Kasashima Hiroaki 笠島裕明

Researcher Number	10899678
Other IDs
Affiliation (Current)	2025: 大阪公立大学, 大学院医学研究科, 講師
Affiliation (based on the past Project Information) *help	2022 – 2025: 大阪公立大学, 大学院医学研究科, 病院講師 2021: 大阪市立大学, 大学院医学研究科, 研究員
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related Except Principal Investigator Basic Section 55020:Digestive surgery-related
Keywords	Principal Investigator 抗原提示細胞 / 免疫療法 / 大腸癌 / 線維芽細胞 Except Principal Investigator 抗原提示 / 線維芽細胞 / 微小環境 / 腫瘍免疫 / 食道癌 / 大腸癌 … More / 炎症性腸疾患 / プロスタグランジン / 炎症性発癌 / 癌微小環境 / コンパニオン診断薬 / CXCL1抗体療法 / 癌関連線維芽細胞 / スキルス胃癌 Less

食道癌微小環境における抗原提示性癌関連線維芽細胞に着目した腫瘍免疫制御機構の解明
- Principal Investigator
  
  豊川貴弘
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka Metropolitan University
Development of companion tools for CXCL1 signaling target therapy against CAF in scirrhous gastric carcinoma
- Principal Investigator
  
  八代正和
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka Metropolitan University
抗原提示性癌関連線維芽細胞の起源に着目した大腸癌腫瘍免疫制御機構の解明Principal Investigator
- Principal Investigator
  
  笠島裕明
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka Metropolitan University
Elucidation of Prostaglandin D Receptor-mediated Carcinogenesis Mechanism of Colitic Cancer
- Principal Investigator
  
  福岡達成
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka Metropolitan University
The role of antigen-presenting CAF for tumor progression in CRCPrincipal Investigator
- Principal Investigator
  
  Kasashima Hiroaki
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Osaka Metropolitan University
  Osaka City University

All 2024 2023 2022

All Journal Article Presentation

[Journal Article] D3 lymph node dissection using intracorporeal ultrasound for robotic right hemicolectomy ? a video vignette2024
- Author(s)
  Fukuoka Tatsunari、Kasashima Hiroaki、Kitayama Kishu、Iseki Yasuhito、Shibutani Masatsune、Maeda Kiyoshi
- Journal Title
  
  Colorectal Disease
  
  Volume: - Issue: 7 Pages: 1463-1464
- DOI
  10.1111/codi.16988
- Data Source
  KAKENHI-PROJECT-23K15480
[Journal Article] An Improvement of Exertional Dyspnea by the Reintroduction of Anti-EGFR Antibody in Patients with Metastatic Rectal Cancer Who Developed Cancerous Lymphangiopathy: A Case Report2024
- Author(s)
  Shibutani Masatsune、Tanda Hideki、Fukuoka Tatsunari、Kasashima Hiroaki、Kashiwagi Shinichiro、Maeda Kiyoshi
- Journal Title
  
  Case Reports in Oncology
  
  Volume: - Issue: 1 Pages: 511-516
- DOI
  10.1159/000538235
- Data Source
  KAKENHI-PROJECT-23K15480
[Journal Article] An 8-mm port site hernia after robotic-assisted ileocecal resection: a case report2024
- Author(s)
  Ahn Changgi、Shibutani Masatsune、Kitayama Kishu、Kasashima Hiroaki、Miki Yuichiro、Yoshii Mami、Fukuoka Tatsunari、Tamura Tatsuro、Toyokawa Takahiro、Lee Shigeru、Maeda Kiyoshi
- Journal Title
  
  Surgical Case Reports
  
  Volume: 10 Issue: 1
- DOI
  10.1186/s40792-024-01878-x
- Data Source
  KAKENHI-PROJECT-23K15480
[Journal Article] Stromal area differences with epithelial-mesenchymal transition gene changes in conjunctival and orbital mucosa-associated lymphoid tissue lymphoma2024
- Author(s)
  Tagami Mizuki、Kasashima Hiroaki、Kakehashi Anna、Yoshikawa Atsuko、Nishio Mizuho、Misawa Norihiko、Sakai Atsushi、Wanibuchi Hideki、Yashiro Masakazu、Azumi Atsushi、Honda Shigeru
- Journal Title
  
