid biosynthesis2023
- Author(s)
  Awakawa Takayoshi、Mori Takahiro、Ushimaru Richiro、Abe Ikuro
- Journal Title
  
  Natural Product Reports
  
  Volume: 40 Issue: 1 Pages: 46-61
- DOI
  10.1039/d2np00014h
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-22H05123, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H00490, KAKENHI-PROJECT-21K14744, KAKENHI-PROJECT-23K21363, KAKENHI-PROJECT-23K13847, KAKENHI-PROJECT-20KK0173
[Journal Article] Photoinduced Reductive Dehalogenation of Phenacyl Bromides with Pyridoxal 5′-Phosphate2023
- Author(s)
  Ueno Koki、Ushimaru Richiro、Abe Ikuro
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 71 Issue: 9 Pages: 675-677
- DOI
  10.1248/cpb.c23-00434
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2023-09-01
- Language
  English
- Data Source
  KAKENHI-PROJECT-23K13847
[Journal Article] Multiple C-C Bond Cleavage Reactions Catalyzed by Tolyporphin Tetrapyrrole Biosynthetic Enzymes2023
- Author(s)
  Richiro Ushimaru, Jiaqi Lyu, Meiqi Ling, Ikuro Abe
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 145 Issue: 17 Pages: 9834-9839
- DOI
  10.1021/jacs.3c01993
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14744, KAKENHI-PROJECT-23K13847, KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-22H04922
[Journal Article] C?N and C?S bond formation by cytochrome P450 enzymes2023
- Author(s)
  Ushimaru Richiro、Abe Ikuro
- Journal Title
  
  Trends in Chemistry
  
  Volume: 5 Issue: 7 Pages: 526-536
- DOI
  10.1016/j.trechm.2023.04.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K13847, KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-20KK0173
[Journal Article] Stereoselectivity and Substrate Specificity of the Fe(II)/α-Ketoglutarate-Dependent Oxygenase TqaL2022
- Author(s)
  Tao Hui、Ushimaru Richiro、Awakawa Takayoshi、Mori Takahiro、Uchiyama Masanobu、Abe Ikuro
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 144 Issue: 47 Pages: 21512-21520
- DOI
  10.1021/jacs.2c08116
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-20KK0173, KAKENHI-PLANNED-22H05123, KAKENHI-PLANNED-22H05125, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H00490, KAKENHI-PROJECT-22H00320, KAKENHI-PROJECT-21K14744, KAKENHI-PROJECT-23K21363
[Journal Article] Unusual Dioxygen-Dependent Reactions Catalyzed by Nonheme Iron Enzymes in Natural Product Biosynthesis2022
- Author(s)
  Ushimaru Richiro、Abe Ikuro
- Journal Title
  
  ACS Catalysis
  
  Volume: 13 Issue: 2 Pages: 1045-1076
- DOI
  10.1021/acscatal.2c05247
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00490, KAKENHI-PROJECT-21K14744, KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-20KK0173
[Journal Article] Characterization of Enzymes Catalyzing the Initial Steps of the β-Lactam Tabtoxin Biosynthesis2022
- Author(s)
  Lyu Jiaqi、Ushimaru Richiro、Abe Ikuro
- Journal Title
  
  Organic Letters
  
  Volume: 24 Issue: 18 Pages: 3337-3341
- DOI
  10.1021/acs.orglett.2c00878
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H00490, KAKENHI-PROJECT-21K14744
[Journal Article] Cordycicadins A?D, Antifeedant Polyketides from the Entomopathogenic Fungus <i>Cordyceps cicadae</i> JXCH12022
- Author(s)
  Li Xinyang、Chen He-Ping、Zhou Lin、Fan Jing、Awakawa Takayoshi、Mori Takahiro、Ushimaru Richiro、Abe Ikuro、Liu Ji-Kai
- Journal Title
  
