Murai Yasuhisa 村井康久

Researcher Number	10910458
Other IDs	https://orcid.org/0000-0002-3305-1248
Affiliation (Current)	2024: 弘前大学, 医学研究科, 客員研究員
Affiliation (based on the past Project Information) *help	2022 – 2023: 弘前大学, 医学研究科, 客員研究員 2021: 弘前大学, 医学研究科, 助手
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / 0902:General internal medicine and related fields
Keywords	Principal Investigator 潰瘍性大腸炎 / Schlafen11 / IBD / ulcerative colitis / バイオマーカー / 腫瘍生物学 / SLFN11 / 炎症性腸疾患

Expression mechanism of Schlafen11 in ulcerative colitis and its usefulness as a biomarkerPrincipal Investigator
- Principal Investigator
  
  村井康久
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hirosaki University
炎症性腸疾患の難治化における抗癌剤感受遺伝子Schlafen11の臨床的意義Principal Investigator
- Principal Investigator
  
  村井康久
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0902:General internal medicine and related fields
- Research Institution
  Hirosaki University

All 2024 2023 2022 2021

All Journal Article Presentation

[Journal Article] Schlafen 11 (SLFN11) Kills Cancer Cells Undergoing Unscheduled Re-replication2023
- Author(s)
  Murai Junko、Ceribelli Michele、Fu Haiqing、Redon Christophe E.、Jo Ukhyun、Murai Yasuhisa、Aladjem Mirit I.、Thomas Craig J.、Pommier Yves
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 22 Issue: 8 Pages: 985-995
- DOI
  10.1158/1535-7163.mct-22-0552
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K15029, KAKENHI-PROJECT-21K20887
[Journal Article] TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor2022
- Author(s)
  Jo Ukhyun、Murai Yasuhisa、Agama Keli K.、Sun Yilun、Saha Liton Kumar、Yang Xi、Arakawa Yasuhiro、Gayle Sophia、Jones Kelli、Paralkar Vishwas、Sundaram Ranjini K.、Van Doorn Jinny、Vasquez Juan C.、Bindra Ranjit S.、Choi Woo Suk、Pommier Yves
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 21 Issue: 7 Pages: 1090-1102
- DOI
  10.1158/1535-7163.mct-21-1000
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20887
[Journal Article] SLFN11’s surveillance role in protein homeostasis2022
- Author(s)
  Murai Yasuhisa、Jo Ukhyun、Arakawa Yasuhiro、Takebe Naoko、Pommier Yves
- Journal Title
  
  Oncoscience
  
  Volume: 9 Pages: 35-37
- DOI
  10.18632/oncoscience.560
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20887
[Journal Article] Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1?DNA complexes2021
- Author(s)
  Saha Liton Kumar、Murai Yasuhisa、Saha Sourav、Jo Ukhyun、Tsuda Masataka、Takeda Shunichi、Pommier Yves
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 49 Issue: 18 Pages: 10493-10506
- DOI
  10.1093/nar/gkab777
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20887
[Journal Article] Precision Oncology with Drugs Targeting the Replication Stress, ATR, and Schlafen 112021
- Author(s)
  Jo Ukhyun、Murai Yasuhisa、Takebe Naoko、Thomas Anish、Pommier Yves
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 18 Pages: 4601-4601
- DOI
  10.3390/cancers13184601
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20887
[Journal Article] Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway2021
- Author(s)
  Murai Yasuhisa、Jo Ukhyun、Murai Junko、Fukuda Shinsaku、Takebe Naoko、Pommier Yves
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 10 Pages: 103173-103173
- DOI
  10.1016/j.isci.2021.103173
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03505, KAKENHI-PROJECT-21K20887
[Journal Article] Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents2021
- Author(s)
  Jo Ukhyun、Senatorov Ilya S.、Zimmermann Astrid、Saha Liton Kumar、Murai Yasuhisa、Kim Se Hyun、Rajapakse Vinodh N.、Elloumi Fathi、Takahashi Nobuyuki、Schultz Christopher W.、Thomas Anish、Zenke Frank T.、Pommier Yves
- Journal Title
  
  Molecular Cancer Therapeutics
  
  Volume: 20 Issue: 8 Pages: 1431-1441
- DOI
  10.1158/1535-7163.mct-20-1026
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20887
[Journal Article] SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-2432021
- Author(s)
  Murai Yasuhisa、Jo Ukhyun、Murai Junko、Jenkins Lisa M.、Huang Shar-Yin N.、Chakka Sirisha、Chen Lu、Cheng Ken、Fukuda Shinsaku、Takebe Naoko、Pommier Yves
- Journal Title
  