  Frontiers in Oncology
  
  Volume: 14
- DOI
  10.3389/fonc.2024.1277749
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K15480, KAKENHI-PROJECT-23KK0148, KAKENHI-PROJECT-22K07665, KAKENHI-PROJECT-23K09013
[Journal Article] Optimal extent of lymph node dissection for high‐risk gastric cancer stratified by a national clinical database risk calculator2024
- Author(s)
  Kuroda Kenji、Miki Yuichiro、Kasashima Hiroaki、Yoshii Mami、Fukuoka Tatsunari、Tamura Tatsuro、Shibutani Masatsune、Toyokawa Takahiro、Lee Shigeru、Maeda Kiyoshi
- Journal Title
  
  World Journal of Surgery
  
  Volume: - Issue: 5 Pages: 1198-1208
- DOI
  10.1002/wjs.12117
- Data Source
  KAKENHI-PROJECT-23K15480
[Journal Article] Prognostic significance of connective tissue growth factor expression in stromal cells in patients with diffuse type gastric cancer2024
- Author(s)
  Yuichiro Miki, Mami Yoshii, Ryoko Miyauchi, Hiroaki Kasashima, Tatsunari Fukuoka, Tatsuro Tamura, Masatsune Shibutani, Takahiro Toyokawa, Shigeru Lee, Masakazu Yashiro, Kiyoshi Maeda
- Journal Title
  
  Oncology Letters
  
  Volume: 27 (6) Issue: 6 Pages: 241-241
- DOI
  10.3892/ol.2024.14374
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17625, KAKENHI-PROJECT-23K15480
[Journal Article] Effects of an artificial pancreas on postoperative inflammation in patients with esophageal cancer2024
- Author(s)
  Miyauchi Ryoko、Miki Yuichiro、Kasashima Hiroaki、Fukuoka Tatsunari、Yoshii Mami、Tamura Tatsuro、Shibutani Masatsune、Toyokawa Takahiro、Lee Shigeru、Maeda Kiyoshi
- Journal Title
  
  BMC Surgery
  
  Volume: 24 Issue: 1
- DOI
  10.1186/s12893-024-02365-8
- Data Source
  KAKENHI-PROJECT-23K15480
[Journal Article] Predictive value of the Naples prognostic score on postoperative outcomes in patients with rectal cancer2023
- Author(s)
  Sugimoto Atsushi、Fukuoka Tatsunari、Nagahara Hisashi、Shibutani Masatsune、Iseki Yasuhito、Kasashima Hiroaki、Sasaki Maho、Ohira Masaichi、Maeda Kiyoshi
- Journal Title
  
  Langenbeck's Archives of Surgery
  
  Volume: 408 Issue: 1 Pages: 113-113
- DOI
  10.1007/s00423-023-02851-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16540, KAKENHI-PROJECT-21K16428
[Journal Article] The Effect of Bidirectional Barbed Sutures on the Duration of Common Enterotomy Closure in Intracorporeal Anastomosis2023
- Author(s)
  SHIBUTANI MASATSUNE、TANDA HIDEKI、FUKUOKA TATSUNARI、KASASHIMA HIROAKI、MAEDA KIYOSHI
- Journal Title
  
  In Vivo
  
  Volume: 38 Issue: 1 Pages: 122-126
- DOI
  10.21873/invivo.13418
- Data Source
  KAKENHI-PROJECT-23K15480
[Journal Article] THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer2023
- Author(s)
  Omatsu Mayuki、Nakanishi Yuki、Kasashima Hiroaki、et al.
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1 Pages: 5534-5534
- DOI
  10.1038/s41467-023-41095-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15480, KAKENHI-PROJECT-22K08504, KAKENHI-PROJECT-21K19480, KAKENHI-PROJECT-22K19458, KAKENHI-PROJECT-21K15948, KAKENHI-PROJECT-22KJ2230, KAKENHI-PROJECT-22KJ2232, KAKENHI-PROJECT-20H05697, KAKENHI-PROJECT-21H04807, KAKENHI-PROJECT-23K27582
[Journal Article] The Significance of the D-Dimer Level as a Prognostic Marker for Survival and Treatment Outcomes in Patients With Stage IV Colorectal Cancer2023
- Author(s)
  SHIBUTANI MASATSUNE、KASHIWAGI SHINICHIRO、FUKUOKA TATSUNARI、ISEKI YASUHITO、KASASHIMA HIROAKI、MAEDA KIYOSHI
- Journal Title
  