  Organic Letters
  
  Volume: 24 Issue: 47 Pages: 8627-8632
- DOI
  10.1021/acs.orglett.2c03432
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20KK0173, KAKENHI-PLANNED-22H05123, KAKENHI-PROJECT-22H04922, KAKENHI-PROJECT-20H00490, KAKENHI-PROJECT-23K21363
[Journal Article] Stereodivergent Nitrocyclopropane Formation during Biosynthesis of Belactosins and Hormaomycins2021
- Author(s)
  Shimo Shotaro、Ushimaru Richiro、Engelbrecht Alicia、Harada Mei、Miyamoto Kazunori、Kulik Andreas、Uchiyama Masanobu、Kaysser Leonard、Abe Ikuro
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 143 Issue: 44 Pages: 18413-18418
- DOI
  10.1021/jacs.1c10201
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22700, KAKENHI-PROJECT-17H06173, KAKENHI-PROJECT-21K18246, KAKENHI-PROJECT-21K14744, KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20H00490, KAKENHI-PROJECT-20H02720
[Journal Article] Molecular insights into the endoperoxide formation by Fe(II)/α-KG-dependent oxygenase NvfI2021
- Author(s)
  Mori Takahiro、Zhai Rui、Ushimaru Richiro、Matsuda Yudai、Abe Ikuro
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 4417-4417
- DOI
  10.1038/s41467-021-24685-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K15703, KAKENHI-PROJECT-20K22700, KAKENHI-PROJECT-21K14744, KAKENHI-PROJECT-20KK0173, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20H00490
[Journal Article] Studies of lincosamide formation complete the biosynthetic pathway for lincomycin A2020
- Author(s)
  Wang Shao-An、Lin Chia-I、Zhang Jiawei、Ushimaru Richiro、Sasaki Eita、Liu Hung-wen
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 40 Pages: 24794-24801
- DOI
  10.1073/pnas.2009306117
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22700
[Journal Article] Identification of the Enzymes Mediating the Maturation of the Seryl‐tRNA Synthetase Inhibitor SB‐217452 during the Biosynthesis of Albomycins2020
- Author(s)
  Ushimaru Richiro、Chen Zhang、Zhao Houyuan、Fan Po‐hsun、Liu Hung‐wen
- Journal Title
  