  Cancer Research
  
  Volume: 81 Issue: 11 Pages: 3067-3078
- DOI
  10.1158/0008-5472.can-20-2694
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03505, KAKENHI-PROJECT-21K20887
[Presentation] 潰瘍性大腸炎の難治化におけるSchlafen11発現の臨床的意義2024
- Author(s)
  村井康久
- Organizer
  第161回弘前医学会例会
- Data Source
  KAKENHI-PROJECT-21K20887
[Presentation] 潰瘍性大腸炎の難治化におけるSchlafen11発現の臨床的意義2024
- Author(s)
  村井康久
- Organizer
  第161回弘前医学会例会
- Data Source
  KAKENHI-PROJECT-23K15029
[Presentation] Schlafen11 is a potential biomarker for mucosal residual inflammation and a target for JAK inhibitor therapy.2022
- Author(s)
  Yasuhisa Murai, Hirotake Sakuraba, Hiroto Hiraga, Keisuke Hasui, Shukuko Yoshida, Hidezumi Kikuchi, Kohei Ogasawara, Naoki Higuchi, Yohei Sawada, Tetsuya Tatsuta, Shogo Kawaguchi, Yui Akemoto, Daisuke Chinda, Tatsuya Mikami, Akira Kurose, Shinsaku Fukuda
- Organizer
  The 10th Annual Meeting of Asian Organization for Crohn’s & Colitis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K20887
[Presentation] 潰瘍性大腸炎の難治化における Schlafen11発現の臨床的意義2022
- Author(s)
  村井康久, 櫻庭裕丈, 平賀寛人, 蓮井桂介, 吉田淑子, 菊池英純, 小笠原公平, 樋口直樹, 澤田洋平, 立田哲也, 川口章吾, 明本由衣, 珍田大輔, 黒瀬顕, 福田眞作
- Organizer
  第59回日本消化器免疫学会総会
- Data Source
  KAKENHI-PROJECT-21K20887
[Presentation] SLFN11の小胞体ストレスと異常タンパク応答抑制機能とSLFN11陰性腫瘍に対する新たな治療戦略への期待2021
- Author(s)
  村井　康久, Ukhyun Jo, 村井　純子, Lisa M. Jenkins, Shar-Yin N. Huang, Sirisha Chakka, Lu Chen, Ken Cheng, 櫻庭　裕丈, 福田　眞作, Naoko Takebe, Yves Pommier
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K20887

1. 村井純子

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Murai Yasuhisa 村井 康久

Research Projects

Research Products

Co-Researchers

Expression mechanism of Schlafen11 in ulcerative colitis and its usefulness as a biomarkerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

炎症性腸疾患の難治化における抗癌剤感受遺伝子Schlafen11の臨床的意義Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Schlafen 11 (SLFN11) Kills Cancer Cells Undergoing Unscheduled Re-replication2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TOP1-DNA Trapping by Exatecan and Combination Therapy with ATR Inhibitor2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SLFN11’s surveillance role in protein homeostasis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Replication-dependent cytotoxicity and Spartan-mediated repair of trapped PARP1?DNA complexes2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Precision Oncology with Drugs Targeting the Replication Stress, ATR, and Schlafen 112021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Schlafen 11 expression in human acute leukemia cells with gain-of-function mutations in the interferon-JAK signaling pathway2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Novel and Highly Potent ATR Inhibitor M4344 Kills Cancer Cells With Replication Stress, and Enhances the Chemotherapeutic Activity of Widely Used DNA Damaging Agents2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] SLFN11 Inactivation Induces Proteotoxic Stress and Sensitizes Cancer Cells to Ubiquitin Activating Enzyme Inhibitor TAK-2432021

Author(s)

Journal Title

DOI

Data Source

[Presentation] 潰瘍性大腸炎の難治化におけるSchlafen11発現の臨床的意義2024

Author(s)

Organizer

Data Source

[Presentation] 潰瘍性大腸炎の難治化におけるSchlafen11発現の臨床的意義2024

Author(s)

Organizer

Data Source

[Presentation] Schlafen11 is a potential biomarker for mucosal residual inflammation and a target for JAK inhibitor therapy.2022

Author(s)

Organizer

Data Source

[Presentation] 潰瘍性大腸炎の難治化における Schlafen11発現の臨床的意義2022

Author(s)

Organizer

Data Source

[Presentation] SLFN11の小胞体ストレスと異常タンパク応答抑制機能とSLFN11陰性腫瘍に対する新たな治療戦略への期待2021

Author(s)

Organizer

Data Source

Murai Yasuhisa 村井康久