  In Vivo
  
  Volume: 37 Issue: 1 Pages: 440-444
- DOI
  10.21873/invivo.13097
- Data Source
  KAKENHI-PROJECT-21K16428
[Journal Article] Prognostic significance of the Naples prognostic score in colorectal cancer patients undergoing curative resection: a propensity score matching analysis2023
- Author(s)
  Sugimoto Atsushi、Fukuoka Tatsunari、Shibutani Masatsune、Kasashima Hiroaki、Kitayama Kishu、Ohira Masaichi、Maeda Kiyoshi
- Journal Title
  
  BMC Gastroenterology
  
  Volume: 23 Issue: 1 Pages: 88-88
- DOI
  10.1186/s12876-023-02722-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16540, KAKENHI-PROJECT-21K16428
[Journal Article] Two families with gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): case reports and literature review2023
- Author(s)
  Sakuma Takashi、Sera Tomohiro、Aoyama Rika、Sawada Akinari、Kasashima Hiroaki、Ogisawa Kana、Bamba Haruka、Yashiro Masakazu
- Journal Title
  
  Journal of Gastrointestinal Oncology
  
  Volume: 14 Issue: 6 Pages: 2650-2657
- DOI
  10.21037/jgo-23-564
- Data Source
  KAKENHI-PROJECT-23K15480
[Journal Article] Enhanced SREBP2-driven cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis2023
- Author(s)
  Muta Yu、Linares Juan F.、Martinez-Ordonez Anxo、Duran Angeles、Cid-Diaz Tania、Kinoshita Hiroto、Zhang Xiao、Han Qixiu、Nakanishi Yuki、Nakanishi Naoko、Cordes Thekla、Arora Gurpreet K.、Ruiz-Martinez Marc、Reina-Campos Miguel、Kasashima Hiroaki、et al.
- Journal Title
  
  Nature Communications
  
  Volume: 14 Issue: 1
- DOI
  10.1038/s41467-023-43690-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15480, KAKENHI-PROJECT-22KJ2230
[Journal Article] Usefulness of intraoperative ultrasound examination for laparoscopic right-side colon cancer surgery: a propensity score-matched study2023
- Author(s)
  Kasashima Hiroaki、Fukuoka Tatsunari、Tsujio Gen、Sugimoto Atsushi、Yonemitsu Ken、Kitayama Kisyu、Iseki Yasuhito、Shibutani Masatsune、Maeda Kiyoshi
- Journal Title
  
  Scientific Reports
  
  Volume: 13 Issue: 1 Pages: 22440-22440
- DOI
  10.1038/s41598-023-49867-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K16540, KAKENHI-PROJECT-23K15480
[Journal Article] Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer2023
- Author(s)
  Martinez-Ordonez A, Duran A, Ruiz-Martinez M, Cid-Diaz T, Zhang X, Han Q, Kinoshita H, Muta Y, Linares JF, Kasashima H, Nakanishi Y, Omar M, Nishimura S, Avila L, Yashiro M, Maeda K, Pannellini T, Pigazzi A, Inghirami G, Marchionni L, Sigal D, Diaz-Meco MT, Moscat J.
- Journal Title
  