  Angewandte Chemie International Edition
  
  Volume: 59 Issue: 9 Pages: 3558-3562
- DOI
  10.1002/anie.201915275
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] Structural and Mechanistic Insights into the C_C Bond Forming Rearrangement Catalyzed by Heterodimeric Hinokiresinol Synthase2024
- Author(s)
  Richiro Ushimaru, Yiling Ding, Takahiro Mori, Ikuro Abe
- Organizer
  Enzyme Mechanisms Conference 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K13847
[Presentation] 天然物生合成酵素の新規触媒機能の探索と反応機構解析2024
- Author(s)
  牛丸理一郎
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K13847
[Presentation] ピリドキサール5'-リン酸を用いたフェナシルブロミドの光誘起還元的脱ハロゲン化反応2024
- Author(s)
  上野幸輝、牛丸理一郎、阿部郁朗
- Organizer
  日本薬学会第144年会
- Data Source
  KAKENHI-PROJECT-23K13847
[Presentation] 天然物生合成におけるラジカル環化酵素の同定と触媒機構解明2023
- Author(s)
  牛丸理一郎
- Organizer
  第69回日本生薬学会年会
- Data Source
  KAKENHI-PROJECT-23K13847
[Presentation] 立体分岐型シクロプロパン化反応を触媒する非ヘム鉄酵素群の同定と解析2023
- Author(s)
  志茂将太朗、森　貴裕、牛丸理一郎、阿部郁朗
- Organizer
  第22回東京大学生命科学シンポジウム
- Data Source
  KAKENHI-PROJECT-23K13847
[Presentation] 藍藻由来薬剤耐性克服剤トリポルフィンの生合成研究2023
- Author(s)
  Jiaqi Lyu、Richiro Ushimaru、Meiqi Ling、Ikuro Abe
- Organizer
  第24回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-23K13847
[Presentation] 酵素機能発掘と合成生物学による次世代型物質生産系の構築2023
- Author(s)
  牛丸理一郎
- Organizer
  予知生合成科学　第2回公開シンポジウム
- Data Source
  KAKENHI-PROJECT-23K13847
[Presentation] Stereochemical control of three-membered ring formation catalyzed by iron-dependent enzymes2023
- Author(s)
  Richiro Ushimaru
- Organizer
  The 143rd Annual Meeting of the Pharmaceutical Society of Japan
- Invited
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] 三員環形成を触媒する非ヘム鉄酵素の機能解析2023
- Author(s)
  牛丸理一郎
- Organizer
  第５６回天然物化学談話会
- Data Source
  KAKENHI-PROJECT-23K13847
[Presentation] 藍藻由来薬剤耐性克服剤トリポルフィンの生合成研究2023
- Author(s)
  呂家斉、牛丸理一郎、凌美_、阿部郁朗
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] 三員環形成を触媒する非ヘム鉄酵素の機能解析2023
- Author(s)
  牛丸理一郎
- Organizer
  酵素応用シンポジウム
- Data Source
  KAKENHI-PROJECT-23K13847
[Presentation] Cyclopropanation by Nonheme Iron Enzymes2023
- Author(s)
  Richiro Ushimaru
- Organizer
  第73回日本錯体化学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K13847
[Presentation] アルボマイシン生合成におけるATP 依存型異性化反応の反応機構解析2023
- Author(s)
  牛丸理一郎、森貴裕、 Ziyang Zheng、 Hung-wen Liu、阿部郁朗
- Organizer
  2023年度（第37回）日本放線菌学会
- Data Source
  KAKENHI-PROJECT-23K13847
[Presentation] Mechanistic Insights into Rearrangement Reaction by Heterodimeric Hinokiresinol Synthase2023
- Author(s)
  Richiro Ushimaru
- Organizer
  第59回植物化学シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K13847
[Presentation] 立体分岐型シクロプロパン化反応を触媒する非ヘム鉄酵素群の同定と解析2023
- Author(s)
  志茂将太朗、森貴裕、牛丸理一郎、阿部郁朗
- Organizer
  日本薬学会第143年会
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] ヒノキレジノール合成酵素が触媒する転位反応の反応機構解析2023
- Author(s)
  牛丸理一郎、丁伊玲、森貴裕、阿部郁朗
- Organizer
  第24回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-23K13847
[Presentation] Characterization of nonheme iron enzymes involved in the biosynthesis of cyclopropane-containing amino acids2022
- Author(s)
  Richiro Ushimaru, Shotaro Shimo, Takahiro Mori, Ikuro Abe
- Organizer
  第３１回金属の関与する生体関連反応シンポジウム
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] Stereodivergent cyclopropanation catalyzed by nonheme iron enzymes2022
- Author(s)
  Richiro Ushimaru, Shotaro Shimo, Takahiro Mori, Ikuro Abe
- Organizer
  Active Enzyme Molecule 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] Stereodivergent cyclopropane formation catalyzed by nonheme iron enzymes2022
- Author(s)
  志茂将太朗、森貴裕、牛丸理一郎、阿部郁朗
- Organizer
  日本-オランダ二国間セミナー
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] 非ヘム鉄酵素が触媒するシクロプロパン化反応の立体化学解析2022
- Author(s)
  志茂将太朗、牛丸理一郎、阿部郁朗
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] 薬用トロパンアルカロイド生合成酵素の反応機構解析2022
- Author(s)
  牛丸理一郎
- Organizer
  日本薬学会第142年会薬用植物化学研究の新展開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] 非ヘム鉄酵素が触媒するシクロプロパン化反応の立体化学解析2022
- Author(s)
  志茂将太朗、牛丸理一郎、阿部郁朗
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] 天然物生合成における新規ラジカル環化酵素の同定と反応機構解明2022
- Author(s)
  牛丸理一郎
- Organizer
  日本化学会第102春季年会若い世代の特別講演会
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] 天然物生合成における新規ラジカル環化酵素の同定と反応機構解明2022
- Author(s)
  牛丸理一郎
- Organizer
  日本化学会第102春季年会若い世代の特別講演会
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] 非ヘム鉄酵素が触媒するシクロプロパン化反応の立体化学解析2022
- Author(s)
  志茂将太朗、牛丸理一郎、阿部郁朗
- Organizer
  日本薬学会第142年会
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] Stereodivergent Nitrocyclopropane Formation during Biosynthesis of Belactosins and Hormaomycins2022
- Author(s)
  Richiro Ushimaru, Shotaro Shimo, Takahiro Mori, Ikuro Abe
- Organizer
  JNU-UTokyo Joint Seminar
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] 藍藻由来テトラピロール天然物の生合成機構解析2022
- Author(s)
  牛丸理一郎、呂家斉、凌美_、阿部郁朗
- Organizer
  日本生薬学会第68回年会
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] 薬用トロパンアルカロイド生合成酵素の反応機構解析2022
- Author(s)
  牛丸理一郎
- Organizer
  日本薬学会第142年会薬用植物化学研究の新展開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] 薬用トロパンアルカロイド生合成酵素の反応機構解析2022
- Author(s)
  牛丸理一郎
- Organizer
  日本薬学会第142年会薬用植物化学研究の新展開シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] 立体分岐型ニトロシクロプロパン化酵素の同定と機能解析2022
- Author(s)
  牛丸理一郎, 志茂将太朗, 森貴裕, 阿部郁朗
- Organizer
  第64回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] 天然物生合成における新規ラジカル環化酵素の同定と反応機構解明2022
- Author(s)
  牛丸理一郎
- Organizer
  日本化学会第102春季年会若い世代の特別講演会
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] 二次代謝産物生合成におけるラジカルS-アデノシルメチオニン酵素による硫黄挿入反応2022
- Author(s)
  牛丸理一郎
- Organizer
  第34回生物無機化学夏季セミナー
- Invited
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] Mechanistic Investigation of the H6H-catalyzed oxidation reactions using substrate analogues2021
- Author(s)
  Richiro Ushimaru, Ri-dao Chen, Xiao Liu, Po-shun Fan, and Hung-wen Liu
- Organizer
  4th European Conference on Natural Products
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] ホルマオマイシンの生合成におけるニトロシクロプロパン環の形成2021
- Author(s)
  志茂将太朗、牛丸理一郎、阿部郁朗
- Organizer
  2021年度(第35回)日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] ホルマオマイシンの生合成におけるニトロシクロプロパン環の形成2021
- Author(s)
  志茂将太朗、牛丸理一郎、阿部郁朗
- Organizer
  2021年度(第35回)日本放線菌学会大会
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] ホルマオマイシンの生合成におけるニトロシクロプロパン環の形成2021
- Author(s)
  志茂将太朗、牛丸理一郎、阿部郁朗
- Organizer
  日本生薬学会第67回年会
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] 薬用トロパンアルカロイド生合成酵素の反応機構解析2021
- Author(s)
  牛丸理一郎
- Organizer
  日本生薬学会第67回年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] Assembly of the Peptidyl Thionucleoside during the Biosynthesis of Albomycins2021
- Author(s)
  Richiro Ushimaru
- Organizer
  The 3nd Lijiang International Forum on Pharmaceutical Sciences
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] Assembly of the Peptidyl Thionucleoside during the Biosynthesis of Albomycins2021
- Author(s)
  Richiro Ushimaru
- Organizer
  The 3nd Lijiang International Forum on Pharmaceutical Sciences
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] Mechanistic Investigation of the H6H-catalyzed oxidation reactions using substrate analogues2021
- Author(s)
  Richiro Ushimaru, Ri-dao Chen, Xiao Liu, Po-shun Fan, and Hung-wen Liu
- Organizer
  4th European Conference on Natural Products
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] チオヌクレオチド天然物の生合成2021
- Author(s)
  牛丸理一郎
- Organizer
  第23回　天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] 薬用トロパンアルカロイド生合成酵素の反応機構解析2021
- Author(s)
  牛丸理一郎
- Organizer
  日本生薬学会第67回年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] ホルマオマイシンを構成する3-(trans-2-ニトロシクロプロピル)アラニンの生合成2021
- Author(s)
  志茂将太朗、牛丸理一郎、阿部郁朗
- Organizer
  第23回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] ホルマオマイシンの生合成におけるニトロシクロプロパン環の形成2021
- Author(s)
  志茂将太朗、牛丸理一郎、阿部郁朗
- Organizer
  日本生薬学会第67回年会
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] ホルマオマイシンの生合成におけるニトロシクロプロパン環の形成2021
- Author(s)
  志茂将太朗、牛丸理一郎、阿部郁朗
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] チオヌクレオチド天然物の生合成2021
- Author(s)
  牛丸理一郎
- Organizer
  第23回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-21K14744
[Presentation] ホルマオマイシンを構成する3-(trans-2-ニトロシクロプロピル)アラニンの生合成2021
- Author(s)
  志茂将太朗、牛丸理一郎、阿部郁朗
- Organizer
  第23回天然薬物の開発と応用シンポジウム
- Data Source
  KAKENHI-PROJECT-20K22700
[Presentation] Albomycin生合成におけるセリルtRNA合成酵素阻害剤SB-217452の形成2020
- Author(s)
  牛丸理一郎、Zhang Chen、Houyuan Zhao、Po-hsun Fan、Hung-wen Liu
- Organizer
  第62回天然有機化合物討論会
- Data Source
  KAKENHI-PROJECT-20K22700

1. Abe Ikuro (40305496)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
2. 淡川孝義 (80609834)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
3. 森貴裕 (60734564)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results

Ushimaru Richiro 牛丸 理一郎

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Co-Researchers

新規リン酸アミド含有天然物の生合成経路の探索と解明Principal Investigator

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酵素的硫黄挿入反応による糖分子リプログラミングPrincipal Investigator

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炭素-硫黄結合形成酵素における鉄硫黄クラスターの硫黄供与機能と再構築機構の解明Principal Investigator

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薬用天然物の複雑骨格構築を担う新奇生合成酵素を用いた革新的次世代型天然物創薬

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微生物由来メチル基転移酵素阻害剤の生合成機構解明と物質生産への応用Principal Investigator

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酵素機能発掘と合成生物学による次世代型物質生産系の構築

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Mechanistic studies on nonheme iron enzymes catalyzing cyclopropanationPrincipal Investigator

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Investigation into the heteroatom incorporation into nucleoside natural productsPrincipal Investigator

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Survey for new drug discovery resources and exploration & elucidation of novel natural product biosynthetic machineries

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Structure-function studies of enzymes involved in natural product biosynthesis for drug discovery

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[Journal Article] Characterization of Aziridine-Forming α-Ketoglutarate-Dependent Oxygenase in L-Isovaline Biosynthesis2024

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[Journal Article] Unusual Enzymatic C–C Bond Formation and Cleavage Reactions during Natural Product Biosynthesis2024

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[Journal Article] Back-to-back cycloadditions in nature2023

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Ushimaru Richiro 牛丸理一郎