  Cancer Cell
  
  Volume: 41 Issue: 2 Pages: 252-271
- DOI
  10.1016/j.ccell.2022.11.016
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KJ2230, KAKENHI-PROJECT-21K16428, KAKENHI-PROJECT-23K15480, KAKENHI-PROJECT-21H03008, KAKENHI-PROJECT-23K21432
[Journal Article] The heterogeneity of cancer‐associated fibroblast subpopulations: Their origins, biomarkers, and roles in the tumor microenvironment2022
- Author(s)
  Yamamoto Yurie、Kasashima Hiroaki、Fukui Yasuhiro、Tsujio Gen、Yashiro Masakazu、Maeda Kiyoshi
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 1 Pages: 16-24
- DOI
  10.1111/cas.15609
- Data Source
  KAKENHI-PROJECT-21K16428
[Presentation] Characteristics of cancer associated fibroblasts isolated from refractory colorectal cancer using RNA sequence2024
- Author(s)
  Hiroaki Kasashima, Yasuhiro Fukui, et al.
- Organizer
  AACR Annual Meeting 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15480
[Presentation] Analysis for the role of antigen-presenting cancer-associated fibroblasts in tumor microenvironment of colorectal cancer2024
- Author(s)
  Yasuhiro Fukui, Hiroaki Kasashima, et al.
- Organizer
  AACR Annual Meeting 2024
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15480
[Presentation] The identification of cancer-associated fibroblast subpoputation with antigen-presentation modulating tumor-immune microenvironment in colorectal cancer2023
- Author(s)
  笠島裕明、福井康裕、他
- Organizer
  JDDW2023シンポジウム
- Data Source
  KAKENHI-PROJECT-23K15480
[Presentation] シングルセルRNAseq解析を用いた腫瘍免疫へ影響を及ぼす癌関連線維芽細胞亜集団の同定と大腸癌免疫療法への応用2023
- Author(s)
  笠島裕明、福井康裕、他
- Organizer
  第 123 回日本外科学会定期学術集会シンポジウム
- Data Source
  KAKENHI-PROJECT-23K15480
[Presentation] The role of antigen-presenting CAFs for tumor-related immune microenvironment in colon cancer2022
- Author(s)
  Hiroaki Kasashima, Kisyu Kitayama, Yuichiro Miki, Mami Yoshii, Tatsunari Fukuoka, Tatsuro Tamura, Masatsune Shibutani, Takahiro Toyokawa, Hiroaki Tanaka, Shigeru Ree, Masakazu Yashiro, Kiyoshi Maeda
- Organizer
  第81回日本癌学会
- Data Source
  KAKENHI-PROJECT-21K16428
[Presentation] 大腸癌同所移植モデルと single-cell RNA sequence を用いた癌関連線維芽細胞が及ぼす腫瘍免疫への影響の解析2022
- Author(s)
  笠島裕明福岡達成渋谷雅常田中浩明八代正和前田清
- Organizer
  第43回癌免疫外科研究会
- Data Source
  KAKENHI-PROJECT-21K16428

1. 八代正和 (60305638)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. 福岡達成 (50793783)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 山本百合恵 (30909924)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 豊川貴弘 (40382105)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 杉本敦史

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
6. 三木友一朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kasashima Hiroaki 笠島 裕明

Research Projects

Research Products

Co-Researchers

食道癌微小環境における抗原提示性癌関連線維芽細胞に着目した腫瘍免疫制御機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of companion tools for CXCL1 signaling target therapy against CAF in scirrhous gastric carcinoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

抗原提示性癌関連線維芽細胞の起源に着目した大腸癌腫瘍免疫制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of Prostaglandin D Receptor-mediated Carcinogenesis Mechanism of Colitic Cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of antigen-presenting CAF for tumor progression in CRCPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] D3 lymph node dissection using intracorporeal ultrasound for robotic right hemicolectomy ? a video vignette2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An Improvement of Exertional Dyspnea by the Reintroduction of Anti-EGFR Antibody in Patients with Metastatic Rectal Cancer Who Developed Cancerous Lymphangiopathy: A Case Report2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An 8-mm port site hernia after robotic-assisted ileocecal resection: a case report2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Stromal area differences with epithelial-mesenchymal transition gene changes in conjunctival and orbital mucosa-associated lymphoid tissue lymphoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Optimal extent of lymph node dissection for high‐risk gastric cancer stratified by a national clinical database risk calculator2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prognostic significance of connective tissue growth factor expression in stromal cells in patients with diffuse type gastric cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effects of an artificial pancreas on postoperative inflammation in patients with esophageal cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Predictive value of the Naples prognostic score on postoperative outcomes in patients with rectal cancer2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The Effect of Bidirectional Barbed Sutures on the Duration of Common Enterotomy Closure in Intracorporeal Anastomosis2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer2023

Kasashima Hiroaki 笠島裕明

[Presentation] シングルセルRNAseq解析を用いた腫瘍免疫へ影響を及ぼす癌関連線維芽細胞亜集団の同定と大腸癌免疫療法への応用2023

[Presentation] 大腸癌同所移植モデルと single-cell RNA sequence を用いた癌関連線維芽細胞が及ぼす腫瘍免疫への影響の解析2022